| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 2,541,937 | 7,412,982 | +4,871,045 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 5,862,436 | 5,924,567 | +62,131 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 5,291,929 | 5,404,674 | +112,745 | 12.60 | 17.72 | +5.12 | buy |
| RTW INVESTMENTS, LP | 5,123,525 | 5,123,525 | 0 | 0.52 | 0.83 | +0.31 | hold |
| BAKER BROS. ADVISORS LP | 4,633,838 | 4,633,838 | 0 | 0.34 | 0.51 | +0.17 | hold |
| Redmile Group, LLC | 4,485,981 | 4,375,931 | -110,050 | 2.82 | 5.29 | +2.47 | sell |
| MORGAN STANLEY | 3,590,825 | 3,573,976 | -16,849 | 0.00 | 0.00 | +0.00 | sell |
| Skorpios Trust | 6,906,181 | 3,256,181 | -3,650,000 | 99.70 | 99.62 | -0.08 | sell |
| TORONTO DOMINION BANK | 3,173,258 | 3,173,258 | 0 | 0.05 | 0.08 | +0.02 | hold |
| VANGUARD GROUP INC | 2,784,202 | 2,946,258 | +162,056 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 2,131,783 | 2,300,554 | +168,771 | 0.02 | 0.03 | +0.01 | buy |
| Siren, L.L.C. | 2,247,347 | 2,247,347 | 0 | 0.84 | 1.32 | +0.48 | hold |
| STATE STREET CORP | 1,575,283 | 1,487,156 | -88,127 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,662,039 | 1,301,381 | -360,658 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 901,986 | 972,921 | +70,935 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 0 | 883,646 | +883,646 | 0.00 | 0.05 | +0.05 | buy |
| MPM BioImpact LLC | 693,988 | 789,698 | +95,710 | 0.79 | 1.55 | +0.76 | buy |
| DIMENSIONAL FUND ADVISORS LP | 664,735 | 673,884 | +9,149 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 659,834 | +659,834 | 0.00 | 0.01 | +0.01 | buy |
| Opaleye Management Inc. | 300,000 | 562,120 | +262,120 | 0.44 | 1.29 | +0.85 | buy |
| BANK OF AMERICA CORP /DE/ | 532,884 | 548,090 | +15,206 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 959,603 | 537,973 | -421,630 | 0.01 | 0.01 | -0.00 | sell |
| Granahan Investment Management, LLC | 660,430 | 532,413 | -128,017 | 0.22 | 0.25 | +0.03 | sell |
| DAFNA Capital Management LLC | 443,998 | 501,972 | +57,974 | 0.84 | 1.57 | +0.74 | buy |
| TANG CAPITAL MANAGEMENT LLC | 500,000 | 500,000 | 0 | 0.18 | 0.29 | +0.10 | hold |
| NORTHERN TRUST CORP | 346,664 | 423,554 | +76,890 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 396,000 | 396,000 | 0 | 0.03 | 0.04 | +0.00 | hold |
| UBS Group AG | 171,831 | 352,715 | +180,884 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 310,307 | 340,779 | +30,472 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 254,161 | 254,161 | 0 | 0.13 | 0.21 | +0.09 | hold |
| Birchview Capital, LP | 210,005 | 210,000 | -5 | 1.21 | 2.37 | +1.15 | sell |
| Schonfeld Strategic Advisors LLC | 335,360 | 174,714 | -160,646 | 0.01 | 0.01 | -0.00 | sell |
| ROYAL BANK OF CANADA | 0 | 144,064 | +144,064 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 68,361 | 139,900 | +71,539 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 135,960 | 137,066 | +1,106 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 105,817 | 129,571 | +23,754 | 0.01 | 0.02 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 14,750 | 126,350 | +111,600 | 0.04 | 0.03 | -0.01 | buy |
| Palo Alto Investors LP | 125,861 | 125,861 | 0 | 0.16 | 0.30 | +0.14 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 357,248 | 123,482 | -233,766 | 0.01 | 0.01 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 82,802 | 107,240 | +24,438 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 89,985 | 103,773 | +13,788 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 107,562 | 103,244 | -4,318 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 108,087 | 102,468 | -5,619 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 95,120 | 95,120 | 0 | 0.00 | 0.01 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 22,314 | 81,395 | +59,081 | 0.00 | 0.00 | +0.00 | buy |
| Fort Point Capital Partners LLC | 75,429 | 75,434 | +5 | 0.06 | 0.09 | +0.03 | buy |
| RHUMBLINE ADVISERS | 49,599 | 66,419 | +16,820 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 67,300 | 62,000 | -5,300 | 0.00 | 0.00 | +0.00 | sell |
| Kennondale Capital Management LLC | 42,100 | 61,183 | +19,083 | 0.31 | 0.71 | +0.40 | buy |
| AQR CAPITAL MANAGEMENT LLC | 12,847 | 54,818 | +41,971 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,167 | 53,411 | +29,244 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 61,706 | 51,458 | -10,248 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 103,779 | 51,238 | -52,541 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 12,598 | 44,215 | +31,617 | 0.00 | 0.00 | +0.00 | buy |
| AVIVA PLC | 0 | 43,955 | +43,955 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 39,098 | 43,735 | +4,637 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,630 | 40,630 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 26,183 | 40,207 | +14,024 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 38,839 | +38,839 | 0.00 | 0.03 | +0.03 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 35,404 | +35,404 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 37,606 | 34,798 | -2,808 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 34,743 | +34,743 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 33,276 | +33,276 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,068 | 32,068 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 35,347 | 31,077 | -4,270 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 30,696 | +30,696 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 39,890 | 29,430 | -10,460 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 0 | 27,339 | +27,339 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 30,085 | 27,285 | -2,800 | 0.04 | 0.05 | +0.01 | sell |
| CITIGROUP INC | 74,620 | 26,230 | -48,390 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 20,257 | 25,655 | +5,398 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 20,254 | 23,863 | +3,609 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 23,458 | +23,458 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 17,680 | 23,005 | +5,325 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 21,055 | +21,055 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 19,620 | 20,396 | +776 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 25,566 | 20,303 | -5,263 | 0.00 | 0.00 | +0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 19,715 | +19,715 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Quantitative Investments LLC | 0 | 19,300 | +19,300 | 0.00 | 0.06 | +0.06 | buy |
| JANUS HENDERSON GROUP PLC | 18,900 | 18,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 22,334 | 18,217 | -4,117 | 0.00 | 0.00 | +0.00 | sell |
| Advantage Alpha Capital Partners LP | 0 | 17,888 | +17,888 | 0.00 | 0.05 | +0.05 | buy |
| Russell Investments Group, Ltd. | 16,119 | 15,750 | -369 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,237 | 15,099 | +1,862 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 13,832 | +13,832 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 5,700 | 13,200 | +7,500 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 11,283 | +11,283 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 23,643 | 11,099 | -12,544 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 12,882 | 10,986 | -1,896 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 10,624 | 10,966 | +342 | 0.01 | 0.01 | +0.01 | buy |
| Dorsey & Whitney Trust CO LLC | 10,815 | 10,815 | 0 | 0.00 | 0.01 | +0.00 | hold |
| CANADA LIFE ASSURANCE Co | 10,889 | 10,665 | -224 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,635 | 10,635 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ProShare Advisors LLC | 10,164 | 10,444 | +280 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 7,174 | 9,558 | +2,384 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,129 | 9,129 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Virtus Investment Advisers, LLC | 13,323 | 7,955 | -5,368 | 0.02 | 0.03 | +0.01 | sell |
| OSAIC HOLDINGS, INC. | 0 | 7,488 | +7,488 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 10,832 | 6,293 | -4,539 | 0.01 | 0.01 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 779 | 4,370 | +3,591 | 0.00 | 0.00 | +0.00 | buy |