| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 7,165,006 | 7,165,006 | 0 | 2.29 | 2.03 | -0.26 | hold |
| BlackRock, Inc. | 6,160,422 | 7,138,811 | +978,389 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,565,992 | 4,474,091 | +908,099 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,917,300 | 3,789,126 | +871,826 | 0.00 | 0.01 | +0.00 | buy |
| ADAMS STREET PARTNERS LLC | 3,275,616 | 3,275,616 | 0 | 18.41 | 11.06 | -7.35 | hold |
| Vivo Capital, LLC | 2,805,816 | 2,805,816 | 0 | 3.41 | 3.83 | +0.42 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 2,318,517 | 2,731,632 | +413,115 | 0.01 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 2,292,441 | 2,667,441 | +375,000 | 0.66 | 0.62 | -0.04 | buy |
| Deep Track Capital, LP | 2,491,539 | 2,491,939 | +400 | 0.75 | 0.55 | -0.20 | buy |
| BRAIDWELL LP | 1,752,798 | 2,126,298 | +373,500 | 0.86 | 1.18 | +0.32 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,712,741 | 1,853,659 | +140,918 | 0.00 | 0.00 | -0.00 | buy |
| Foresite Capital Management VI LLC | 1,831,233 | 1,831,233 | 0 | 5.82 | 4.26 | -1.56 | hold |
| GOLDMAN SACHS GROUP INC | 1,540,809 | 1,576,352 | +35,543 | 0.00 | 0.00 | -0.00 | buy |
| Hood River Capital Management LLC | 1,335,109 | 1,571,805 | +236,696 | 0.20 | 0.17 | -0.03 | buy |
| MORGAN STANLEY | 2,498,825 | 1,344,736 | -1,154,089 | 0.00 | 0.00 | -0.00 | sell |
| Boxer Capital Management, LLC | 1,100,000 | 1,100,000 | 0 | 2.11 | 1.24 | -0.88 | hold |
| Catalio Capital Management, LP | 891,933 | 1,080,888 | +188,955 | 2.73 | 3.03 | +0.31 | buy |
| MILLENNIUM MANAGEMENT LLC | 866,362 | 1,047,985 | +181,623 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 539,869 | 785,208 | +245,339 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 237,004 | 757,798 | +520,794 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 750,000 | 750,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Eversept Partners, LP | 0 | 747,994 | +747,994 | 0.00 | 0.61 | +0.61 | buy |
| EMERALD ADVISERS, LLC | 686,216 | 685,683 | -533 | 0.32 | 0.24 | -0.08 | sell |
| DCF Advisers, LLC | 637,500 | 637,500 | 0 | 3.52 | 2.49 | -1.02 | hold |
| Blue Owl Capital Holdings LP | 545,000 | 608,600 | +63,600 | 2.14 | 1.38 | -0.76 | buy |
| NORTHERN TRUST CORP | 506,104 | 575,158 | +69,054 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 459,253 | 526,389 | +67,136 | 0.33 | 0.28 | -0.05 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 450,000 | 450,000 | 0 | 0.07 | 0.06 | -0.01 | hold |
| Nextech Invest, Ltd. | 450,000 | 450,000 | 0 | 0.46 | 0.32 | -0.14 | hold |
| CITADEL ADVISORS LLC | 442,522 | 397,951 | -44,571 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 289,114 | 396,116 | +107,002 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 243,776 | 315,749 | +71,973 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 147,850 | 313,400 | +165,550 | 0.03 | 0.04 | +0.01 | buy |
| Trexquant Investment LP | 0 | 296,347 | +296,347 | 0.00 | 0.03 | +0.03 | buy |
| DIADEMA PARTNERS LP | 244,811 | 294,811 | +50,000 | 1.48 | 1.56 | +0.08 | buy |
| Polymer Capital Management (HK) LTD | 183,187 | 263,662 | +80,475 | 0.38 | 0.40 | +0.02 | buy |
| Brevan Howard Capital Management LP | 167,971 | 250,291 | +82,320 | 0.02 | 0.05 | +0.03 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 247,961 | 244,961 | -3,000 | 0.62 | 0.52 | -0.10 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 128,352 | 220,761 | +92,409 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 83,907 | 217,750 | +133,843 | 0.00 | 0.01 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 208,119 | +208,119 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 188,129 | 208,119 | +19,990 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 185,347 | 202,609 | +17,262 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,636 | 190,641 | +152,005 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 100,029 | 167,165 | +67,136 | 0.10 | 0.13 | +0.03 | buy |
| Nuveen, LLC | 149,126 | 161,821 | +12,695 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 145,157 | 141,986 | -3,171 | 0.00 | 0.00 | -0.00 | sell |
| Tidal Investments LLC | 107,775 | 136,276 | +28,501 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 107,775 | 136,276 | +28,501 | 0.11 | 0.07 | -0.04 | buy |
| D. E. Shaw & Co., Inc. | 0 | 133,177 | +133,177 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 126,500 | +126,500 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 99,631 | 123,379 | +23,748 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 102,364 | 118,000 | +15,636 | 0.04 | 0.06 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 87,901 | 117,101 | +29,200 | 0.08 | 0.08 | +0.00 | buy |
| CITIGROUP INC | 14,845 | 115,323 | +100,478 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 548,285 | 100,474 | -447,811 | 0.01 | 0.00 | -0.01 | sell |
| RAYMOND JAMES FINANCIAL INC | 99,883 | 99,012 | -871 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 34,723 | 92,343 | +57,620 | 0.02 | 0.04 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 61,740 | 90,420 | +28,680 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 76,514 | 86,020 | +9,506 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 68,194 | 85,340 | +17,146 | 0.00 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 101,779 | 82,907 | -18,872 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 123,738 | 82,596 | -41,142 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 112,608 | 81,494 | -31,114 | 0.01 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 60,848 | 80,006 | +19,158 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 115,000 | 80,000 | -35,000 | 0.34 | 0.19 | -0.15 | sell |
| Persistent Asset Partners Ltd | 62,051 | 74,796 | +12,745 | 0.35 | 0.35 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 54,479 | 74,529 | +20,050 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 6,116 | 74,369 | +68,253 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,498 | 70,920 | +67,422 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 85,791 | 70,380 | -15,411 | 0.79 | 0.55 | -0.24 | sell |
| TOWERVIEW LLC | 70,000 | 70,000 | 0 | 0.66 | 0.69 | +0.02 | hold |
| Caption Management, LLC | 0 | 64,034 | +64,034 | 0.00 | 0.03 | +0.03 | buy |
| JACKSON SQUARE CAPITAL, LLC | 63,773 | 63,773 | 0 | 0.20 | 0.13 | -0.06 | hold |
| WELLS FARGO & COMPANY/MN | 23,369 | 61,765 | +38,396 | 0.00 | 0.00 | +0.00 | buy |
| Ancora Advisors LLC | 54,768 | 56,723 | +1,955 | 0.02 | 0.02 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 39,081 | 56,703 | +17,622 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 50,000 | 50,000 | 0 | 0.05 | 0.03 | -0.02 | hold |
| Hikari Power Ltd | 49,959 | 49,959 | 0 | 0.06 | 0.09 | +0.02 | hold |
| GROUP ONE TRADING LLC | 0 | 48,292 | +48,292 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 123,896 | 44,205 | -79,691 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 43,769 | +43,769 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 43,032 | 42,174 | -858 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 38,212 | 41,702 | +3,490 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 5,678 | 41,697 | +36,019 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 50,235 | 41,044 | -9,191 | 0.03 | 0.02 | -0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,152 | 40,646 | +2,494 | 0.00 | 0.00 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 41,416 | 39,828 | -1,588 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 33,100 | 39,648 | +6,548 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 37,427 | +37,427 | 0.00 | 0.00 | +0.00 | buy |
| AVITY INVESTMENT MANAGEMENT INC. | 33,200 | 37,150 | +3,950 | 0.04 | 0.04 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 36,019 | +36,019 | 0.00 | 0.01 | +0.01 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 8,000 | 33,458 | +25,458 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 35,420 | 30,994 | -4,426 | 0.00 | 0.00 | -0.00 | sell |
| Optimize Financial Inc | 28,060 | 27,963 | -97 | 0.20 | 0.15 | -0.05 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 27,759 | +27,759 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 32,579 | 27,427 | -5,152 | 0.13 | 0.10 | -0.04 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,100 | 25,100 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| SIMON QUICK ADVISORS, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.02 | +0.02 | buy |
| WINTON GROUP Ltd | 26,620 | 23,200 | -3,420 | 0.01 | 0.01 | -0.00 | sell |