| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TORONTO DOMINION BANK | 0 | 3,173,258 | +3,173,258 | 0.00 | 0.07 | +0.07 | buy |
| Siren, L.L.C. | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.97 | +0.97 | buy |
| RTW INVESTMENTS, LP | 4,652,285 | 5,123,525 | +471,240 | 0.83 | 0.85 | +0.03 | buy |
| BlackRock, Inc. | 5,570,150 | 5,887,511 | +317,361 | 0.00 | 0.00 | -0.00 | buy |
| NORGES BANK | 0 | 314,800 | +314,800 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 300,000 | +300,000 | 0.00 | 0.22 | +0.22 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 291,795 | +291,795 | 0.00 | 0.02 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 265,010 | 538,900 | +273,890 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 4,368,443 | 4,633,838 | +265,395 | 0.56 | 0.55 | -0.01 | buy |
| MPM BioImpact LLC | 479,452 | 685,826 | +206,374 | 0.88 | 1.07 | +0.19 | buy |
| Checkpoint Capital L.P. | 157,514 | 305,387 | +147,873 | 0.96 | 1.71 | +0.75 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 129,043 | +129,043 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 104,272 | +104,272 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 78,312 | 177,844 | +99,532 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 6,950 | 92,580 | +85,630 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 14,835 | 76,829 | +61,994 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 134,141 | 187,908 | +53,767 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 42,692 | 95,505 | +52,813 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 42,830 | +42,830 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 1,312,479 | 1,350,925 | +38,446 | 0.03 | 0.03 | -0.01 | buy |
| CITIGROUP INC | 25,666 | 58,133 | +32,467 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 31,968 | +31,968 | 0.00 | 0.15 | +0.15 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 316,134 | 342,129 | +25,995 | 0.00 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 0 | 25,000 | +25,000 | 0.00 | 0.05 | +0.05 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 18,258 | +18,258 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 15,160 | +15,160 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 12,626 | +12,626 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 12,065 | +12,065 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 339,153 | 350,788 | +11,635 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 55,900 | 67,300 | +11,400 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 11,231 | +11,231 | 0.00 | 0.01 | +0.01 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 10,219 | +10,219 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 112,667 | 120,242 | +7,575 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 870,831 | 877,095 | +6,264 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 11,104 | 16,786 | +5,682 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 7,012 | 11,930 | +4,918 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 15,452 | 19,964 | +4,512 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,600 | 32,068 | +4,468 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 13,052 | 16,416 | +3,364 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 46,587 | 49,374 | +2,787 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 101,774 | 104,411 | +2,637 | 0.05 | 0.04 | -0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 35,240 | 37,455 | +2,215 | 0.00 | 0.00 | -0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 90,755 | 92,546 | +1,791 | 0.01 | 0.01 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,765 | +1,765 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 33,807 | 35,347 | +1,540 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 2,300 | 3,800 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 17,181 | 18,634 | +1,453 | 0.01 | 0.01 | -0.00 | buy |
| Bank of New York Mellon Corp | 91,865 | 93,195 | +1,330 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 50 | 1,050 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 24,205 | 25,005 | +800 | 0.01 | 0.00 | -0.00 | buy |
| VALLEY NATIONAL ADVISERS INC | 0 | 750 | +750 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 560 | +560 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 94,382 | 94,903 | +521 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 5,256 | 5,770 | +514 | 0.03 | 0.03 | -0.00 | buy |
| BARCLAYS PLC | 79,740 | 80,112 | +372 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,705 | 23,018 | +313 | 0.00 | 0.00 | -0.00 | buy |
| Mesirow Financial Investment Management, Inc. | 15,604 | 15,779 | +175 | 0.00 | 0.00 | -0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 175 | +175 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 40 | 50 | +10 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,694 | 2,704 | +10 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,484 | 3,484 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 40,630 | 40,630 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 58 | 58 | 0 | 0.00 | 0.00 | 0.00 | hold |
| JANUS HENDERSON GROUP PLC | 18,900 | 18,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Palo Alto Investors LP | 125,861 | 125,861 | 0 | 0.20 | 0.22 | +0.01 | hold |
| Sterling Capital Management LLC | 37 | 37 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,129 | 9,129 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Dorsey & Whitney Trust CO LLC | 10,815 | 10,815 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MetLife Investment Management, LLC | 20,805 | 20,805 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fort Point Capital Partners LLC | 75,429 | 75,429 | 0 | 0.12 | 0.09 | -0.02 | hold |
| Birchview Capital, LP | 210,000 | 210,000 | 0 | 2.23 | 1.88 | -0.35 | hold |
| Lynx1 Capital Management LP | 5,187,191 | 5,187,191 | 0 | 22.59 | 21.45 | -1.14 | hold |
| Farther Finance Advisors, LLC | 7 | 7 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 22,314 | 22,314 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,635 | 10,635 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Wilmington Savings Fund Society, FSB | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 979 | 979 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AlphaQuest LLC | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| BESSEMER GROUP INC | 15 | 0 | -15 | 0.00 | 0.00 | 0.00 | sell |
| Ikarian Capital, LLC | 6,816 | 6,798 | -18 | 0.03 | 0.02 | -0.00 | sell |
| EARNED WEALTH ADVISORS, LLC | 32 | 0 | -32 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 13,984 | 13,942 | -42 | 0.02 | 0.01 | -0.00 | sell |
| US BANCORP \DE\ | 184 | 114 | -70 | 0.00 | 0.00 | -0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 119 | 0 | -119 | 0.00 | 0.00 | -0.00 | sell |
| True Wealth Design, LLC | 139 | 0 | -139 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 984 | 841 | -143 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 523 | 276 | -247 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,618 | 13,304 | -314 | 0.00 | 0.00 | -0.00 | sell |
| Stone House Investment Management, LLC | 500 | 0 | -500 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 11,840 | 11,100 | -740 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 19,016 | 17,861 | -1,155 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 2,638 | 1,481 | -1,157 | 0.00 | 0.00 | -0.00 | sell |
| CANADA LIFE ASSURANCE Co | 11,349 | 9,716 | -1,633 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,845 | 0 | -1,845 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 136,975 | 134,812 | -2,163 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 16,401 | 13,148 | -3,253 | 0.01 | 0.01 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 14,315 | 10,527 | -3,788 | 0.00 | 0.00 | -0.00 | sell |