| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 0 | 1,497,268 | +1,497,268 | 0.00 | 0.65 | +0.65 | buy |
| VANGUARD GROUP INC | 1,650,500 | 2,420,619 | +770,119 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 393,262 | +393,262 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 376,121 | +376,121 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 331,360 | +331,360 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 74,559 | 323,211 | +248,652 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 218,962 | +218,962 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 127,332 | +127,332 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 122,858 | +122,858 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 204,598 | 311,288 | +106,690 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 460,140 | 563,009 | +102,869 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 79,735 | +79,735 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 120,303 | 178,246 | +57,943 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 83,222 | 137,031 | +53,809 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 50,221 | +50,221 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 49,556 | +49,556 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 53,010 | 97,073 | +44,063 | 0.00 | 0.00 | +0.00 | buy |
| MISSION WEALTH MANAGEMENT, LP | 0 | 40,000 | +40,000 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 47,786 | 71,552 | +23,766 | 0.00 | 0.00 | +0.00 | buy |
| Ancora Advisors LLC | 0 | 23,285 | +23,285 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 82,990 | 105,450 | +22,460 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 0 | 16,947 | +16,947 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 16,734 | +16,734 | 0.00 | 0.00 | +0.00 | buy |
| AVITY INVESTMENT MANAGEMENT INC. | 11,580 | 27,580 | +16,000 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 15,694 | +15,694 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 14,086 | +14,086 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 12,080 | +12,080 | 0.00 | 0.00 | +0.00 | buy |
| NWAM LLC | 0 | 10,050 | +10,050 | 0.00 | 0.00 | +0.00 | buy |
| WEALTHGARDEN F.S. LLC | 0 | 10,050 | +10,050 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 5,560 | +5,560 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 2,212 | 5,670 | +3,458 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 3,110 | +3,110 | 0.00 | 0.00 | +0.00 | buy |
| Western Pacific Wealth Management, LP | 0 | 2,000 | +2,000 | 0.00 | 0.01 | +0.01 | buy |
| COMMERCE BANK | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ORBIMED ADVISORS LLC | 6,943,654 | 6,943,654 | 0 | 0.25 | 0.67 | +0.42 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 127,300 | 127,300 | 0 | 0.01 | 0.01 | +0.01 | hold |
| RHUMBLINE ADVISERS | 791 | 791 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAMS STREET PARTNERS LLC | 3,275,616 | 3,275,616 | 0 | 2.46 | 9.52 | +7.06 | hold |
| WHITTIER TRUST CO OF NEVADA INC | 11,200 | 11,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Hikari Power Ltd | 49,959 | 49,959 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Quinn Opportunity Partners LLC | 22,327 | 22,327 | 0 | 0.00 | 0.01 | +0.01 | hold |
| IFP Advisors, Inc | 24 | 24 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Northwest Capital Management Inc | 3,397 | 3,397 | 0 | 0.00 | 0.01 | +0.00 | hold |
| JACKSON SQUARE CAPITAL, LLC | 63,773 | 63,773 | 0 | 0.03 | 0.08 | +0.06 | hold |
| Masso Torrence Wealth Management Inc. | 10,000 | 10,000 | 0 | 0.01 | 0.03 | +0.02 | hold |
| BARCLAYS PLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 11,924 | 11,924 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 7,000 | 7,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15,668 | 15,668 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 18,248 | 18,208 | -40 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 53 | 0 | -53 | 0.00 | 0.00 | -0.00 | sell |
| OneDigital Investment Advisors LLC | 14,550 | 10,000 | -4,550 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 11,384 | 0 | -11,384 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 24,364 | 10,026 | -14,338 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 15,300 | 0 | -15,300 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 113,400 | 61,300 | -52,100 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 563,932 | 386,588 | -177,344 | 0.00 | 0.00 | +0.00 | sell |
| TOWERVIEW LLC | 400,000 | 117,500 | -282,500 | 0.48 | 0.40 | -0.08 | sell |
| Point72 Asset Management, L.P. | 5,964,510 | 5,562,729 | -401,781 | 0.04 | 0.10 | +0.07 | sell |
| SAMLYN CAPITAL, LLC | 6,123,021 | 4,530,333 | -1,592,688 | 0.19 | 0.39 | +0.19 | sell |