| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,412,982 | 6,865,057 | -547,925 | 0.00 | 0.01 | +0.00 | sell |
| BlackRock, Inc. | 5,924,567 | 5,987,441 | +62,874 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 5,404,674 | 5,404,674 | 0 | 17.72 | 22.37 | +4.65 | hold |
| RTW INVESTMENTS, LP | 5,123,525 | 5,123,525 | 0 | 0.83 | 1.48 | +0.66 | hold |
| BAKER BROS. ADVISORS LP | 4,633,838 | 4,633,838 | 0 | 0.51 | 0.79 | +0.28 | hold |
| Redmile Group, LLC | 4,375,931 | 4,175,542 | -200,389 | 5.29 | 9.55 | +4.26 | sell |
| MORGAN STANLEY | 3,573,976 | 3,537,050 | -36,926 | 0.00 | 0.01 | +0.00 | sell |
| TORONTO DOMINION BANK | 3,173,258 | 3,173,258 | 0 | 0.08 | 0.14 | +0.07 | hold |
| VANGUARD GROUP INC | 2,946,258 | 3,163,874 | +217,616 | 0.00 | 0.00 | +0.00 | buy |
| Skorpios Trust | 3,256,181 | 2,256,181 | -1,000,000 | 99.62 | 99.68 | +0.06 | sell |
| Siren, L.L.C. | 2,247,347 | 2,247,347 | 0 | 1.32 | 2.07 | +0.75 | hold |
| BVF INC/IL | 0 | 1,657,096 | +1,657,096 | 0.00 | 1.58 | +1.58 | buy |
| STATE STREET CORP | 1,487,156 | 1,425,873 | -61,283 | 0.00 | 0.00 | +0.00 | sell |
| Polar Capital Holdings Plc | 883,646 | 1,323,470 | +439,824 | 0.05 | 0.15 | +0.10 | buy |
| Point72 Asset Management, L.P. | 0 | 1,306,698 | +1,306,698 | 0.00 | 0.07 | +0.07 | buy |
| GOLDMAN SACHS GROUP INC | 1,301,381 | 1,150,929 | -150,452 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 972,921 | 1,147,000 | +174,079 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 144,064 | 915,786 | +771,722 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 537,973 | 900,272 | +362,299 | 0.01 | 0.03 | +0.02 | buy |
| MPM BioImpact LLC | 789,698 | 789,698 | 0 | 1.55 | 3.04 | +1.48 | hold |
| MARSHALL WACE, LLP | 2,300,554 | 768,287 | -1,532,267 | 0.03 | 0.02 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 137,066 | 737,753 | +600,687 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 562,120 | 682,017 | +119,897 | 1.29 | 2.27 | +0.97 | buy |
| DIMENSIONAL FUND ADVISORS LP | 673,884 | 678,307 | +4,423 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 500,000 | 500,000 | 0 | 0.29 | 0.45 | +0.17 | hold |
| NORTHERN TRUST CORP | 423,554 | 414,917 | -8,637 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 340,779 | 402,909 | +62,130 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 396,000 | 396,000 | 0 | 0.04 | 0.09 | +0.06 | hold |
| JANUS HENDERSON GROUP PLC | 18,900 | 334,481 | +315,581 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 352,715 | 306,037 | -46,678 | 0.00 | 0.00 | +0.00 | sell |
| Granahan Investment Management, LLC | 532,413 | 253,899 | -278,514 | 0.25 | 0.24 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 0 | 250,000 | +250,000 | 0.00 | 0.65 | +0.65 | buy |
| Parkman Healthcare Partners LLC | 0 | 250,000 | +250,000 | 0.00 | 0.65 | +0.65 | buy |
| BANK OF AMERICA CORP /DE/ | 548,090 | 249,451 | -298,639 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 174,714 | 238,015 | +63,301 | 0.01 | 0.04 | +0.02 | buy |
| Checkpoint Capital L.P. | 0 | 212,049 | +212,049 | 0.00 | 1.67 | +1.67 | buy |
| Birchview Capital, LP | 210,000 | 210,000 | 0 | 2.37 | 3.73 | +1.36 | hold |
| Invesco Ltd. | 40,207 | 208,075 | +167,868 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 501,972 | 169,791 | -332,181 | 1.57 | 0.99 | -0.59 | sell |
| GILDER GAGNON HOWE & CO LLC | 129,571 | 155,166 | +25,595 | 0.02 | 0.04 | +0.02 | buy |
| FIRST TRUST ADVISORS LP | 0 | 152,299 | +152,299 | 0.00 | 0.00 | +0.00 | buy |
| Penserra Capital Management LLC | 0 | 150,599 | +150,599 | 0.00 | 0.04 | +0.04 | buy |
| Susquehanna Portfolio Strategies, LLC | 126,350 | 126,350 | 0 | 0.03 | 0.05 | +0.02 | hold |
| Bank of New York Mellon Corp | 103,773 | 120,436 | +16,663 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 120,181 | +120,181 | 0.00 | 0.32 | +0.32 | buy |
| FRANKLIN RESOURCES INC | 81,395 | 115,833 | +34,438 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 139,900 | 107,723 | -32,177 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 102,468 | 105,994 | +3,526 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 125,861 | 105,427 | -20,434 | 0.30 | 0.46 | +0.15 | sell |
| AMERICAN CENTURY COMPANIES INC | 27,339 | 99,092 | +71,753 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 95,120 | 95,120 | 0 | 0.01 | 0.01 | +0.00 | hold |
| NOMURA HOLDINGS INC | 0 | 81,209 | +81,209 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 107,240 | 75,858 | -31,382 | 0.00 | 0.00 | +0.00 | sell |
| Fort Point Capital Partners LLC | 75,434 | 75,429 | -5 | 0.09 | 0.23 | +0.14 | sell |
| Swiss National Bank | 62,000 | 74,100 | +12,100 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 103,244 | 74,056 | -29,188 | 0.00 | 0.00 | +0.00 | sell |
| Kennondale Capital Management LLC | 61,183 | 69,732 | +8,549 | 0.71 | 1.25 | +0.55 | buy |
| RHUMBLINE ADVISERS | 66,419 | 68,304 | +1,885 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 20,396 | 61,048 | +40,652 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 30,696 | 52,613 | +21,917 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 43,735 | 51,263 | +7,528 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 53,411 | 50,463 | -2,948 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 38,839 | 47,583 | +8,744 | 0.03 | 0.09 | +0.06 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 45,205 | +45,205 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 29,430 | 44,664 | +15,234 | 0.00 | 0.01 | +0.00 | buy |
| Creative Planning | 44,215 | 43,304 | -911 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 40,630 | 40,630 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quantedge Capital Pte Ltd | 0 | 40,000 | +40,000 | 0.00 | 0.51 | +0.51 | buy |
| Legal & General Group Plc | 31,077 | 37,783 | +6,706 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 51,458 | 35,327 | -16,131 | 0.00 | 0.00 | +0.00 | sell |
| Allspring Global Investments Holdings, LLC | 35,404 | 35,058 | -346 | 0.00 | 0.00 | +0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 32,901 | +32,901 | 0.00 | 0.05 | +0.05 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,068 | 32,070 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 30,418 | +30,418 | 0.00 | 0.05 | +0.05 | buy |
| AQR CAPITAL MANAGEMENT LLC | 54,818 | 29,113 | -25,705 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 23,005 | 28,071 | +5,066 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,238 | 26,792 | -24,446 | 0.00 | 0.00 | +0.00 | sell |
| Cresset Asset Management, LLC | 0 | 26,736 | +26,736 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 23,863 | 25,320 | +1,457 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 25,655 | 24,376 | -1,279 | 0.00 | 0.00 | +0.00 | sell |
| Jain Global LLC | 0 | 24,340 | +24,340 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 20,303 | 24,230 | +3,927 | 0.00 | 0.00 | +0.00 | buy |
| AVIVA PLC | 43,955 | 22,318 | -21,637 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 20,996 | +20,996 | 0.00 | 0.00 | +0.00 | buy |
| Advantage Alpha Capital Partners LP | 17,888 | 16,941 | -947 | 0.05 | 0.12 | +0.07 | sell |
| SEI INVESTMENTS CO | 0 | 16,450 | +16,450 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 6,293 | 15,095 | +8,802 | 0.01 | 0.02 | +0.02 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 123,482 | 15,085 | -108,397 | 0.01 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,099 | 15,044 | -55 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,635 | 15,035 | +4,400 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 13,630 | +13,630 | 0.00 | 0.05 | +0.05 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,186 | 13,401 | +9,215 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 18,217 | 13,147 | -5,070 | 0.00 | 0.00 | +0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 9,558 | 12,421 | +2,863 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 12,100 | +12,100 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 10,665 | 11,978 | +1,313 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 11,294 | +11,294 | 0.00 | 0.00 | +0.00 | buy |
| Dorsey & Whitney Trust CO LLC | 10,815 | 10,815 | 0 | 0.01 | 0.01 | +0.01 | hold |
| OSAIC HOLDINGS, INC. | 7,488 | 10,205 | +2,717 | 0.00 | 0.00 | +0.00 | buy |
| Vestcor Inc | 0 | 10,171 | +10,171 | 0.00 | 0.01 | +0.01 | buy |