| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 7,165,006 | 7,165,006 | 0 | 1.13 | 2.29 | +1.16 | hold |
| BlackRock, Inc. | 5,056,361 | 6,160,422 | +1,104,061 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,788,223 | 3,565,992 | +777,769 | 0.00 | 0.00 | +0.00 | buy |
| ADAMS STREET PARTNERS LLC | 3,275,616 | 3,275,616 | 0 | 9.56 | 18.41 | +8.85 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 34,105 | 2,917,300 | +2,883,195 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 2,234,566 | 2,805,816 | +571,250 | 1.11 | 3.41 | +2.30 | buy |
| MORGAN STANLEY | 3,567,908 | 2,498,825 | -1,069,083 | 0.00 | 0.00 | +0.00 | sell |
| Deep Track Capital, LP | 0 | 2,491,539 | +2,491,539 | 0.00 | 0.75 | +0.75 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 314,683 | 2,318,517 | +2,003,834 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 692,441 | 2,292,441 | +1,600,000 | 0.10 | 0.66 | +0.56 | buy |
| Commodore Capital LP | 0 | 2,258,735 | +2,258,735 | 0.00 | 1.91 | +1.91 | buy |
| Foresite Capital Management VI LLC | 1,381,233 | 1,831,233 | +450,000 | 3.21 | 5.82 | +2.61 | buy |
| BRAIDWELL LP | 0 | 1,752,798 | +1,752,798 | 0.00 | 0.86 | +0.86 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,473,026 | 1,712,741 | +239,715 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 2,743,671 | 1,674,875 | -1,068,796 | 2.42 | 1.89 | -0.53 | sell |
| GOLDMAN SACHS GROUP INC | 553,327 | 1,540,809 | +987,482 | 0.00 | 0.00 | +0.00 | buy |
| Hood River Capital Management LLC | 0 | 1,335,109 | +1,335,109 | 0.00 | 0.20 | +0.20 | buy |
| Boxer Capital Management, LLC | 0 | 1,100,000 | +1,100,000 | 0.00 | 2.11 | +2.11 | buy |
| Polar Capital Holdings Plc | 0 | 1,070,174 | +1,070,174 | 0.00 | 0.07 | +0.07 | buy |
| Catalio Capital Management, LP | 0 | 891,933 | +891,933 | 0.00 | 2.73 | +2.73 | buy |
| MILLENNIUM MANAGEMENT LLC | 688,770 | 866,362 | +177,592 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 750,000 | +750,000 | 0.00 | 0.02 | +0.02 | buy |
| EMERALD ADVISERS, LLC | 0 | 686,216 | +686,216 | 0.00 | 0.32 | +0.32 | buy |
| DCF Advisers, LLC | 729,000 | 637,500 | -91,500 | 1.85 | 3.52 | +1.66 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 550,000 | +550,000 | 0.00 | 0.13 | +0.13 | buy |
| MARSHALL WACE, LLP | 216,248 | 548,285 | +332,037 | 0.00 | 0.01 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 0 | 545,000 | +545,000 | 0.00 | 2.14 | +2.14 | buy |
| TWO SIGMA INVESTMENTS, LP | 143,598 | 539,869 | +396,271 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 429,771 | 506,104 | +76,333 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 459,253 | +459,253 | 0.00 | 0.33 | +0.33 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 450,000 | +450,000 | 0.00 | 0.07 | +0.07 | buy |
| Nextech Invest, Ltd. | 0 | 450,000 | +450,000 | 0.00 | 0.46 | +0.46 | buy |
| Logos Global Management LP | 500,000 | 450,000 | -50,000 | 0.26 | 0.34 | +0.08 | sell |
| CITADEL ADVISORS LLC | 208,182 | 442,522 | +234,340 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 212,006 | 289,114 | +77,108 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 278,007 | +278,007 | 0.00 | 0.02 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 407,709 | 247,961 | -159,748 | 0.66 | 0.62 | -0.03 | sell |
| DIADEMA PARTNERS LP | 0 | 244,811 | +244,811 | 0.00 | 1.48 | +1.48 | buy |
| BARCLAYS PLC | 394,766 | 243,776 | -150,990 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 236,495 | 237,004 | +509 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 171,173 | 188,129 | +16,956 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 131,628 | 185,347 | +53,719 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 183,187 | +183,187 | 0.00 | 0.38 | +0.38 | buy |
| Brevan Howard Capital Management LP | 0 | 167,971 | +167,971 | 0.00 | 0.02 | +0.02 | buy |
| Nuveen, LLC | 68,064 | 149,126 | +81,062 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 147,850 | +147,850 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 30,655 | 145,157 | +114,502 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 138,148 | +138,148 | 0.00 | 0.23 | +0.23 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 128,352 | +128,352 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 104,820 | 123,896 | +19,076 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 123,738 | +123,738 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 115,000 | +115,000 | 0.00 | 0.34 | +0.34 | buy |
| Rafferty Asset Management, LLC | 99,724 | 112,608 | +12,884 | 0.00 | 0.01 | +0.00 | buy |
| Tidal Investments LLC | 0 | 107,775 | +107,775 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 79,698 | 107,775 | +28,077 | 0.05 | 0.11 | +0.06 | buy |
| Aquatic Capital Management LLC | 0 | 102,364 | +102,364 | 0.00 | 0.04 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,497 | 101,779 | +84,282 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 0 | 100,029 | +100,029 | 0.00 | 0.10 | +0.10 | buy |
| RAYMOND JAMES FINANCIAL INC | 121,157 | 99,883 | -21,274 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 27,661 | 99,631 | +71,970 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 465,875 | 87,901 | -377,974 | 0.27 | 0.08 | -0.19 | sell |
| Propel Bio Management, LLC | 0 | 85,791 | +85,791 | 0.00 | 0.79 | +0.79 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 28,117 | 83,907 | +55,790 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 81,310 | +81,310 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 70,727 | 76,514 | +5,787 | 0.00 | 0.00 | +0.00 | buy |
| TOWERVIEW LLC | 140,000 | 70,000 | -70,000 | 0.78 | 0.66 | -0.12 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 69,152 | +69,152 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 61,318 | 68,194 | +6,876 | 0.00 | 0.00 | +0.00 | buy |
| JACKSON SQUARE CAPITAL, LLC | 63,773 | 63,773 | 0 | 0.10 | 0.20 | +0.10 | hold |
| Persistent Asset Partners Ltd | 0 | 62,051 | +62,051 | 0.00 | 0.35 | +0.35 | buy |
| ALLIANCEBERNSTEIN L.P. | 17,120 | 61,740 | +44,620 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 60,848 | +60,848 | 0.00 | 0.00 | +0.00 | buy |
| Ancora Advisors LLC | 47,667 | 54,768 | +7,101 | 0.01 | 0.02 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 56,039 | 54,479 | -1,560 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 37,063 | 50,235 | +13,172 | 0.01 | 0.03 | +0.02 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.05 | +0.05 | buy |
| Hikari Power Ltd | 49,959 | 49,959 | 0 | 0.03 | 0.06 | +0.03 | hold |
| JANE STREET GROUP, LLC | 378,297 | 44,473 | -333,824 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 39,178 | 43,032 | +3,854 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 41,416 | +41,416 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 39,081 | +39,081 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61,754 | 38,636 | -23,118 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 43,583 | 38,212 | -5,371 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,409 | 38,152 | +5,743 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 20,021 | 35,420 | +15,399 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 34,723 | +34,723 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 0 | 34,305 | +34,305 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 114,500 | 33,228 | -81,272 | 0.00 | 0.00 | -0.00 | sell |
| AVITY INVESTMENT MANAGEMENT INC. | 32,680 | 33,200 | +520 | 0.02 | 0.04 | +0.02 | buy |
| MetLife Investment Management, LLC | 30,782 | 33,100 | +2,318 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 31,783 | 32,579 | +796 | 0.07 | 0.13 | +0.06 | buy |
| Miracle Mile Advisors, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.01 | +0.01 | buy |
| Optimize Financial Inc | 0 | 28,060 | +28,060 | 0.00 | 0.20 | +0.20 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 27,494 | +27,494 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 18,169 | 27,155 | +8,986 | 0.01 | 0.03 | +0.02 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 26,700 | 26,700 | 0 | 0.00 | 0.01 | +0.00 | hold |
| WINTON GROUP Ltd | 0 | 26,620 | +26,620 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 35,973 | 23,381 | -12,592 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 62,623 | 23,369 | -39,254 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 0 | 22,982 | +22,982 | 0.00 | 0.00 | +0.00 | buy |