| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 5,385,714 | 5,877,357 | +491,643 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 5,623,525 | 5,623,525 | 0 | 1.82 | 1.57 | -0.25 | hold |
| FMR LLC | 5,383,666 | 5,313,100 | -70,566 | 0.01 | 0.01 | -0.00 | sell |
| Lynx1 Capital Management LP | 4,763,673 | 4,038,404 | -725,269 | 24.51 | 15.27 | -9.25 | sell |
| Redmile Group, LLC | 4,164,120 | 3,945,920 | -218,200 | 8.98 | 8.67 | -0.31 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 3,095,700 | 3,519,301 | +423,601 | 0.02 | 0.02 | +0.00 | buy |
| MORGAN STANLEY | 3,423,280 | 3,452,795 | +29,515 | 0.01 | 0.01 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 3,336,697 | 3,336,697 | 0 | 0.62 | 0.55 | -0.08 | hold |
| TORONTO DOMINION BANK | 3,173,258 | 3,173,258 | 0 | 0.20 | 0.17 | -0.03 | hold |
| STATE STREET CORP | 2,276,512 | 2,852,240 | +575,728 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,934,171 | 2,661,739 | +727,568 | 0.01 | 0.01 | +0.00 | buy |
| BVF INC/IL | 2,547,557 | 2,547,557 | 0 | 2.64 | 2.13 | -0.51 | hold |
| T. Rowe Price Investment Management, Inc. | 250,913 | 2,415,139 | +2,164,226 | 0.01 | 0.05 | +0.05 | buy |
| Siren, L.L.C. | 1,995,347 | 1,995,347 | 0 | 1.80 | 1.33 | -0.48 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,823,500 | 1,823,500 | 0 | 0.70 | 0.62 | -0.08 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,322,260 | 1,524,309 | +202,049 | 0.00 | 0.00 | -0.00 | buy |
| Assenagon Asset Management S.A. | 907,015 | 1,128,388 | +221,373 | 0.05 | 0.05 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 989,936 | 1,013,911 | +23,975 | 0.01 | 0.01 | -0.00 | buy |
| Polar Capital Holdings Plc | 1,132,511 | 833,716 | -298,795 | 0.16 | 0.08 | -0.08 | sell |
| EcoR1 Capital, LLC | 100,000 | 735,000 | +635,000 | 0.14 | 1.19 | +1.05 | buy |
| MPM BioImpact LLC | 767,038 | 723,314 | -43,724 | 1.93 | 1.44 | -0.49 | sell |
| Opaleye Management Inc. | 700,000 | 700,000 | 0 | 3.00 | 2.07 | -0.93 | hold |
| GOLDMAN SACHS GROUP INC | 830,702 | 575,344 | -255,358 | 0.00 | 0.00 | -0.00 | sell |
| BAILLIE GIFFORD & CO | 575,182 | 517,275 | -57,907 | 0.02 | 0.02 | -0.00 | sell |
| NORTHERN TRUST CORP | 431,630 | 500,124 | +68,494 | 0.00 | 0.00 | +0.00 | buy |
| Troluce Capital Advisors LLC | 652,800 | 496,416 | -156,384 | 2.25 | 6.08 | +3.83 | sell |
| FIRST TRUST ADVISORS LP | 163,459 | 490,913 | +327,454 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 123,022 | 489,301 | +366,279 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 502,020 | 480,136 | -21,884 | 0.08 | 0.07 | -0.01 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 467,012 | +467,012 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 437,175 | 467,012 | +29,837 | 0.00 | 0.00 | -0.00 | buy |
| Granahan Investment Management, LLC | 335,586 | 461,608 | +126,022 | 0.53 | 0.54 | +0.01 | buy |
| Erste Asset Management GmbH | 446,000 | 428,381 | -17,619 | 0.13 | 0.11 | -0.02 | sell |
| Parkman Healthcare Partners LLC | 336,519 | 355,443 | +18,924 | 1.14 | 1.19 | +0.06 | buy |
| Artisan Partners Limited Partnership | 315,492 | 355,153 | +39,661 | 0.02 | 0.02 | +0.00 | buy |
| JANE STREET GROUP, LLC | 64,349 | 331,701 | +267,352 | 0.00 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 500,000 | 300,000 | -200,000 | 0.83 | 0.45 | -0.38 | sell |
| MILLENNIUM MANAGEMENT LLC | 472,141 | 261,028 | -211,113 | 0.01 | 0.01 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 543,095 | 259,708 | -283,387 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 265,473 | 259,352 | -6,121 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 158,304 | 207,112 | +48,808 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 210,000 | 178,110 | -31,890 | 3.89 | 2.73 | -1.17 | sell |
| Bank of New York Mellon Corp | 143,407 | 164,273 | +20,866 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 163,200 | +163,200 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 142,793 | 146,395 | +3,602 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 130,875 | 130,875 | 0 | 0.97 | 0.82 | -0.15 | hold |
| ExodusPoint Capital Management, LP | 0 | 129,660 | +129,660 | 0.00 | 0.04 | +0.04 | buy |
| Nuveen, LLC | 108,617 | 122,877 | +14,260 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 112,627 | 113,065 | +438 | 0.04 | 0.04 | -0.01 | buy |
| Jump Financial, LLC | 0 | 104,350 | +104,350 | 0.00 | 0.03 | +0.03 | buy |
| Schonfeld Strategic Advisors LLC | 49,302 | 102,229 | +52,927 | 0.01 | 0.02 | +0.00 | buy |
| Palo Alto Investors LP | 84,631 | 84,631 | 0 | 0.42 | 0.38 | -0.04 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 47,307 | 80,968 | +33,661 | 0.04 | 0.05 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 33,873 | 80,522 | +46,649 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 8,054 | 79,613 | +71,559 | 0.00 | 0.03 | +0.03 | buy |
| RHUMBLINE ADVISERS | 67,315 | 75,931 | +8,616 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 79,100 | 74,200 | -4,900 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 73,475 | +73,475 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 63,933 | 69,880 | +5,947 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 12,726 | 69,326 | +56,600 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 150,045 | 67,660 | -82,385 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 74,400 | 67,200 | -7,200 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69,222 | 66,160 | -3,062 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 58,185 | 65,228 | +7,043 | 0.00 | 0.00 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 83,000 | 64,500 | -18,500 | 0.33 | 0.20 | -0.13 | sell |
| ALPS ADVISORS INC | 46,498 | 63,010 | +16,512 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 41,830 | 62,390 | +20,560 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 62,371 | +62,371 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 62,617 | 61,316 | -1,301 | 0.56 | 0.46 | -0.11 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 47,859 | 60,167 | +12,308 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 58,843 | +58,843 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 49,972 | 57,847 | +7,875 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 40,596 | 57,784 | +17,188 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 19,869 | 50,835 | +30,966 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,606 | 50,138 | -1,468 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 50,120 | 50,120 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Quantinno Capital Management LP | 9,773 | 49,928 | +40,155 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 39,158 | 49,611 | +10,453 | 0.00 | 0.00 | +0.00 | buy |
| Moran Wealth Management, LLC | 40,552 | 47,977 | +7,425 | 0.04 | 0.04 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 33,890 | 44,900 | +11,010 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 48,108 | 44,368 | -3,740 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 59,898 | 43,742 | -16,156 | 0.01 | 0.00 | -0.00 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 84,000 | 42,000 | -42,000 | 0.59 | 0.32 | -0.27 | sell |
| Quadrature Capital Ltd | 10,293 | 41,225 | +30,932 | 0.00 | 0.01 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 40,815 | 40,815 | 0 | 0.33 | 0.33 | -0.01 | hold |
| Legal & General Group Plc | 32,048 | 35,705 | +3,657 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 30,479 | 35,598 | +5,119 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 34,102 | 34,102 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Generali Investments, Management Co LLC | 6,912 | 33,149 | +26,237 | 0.05 | 0.24 | +0.18 | buy |
| MetLife Investment Management, LLC | 26,106 | 32,132 | +6,026 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 30,823 | +30,823 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 41,500 | 30,000 | -11,500 | 0.01 | 0.01 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 29,310 | +29,310 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 56,128 | 27,012 | -29,116 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 46,459 | 26,449 | -20,010 | 0.00 | 0.00 | -0.00 | sell |
| CANADA LIFE ASSURANCE Co | 18,830 | 25,197 | +6,367 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 24,494 | 24,411 | -83 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 26,985 | 22,416 | -4,569 | 0.03 | 0.02 | -0.01 | sell |
| Allspring Global Investments Holdings, LLC | 20,985 | 21,739 | +754 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 36,047 | 20,645 | -15,402 | 0.00 | 0.00 | -0.00 | sell |