| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 5,148,657 | 7,549,249 | +2,400,592 | 1.68 | 3.05 | +1.37 | buy |
| JANUS HENDERSON GROUP PLC | 2,199,480 | 3,912,119 | +1,712,639 | 0.04 | 0.07 | 0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 567,105 | 1,654,895 | +1,087,790 | 0.05 | 0.14 | 0.00 | buy |
| Woodline Partners LP | 2,960,040 | 3,797,148 | +837,108 | 0.93 | 1.13 | +0.21 | buy |
| Avidity Partners Management LP | 60,000 | 635,000 | +575,000 | 0.07 | 0.73 | +0.66 | buy |
| Soleus Capital Management, L.P. | 252,000 | 728,700 | +476,700 | 0.80 | 2.06 | +1.26 | buy |
| Integral Health Asset Management, LLC | 200,000 | 420,000 | +220,000 | 0.83 | 1.33 | +0.50 | buy |
| Rock Springs Capital Management LP | 725,152 | 923,681 | +198,529 | 0.51 | 0.76 | +0.24 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,636,353 | 4,814,310 | +177,957 | 0.02 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,978,784 | 3,052,691 | +73,907 | 0.01 | 0.01 | 0.00 | buy |
| AMERIPRISE FINANCIAL INC | 1,623,021 | 1,694,501 | +71,480 | 0.01 | 0.02 | +0.00 | buy |
| Finepoint Capital LP | 617,100 | 677,100 | +60,000 | 5.58 | 5.60 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 558,369 | 600,581 | +42,212 | 0.02 | 0.02 | +0.00 | buy |
| PROFUND ADVISORS LLC | 61,107 | 46,114 | +14,993 | 0.08 | 0.06 | 0.00 | sell |
| ALGERT GLOBAL LLC | 20,600 | 6,460 | +14,140 | 0.02 | 0.01 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 18,941 | 31,637 | +12,696 | 0.11 | 0.13 | +0.02 | buy |
| ALPS ADVISORS INC | 111,204 | 116,156 | +4,952 | 0.03 | 0.03 | +0.00 | buy |
| NEOS Investment Management LLC | 10,904 | 15,384 | +4,480 | 0.03 | 0.03 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 51,647 | 48,590 | +3,057 | 0.01 | 0.01 | 0.00 | sell |
| Clear Harbor Asset Management, LLC | 7,200 | 10,188 | +2,988 | 0.02 | 0.03 | +0.01 | buy |
| CSS LLC/IL | 11,881 | 14,856 | +2,975 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 34,274 | 36,605 | +2,331 | 0.00 | 0.00 | 0.00 | buy |
| MPM BioImpact LLC | 273,408 | 273,217 | -191 | 1.83 | 1.42 | -0.42 | sell |
| VIRTUS ADVISERS, LLC | 3,540 | 3,311 | -229 | 0.06 | 0.06 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 13,710 | 12,910 | -800 | 0.17 | 0.16 | -0.01 | sell |
| Ameritas Investment Partners, Inc. | 14,889 | 13,911 | -978 | 0.02 | 0.02 | -0.00 | sell |
| E Fund Management Co., Ltd. | 19,532 | 13,438 | -6,094 | 0.04 | 0.03 | -0.01 | sell |
| HighVista Strategies LLC | 22,650 | 14,325 | -8,325 | 0.24 | 0.16 | -0.07 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 160,000 | 143,777 | -16,223 | 2.58 | 3.01 | +0.43 | sell |
| TD ASSET MANAGEMENT INC | 271,760 | 254,594 | -17,166 | 0.01 | 0.01 | -0.00 | sell |
| Bellevue Group AG | 5,091,000 | 5,073,600 | -17,400 | 2.23 | 2.49 | +0.26 | sell |
| Candriam S.C.A. | 606,950 | 583,950 | -23,000 | 0.12 | 0.12 | +0.00 | sell |
| Cinctive Capital Management LP | 65,108 | 38,161 | -26,947 | 0.13 | 0.06 | -0.07 | sell |
| Rafferty Asset Management, LLC | 365,095 | 284,352 | -80,743 | 0.04 | 0.03 | -0.01 | sell |
| Casdin Capital, LLC | 5,714,775 | 5,617,599 | -97,176 | 16.09 | 13.46 | -2.63 | sell |
| PERCEPTIVE ADVISORS LLC | 818,882 | 618,885 | -199,997 | 0.52 | 0.35 | -0.18 | sell |
| Artal Group S.A. | 1,695,949 | 1,318,649 | -377,300 | 1.62 | 1.08 | -0.53 | sell |
| Holocene Advisors, LP | 2,882,155 | 2,422,411 | -459,744 | 0.32 | 0.29 | -0.04 | sell |
| AH Capital Management, L.L.C. | 5,697,067 | 2,748,523 | -2,948,544 | 10.06 | 6.41 | -3.65 | sell |