| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 7,165,006 | 7,165,006 | 0 | 1.27 | 1.13 | -0.14 | hold |
| BlackRock, Inc. | 4,710,442 | 5,056,361 | +345,919 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,471,925 | 3,873,482 | +401,557 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 617,224 | 3,567,908 | +2,950,684 | 0.00 | 0.00 | +0.00 | buy |
| ADAMS STREET PARTNERS LLC | 3,275,616 | 3,275,616 | 0 | 15.76 | 9.56 | -6.20 | hold |
| Point72 Asset Management, L.P. | 6,454,274 | 2,875,000 | -3,579,274 | 0.10 | 0.03 | -0.07 | sell |
| STATE STREET CORP | 1,006,319 | 2,788,223 | +1,781,904 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 2,743,671 | +2,743,671 | 0.00 | 2.42 | +2.42 | buy |
| Vivo Capital, LLC | 2,234,566 | 2,234,566 | 0 | 1.33 | 1.11 | -0.21 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,456,528 | 1,473,026 | +16,498 | 0.00 | 0.00 | +0.00 | buy |
| Foresite Capital Management VI LLC | 1,731,233 | 1,381,233 | -350,000 | 4.93 | 3.21 | -1.71 | sell |
| DCF Advisers, LLC | 0 | 729,000 | +729,000 | 0.00 | 1.85 | +1.85 | buy |
| PERCEPTIVE ADVISORS LLC | 1,438,595 | 692,441 | -746,154 | 0.31 | 0.10 | -0.21 | sell |
| MILLENNIUM MANAGEMENT LLC | 0 | 688,770 | +688,770 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 445,670 | 553,327 | +107,657 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 500,000 | +500,000 | 0.00 | 0.26 | +0.26 | buy |
| ADAR1 Capital Management, LLC | 0 | 465,875 | +465,875 | 0.00 | 0.27 | +0.27 | buy |
| RTW INVESTMENTS, LP | 2,679,479 | 447,607 | -2,231,872 | 0.24 | 0.03 | -0.21 | sell |
| NORTHERN TRUST CORP | 466,486 | 429,771 | -36,715 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 407,709 | 407,709 | 0 | 0.71 | 0.66 | -0.06 | hold |
| BARCLAYS PLC | 309,152 | 394,766 | +85,614 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 68,066 | 378,297 | +310,231 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 180,175 | 314,683 | +134,508 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 151,966 | 236,495 | +84,529 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 216,248 | +216,248 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 162,074 | 212,006 | +49,932 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 42,766 | 208,182 | +165,416 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 177,788 | 171,173 | -6,615 | 0.00 | 0.00 | -0.00 | sell |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 169,200 | 167,400 | -1,800 | 0.03 | 0.02 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 0 | 144,381 | +144,381 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 203,360 | 143,598 | -59,762 | 0.00 | 0.00 | -0.00 | sell |
| TOWERVIEW LLC | 170,000 | 140,000 | -30,000 | 0.91 | 0.78 | -0.13 | sell |
| Bank of New York Mellon Corp | 126,528 | 131,628 | +5,100 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 124,496 | 121,157 | -3,339 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 114,500 | +114,500 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 104,820 | +104,820 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 99,724 | +99,724 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 86,720 | +86,720 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 59,202 | 80,893 | +21,691 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 59,202 | 79,698 | +20,496 | 0.04 | 0.05 | +0.01 | buy |
| RHUMBLINE ADVISERS | 82,590 | 70,727 | -11,863 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 68,064 | 68,064 | 0 | 0.00 | 0.00 | +0.00 | hold |
| OSAIC HOLDINGS, INC. | 67,992 | 67,993 | +1 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 25,575 | 64,915 | +39,340 | 0.00 | 0.00 | +0.00 | buy |
| JACKSON SQUARE CAPITAL, LLC | 63,773 | 63,773 | 0 | 0.10 | 0.10 | -0.01 | hold |
| WELLS FARGO & COMPANY/MN | 36,395 | 62,623 | +26,228 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 61,754 | +61,754 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 61,318 | +61,318 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 82,387 | 59,269 | -23,118 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 53,639 | 56,039 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| Hikari Power Ltd | 49,959 | 49,959 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Caption Management, LLC | 21,827 | 49,325 | +27,498 | 0.01 | 0.02 | +0.01 | buy |
| Ancora Advisors LLC | 47,290 | 47,667 | +377 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 38,673 | 43,583 | +4,910 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 25,299 | 39,178 | +13,879 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 37,063 | +37,063 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 26,161 | 35,973 | +9,812 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 35,972 | +35,972 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 32,409 | 34,105 | +1,696 | 0.00 | 0.00 | +0.00 | buy |
| AVITY INVESTMENT MANAGEMENT INC. | 32,680 | 32,680 | 0 | 0.02 | 0.02 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,525 | 32,409 | +4,884 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 26,837 | 31,783 | +4,946 | 0.06 | 0.07 | +0.01 | buy |
| MetLife Investment Management, LLC | 33,594 | 30,782 | -2,812 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 32,232 | 30,655 | -1,577 | 0.00 | 0.00 | +0.00 | sell |
| Argent Advisors, Inc. | 30,000 | 30,000 | 0 | 0.07 | 0.06 | -0.00 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 28,117 | +28,117 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 27,661 | +27,661 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 66,700 | 26,700 | -40,000 | 0.01 | 0.00 | -0.01 | sell |
| GROUP ONE TRADING LLC | 0 | 26,667 | +26,667 | 0.00 | 0.01 | +0.01 | buy |
| Palumbo Wealth Management LLC | 23,614 | 26,255 | +2,641 | 0.06 | 0.05 | -0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 25,572 | 25,031 | -541 | 0.00 | 0.00 | -0.00 | sell |
| DRW Securities, LLC | 0 | 23,384 | +23,384 | 0.00 | 0.01 | +0.01 | buy |
| Three Bridge Wealth Advisors, LLC | 22,371 | 22,371 | 0 | 0.04 | 0.05 | +0.00 | hold |
| Verition Fund Management LLC | 0 | 21,382 | +21,382 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 20,021 | +20,021 | 0.00 | 0.00 | +0.00 | buy |
| COMMERCE BANK | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Graham Capital Management, L.P. | 0 | 19,274 | +19,274 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 161,600 | 18,900 | -142,700 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,800 | 18,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| China Universal Asset Management Co., Ltd. | 13,061 | 18,169 | +5,108 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,726 | 17,497 | -1,229 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 17,120 | 17,120 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sowell Financial Services LLC | 12,000 | 17,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| SHELTON WEALTH MANAGEMENT, LLC | 13,742 | 15,638 | +1,896 | 0.05 | 0.05 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 15,530 | 15,530 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 3,948 | 14,858 | +10,910 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 401,407 | 14,188 | -387,219 | 0.25 | 0.01 | -0.24 | sell |
| ProShare Advisors LLC | 12,785 | 13,764 | +979 | 0.00 | 0.00 | -0.00 | buy |
| AXQ CAPITAL, LP | 27,051 | 12,601 | -14,450 | 0.08 | 0.02 | -0.05 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 11,220 | +11,220 | 0.00 | 0.01 | +0.01 | buy |
| WHITTIER TRUST CO OF NEVADA INC | 11,200 | 11,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CAPTRUST FINANCIAL ADVISORS | 0 | 11,051 | +11,051 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 5,513 | 10,257 | +4,744 | 0.01 | 0.01 | +0.01 | buy |
| OneDigital Investment Advisors LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 7,000 | 7,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 6,661 | 6,661 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 12,516 | 6,566 | -5,950 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 6,524 | 5,787 | -737 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 5,348 | 5,348 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 2,881 | 3,629 | +748 | 0.00 | 0.00 | +0.00 | buy |