| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 6,943,654 | 6,943,654 | 0 | 0.24 | 0.23 | -0.02 | hold |
| ADAMS STREET PARTNERS LLC | 3,275,616 | 3,275,616 | 0 | 1.78 | 2.32 | +0.54 | hold |
| SAMLYN CAPITAL, LLC | 2,496,259 | 2,348,363 | -147,896 | 0.10 | 0.07 | -0.02 | sell |
| VANGUARD GROUP INC | 1,350,633 | 1,493,357 | +142,724 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 587,432 | 637,032 | +49,600 | 0.00 | 0.00 | +0.00 | buy |
| TOWERVIEW LLC | 436,873 | 382,500 | -54,373 | 0.47 | 0.45 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 360,380 | 371,763 | +11,383 | 0.00 | 0.00 | -0.00 | buy |
| BVF INC/IL | 1,370,947 | 361,406 | -1,009,541 | 0.06 | 0.02 | -0.04 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 149,300 | 224,300 | +75,000 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 235,600 | 185,100 | -50,500 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 138,403 | 120,303 | -18,100 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 220,296 | 105,026 | -115,270 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 180,704 | 102,449 | -78,255 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 71,208 | 88,008 | +16,800 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 65,017 | 64,949 | -68 | 0.00 | 0.00 | -0.00 | sell |
| JACKSON SQUARE CAPITAL, LLC | 63,773 | 63,773 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Hikari Power Ltd | 49,959 | 49,959 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 40,835 | 23,281 | -17,554 | 0.00 | 0.00 | -0.00 | sell |
| Quinn Opportunity Partners LLC | 0 | 22,327 | +22,327 | 0.00 | 0.00 | +0.00 | buy |
| COMMERCE BANK | 20,000 | 20,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 18,462 | 18,248 | -214 | 0.00 | 0.00 | -0.00 | sell |
| OneDigital Investment Advisors LLC | 12,400 | 17,950 | +5,550 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15,668 | 15,668 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Virtu Financial LLC | 0 | 12,570 | +12,570 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 11,924 | 11,924 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 8,503 | 11,511 | +3,008 | 0.00 | 0.00 | +0.00 | buy |
| AVITY INVESTMENT MANAGEMENT INC. | 11,480 | 11,480 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WHITTIER TRUST CO OF NEVADA INC | 11,200 | 11,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FORTEM FINANCIAL GROUP, LLC | 0 | 11,000 | +11,000 | 0.00 | 0.01 | +0.01 | buy |
| Masso Torrence Wealth Management Inc. | 10,000 | 10,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 49,631 | 9,346 | -40,285 | 0.00 | 0.00 | -0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 0 | 7,000 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 36,664 | 4,604 | -32,060 | 0.00 | 0.00 | -0.00 | sell |
| Northwest Capital Management Inc | 3,397 | 3,397 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qube Research & Technologies Ltd | 0 | 2,378 | +2,378 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 791 | 791 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 24 | 24 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIXIS | 800 | 0 | -800 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 21,219 | 0 | -21,219 | 0.00 | 0.00 | -0.00 | sell |
| MYDA Advisors LLC | 71,011 | 0 | -71,011 | 0.05 | 0.00 | -0.05 | sell |
| XTX Topco Ltd | 23,415 | 0 | -23,415 | 0.01 | 0.00 | -0.01 | sell |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |