| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 1,657,096 | 2,265,674 | +608,578 | 1.58 | 2.42 | +0.84 | buy |
| RTW INVESTMENTS, LP | 5,123,525 | 5,546,856 | +423,331 | 1.48 | 1.76 | +0.28 | buy |
| Parkman Healthcare Partners LLC | 250,000 | 430,155 | +180,155 | 0.65 | 1.30 | +0.65 | buy |
| Penserra Capital Management LLC | 150,599 | 88,507 | +62,092 | 0.04 | 0.03 | -0.01 | sell |
| Rafferty Asset Management, LLC | 35,327 | 90,193 | +54,866 | 0.00 | 0.01 | +0.01 | buy |
| Birchview Capital, LP | 210,000 | 260,000 | +50,000 | 3.73 | 4.83 | +1.11 | buy |
| Quantedge Capital Pte Ltd | 40,000 | 87,200 | +47,200 | 0.51 | 1.32 | +0.80 | buy |
| ALPS ADVISORS INC | 44,664 | 66,502 | +21,838 | 0.01 | 0.01 | 0.00 | buy |
| Opaleye Management Inc. | 682,017 | 695,000 | +12,983 | 2.27 | 2.91 | +0.64 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 32,901 | 40,815 | +7,914 | 0.05 | 0.30 | +0.25 | buy |
| China Universal Asset Management Co., Ltd. | 9,605 | 12,907 | +3,302 | 0.02 | 0.03 | +0.01 | buy |
| Generali Investments, Management Co LLC | 1,753 | 2,471 | +718 | 0.01 | 0.02 | +0.01 | buy |
| J.Safra Asset Management Corp | 134 | 97 | -37 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,179 | 1,121 | -58 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 9,627 | 8,214 | -1,413 | 0.06 | 0.07 | +0.01 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 15,085 | 12,878 | -2,207 | 0.00 | 0.00 | +0.00 | sell |
| Informed Momentum Co LLC | 120,181 | 117,823 | -2,358 | 0.32 | 0.42 | +0.10 | sell |
| Dynamic Technology Lab Private Ltd | 13,630 | 8,054 | -5,576 | 0.05 | 0.06 | +0.00 | sell |
| AVIVA PLC | 22,318 | 15,871 | -6,447 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 789,698 | 770,289 | -19,409 | 3.04 | 2.80 | -0.24 | sell |
| Kennondale Capital Management LLC | 69,732 | 38,731 | -31,001 | 1.25 | 0.90 | -0.35 | sell |
| GILDER GAGNON HOWE & CO LLC | 155,166 | 122,448 | -32,718 | 0.04 | 0.04 | +0.00 | sell |
| Palo Alto Investors LP | 105,427 | 72,022 | -33,405 | 0.46 | 0.32 | -0.14 | sell |
| Rhenman & Partners Asset Management AB | 250,000 | 216,000 | -34,000 | 0.65 | 0.64 | -0.01 | sell |
| Polar Capital Holdings Plc | 1,323,470 | 1,269,131 | -54,339 | 0.15 | 0.18 | +0.03 | sell |
| DAFNA Capital Management LLC | 169,791 | 108,875 | -60,916 | 0.99 | 0.80 | -0.18 | sell |
| Granahan Investment Management, LLC | 253,899 | 191,397 | -62,502 | 0.24 | 0.26 | +0.02 | sell |
| Redmile Group, LLC | 4,175,542 | 4,034,070 | -141,472 | 9.55 | 9.43 | -0.12 | sell |
| BAKER BROS. ADVISORS LP | 4,633,838 | 3,336,697 | -1,297,141 | 0.79 | 0.62 | -0.17 | sell |