| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 0 | 1,657,096 | +1,657,096 | 0.00 | 1.58 | +1.58 | buy |
| Point72 Asset Management, L.P. | 0 | 1,306,698 | +1,306,698 | 0.00 | 0.07 | +0.07 | buy |
| ROYAL BANK OF CANADA | 144,064 | 915,786 | +771,722 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 137,066 | 737,753 | +600,687 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 883,646 | 1,323,470 | +439,824 | 0.05 | 0.15 | +0.10 | buy |
| Assenagon Asset Management S.A. | 537,973 | 900,272 | +362,299 | 0.01 | 0.03 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 18,900 | 334,481 | +315,581 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 250,000 | +250,000 | 0.00 | 0.65 | +0.65 | buy |
| Parkman Healthcare Partners LLC | 0 | 250,000 | +250,000 | 0.00 | 0.65 | +0.65 | buy |
| VANGUARD GROUP INC | 2,946,258 | 3,163,874 | +217,616 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 0 | 212,049 | +212,049 | 0.00 | 1.67 | +1.67 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 972,921 | 1,147,000 | +174,079 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 40,207 | 208,075 | +167,868 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 152,299 | +152,299 | 0.00 | 0.00 | +0.00 | buy |
| Penserra Capital Management LLC | 0 | 150,599 | +150,599 | 0.00 | 0.04 | +0.04 | buy |
| Informed Momentum Co LLC | 0 | 120,181 | +120,181 | 0.00 | 0.32 | +0.32 | buy |
| Opaleye Management Inc. | 562,120 | 682,017 | +119,897 | 1.29 | 2.27 | +0.97 | buy |
| NOMURA HOLDINGS INC | 0 | 81,209 | +81,209 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 27,339 | 99,092 | +71,753 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 174,714 | 238,015 | +63,301 | 0.01 | 0.04 | +0.02 | buy |
| BlackRock, Inc. | 5,924,567 | 5,987,441 | +62,874 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 340,779 | 402,909 | +62,130 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 45,205 | +45,205 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 20,396 | 61,048 | +40,652 | 0.00 | 0.00 | +0.00 | buy |
| Quantedge Capital Pte Ltd | 0 | 40,000 | +40,000 | 0.00 | 0.51 | +0.51 | buy |
| FRANKLIN RESOURCES INC | 81,395 | 115,833 | +34,438 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 32,901 | +32,901 | 0.00 | 0.05 | +0.05 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 30,418 | +30,418 | 0.00 | 0.05 | +0.05 | buy |
| Cresset Asset Management, LLC | 0 | 26,736 | +26,736 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 129,571 | 155,166 | +25,595 | 0.02 | 0.04 | +0.02 | buy |
| Jain Global LLC | 0 | 24,340 | +24,340 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 30,696 | 52,613 | +21,917 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 20,996 | +20,996 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 103,773 | 120,436 | +16,663 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 16,450 | +16,450 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 29,430 | 44,664 | +15,234 | 0.00 | 0.01 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 13,630 | +13,630 | 0.00 | 0.05 | +0.05 | buy |
| OMERS ADMINISTRATION Corp | 0 | 12,100 | +12,100 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 62,000 | 74,100 | +12,100 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 11,294 | +11,294 | 0.00 | 0.00 | +0.00 | buy |
| Vestcor Inc | 0 | 10,171 | +10,171 | 0.00 | 0.01 | +0.01 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 9,358 | +9,358 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,186 | 13,401 | +9,215 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 8,996 | +8,996 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 6,293 | 15,095 | +8,802 | 0.01 | 0.02 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 38,839 | 47,583 | +8,744 | 0.03 | 0.09 | +0.06 | buy |
| Kennondale Capital Management LLC | 61,183 | 69,732 | +8,549 | 0.71 | 1.25 | +0.55 | buy |
| State of Wyoming | 0 | 7,844 | +7,844 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 43,735 | 51,263 | +7,528 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 31,077 | 37,783 | +6,706 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 6,400 | +6,400 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 23,005 | 28,071 | +5,066 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 673,884 | 678,307 | +4,423 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,635 | 15,035 | +4,400 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 20,303 | 24,230 | +3,927 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 102,468 | 105,994 | +3,526 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,558 | 12,421 | +2,863 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 7,488 | 10,205 | +2,717 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 66,419 | 68,304 | +1,885 | 0.00 | 0.00 | +0.00 | buy |
| Generali Investments, Management Co LLC | 0 | 1,753 | +1,753 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 7,955 | 9,627 | +1,672 | 0.03 | 0.06 | +0.03 | buy |
| MetLife Investment Management, LLC | 23,863 | 25,320 | +1,457 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 10,665 | 11,978 | +1,313 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 956 | +956 | 0.00 | 0.01 | +0.01 | buy |
| Optiver Holding B.V. | 0 | 354 | +354 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 317 | +317 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 50 | 287 | +237 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 177 | +177 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 0 | 134 | +134 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 22 | 114 | +92 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 83 | +83 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 4 | 56 | +52 | 0.00 | 0.00 | +0.00 | buy |
| Wealthspire Advisors, LLC | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 639 | 680 | +41 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 508 | 548 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 99 | 109 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 7 | 17 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,109 | 2,118 | +9 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 5 | +5 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,068 | 32,070 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,630 | 40,630 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 500,000 | 500,000 | 0 | 0.29 | 0.45 | +0.17 | hold |
| BAKER BROS. ADVISORS LP | 4,633,838 | 4,633,838 | 0 | 0.51 | 0.79 | +0.28 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,129 | 9,129 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Dorsey & Whitney Trust CO LLC | 10,815 | 10,815 | 0 | 0.01 | 0.01 | +0.01 | hold |
| Daiwa Securities Group Inc. | 175 | 175 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 5,123,525 | 5,123,525 | 0 | 0.83 | 1.48 | +0.66 | hold |
| Birchview Capital, LP | 210,000 | 210,000 | 0 | 2.37 | 3.73 | +1.36 | hold |
| MPM BioImpact LLC | 789,698 | 789,698 | 0 | 1.55 | 3.04 | +1.48 | hold |
| Stone House Investment Management, LLC | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Versant Capital Management, Inc | 1,592 | 1,592 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Woodline Partners LP | 95,120 | 95,120 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Concord Wealth Partners | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Lynx1 Capital Management LP | 5,404,674 | 5,404,674 | 0 | 17.72 | 22.37 | +4.65 | hold |
| True Wealth Design, LLC | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 126,350 | 126,350 | 0 | 0.03 | 0.05 | +0.02 | hold |
| Siren, L.L.C. | 2,247,347 | 2,247,347 | 0 | 1.32 | 2.07 | +0.75 | hold |