| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 0 | 2,679,479 | +2,679,479 | 0.00 | 0.22 | +0.22 | buy |
| SAMLYN CAPITAL, LLC | 4,530,333 | 6,667,105 | +2,136,772 | 0.39 | 0.57 | +0.18 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.10 | +0.10 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 218,962 | 1,015,083 | +796,121 | 0.00 | 0.01 | +0.01 | buy |
| Vivo Capital, LLC | 1,497,268 | 2,234,566 | +737,298 | 0.65 | 1.34 | +0.69 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 500,491 | +500,491 | 0.00 | 0.49 | +0.49 | buy |
| BlackRock, Inc. | 603,877 | 1,072,941 | +469,064 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 127,332 | 450,050 | +322,718 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 376,121 | 584,546 | +208,425 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 5,670 | 139,933 | +134,263 | 0.00 | 0.02 | +0.02 | buy |
| EntryPoint Capital, LLC | 0 | 116,645 | +116,645 | 0.00 | 0.26 | +0.26 | buy |
| BARCLAYS PLC | 1 | 106,019 | +106,018 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 96,981 | +96,981 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 12,080 | 98,144 | +86,064 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 84,612 | +84,612 | 0.00 | 0.01 | +0.01 | buy |
| OMERS ADMINISTRATION Corp | 0 | 75,500 | +75,500 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 74,307 | +74,307 | 0.00 | 0.40 | +0.40 | buy |
| JANE STREET GROUP, LLC | 50,221 | 114,952 | +64,731 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 16,734 | 67,989 | +51,255 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 48,335 | +48,335 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 5,560 | 52,768 | +47,208 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 14,086 | 57,213 | +43,127 | 0.01 | 0.03 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 40,000 | +40,000 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 36,096 | +36,096 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 2,420,619 | 2,454,596 | +33,977 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 178,246 | 205,538 | +27,292 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 18,208 | 43,774 | +25,566 | 0.00 | 0.00 | +0.00 | buy |
| Three Bridge Wealth Advisors, LLC | 0 | 22,371 | +22,371 | 0.00 | 0.04 | +0.04 | buy |
| Masso Torrence Wealth Management Inc. | 10,000 | 30,000 | +20,000 | 0.03 | 0.08 | +0.06 | buy |
| Graham Capital Management, L.P. | 0 | 18,305 | +18,305 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 16,388 | +16,388 | 0.00 | 0.00 | +0.00 | buy |
| Ancora Advisors LLC | 23,285 | 37,869 | +14,584 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15,668 | 29,968 | +14,300 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 13,822 | +13,822 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 13,625 | +13,625 | 0.00 | 0.01 | +0.01 | buy |
| Man Group plc | 0 | 13,594 | +13,594 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 13,516 | +13,516 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 11,641 | +11,641 | 0.00 | 0.02 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 11,924 | 22,793 | +10,869 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 8,799 | +8,799 | 0.00 | 0.02 | +0.02 | buy |
| NWAM LLC | 10,050 | 15,500 | +5,450 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 393,262 | 397,364 | +4,102 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 386,588 | 390,688 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 563,009 | 566,863 | +3,854 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 2,141 | +2,141 | 0.00 | 0.00 | +0.00 | buy |
| AVITY INVESTMENT MANAGEMENT INC. | 27,580 | 29,680 | +2,100 | 0.01 | 0.01 | +0.00 | buy |
| OPPENHEIMER & CO INC | 16,947 | 18,044 | +1,097 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 105,450 | 106,013 | +563 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 15,694 | 16,038 | +344 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 0 | 224 | +224 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| COMMERCE BANK | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ORBIMED ADVISORS LLC | 6,943,654 | 6,943,654 | 0 | 0.67 | 0.77 | +0.10 | hold |
| RHUMBLINE ADVISERS | 791 | 791 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAMS STREET PARTNERS LLC | 3,275,616 | 3,275,616 | 0 | 9.52 | 15.53 | +6.02 | hold |
| WHITTIER TRUST CO OF NEVADA INC | 11,200 | 11,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Hikari Power Ltd | 49,959 | 49,959 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Quinn Opportunity Partners LLC | 22,327 | 22,327 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Northwest Capital Management Inc | 3,397 | 3,397 | 0 | 0.01 | 0.01 | +0.00 | hold |
| JACKSON SQUARE CAPITAL, LLC | 63,773 | 63,773 | 0 | 0.08 | 0.08 | -0.00 | hold |
| Western Pacific Wealth Management, LP | 2,000 | 2,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 7,000 | 7,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 20 | 0 | -20 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 24 | 0 | -24 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 3,110 | 861 | -2,249 | 0.00 | 0.00 | -0.00 | sell |
| OneDigital Investment Advisors LLC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 10,026 | 0 | -10,026 | 0.00 | 0.00 | -0.00 | sell |
| WEALTHGARDEN F.S. LLC | 10,050 | 0 | -10,050 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 97,073 | 78,712 | -18,361 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 49,556 | 24,455 | -25,101 | 0.00 | 0.00 | -0.00 | sell |
| TOWERVIEW LLC | 117,500 | 77,500 | -40,000 | 0.40 | 0.30 | -0.10 | sell |
| MISSION WEALTH MANAGEMENT, LP | 40,000 | 0 | -40,000 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 71,552 | 30,304 | -41,248 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 61,300 | 17,900 | -43,400 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 122,858 | 48,222 | -74,636 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 79,735 | 0 | -79,735 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 127,300 | 41,300 | -86,000 | 0.01 | 0.00 | -0.01 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 137,031 | 0 | -137,031 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 311,288 | 154,901 | -156,387 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 331,360 | 129,076 | -202,284 | 0.01 | 0.00 | -0.01 | sell |
| MARSHALL WACE, LLP | 323,211 | 0 | -323,211 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 5,562,729 | 3,030,011 | -2,532,718 | 0.10 | 0.04 | -0.06 | sell |