| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 6,865,057 | 5,600,920 | -1,264,137 | 0.01 | 0.01 | +0.00 | sell |
| RTW INVESTMENTS, LP | 5,123,525 | 5,546,856 | +423,331 | 1.48 | 1.76 | +0.28 | buy |
| Lynx1 Capital Management LP | 5,404,674 | 5,404,674 | 0 | 22.37 | 34.73 | +12.36 | hold |
| BlackRock, Inc. | 5,987,441 | 5,212,554 | -774,887 | 0.00 | 0.00 | +0.00 | sell |
| Redmile Group, LLC | 4,175,542 | 4,034,070 | -141,472 | 9.55 | 9.43 | -0.12 | sell |
| MORGAN STANLEY | 3,537,050 | 3,546,158 | +9,108 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 4,633,838 | 3,336,697 | -1,297,141 | 0.79 | 0.62 | -0.17 | sell |
| TORONTO DOMINION BANK | 3,173,258 | 3,173,258 | 0 | 0.14 | 0.18 | +0.03 | hold |
| VANGUARD GROUP INC | 3,163,874 | 3,149,239 | -14,635 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 1,425,873 | 2,498,049 | +1,072,176 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 1,657,096 | 2,265,674 | +608,578 | 1.58 | 2.42 | +0.84 | buy |
| Siren, L.L.C. | 2,247,347 | 2,247,347 | 0 | 2.07 | 2.13 | +0.06 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,823,500 | +1,823,500 | 0.00 | 0.74 | +0.74 | buy |
| JANUS HENDERSON GROUP PLC | 334,481 | 1,450,933 | +1,116,452 | 0.00 | 0.02 | +0.02 | buy |
| Polar Capital Holdings Plc | 1,323,470 | 1,269,131 | -54,339 | 0.15 | 0.18 | +0.03 | sell |
| Assenagon Asset Management S.A. | 900,272 | 1,227,723 | +327,451 | 0.03 | 0.06 | +0.03 | buy |
| Point72 Asset Management, L.P. | 1,306,698 | 1,222,213 | -84,485 | 0.07 | 0.06 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,147,000 | 1,166,145 | +19,145 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,150,929 | 1,142,737 | -8,192 | 0.00 | 0.01 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 678,307 | 827,139 | +148,832 | 0.00 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 789,698 | 770,289 | -19,409 | 3.04 | 2.80 | -0.24 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 737,753 | 735,799 | -1,954 | 0.00 | 0.00 | +0.00 | sell |
| Opaleye Management Inc. | 682,017 | 695,000 | +12,983 | 2.27 | 2.91 | +0.64 | buy |
| TANG CAPITAL MANAGEMENT LLC | 500,000 | 500,000 | 0 | 0.45 | 0.78 | +0.33 | hold |
| Candriam S.C.A. | 0 | 446,690 | +446,690 | 0.00 | 0.07 | +0.07 | buy |
| Parkman Healthcare Partners LLC | 250,000 | 430,155 | +180,155 | 0.65 | 1.30 | +0.65 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 402,909 | 410,906 | +7,997 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 414,917 | 403,168 | -11,749 | 0.00 | 0.00 | +0.00 | sell |
| Erste Asset Management GmbH | 396,000 | 396,000 | 0 | 0.09 | 0.11 | +0.01 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 51,263 | 372,334 | +321,071 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 24,376 | 277,930 | +253,554 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 210,000 | 260,000 | +50,000 | 3.73 | 4.83 | +1.11 | buy |
| Invesco Ltd. | 208,075 | 259,543 | +51,468 | 0.00 | 0.00 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 0 | 246,900 | +246,900 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 250,000 | 216,000 | -34,000 | 0.65 | 0.64 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 249,451 | 206,164 | -43,287 | 0.00 | 0.00 | +0.00 | sell |
| Granahan Investment Management, LLC | 253,899 | 191,397 | -62,502 | 0.24 | 0.26 | +0.02 | sell |
| UBS Group AG | 306,037 | 169,713 | -136,324 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 152,299 | 162,679 | +10,380 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 107,723 | 150,945 | +43,222 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 120,436 | 140,802 | +20,366 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 115,833 | 132,222 | +16,389 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 126,350 | 126,350 | 0 | 0.05 | 0.06 | +0.01 | hold |
| GILDER GAGNON HOWE & CO LLC | 155,166 | 122,448 | -32,718 | 0.04 | 0.04 | +0.00 | sell |
| Informed Momentum Co LLC | 120,181 | 117,823 | -2,358 | 0.32 | 0.42 | +0.10 | sell |
| HighVista Strategies LLC | 0 | 115,539 | +115,539 | 0.00 | 0.94 | +0.94 | buy |
| AMERICAN CENTURY COMPANIES INC | 99,092 | 115,118 | +16,026 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 169,791 | 108,875 | -60,916 | 0.99 | 0.80 | -0.18 | sell |
| Nuveen, LLC | 105,994 | 104,261 | -1,733 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 35,327 | 90,193 | +54,866 | 0.00 | 0.01 | +0.01 | buy |
| Penserra Capital Management LLC | 150,599 | 88,507 | -62,092 | 0.04 | 0.03 | -0.01 | sell |
| Quantedge Capital Pte Ltd | 40,000 | 87,200 | +47,200 | 0.51 | 1.32 | +0.80 | buy |
| Swiss National Bank | 74,100 | 75,700 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 75,000 | +75,000 | 0.00 | 0.01 | +0.01 | buy |
| Palo Alto Investors LP | 105,427 | 72,022 | -33,405 | 0.46 | 0.32 | -0.14 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 45,205 | 70,282 | +25,077 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 67,112 | +67,112 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 44,664 | 66,502 | +21,838 | 0.01 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 238,015 | 63,109 | -174,906 | 0.04 | 0.01 | -0.03 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 63,000 | +63,000 | 0.00 | 0.48 | +0.48 | buy |
| RHUMBLINE ADVISERS | 68,304 | 62,414 | -5,890 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 75,858 | 57,212 | -18,646 | 0.00 | 0.00 | -0.00 | sell |
| Privium Fund Management B.V. | 0 | 55,000 | +55,000 | 0.00 | 0.32 | +0.32 | buy |
| Woodline Partners LP | 95,120 | 50,120 | -45,000 | 0.01 | 0.01 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 52,613 | 49,901 | -2,712 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 28,071 | 49,585 | +21,514 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,792 | 46,022 | +19,230 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 81,209 | 44,352 | -36,857 | 0.01 | 0.00 | -0.00 | sell |
| Creative Planning | 43,304 | 41,712 | -1,592 | 0.00 | 0.00 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 41,140 | +41,140 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 32,901 | 40,815 | +7,914 | 0.05 | 0.30 | +0.25 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,630 | 40,630 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Kennondale Capital Management LLC | 69,732 | 38,731 | -31,001 | 1.25 | 0.90 | -0.35 | sell |
| Harvest Investment Services, LLC | 0 | 38,347 | +38,347 | 0.00 | 0.23 | +0.23 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,070 | 37,127 | +5,057 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 37,783 | 36,366 | -1,417 | 0.00 | 0.00 | +0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 35,200 | +35,200 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 24,230 | 33,406 | +9,176 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 33,388 | +33,388 | 0.00 | 0.03 | +0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 50,463 | 32,515 | -17,948 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 29,113 | 29,467 | +354 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 29,059 | +29,059 | 0.00 | 0.04 | +0.04 | buy |
| Cresset Asset Management, LLC | 26,736 | 26,325 | -411 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 8,996 | 25,836 | +16,840 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 25,320 | 25,320 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allspring Global Investments Holdings, LLC | 35,058 | 24,462 | -10,596 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 20,996 | 21,076 | +80 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 19,309 | +19,309 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 19,101 | +19,101 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 13,147 | 18,652 | +5,505 | 0.00 | 0.01 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 17,181 | +17,181 | 0.00 | 0.32 | +0.32 | buy |
| SEI INVESTMENTS CO | 16,450 | 16,631 | +181 | 0.00 | 0.00 | +0.00 | buy |
| AVIVA PLC | 22,318 | 15,871 | -6,447 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 74,056 | 15,851 | -58,205 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 15,095 | 15,036 | -59 | 0.02 | 0.03 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,035 | 15,035 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 14,819 | +14,819 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 11,978 | 14,768 | +2,790 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 14,281 | +14,281 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 14,134 | +14,134 | 0.00 | 0.00 | +0.00 | buy |