| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 0 | 2,914,975 | +2,914,975 | 0.00 | 3.31 | +3.31 | buy |
| BAKER BROS. ADVISORS LP | 5,148,657 | 7,549,249 | +2,400,592 | 1.68 | 3.05 | +1.37 | buy |
| LMR Partners LLP | 0 | 2,185,658 | +2,185,658 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 2,199,480 | 3,912,119 | +1,712,639 | 0.04 | 0.07 | +0.03 | buy |
| NORGES BANK | 281,705 | 1,708,276 | +1,426,571 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 567,105 | 1,654,895 | +1,087,790 | 0.05 | 0.14 | +0.09 | buy |
| Woodline Partners LP | 2,960,040 | 3,797,148 | +837,108 | 0.93 | 1.13 | +0.21 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 6,736,854 | 7,507,872 | +771,018 | 1.21 | 1.42 | +0.21 | buy |
| Avidity Partners Management LP | 60,000 | 635,000 | +575,000 | 0.07 | 0.73 | +0.66 | buy |
| Soleus Capital Management, L.P. | 252,000 | 728,700 | +476,700 | 0.80 | 2.06 | +1.26 | buy |
| MARSHALL WACE, LLP | 1,208,929 | 1,535,940 | +327,011 | 0.07 | 0.08 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 246,007 | 544,086 | +298,079 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 288,820 | +288,820 | 0.00 | 0.08 | +0.08 | buy |
| Integral Health Asset Management, LLC | 200,000 | 420,000 | +220,000 | 0.83 | 1.33 | +0.50 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 206,513 | +206,513 | 0.00 | 0.31 | +0.31 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 200,000 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 725,152 | 923,681 | +198,529 | 0.51 | 0.76 | +0.24 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,636,353 | 4,814,310 | +177,957 | 0.02 | 0.02 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 167,149 | +167,149 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 25,515 | 167,480 | +141,965 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 14,634,391 | 14,757,112 | +122,721 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 161,041 | 277,675 | +116,634 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 183,181 | 291,465 | +108,284 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,978,784 | 3,052,691 | +73,907 | 0.01 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 1,623,021 | 1,694,501 | +71,480 | 0.01 | 0.02 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 70,833 | +70,833 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,053,257 | 1,123,450 | +70,193 | 0.01 | 0.01 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 67,300 | +67,300 | 0.00 | 0.08 | +0.08 | buy |
| HRT FINANCIAL LP | 0 | 64,053 | +64,053 | 0.00 | 0.01 | +0.01 | buy |
| Finepoint Capital LP | 617,100 | 677,100 | +60,000 | 6.12 | 5.60 | -0.53 | buy |
| Neuberger Berman Group LLC | 85,782 | 143,359 | +57,577 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 44,938 | +44,938 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 558,369 | 600,581 | +42,212 | 0.02 | 0.02 | +0.00 | buy |
| Walleye Capital LLC | 0 | 34,957 | +34,957 | 0.00 | 0.01 | +0.01 | buy |
| Man Group plc | 0 | 29,297 | +29,297 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 27,904 | +27,904 | 0.00 | 0.00 | +0.00 | buy |
| DUALITY ADVISERS, LP | 0 | 25,623 | +25,623 | 0.00 | 0.08 | +0.08 | buy |
| Allianz Asset Management GmbH | 0 | 23,720 | +23,720 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 51,073 | 73,657 | +22,584 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 178,987 | 199,050 | +20,063 | 0.00 | 0.01 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 18,936 | +18,936 | 0.00 | 0.06 | +0.06 | buy |
| SEI INVESTMENTS CO | 0 | 16,371 | +16,371 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 16,362 | +16,362 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 14,000 | +14,000 | 0.00 | 0.05 | +0.05 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 13,889 | +13,889 | 0.00 | 0.03 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 18,941 | 31,637 | +12,696 | 0.11 | 0.13 | +0.02 | buy |
| Pictet Asset Management Holding SA | 0 | 12,532 | +12,532 | 0.00 | 0.00 | +0.00 | buy |
| Paloma Partners Management Co | 0 | 11,545 | +11,545 | 0.00 | 0.05 | +0.05 | buy |
| Engineers Gate Manager LP | 0 | 11,208 | +11,208 | 0.00 | 0.01 | +0.01 | buy |
| Bayesian Capital Management, LP | 0 | 10,500 | +10,500 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,042,967 | 1,052,263 | +9,296 | 0.01 | 0.01 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 9,200 | +9,200 | 0.00 | 0.07 | +0.07 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 8,320 | +8,320 | 0.00 | 0.03 | +0.03 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 8,100 | +8,100 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 7,856 | +7,856 | 0.00 | 0.09 | +0.09 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 7,801 | +7,801 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 7,661 | +7,661 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 0 | 7,300 | +7,300 | 0.00 | 0.22 | +0.22 | buy |
| CANADA LIFE ASSURANCE Co | 8,950 | 15,646 | +6,696 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 6,075 | +6,075 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 3,595 | 9,129 | +5,534 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 111,204 | 116,156 | +4,952 | 0.03 | 0.03 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 10,334 | 14,959 | +4,625 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 10,904 | 15,384 | +4,480 | 0.03 | 0.03 | +0.00 | buy |
| RHUMBLINE ADVISERS | 205,358 | 209,310 | +3,952 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 39,966 | 43,802 | +3,836 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 3,335 | +3,335 | 0.00 | 0.10 | +0.10 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 3,218 | +3,218 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 320,245 | 323,364 | +3,119 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 7,200 | 10,188 | +2,988 | 0.02 | 0.03 | +0.01 | buy |
| CSS LLC/IL | 11,881 | 14,856 | +2,975 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 4,164,150 | 4,166,765 | +2,615 | 0.01 | 0.01 | -0.00 | buy |
| ProShare Advisors LLC | 34,274 | 36,605 | +2,331 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 1,700 | +1,700 | 0.00 | 0.02 | +0.02 | buy |
| Pacer Advisors, Inc. | 0 | 1,326 | +1,326 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 9,700 | 11,000 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 8,502 | 9,649 | +1,147 | 0.01 | 0.01 | +0.00 | buy |
| BARTLETT & CO. WEALTH MANAGEMENT LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 628 | 1,513 | +885 | 0.01 | 0.01 | +0.01 | buy |
| CIBC Private Wealth Group LLC | 0 | 700 | +700 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,431 | 3,058 | +627 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 563 | +563 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 2,259 | 2,781 | +522 | 0.00 | 0.00 | +0.00 | buy |
| FIDELIS CAPITAL PARTNERS, LLC | 0 | 512 | +512 | 0.00 | 0.04 | +0.04 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 1,940 | 2,241 | +301 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 8,652 | 8,932 | +280 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 8,801 | 9,018 | +217 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 197 | 256 | +59 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 30,194 | 30,227 | +33 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 323 | 353 | +30 | 0.01 | 0.01 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 27 | +27 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 17 | 39 | +22 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 40 | 61 | +21 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Private Wealth Management Group, LLC | 36 | 53 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Riggs Asset Managment Co. Inc. | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Continuum Advisory, LLC | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |