| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,823,500 | +1,823,500 | 0.00 | 0.74 | +0.74 | buy |
| JANUS HENDERSON GROUP PLC | 334,481 | 1,450,933 | +1,116,452 | 0.00 | 0.02 | +0.02 | buy |
| STATE STREET CORP | 1,425,873 | 2,498,049 | +1,072,176 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 1,657,096 | 2,265,674 | +608,578 | 1.58 | 2.42 | +0.84 | buy |
| Candriam S.C.A. | 0 | 446,690 | +446,690 | 0.00 | 0.07 | +0.07 | buy |
| RTW INVESTMENTS, LP | 5,123,525 | 5,546,856 | +423,331 | 1.48 | 1.76 | +0.28 | buy |
| Assenagon Asset Management S.A. | 900,272 | 1,227,723 | +327,451 | 0.03 | 0.06 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 51,263 | 372,334 | +321,071 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 24,376 | 277,930 | +253,554 | 0.00 | 0.00 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 0 | 246,900 | +246,900 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 250,000 | 430,155 | +180,155 | 0.65 | 1.30 | +0.65 | buy |
| DIMENSIONAL FUND ADVISORS LP | 678,307 | 827,139 | +148,832 | 0.00 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 115,539 | +115,539 | 0.00 | 0.94 | +0.94 | buy |
| Alyeska Investment Group, L.P. | 0 | 75,000 | +75,000 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 67,112 | +67,112 | 0.00 | 0.00 | +0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 63,000 | +63,000 | 0.00 | 0.48 | +0.48 | buy |
| Privium Fund Management B.V. | 0 | 55,000 | +55,000 | 0.00 | 0.32 | +0.32 | buy |
| Rafferty Asset Management, LLC | 35,327 | 90,193 | +54,866 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 208,075 | 259,543 | +51,468 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 210,000 | 260,000 | +50,000 | 3.73 | 4.83 | +1.11 | buy |
| Quantedge Capital Pte Ltd | 40,000 | 87,200 | +47,200 | 0.51 | 1.32 | +0.80 | buy |
| BARCLAYS PLC | 107,723 | 150,945 | +43,222 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 41,140 | +41,140 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 0 | 38,347 | +38,347 | 0.00 | 0.23 | +0.23 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 35,200 | +35,200 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 33,388 | +33,388 | 0.00 | 0.03 | +0.03 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 29,059 | +29,059 | 0.00 | 0.04 | +0.04 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 45,205 | 70,282 | +25,077 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 44,664 | 66,502 | +21,838 | 0.01 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 28,071 | 49,585 | +21,514 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 120,436 | 140,802 | +20,366 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 19,309 | +19,309 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,792 | 46,022 | +19,230 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,147,000 | 1,166,145 | +19,145 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 19,101 | +19,101 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 17,181 | +17,181 | 0.00 | 0.32 | +0.32 | buy |
| SG Americas Securities, LLC | 8,996 | 25,836 | +16,840 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 115,833 | 132,222 | +16,389 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 99,092 | 115,118 | +16,026 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 14,819 | +14,819 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 14,281 | +14,281 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 14,134 | +14,134 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 682,017 | 695,000 | +12,983 | 2.27 | 2.91 | +0.64 | buy |
| Entropy Technologies, LP | 0 | 11,764 | +11,764 | 0.00 | 0.02 | +0.02 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 11,717 | +11,717 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 11,088 | +11,088 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 0 | 10,403 | +10,403 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 152,299 | 162,679 | +10,380 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 9,340 | +9,340 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 24,230 | 33,406 | +9,176 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 3,537,050 | 3,546,158 | +9,108 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 9,055 | +9,055 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 9,000 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 0 | 8,355 | +8,355 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 402,909 | 410,906 | +7,997 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 32,901 | 40,815 | +7,914 | 0.05 | 0.30 | +0.25 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 7,761 | +7,761 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 6,515 | 13,603 | +7,088 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 6,827 | +6,827 | 0.00 | 0.01 | +0.01 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 6,550 | +6,550 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 6,369 | +6,369 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 13,147 | 18,652 | +5,505 | 0.00 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,070 | 37,127 | +5,057 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 4,576 | +4,576 | 0.00 | 0.07 | +0.07 | buy |
| GROUP ONE TRADING LLC | 0 | 4,110 | +4,110 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,605 | 12,907 | +3,302 | 0.02 | 0.03 | +0.01 | buy |
| CANADA LIFE ASSURANCE Co | 11,978 | 14,768 | +2,790 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 74,100 | 75,700 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 9,622 | 10,721 | +1,099 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 287 | 1,185 | +898 | 0.00 | 0.00 | +0.00 | buy |
| Kestra Advisory Services, LLC | 0 | 818 | +818 | 0.00 | 0.00 | +0.00 | buy |
| Generali Investments, Management Co LLC | 1,753 | 2,471 | +718 | 0.01 | 0.02 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,118 | 2,776 | +658 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 17 | 622 | +605 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 6,400 | 7,000 | +600 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 29,113 | 29,467 | +354 | 0.00 | 0.00 | +0.00 | buy |
| Prestige Wealth Management Group LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 109 | 298 | +189 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 16,450 | 16,631 | +181 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,240 | 1,409 | +169 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 317 | 476 | +159 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 155 | +155 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 680 | 830 | +150 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 12,421 | 12,535 | +114 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 98 | +98 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 88 | +88 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 20,996 | 21,076 | +80 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 10,205 | 10,260 | +55 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 548 | 565 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| Root Financial Partners, LLC | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 2 | 7 | +5 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 290 | 293 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 17 | 18 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,748 | 3,748 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 40,630 | 40,630 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 500,000 | 500,000 | 0 | 0.45 | 0.78 | +0.33 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,129 | 9,129 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Dorsey & Whitney Trust CO LLC | 10,815 | 10,815 | 0 | 0.01 | 0.02 | +0.00 | hold |
| SIGNATUREFD, LLC | 83 | 83 | 0 | 0.00 | 0.00 | +0.00 | hold |