| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 6,943,654 | 7,165,006 | +221,352 | 0.53 | 0.72 | +0.19 | buy |
| Point72 Asset Management, L.P. | 2,787,631 | 7,042,373 | +4,254,742 | 0.02 | 0.07 | +0.04 | buy |
| BlackRock, Inc. | 1,057,018 | 4,238,410 | +3,181,392 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,494,145 | 3,280,709 | +786,564 | 0.00 | 0.00 | +0.00 | buy |
| ADAMS STREET PARTNERS LLC | 3,275,616 | 3,275,616 | 0 | 9.22 | 9.23 | +0.01 | hold |
| RTW INVESTMENTS, LP | 2,679,479 | 2,679,479 | 0 | 0.13 | 0.15 | +0.02 | hold |
| Vivo Capital, LLC | 2,234,566 | 2,234,566 | 0 | 0.94 | 0.91 | -0.03 | hold |
| Foresite Capital Management VI LLC | 1,581,233 | 1,731,233 | +150,000 | 2.75 | 3.89 | +1.14 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,438,595 | +1,438,595 | 0.00 | 0.22 | +0.22 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 590,286 | 1,361,740 | +771,454 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 673,524 | 894,405 | +220,881 | 0.00 | 0.00 | +0.00 | buy |
| DCF Advisers, LLC | 400,000 | 757,500 | +357,500 | 0.68 | 1.46 | +0.77 | buy |
| STATE STREET CORP | 230,038 | 664,768 | +434,730 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 109,296 | 403,149 | +293,853 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 83,231 | 343,526 | +260,295 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 318,732 | +318,732 | 0.00 | 0.09 | +0.09 | buy |
| TWO SIGMA INVESTMENTS, LP | 308,350 | 223,913 | -84,437 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 236,400 | 212,700 | -23,700 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 154,771 | 201,651 | +46,880 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 205,859 | 183,094 | -22,765 | 0.16 | 0.19 | +0.03 | sell |
| GOLDMAN SACHS GROUP INC | 368,318 | 170,211 | -198,107 | 0.00 | 0.00 | -0.00 | sell |
| TOWERVIEW LLC | 127,500 | 170,000 | +42,500 | 0.29 | 0.48 | +0.19 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 0 | 168,000 | +168,000 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 264,988 | 165,188 | -99,800 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,968 | 161,821 | +131,853 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 101,032 | 138,462 | +37,430 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 98,549 | 132,729 | +34,180 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 108,117 | 124,496 | +16,379 | 0.00 | 0.00 | +0.00 | buy |
| BML Capital Management, LLC | 0 | 118,766 | +118,766 | 0.00 | 0.36 | +0.36 | buy |
| ROYAL BANK OF CANADA | 0 | 114,954 | +114,954 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 110,688 | +110,688 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 104,872 | 102,347 | -2,525 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 0 | 84,273 | +84,273 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 791 | 75,950 | +75,159 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 68,064 | +68,064 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 67,989 | 67,322 | -667 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 41,300 | 66,700 | +25,400 | 0.00 | 0.01 | +0.00 | buy |
| JACKSON SQUARE CAPITAL, LLC | 63,773 | 63,773 | 0 | 0.07 | 0.06 | -0.01 | hold |
| Masso Torrence Wealth Management Inc. | 35,000 | 50,000 | +15,000 | 0.06 | 0.09 | +0.03 | buy |
| Hikari Power Ltd | 49,959 | 49,959 | 0 | 0.01 | 0.02 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 0 | 43,988 | +43,988 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 449,080 | 43,969 | -405,111 | 0.00 | 0.00 | -0.00 | sell |
| Ancora Advisors LLC | 37,869 | 43,107 | +5,238 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 40,607 | +40,607 | 0.00 | 0.00 | +0.00 | buy |
| AVITY INVESTMENT MANAGEMENT INC. | 32,680 | 32,680 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MetLife Investment Management, LLC | 0 | 32,091 | +32,091 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 30,420 | +30,420 | 0.00 | 0.00 | +0.00 | buy |
| Argent Advisors, Inc. | 0 | 30,000 | +30,000 | 0.00 | 0.04 | +0.04 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 28,661 | +28,661 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 27,070 | +27,070 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 26,299 | +26,299 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 25,778 | +25,778 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 23,800 | +23,800 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,521 | 23,672 | +22,151 | 0.00 | 0.00 | +0.00 | buy |
| Three Bridge Wealth Advisors, LLC | 22,371 | 22,371 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Virtus Investment Advisers, LLC | 20,315 | 22,177 | +1,862 | 0.02 | 0.03 | +0.01 | buy |
| Caption Management, LLC | 0 | 21,827 | +21,827 | 0.00 | 0.01 | +0.01 | buy |
| COMMERCE BANK | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 19,098 | +19,098 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 17,500 | +17,500 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 17,120 | +17,120 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,889 | 15,488 | +2,599 | 0.00 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 14,774 | +14,774 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 13,620 | +13,620 | 0.00 | 0.00 | +0.00 | buy |
| Sender Co & Partners, Inc. | 0 | 12,995 | +12,995 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 12,258 | +12,258 | 0.00 | 0.00 | +0.00 | buy |
| Sowell Financial Services LLC | 12,000 | 12,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WHITTIER TRUST CO OF NEVADA INC | 11,200 | 11,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PKS Advisory Services, LLC | 10,500 | 10,500 | 0 | 0.01 | 0.01 | +0.00 | hold |
| OneDigital Investment Advisors LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 7,000 | 7,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 0 | 5,833 | +5,833 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 933 | 5,541 | +4,608 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 5,348 | +5,348 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 4,775 | +4,775 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,999 | 4,226 | +1,227 | 0.00 | 0.00 | +0.00 | buy |
| Northwest Capital Management Inc | 3,397 | 3,397 | 0 | 0.00 | 0.01 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 3,268 | +3,268 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,048 | 2,979 | +931 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 287 | 2,032 | +1,745 | 0.00 | 0.01 | +0.01 | buy |
| FNY Investment Advisers, LLC | 0 | 2,005 | +2,005 | 0.00 | 0.00 | +0.00 | buy |
| Western Pacific Wealth Management, LP | 2,000 | 2,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| AMALGAMATED BANK | 0 | 1,789 | +1,789 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,594 | 1,594 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 400 | 400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 0 | 365 | +365 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 234 | +234 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 127 | +127 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 82,300 | 0 | -82,300 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 20,850 | 0 | -20,850 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 57,827 | 0 | -57,827 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,637,138 | 0 | -1,637,138 | 0.01 | 0.00 | -0.01 | sell |
| Graham Capital Management, L.P. | 67,550 | 0 | -67,550 | 0.01 | 0.00 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,027 | 0 | -10,027 | 0.00 | 0.00 | -0.00 | sell |
| SAMLYN CAPITAL, LLC | 4,065,935 | 0 | -4,065,935 | 0.21 | 0.00 | -0.21 | sell |
| CITADEL ADVISORS LLC | 61,676 | 0 | -61,676 | 0.00 | 0.00 | -0.00 | sell |
| CAPSTONE INVESTMENT ADVISORS, LLC | 12,644 | 0 | -12,644 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 951,343 | 0 | -951,343 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 24,413 | 0 | -24,413 | 0.00 | 0.00 | -0.00 | sell |