| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Skorpios Trust | 10,843,681 | 8,906,181 | -1,937,500 | 99.89 | 99.85 | -0.05 | sell |
| Lynx1 Capital Management LP | 5,185,191 | 5,187,191 | +2,000 | 25.32 | 22.59 | -2.73 | buy |
| Redmile Group, LLC | 4,721,054 | 4,713,509 | -7,545 | 3.86 | 3.41 | -0.44 | sell |
| RTW INVESTMENTS, LP | 4,224,838 | 4,652,285 | +427,447 | 0.88 | 0.83 | -0.06 | buy |
| BAKER BROS. ADVISORS LP | 4,368,443 | 4,368,443 | 0 | 0.75 | 0.56 | -0.20 | hold |
| MORGAN STANLEY | 3,478,797 | 4,205,307 | +726,510 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,687,658 | 2,759,247 | +71,589 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,591,743 | 1,728,888 | +137,145 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 1,161,037 | 1,670,733 | +509,696 | 0.02 | 0.03 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,367,517 | 1,393,760 | +26,243 | 0.00 | 0.00 | -0.00 | buy |
| Assenagon Asset Management S.A. | 1,468,202 | 1,312,479 | -155,723 | 0.05 | 0.03 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 794,170 | 870,831 | +76,661 | 0.00 | 0.00 | -0.00 | buy |
| Granahan Investment Management, LLC | 598,401 | 644,970 | +46,569 | 0.32 | 0.31 | -0.01 | buy |
| MPM BioImpact LLC | 0 | 479,452 | +479,452 | 0.00 | 0.88 | +0.88 | buy |
| DEUTSCHE BANK AG\ | 16,030 | 462,475 | +446,445 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 427,163 | 427,163 | 0 | 0.34 | 0.28 | -0.06 | hold |
| NORTHERN TRUST CORP | 282,615 | 339,153 | +56,538 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 75,414 | 330,442 | +255,028 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 398,019 | 322,949 | -75,070 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 289,264 | 316,134 | +26,870 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 191,360 | 265,010 | +73,650 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 210,000 | 210,000 | 0 | 2.62 | 2.23 | -0.39 | hold |
| DAFNA Capital Management LLC | 207,427 | 207,427 | 0 | 0.67 | 0.60 | -0.07 | hold |
| Exome Asset Management LLC | 0 | 176,600 | +176,600 | 0.00 | 1.47 | +1.47 | buy |
| D. E. Shaw & Co., Inc. | 137,010 | 171,246 | +34,236 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 179,613 | 161,749 | -17,864 | 0.04 | 0.03 | -0.01 | sell |
| Checkpoint Capital L.P. | 0 | 157,514 | +157,514 | 0.00 | 0.96 | +0.96 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 143,636 | 136,975 | -6,661 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,227 | 134,141 | +123,914 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 125,861 | 125,861 | 0 | 0.20 | 0.20 | +0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 97,798 | 124,648 | +26,850 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 198,280 | 123,149 | -75,131 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 114,905 | 116,678 | +1,773 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 15,042 | 112,667 | +97,625 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 66,765 | 103,005 | +36,240 | 0.00 | 0.01 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 101,774 | +101,774 | 0.00 | 0.05 | +0.05 | buy |
| ELEMENT CAPITAL MANAGEMENT LLC | 0 | 96,380 | +96,380 | 0.00 | 0.05 | +0.05 | buy |
| Woodline Partners LP | 100,182 | 94,382 | -5,800 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 115,892 | 91,865 | -24,027 | 0.00 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 88,577 | 90,755 | +2,178 | 0.01 | 0.01 | -0.00 | buy |
| Rafferty Asset Management, LLC | 79,885 | 82,788 | +2,903 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 32,501 | 79,740 | +47,239 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 118,254 | 78,312 | -39,942 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 4,507 | 76,154 | +71,647 | 0.00 | 0.00 | +0.00 | buy |
| Fort Point Capital Partners LLC | 75,429 | 75,429 | 0 | 0.13 | 0.12 | -0.01 | hold |
| AQR CAPITAL MANAGEMENT LLC | 0 | 75,089 | +75,089 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 66,400 | 55,900 | -10,500 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 61,277 | 52,006 | -9,271 | 0.06 | 0.05 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 49,900 | +49,900 | 0.00 | 0.05 | +0.05 | buy |
| RHUMBLINE ADVISERS | 47,860 | 46,587 | -1,273 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 57,399 | 42,692 | -14,707 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 40,630 | 40,630 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 40,602 | 39,114 | -1,488 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 35,046 | 35,240 | +194 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 32,790 | 33,807 | +1,017 | 0.00 | 0.00 | -0.00 | buy |
| Informed Momentum Co LLC | 37,637 | 30,781 | -6,856 | 0.08 | 0.06 | -0.03 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,087 | 27,600 | -5,487 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 15,144 | 25,666 | +10,522 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 27,924 | 24,205 | -3,719 | 0.01 | 0.01 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,651 | 22,705 | +5,054 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,216,200 | 22,314 | -1,193,886 | 0.01 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 97,798 | 21,432 | -76,366 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 20,805 | 20,805 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Corebridge Financial, Inc. | 19,133 | 19,016 | -117 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 18,900 | 18,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Graham Capital Management, L.P. | 0 | 17,181 | +17,181 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 14,893 | 16,401 | +1,508 | 0.01 | 0.01 | +0.00 | buy |
| Mesirow Financial Investment Management, Inc. | 0 | 15,604 | +15,604 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 15,452 | +15,452 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 68,601 | 14,917 | -53,684 | 0.01 | 0.00 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 289,067 | 14,835 | -274,232 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 19,700 | 14,500 | -5,200 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 10,305 | 14,315 | +4,010 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 14,039 | 13,984 | -55 | 0.02 | 0.02 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,964 | 13,618 | -346 | 0.00 | 0.00 | -0.00 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 13,337 | +13,337 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 13,052 | +13,052 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 11,955 | +11,955 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 11,932 | 11,840 | -92 | 0.00 | 0.00 | -0.00 | sell |
| CANADA LIFE ASSURANCE Co | 10,043 | 11,349 | +1,306 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 11,387 | 11,104 | -283 | 0.00 | 0.00 | -0.00 | sell |
| Dorsey & Whitney Trust CO LLC | 10,815 | 10,815 | 0 | 0.01 | 0.01 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,635 | 10,635 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,129 | 9,129 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 4,018 | 7,012 | +2,994 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 6,950 | +6,950 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 6,816 | 6,816 | 0 | 0.03 | 0.03 | -0.00 | hold |
| VIRTUS ADVISERS, LLC | 5,167 | 5,256 | +89 | 0.03 | 0.03 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,484 | 3,484 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 2,989 | 2,694 | -295 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 4,727 | 2,638 | -2,089 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 2,300 | 2,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,845 | +1,845 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 110 | 984 | +874 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 979 | 979 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 253 | 523 | +270 | 0.00 | 0.00 | +0.00 | buy |
| Stone House Investment Management, LLC | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Wilmington Savings Fund Society, FSB | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 396 | 184 | -212 | 0.00 | 0.00 | -0.00 | sell |
| True Wealth Design, LLC | 0 | 139 | +139 | 0.00 | 0.00 | +0.00 | buy |