| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 14,634,391 | 14,757,112 | +122,721 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 14,882,086 | 14,714,726 | -167,360 | 0.08 | 0.08 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 5,148,657 | 7,549,249 | +2,400,592 | 1.68 | 3.05 | +1.37 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 6,736,854 | 7,507,872 | +771,018 | 1.21 | 1.42 | +0.21 | buy |
| BVF INC/IL | 5,981,212 | 5,981,212 | 0 | 4.29 | 5.30 | +1.01 | hold |
| Casdin Capital, LLC | 5,714,775 | 5,617,599 | -97,176 | 16.16 | 13.47 | -2.69 | sell |
| STATE STREET CORP | 6,253,361 | 5,386,020 | -867,341 | 0.01 | 0.01 | -0.00 | sell |
| Alphabet Inc. | 5,301,512 | 5,301,512 | 0 | 7.05 | 6.80 | -0.25 | hold |
| Bellevue Group AG | 5,091,000 | 5,073,600 | -17,400 | 2.23 | 2.49 | +0.26 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,636,353 | 4,814,310 | +177,957 | 0.02 | 0.02 | +0.00 | buy |
| FMR LLC | 4,164,150 | 4,166,765 | +2,615 | 0.01 | 0.01 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 2,199,480 | 3,912,119 | +1,712,639 | 0.04 | 0.07 | +0.03 | buy |
| Woodline Partners LP | 2,960,040 | 3,797,148 | +837,108 | 0.93 | 1.13 | +0.21 | buy |
| JPMORGAN CHASE & CO | 4,391,629 | 3,509,104 | -882,525 | 0.01 | 0.01 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,090,073 | 3,090,073 | 0 | 1.64 | 1.73 | +0.10 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 2,978,784 | 3,052,691 | +73,907 | 0.01 | 0.01 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 2,914,975 | +2,914,975 | 0.00 | 3.31 | +3.31 | buy |
| AH Capital Management, L.L.C. | 5,697,067 | 2,748,523 | -2,948,544 | 10.06 | 6.41 | -3.65 | sell |
| Holocene Advisors, LP | 2,882,155 | 2,422,411 | -459,744 | 0.32 | 0.29 | -0.04 | sell |
| LMR Partners LLP | 0 | 2,185,658 | +2,185,658 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 281,705 | 1,708,276 | +1,426,571 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 1,623,021 | 1,694,501 | +71,480 | 0.01 | 0.02 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 567,105 | 1,654,895 | +1,087,790 | 0.05 | 0.14 | +0.09 | buy |
| MARSHALL WACE, LLP | 1,208,929 | 1,535,940 | +327,011 | 0.07 | 0.08 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 1,347,439 | 1,347,439 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 1,795,421 | 1,331,259 | -464,162 | 0.02 | 0.01 | -0.00 | sell |
| Artal Group S.A. | 1,695,949 | 1,318,649 | -377,300 | 1.66 | 1.10 | -0.56 | sell |
| NORTHERN TRUST CORP | 1,270,795 | 1,214,271 | -56,524 | 0.01 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,053,257 | 1,123,450 | +70,193 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,042,967 | 1,052,263 | +9,296 | 0.01 | 0.01 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 997,455 | 997,455 | 0 | 1.53 | 1.36 | -0.17 | hold |
| MORGAN STANLEY | 1,653,174 | 927,070 | -726,104 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 725,152 | 923,681 | +198,529 | 0.51 | 0.76 | +0.24 | buy |
| Soleus Capital Management, L.P. | 252,000 | 728,700 | +476,700 | 0.80 | 2.06 | +1.26 | buy |
| Finepoint Capital LP | 617,100 | 677,100 | +60,000 | 6.12 | 5.60 | -0.53 | buy |
| Avidity Partners Management LP | 60,000 | 635,000 | +575,000 | 0.07 | 0.73 | +0.66 | buy |
| PERCEPTIVE ADVISORS LLC | 818,882 | 618,885 | -199,997 | 0.53 | 0.35 | -0.17 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 608,474 | 607,436 | -1,038 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 558,369 | 600,581 | +42,212 | 0.02 | 0.02 | +0.00 | buy |
| CITADEL ADVISORS LLC | 904,029 | 588,088 | -315,941 | 0.03 | 0.02 | -0.01 | sell |
| Candriam S.C.A. | 606,950 | 583,950 | -23,000 | 0.12 | 0.12 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 246,007 | 544,086 | +298,079 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 581,216 | 529,409 | -51,807 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 511,894 | 511,894 | 0 | 3.52 | 3.76 | +0.24 | hold |
| MIC Capital Management UK LLP | 508,569 | 508,569 | 0 | 2.83 | 3.11 | +0.28 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 500,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Integral Health Asset Management, LLC | 200,000 | 420,000 | +220,000 | 0.83 | 1.33 | +0.50 | buy |
| SOROS CAPITAL MANAGEMENT LLC | 364,824 | 364,824 | 0 | 0.09 | 0.02 | -0.07 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 361,000 | 361,000 | 0 | 0.17 | 0.18 | +0.01 | hold |
| Walleye Capital LLC | 595,986 | 356,667 | -239,319 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 320,245 | 323,364 | +3,119 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 306,558 | 304,979 | -1,579 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 183,181 | 291,465 | +108,284 | 0.01 | 0.01 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 288,820 | +288,820 | 0.00 | 0.08 | +0.08 | buy |
| Rafferty Asset Management, LLC | 365,095 | 284,352 | -80,743 | 0.04 | 0.03 | -0.01 | sell |
| Mubadala Investment Co PJSC | 278,000 | 278,000 | 0 | 0.03 | 0.04 | +0.01 | hold |
| CITIGROUP INC | 161,041 | 277,675 | +116,634 | 0.01 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 273,408 | 273,217 | -191 | 1.83 | 1.42 | -0.42 | sell |
| TD ASSET MANAGEMENT INC | 271,760 | 254,594 | -17,166 | 0.01 | 0.01 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 250,000 | 250,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BESSEMER GROUP INC | 243,442 | 243,442 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RHUMBLINE ADVISERS | 205,358 | 209,310 | +3,952 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 206,513 | +206,513 | 0.00 | 0.31 | +0.31 | buy |
| Swiss National Bank | 200,131 | 200,131 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 200,000 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| Bleichroeder LP | 200,000 | 200,000 | 0 | 0.01 | 0.01 | -0.01 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 178,987 | 199,050 | +20,063 | 0.00 | 0.01 | +0.00 | buy |
| Sculptor Capital LP | 178,107 | 178,107 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qube Research & Technologies Ltd | 25,515 | 167,480 | +141,965 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 0 | 167,149 | +167,149 | 0.00 | 0.00 | +0.00 | buy |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 150,000 | 150,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 160,000 | 143,777 | -16,223 | 2.58 | 3.01 | +0.43 | sell |
| Neuberger Berman Group LLC | 85,782 | 143,359 | +57,577 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 353,785 | 135,416 | -218,369 | 0.01 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 133,174 | 133,174 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANE STREET GROUP, LLC | 196,232 | 129,467 | -66,765 | 0.01 | 0.01 | -0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 120,085 | 120,085 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Magnetar Financial LLC | 119,289 | 119,289 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALPS ADVISORS INC | 111,204 | 116,156 | +4,952 | 0.03 | 0.03 | +0.00 | buy |
| Legal & General Group Plc | 108,682 | 106,129 | -2,553 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 114,105 | 105,373 | -8,732 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 117,835 | 96,861 | -20,974 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 128,818 | 94,431 | -34,387 | 0.00 | 0.00 | -0.00 | sell |
| State of New Jersey Common Pension Fund D | 113,390 | 91,775 | -21,615 | 0.01 | 0.01 | -0.00 | sell |
| DLK Investment Management, LLC | 77,000 | 77,000 | 0 | 0.01 | 0.01 | -0.01 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 83,583 | 74,112 | -9,471 | 0.01 | 0.01 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 51,073 | 73,657 | +22,584 | 0.00 | 0.00 | +0.00 | buy |
| Weiss Asset Management LP | 73,640 | 73,640 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 148,652 | 72,637 | -76,015 | 0.01 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 75,397 | 71,207 | -4,190 | 0.02 | 0.02 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 70,833 | +70,833 | 0.00 | 0.01 | +0.01 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 70,349 | 70,349 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 71,494 | 68,744 | -2,750 | 0.01 | 0.01 | -0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 67,300 | +67,300 | 0.00 | 0.08 | +0.08 | buy |
| HRT FINANCIAL LP | 0 | 64,053 | +64,053 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 60,842 | 60,387 | -455 | 0.00 | 0.00 | +0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 55,600 | 55,600 | 0 | 0.04 | 0.04 | -0.00 | hold |
| TWO SIGMA ADVISERS, LP | 65,791 | 51,991 | -13,800 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 80,405 | 51,059 | -29,346 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 50,000 | 50,000 | 0 | 0.00 | 0.00 | -0.00 | hold |