| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 300,000 | 562,120 | +262,120 | 0.44 | 1.29 | +0.85 | buy |
| Lynx1 Capital Management LP | 5,291,929 | 5,404,674 | +112,745 | 12.60 | 17.72 | +5.12 | buy |
| Susquehanna Portfolio Strategies, LLC | 14,750 | 126,350 | +111,600 | 0.04 | 0.03 | -0.01 | buy |
| MPM BioImpact LLC | 693,988 | 789,698 | +95,710 | 0.79 | 1.55 | +0.76 | buy |
| DAFNA Capital Management LLC | 443,998 | 501,972 | +57,974 | 0.84 | 1.57 | +0.74 | buy |
| GILDER GAGNON HOWE & CO LLC | 105,817 | 129,571 | +23,754 | 0.01 | 0.02 | +0.01 | buy |
| Kennondale Capital Management LLC | 42,100 | 61,183 | +19,083 | 0.31 | 0.71 | +0.40 | buy |
| ALPS ADVISORS INC | 39,890 | 29,430 | +10,460 | 0.00 | 0.00 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 10,624 | 10,966 | +342 | 0.01 | 0.01 | +0.01 | buy |
| Fort Point Capital Partners LLC | 75,429 | 75,434 | +5 | 0.06 | 0.06 | +0.01 | buy |
| Birchview Capital, LP | 210,005 | 210,000 | -5 | 1.21 | 2.37 | +1.15 | sell |
| PROFUND ADVISORS LLC | 12,882 | 10,986 | -1,896 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 30,085 | 27,285 | -2,800 | 0.04 | 0.05 | +0.01 | sell |
| Virtus Investment Advisers, LLC | 13,323 | 7,955 | -5,368 | 0.02 | 0.03 | +0.01 | sell |
| Rafferty Asset Management, LLC | 61,706 | 51,458 | -10,248 | 0.00 | 0.00 | +0.00 | sell |
| Redmile Group, LLC | 4,485,981 | 4,375,931 | -110,050 | 2.82 | 5.29 | +2.47 | sell |
| Granahan Investment Management, LLC | 660,430 | 532,413 | -128,017 | 0.22 | 0.25 | +0.03 | sell |
| Skorpios Trust | 6,906,181 | 3,256,181 | -3,650,000 | 99.70 | 99.62 | -0.08 | sell |