| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 4,652,285 | 5,123,525 | +471,240 | 0.83 | 0.85 | +0.03 | buy |
| BAKER BROS. ADVISORS LP | 4,368,443 | 4,633,838 | +265,395 | 0.56 | 0.55 | -0.01 | buy |
| MPM BioImpact LLC | 479,452 | 685,826 | +206,374 | 0.88 | 1.07 | +0.19 | buy |
| Checkpoint Capital L.P. | 157,514 | 305,387 | +147,873 | 0.96 | 1.71 | +0.75 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 103,005 | 43,438 | +59,567 | 0.01 | 0.00 | 0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 90,755 | 92,546 | +1,791 | 0.01 | 0.01 | -0.00 | buy |
| Woodline Partners LP | 94,382 | 94,903 | +521 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 5,256 | 5,770 | +514 | 0.03 | 0.03 | -0.00 | buy |
| Mesirow Financial Investment Management, Inc. | 15,604 | 15,779 | +175 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 6,816 | 6,798 | -18 | 0.01 | 0.01 | -0.00 | sell |
| PDT Partners, LLC | 13,984 | 13,942 | -42 | 0.02 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 82,788 | 67,227 | -15,561 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 49,900 | 29,528 | -20,372 | 0.05 | 0.03 | -0.02 | sell |
| DAFNA Capital Management LLC | 207,427 | 171,097 | -36,330 | 0.60 | 0.48 | -0.12 | sell |
| Exome Asset Management LLC | 176,600 | 113,096 | -63,504 | 1.47 | 0.94 | -0.53 | sell |
| Granahan Investment Management, LLC | 644,970 | 567,689 | -77,281 | 0.31 | 0.26 | -0.05 | sell |
| Redmile Group, LLC | 4,713,509 | 4,593,629 | -119,880 | 3.41 | 3.53 | +0.12 | sell |
| Cormorant Asset Management, LP | 427,163 | 254,161 | -173,002 | 0.28 | 0.15 | -0.12 | sell |
| Skorpios Trust | 8,906,181 | 6,906,181 | -2,000,000 | 99.85 | 99.80 | -0.05 | sell |