| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GOLDMAN SACHS GROUP INC | 129,305 | 1,391,431 | +1,262,126 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 1,710,154 | 2,956,918 | +1,246,764 | 4.46 | 6.12 | +1.66 | buy |
| BAKER BROS. ADVISORS LP | 1,485,915 | 2,030,134 | +544,219 | 0.03 | 0.12 | +0.09 | buy |
| MORGAN STANLEY | 2,913,784 | 3,370,362 | +456,578 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 13,762 | 412,778 | +399,016 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 851,201 | 1,137,887 | +286,686 | 0.12 | 0.20 | +0.08 | buy |
| Birchview Capital, LP | 85,000 | 210,000 | +125,000 | 0.28 | 0.86 | +0.58 | buy |
| JANE STREET GROUP, LLC | 0 | 50,786 | +50,786 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 8,440 | 39,271 | +30,831 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 591,117 | 615,724 | +24,607 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,630,688 | 1,648,502 | +17,814 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 57,558 | 75,339 | +17,781 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 17,100 | +17,100 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 15,361 | +15,361 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 47,747 | 62,257 | +14,510 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 14,064 | +14,064 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 20,275 | 29,773 | +9,498 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 8,500 | +8,500 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 79,524 | 86,600 | +7,076 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 2,681 | 7,979 | +5,298 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 16,143 | 21,036 | +4,893 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 15,210 | 19,096 | +3,886 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 600 | 3,972 | +3,372 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 65 | 1,934 | +1,869 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 13,557 | 15,101 | +1,544 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,741 | 5,039 | +1,298 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 3,728 | 5,000 | +1,272 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 16,335 | 17,283 | +948 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 5,557 | 5,779 | +222 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,278 | 2,278 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 11,175 | 11,175 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Dorsey & Whitney Trust CO LLC | 10,815 | 10,815 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 14,616 | 14,616 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 239,300 | 239,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cormorant Asset Management, LP | 1,087,807 | 1,087,807 | 0 | 0.25 | 0.27 | +0.02 | hold |
| Fort Point Capital Partners LLC | 75,429 | 75,429 | 0 | 0.05 | 0.06 | +0.01 | hold |
| Ikarian Capital, LLC | 12,116 | 12,116 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Woodline Partners LP | 56,904 | 56,904 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Skorpios Trust | 14,443,681 | 14,443,681 | 0 | 99.78 | 99.80 | +0.02 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,515 | 1,515 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 29,789 | 29,789 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,916 | 11,916 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GILDER GAGNON HOWE & CO LLC | 62,259 | 62,248 | -11 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 41,009 | 40,971 | -38 | 0.00 | 0.00 | +0.00 | sell |
| Beaird Harris Wealth Management, LLC | 38 | 0 | -38 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,688 | 10,642 | -46 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 13,767 | 13,711 | -56 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 12,131 | 12,037 | -94 | 0.00 | 0.00 | +0.00 | sell |
| Daiwa Securities Group Inc. | 126 | 0 | -126 | 0.00 | 0.00 | 0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 221 | 0 | -221 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,333 | 2,099 | -234 | 0.00 | 0.00 | +0.00 | sell |
| US BANCORP \DE\ | 538 | 0 | -538 | 0.00 | 0.00 | -0.00 | sell |
| CANADA LIFE ASSURANCE Co | 2,968 | 2,110 | -858 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 1,076 | 0 | -1,076 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 1,132 | 0 | -1,132 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 13,800 | 11,000 | -2,800 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 41,320 | 37,340 | -3,980 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 16,550 | 12,540 | -4,010 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 265,373 | 257,592 | -7,781 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 10,934 | 3,129 | -7,805 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 7,893 | 0 | -7,893 | 0.02 | 0.00 | -0.02 | sell |
| JPMORGAN CHASE & CO | 26,530 | 18,133 | -8,397 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 107,254 | 98,328 | -8,926 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 33,032 | 22,054 | -10,978 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 11,398 | 0 | -11,398 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 217,339 | 205,242 | -12,097 | 0.00 | 0.00 | +0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 12,295 | 0 | -12,295 | 0.02 | 0.00 | -0.02 | sell |
| Corton Capital Inc. | 14,749 | 0 | -14,749 | 0.03 | 0.00 | -0.03 | sell |
| Allspring Global Investments Holdings, LLC | 14,790 | 0 | -14,790 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 15,255 | 0 | -15,255 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 28,300 | 11,200 | -17,100 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 18,252 | 0 | -18,252 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,651 | 4,540 | -19,111 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 28,152 | 7,694 | -20,458 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 32,647 | 0 | -32,647 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 586,008 | 543,533 | -42,475 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 258,422 | 215,294 | -43,128 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 43,300 | 0 | -43,300 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 48,001 | 0 | -48,001 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 217,605 | 168,028 | -49,577 | 0.01 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 76,120 | 15,577 | -60,543 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 205,166 | 142,711 | -62,455 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 67,351 | 0 | -67,351 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 72,241 | 0 | -72,241 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 127,581 | 39,800 | -87,781 | 0.01 | 0.00 | -0.01 | sell |
| Simplify Asset Management Inc. | 102,985 | 0 | -102,985 | 0.07 | 0.00 | -0.07 | sell |
| Mirae Asset Global Investments Co., Ltd. | 146,076 | 0 | -146,076 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 174,332 | 0 | -174,332 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 348,069 | 102,107 | -245,962 | 0.12 | 0.05 | -0.07 | sell |
| MILLENNIUM MANAGEMENT LLC | 275,339 | 23,914 | -251,425 | 0.00 | 0.00 | -0.00 | sell |
| RTW INVESTMENTS, LP | 4,390,558 | 4,131,045 | -259,513 | 0.36 | 0.34 | -0.03 | sell |
| Redmile Group, LLC | 3,872,696 | 2,625,506 | -1,247,190 | 0.73 | 0.49 | -0.23 | sell |