| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 9,555,357 | 11,443,357 | +1,888,000 | 5.34 | 10.74 | +5.40 | buy |
| PERCEPTIVE ADVISORS LLC | 258,600 | 527,600 | +269,000 | 0.49 | 1.48 | +0.99 | buy |
| Zweig-DiMenna Associates LLC | 8,287 | 120,200 | +111,913 | 0.11 | 2.04 | +1.93 | buy |
| BVF INC/IL | 2,856,782 | 2,965,160 | +108,378 | 8.85 | 14.20 | +5.35 | buy |
| AVIVA PLC | 21,460 | 118,070 | +96,610 | 0.00 | 0.03 | +0.03 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,297,000 | 2,392,000 | +95,000 | 2.64 | 4.67 | +2.04 | buy |
| Duquesne Family Office LLC | 315,860 | 399,587 | +83,727 | 0.91 | 1.44 | +0.53 | buy |
| BAILLIE GIFFORD & CO | 187,072 | 263,466 | +76,394 | 0.02 | 0.04 | +0.03 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 55,600 | 81,700 | +26,100 | 0.11 | 0.23 | +0.12 | buy |
| BAMCO INC /NY/ | 2,500 | 12,500 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| FJARDE AP-FONDEN /FOURTH SWEDISH NATIONAL PENSION FUND | 46,900 | 56,300 | +9,400 | 0.02 | 0.05 | +0.03 | buy |
| Asset Management One Co., Ltd. | 55,816 | 62,267 | +6,451 | 0.02 | 0.03 | +0.01 | buy |
| IFM Investors Pty Ltd | 28,809 | 35,035 | +6,226 | 0.02 | 0.04 | +0.02 | buy |
| ABN AMRO INVESTMENT SOLUTIONS | 6,794 | 11,990 | +5,196 | 0.01 | 0.02 | +0.01 | buy |
| BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp | 19,983 | 24,256 | +4,273 | 0.01 | 0.03 | +0.02 | buy |
| Calamos Advisors LLC | 15,463 | 19,711 | +4,248 | 0.01 | 0.01 | +0.01 | buy |
| Gulf International Bank (UK) Ltd | 11,123 | 14,362 | +3,239 | 0.02 | 0.05 | +0.03 | buy |
| PFM Health Sciences, LP | 140,770 | 143,222 | +2,452 | 1.25 | 2.30 | +1.05 | buy |
| Lombard Odier Asset Management (Switzerland) SA | 2,544 | 4,832 | +2,288 | 0.01 | 0.03 | +0.02 | buy |
| PRAXIS INVESTMENT MANAGEMENT INC | 5,402 | 6,152 | +750 | 0.03 | 0.06 | +0.03 | buy |
| PKO Investment Management Joint-Stock Co | 1,500 | 2,200 | +700 | 0.01 | 0.03 | +0.02 | buy |
| Aaron Wealth Advisors LLC | 2,426 | 2,670 | +244 | 0.01 | 0.03 | +0.01 | buy |
| Sumitomo Mitsui DS Asset Management Company, Ltd | 17,078 | 17,140 | +62 | 0.01 | 0.02 | +0.01 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 146 | 207 | +61 | 0.01 | 0.01 | +0.01 | buy |
| Wedmont Private Capital | 40,231 | 40,281 | +50 | 0.13 | 0.21 | +0.08 | buy |
| J.Safra Asset Management Corp | 63 | 81 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Dogwood Wealth Management LLC | 24 | 39 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Retirement Wealth Solutions LLC | 31 | 37 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Quaker Wealth Management, LLC | 9 | 8 | -1 | 0.00 | 0.00 | +0.00 | sell |
| MEEDER ASSET MANAGEMENT INC | 106 | 39 | -67 | 0.00 | 0.00 | -0.00 | sell |
| Abel Hall, LLC | 5,842 | 5,394 | -448 | 0.12 | 0.17 | +0.05 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 7,905 | 7,290 | -615 | 0.01 | 0.01 | +0.00 | sell |
| Informed Momentum Co LLC | 50,122 | 49,357 | -765 | 0.56 | 0.82 | +0.26 | sell |
| China Universal Asset Management Co., Ltd. | 35,167 | 33,835 | -1,332 | 0.26 | 0.38 | +0.12 | sell |
| Avior Wealth Management, LLC | 3,327 | 1,769 | -1,558 | 0.01 | 0.01 | -0.00 | sell |
| HARVEST MANAGEMENT LLC | 9,524 | 7,221 | -2,303 | 0.45 | 0.53 | +0.08 | sell |
| HighVista Strategies LLC | 69,309 | 66,983 | -2,326 | 1.86 | 2.86 | +1.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 20,813 | 16,994 | -3,819 | 0.51 | 0.78 | +0.27 | sell |
| Legato Capital Management LLC | 37,394 | 33,042 | -4,352 | 0.33 | 0.51 | +0.18 | sell |
| Korea Investment CORP | 66,461 | 60,100 | -6,361 | 0.01 | 0.02 | +0.01 | sell |
| Jasper Ridge Partners, L.P. | 14,368 | 5,809 | -8,559 | 0.03 | 0.02 | -0.01 | sell |
| J. Safra Sarasin Holding AG | 21,001 | 8,007 | -12,994 | 0.03 | 0.02 | -0.01 | sell |
| Nicholas Investment Partners, LP | 261,166 | 244,594 | -16,572 | 1.83 | 2.58 | +0.75 | sell |
| DAFNA Capital Management LLC | 580,678 | 562,630 | -18,048 | 12.85 | 20.09 | +7.25 | sell |
| Candriam S.C.A. | 580,677 | 556,392 | -24,285 | 0.29 | 0.47 | +0.18 | sell |
| TEMA ETFS LLC | 98,178 | 71,735 | -26,443 | 0.64 | 0.43 | -0.21 | sell |
| Empyrean Capital Partners, LP | 102,400 | 75,400 | -27,000 | 0.32 | 0.47 | +0.14 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 55,110 | 22,400 | -32,710 | 0.85 | 0.55 | -0.30 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 261,425 | 227,845 | -33,580 | 0.42 | 0.57 | +0.15 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 104,989 | 58,074 | -46,915 | 0.02 | 0.02 | -0.00 | sell |
| Avoro Capital Advisors LLC | 2,344,444 | 2,297,000 | -47,444 | 2.24 | 3.86 | +1.62 | sell |
| a16z Perennial Management, L.P. | 104,214 | 51,490 | -52,724 | 0.84 | 0.78 | -0.06 | sell |
| Rangeley Capital, LLC | 66,700 | 8,700 | -58,000 | 1.20 | 1.49 | +0.29 | sell |
| Edgestream Partners, L.P. | 69,262 | 5,907 | -63,355 | 0.22 | 0.03 | -0.19 | sell |
| Rock Springs Capital Management LP | 1,209,465 | 1,105,210 | -104,255 | 6.93 | 10.10 | +3.17 | sell |
| SAMLYN CAPITAL, LLC | 371,948 | 151,290 | -220,658 | 0.62 | 0.46 | -0.16 | sell |
| Sculptor Capital LP | 958,822 | 709,670 | -249,152 | 0.42 | 0.05 | -0.37 | sell |
| GENERAL ATLANTIC, L.P. | 707,791 | 357,791 | -350,000 | 3.20 | 2.31 | -0.90 | sell |
| Bellevue Group AG | 1,544,456 | 1,048,014 | -496,442 | 3.57 | 4.13 | +0.56 | sell |
| Atle Fund Management AB | 617,245 | 73,077 | -544,168 | 2.93 | 3.68 | +0.75 | sell |
| Alyeska Investment Group, L.P. | 1,885,821 | 659,279 | -1,226,542 | 0.52 | 0.32 | -0.20 | sell |