| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 2,211,018 | 10,629,822 | +8,418,804 | 5.44 | 54.45 | +49.02 | buy |
| Capital World Investors | 0 | 4,008,244 | +4,008,244 | 0.00 | 0.09 | +0.09 | buy |
| FMR LLC | 8,464,314 | 12,200,422 | +3,736,108 | 0.04 | 0.10 | +0.06 | buy |
| JPMORGAN CHASE & CO | 301,393 | 3,298,066 | +2,996,673 | 0.00 | 0.04 | +0.04 | buy |
| BlackRock, Inc. | 11,212,706 | 13,695,790 | +2,483,084 | 0.02 | 0.04 | +0.02 | buy |
| NORGES BANK | 0 | 2,157,479 | +2,157,479 | 0.00 | 0.04 | +0.04 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 2,012,317 | +2,012,317 | 0.00 | 0.12 | +0.12 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,917,025 | +1,917,025 | 0.00 | 0.05 | +0.05 | buy |
| BAKER BROS. ADVISORS LP | 9,555,357 | 11,443,357 | +1,888,000 | 5.34 | 10.74 | +5.40 | buy |
| Nearwater Capital Markets, Ltd | 678,000 | 2,097,000 | +1,419,000 | 1.56 | 6.77 | +5.22 | buy |
| LMR Partners LLP | 3,838,024 | 5,066,598 | +1,228,574 | 0.06 | 0.35 | +0.29 | buy |
| AQR CAPITAL MANAGEMENT LLC | 116,787 | 1,295,450 | +1,178,663 | 0.01 | 0.08 | +0.08 | buy |
| UBS Group AG | 4,386,791 | 5,448,364 | +1,061,573 | 0.08 | 0.16 | +0.09 | buy |
| LORD, ABBETT & CO. LLC | 134,233 | 789,241 | +655,008 | 0.04 | 0.42 | +0.38 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,338,142 | 3,942,676 | +604,534 | 0.02 | 0.04 | +0.02 | buy |
| STATE STREET CORP | 4,402,662 | 4,897,051 | +494,389 | 0.01 | 0.03 | +0.01 | buy |
| Pictet Asset Management Holding SA | 557,560 | 1,014,894 | +457,334 | 0.06 | 0.18 | +0.13 | buy |
| DEUTSCHE BANK AG\ | 465,758 | 888,019 | +422,261 | 0.01 | 0.05 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 500,595 | 912,335 | +411,740 | 0.01 | 0.03 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 614,157 | 983,911 | +369,754 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 1,133,546 | 1,488,394 | +354,848 | 0.03 | 0.06 | +0.03 | buy |
| 1832 Asset Management L.P. | 0 | 309,200 | +309,200 | 0.00 | 0.07 | +0.07 | buy |
| Caligan Partners LP | 1,652,808 | 1,961,795 | +308,987 | 11.37 | 17.73 | +6.36 | buy |
| Patient Square Capital LP | 0 | 276,000 | +276,000 | 0.00 | 8.01 | +8.01 | buy |
| National Pension Service | 0 | 273,604 | +273,604 | 0.00 | 0.03 | +0.03 | buy |
| PERCEPTIVE ADVISORS LLC | 258,600 | 527,600 | +269,000 | 0.50 | 1.53 | +1.04 | buy |
| Chicago Capital, LLC | 0 | 251,847 | +251,847 | 0.00 | 1.14 | +1.14 | buy |
| FRED ALGER MANAGEMENT, LLC | 21,374 | 259,468 | +238,094 | 0.01 | 0.16 | +0.15 | buy |
| Assenagon Asset Management S.A. | 0 | 200,486 | +200,486 | 0.00 | 0.05 | +0.05 | buy |
| CITADEL ADVISORS LLC | 400,053 | 589,906 | +189,853 | 0.03 | 0.06 | +0.04 | buy |
| Invesco Ltd. | 392,844 | 578,287 | +185,443 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,735,476 | 1,917,025 | +181,549 | 0.03 | 0.05 | +0.02 | buy |
| NWI MANAGEMENT LP | 0 | 180,000 | +180,000 | 0.00 | 2.15 | +2.15 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,385 | 227,985 | +176,600 | 0.01 | 0.04 | +0.03 | buy |
| Hood River Capital Management LLC | 0 | 170,422 | +170,422 | 0.00 | 0.23 | +0.23 | buy |
| NORTHERN TRUST CORP | 954,256 | 1,117,110 | +162,854 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 89,742 | 247,052 | +157,310 | 0.01 | 0.02 | +0.02 | buy |
| Tri Locum Partners LP | 0 | 151,822 | +151,822 | 0.00 | 3.50 | +3.50 | buy |
| Handelsbanken Fonder AB | 61,775 | 212,275 | +150,500 | 0.02 | 0.11 | +0.09 | buy |
| Affinity Asset Advisors, LLC | 100,000 | 250,000 | +150,000 | 0.57 | 2.29 | +1.72 | buy |
| Checkpoint Capital L.P. | 262,539 | 410,353 | +147,814 | 9.16 | 19.72 | +10.55 | buy |
| WELLS FARGO & COMPANY/MN | 34,241 | 178,780 | +144,539 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 340,611 | 475,231 | +134,620 | 0.01 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 705,793 | 838,249 | +132,456 | 0.00 | 0.01 | +0.00 | buy |
| Amundi | 138,560 | 269,701 | +131,141 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 422,443 | 552,710 | +130,267 | 0.03 | 0.05 | +0.03 | buy |
| Zweig-DiMenna Associates LLC | 8,287 | 120,200 | +111,913 | 0.11 | 2.04 | +1.93 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 47,766 | 156,169 | +108,403 | 0.00 | 0.03 | +0.02 | buy |
| BVF INC/IL | 2,856,782 | 2,965,160 | +108,378 | 8.85 | 14.20 | +5.35 | buy |
| PARNASSUS INVESTMENTS, LLC | 0 | 99,988 | +99,988 | 0.00 | 0.05 | +0.05 | buy |
| AVIVA PLC | 21,460 | 118,070 | +96,610 | 0.00 | 0.03 | +0.03 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,297,000 | 2,392,000 | +95,000 | 2.64 | 4.67 | +2.04 | buy |
| Warberg Asset Management LLC | 0 | 94,797 | +94,797 | 0.00 | 0.26 | +0.26 | buy |
| FEDERATED HERMES, INC. | 0 | 90,878 | +90,878 | 0.00 | 0.02 | +0.02 | buy |
| Neuberger Berman Group LLC | 20,118 | 109,221 | +89,103 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 88,913 | +88,913 | 0.00 | 0.10 | +0.10 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 142,578 | 230,909 | +88,331 | 0.01 | 0.02 | +0.02 | buy |
| Atika Capital Management LLC | 0 | 88,000 | +88,000 | 0.00 | 1.64 | +1.64 | buy |
| Duquesne Family Office LLC | 315,860 | 399,587 | +83,727 | 1.05 | 1.72 | +0.67 | buy |
| DLK Investment Management, LLC | 0 | 77,000 | +77,000 | 0.00 | 0.00 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 187,072 | 263,466 | +76,394 | 0.02 | 0.04 | +0.03 | buy |
| Quadrature Capital Ltd | 16,667 | 92,717 | +76,050 | 0.02 | 0.15 | +0.13 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 0 | 74,036 | +74,036 | 0.00 | 0.17 | +0.17 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 165,277 | 238,463 | +73,186 | 0.02 | 0.04 | +0.02 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 281,960 | 349,929 | +67,969 | 0.02 | 0.04 | +0.02 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 67,000 | +67,000 | 0.00 | 0.02 | +0.02 | buy |
| AGF MANAGEMENT LTD | 0 | 66,941 | +66,941 | 0.00 | 0.05 | +0.05 | buy |
| Freestone Grove Partners LP | 0 | 64,813 | +64,813 | 0.00 | 0.08 | +0.08 | buy |
| BANK OF NOVA SCOTIA | 10,305 | 73,879 | +63,574 | 0.00 | 0.02 | +0.02 | buy |
| CSS LLC/IL | 17,505 | 78,367 | +60,862 | 0.02 | 0.29 | +0.28 | buy |
| Artia Global Partners LP | 124,990 | 185,390 | +60,400 | 2.74 | 6.60 | +3.86 | buy |
| Point72 Asset Management, L.P. | 0 | 60,276 | +60,276 | 0.00 | 0.02 | +0.02 | buy |
| DIADEMA PARTNERS LP | 80,872 | 139,218 | +58,346 | 3.25 | 9.21 | +5.96 | buy |
| Trexquant Investment LP | 68,609 | 120,122 | +51,513 | 0.05 | 0.14 | +0.09 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 51,053 | +51,053 | 0.00 | 6.04 | +6.04 | buy |
| STRS OHIO | 4,068 | 54,428 | +50,360 | 0.00 | 0.04 | +0.04 | buy |
| Ghisallo Capital Management LLC | 0 | 50,000 | +50,000 | 0.00 | 0.18 | +0.18 | buy |
| Burkehill Global Management, LP | 0 | 50,000 | +50,000 | 0.00 | 0.34 | +0.34 | buy |
| Empowered Funds, LLC | 3,174 | 52,086 | +48,912 | 0.00 | 0.05 | +0.05 | buy |
| Lansforsakringar Fondforvaltning AB (publ) | 0 | 48,442 | +48,442 | 0.00 | 0.04 | +0.04 | buy |
| SONA ASSET MANAGEMENT (US) LLC | 0 | 46,450 | +46,450 | 0.00 | 0.32 | +0.32 | buy |
| RHUMBLINE ADVISERS | 179,942 | 226,008 | +46,066 | 0.01 | 0.03 | +0.02 | buy |
| LPL Financial LLC | 22,619 | 67,500 | +44,881 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 43,794 | +43,794 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 341,148 | 381,366 | +40,218 | 0.01 | 0.01 | +0.01 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 40,000 | +40,000 | 0.00 | 0.30 | +0.30 | buy |
| HSBC HOLDINGS PLC | 32,791 | 71,816 | +39,025 | 0.00 | 0.01 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 137,160 | 174,434 | +37,274 | 0.00 | 0.01 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 270,972 | 306,300 | +35,328 | 0.02 | 0.03 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 34,061 | +34,061 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 99,117 | 133,059 | +33,942 | 0.01 | 0.02 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 10,536 | 44,020 | +33,484 | 0.01 | 0.08 | +0.07 | buy |
| SHIKIAR ASSET MANAGEMENT INC | 0 | 33,205 | +33,205 | 0.00 | 1.57 | +1.57 | buy |
| Zurich Insurance Group Ltd/FI | 0 | 31,880 | +31,880 | 0.00 | 0.04 | +0.04 | buy |
| Swiss National Bank | 425,431 | 456,331 | +30,900 | 0.02 | 0.04 | +0.02 | buy |
| Aberdeen Group plc | 114,767 | 142,978 | +28,211 | 0.02 | 0.04 | +0.02 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 49,509 | 77,402 | +27,893 | 0.02 | 0.04 | +0.03 | buy |
| MARSHALL WACE, LLP | 216,661 | 244,544 | +27,883 | 0.02 | 0.04 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 438,595 | 465,787 | +27,192 | 0.98 | 1.63 | +0.64 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 55,600 | 81,700 | +26,100 | 0.20 | 0.35 | +0.15 | buy |