| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5,799 | 1,064,046 | +1,058,247 | 0.00 | 0.18 | +0.18 | buy |
| BVF INC/IL | 4,181,179 | 4,982,384 | +801,205 | 6.20 | 7.18 | +0.98 | buy |
| JANUS HENDERSON GROUP PLC | 9,483,999 | 10,190,071 | +706,072 | 0.21 | 0.21 | 0.00 | buy |
| Holocene Advisors, LP | 2,996,710 | 3,691,744 | +695,034 | 0.42 | 0.38 | -0.04 | buy |
| Edgestream Partners, L.P. | 7,779 | 215,717 | +207,938 | 0.01 | 0.26 | +0.24 | buy |
| Checkpoint Capital L.P. | 210,000 | 392,011 | +182,011 | 4.67 | 7.61 | +2.93 | buy |
| Logos Global Management LP | 1,450,000 | 1,600,000 | +150,000 | 7.42 | 10.06 | +2.64 | buy |
| STEMPOINT CAPITAL LP | 193,535 | 318,782 | +125,247 | 2.12 | 3.60 | +1.48 | buy |
| AMERICAN CENTURY COMPANIES INC | 641,646 | 741,860 | +100,214 | 0.02 | 0.02 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 430,462 | 337,881 | +92,581 | 0.02 | 0.01 | -0.01 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 157,477 | 245,997 | +88,520 | 0.02 | 0.02 | +0.01 | buy |
| Rock Springs Capital Management LP | 1,213,257 | 1,281,640 | +68,383 | 2.02 | 2.59 | +0.57 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,258,332 | 3,317,332 | +59,000 | 2.70 | 2.32 | -0.38 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,086,199 | 4,142,414 | +56,215 | 0.01 | 0.01 | 0.00 | buy |
| TEMA ETFS LLC | 45,522 | 94,578 | +49,056 | 0.83 | 1.00 | +0.17 | buy |
| Swiss National Bank | 229,931 | 276,531 | +46,600 | 0.01 | 0.01 | +0.00 | buy |
| NEOS Investment Management LLC | 48,239 | 94,578 | +46,339 | 0.05 | 0.06 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 281,386 | 325,876 | +44,490 | 0.01 | 0.01 | -0.00 | buy |
| Hood River Capital Management LLC | 1,678,434 | 1,717,048 | +38,614 | 1.08 | 1.04 | -0.05 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 72,328 | 107,628 | +35,300 | 0.03 | 0.04 | +0.01 | buy |
| Magnetar Financial LLC | 90 | 32,972 | +32,882 | 0.00 | 0.02 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 208,401 | 179,762 | +28,639 | 0.04 | 0.03 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 61,980 | 89,962 | +27,982 | 0.25 | 0.30 | +0.04 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 113,036 | 139,640 | +26,604 | 0.01 | 0.01 | +0.00 | buy |
| CSS LLC/IL | 26,268 | 51,388 | +25,120 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 631,176 | 656,176 | +25,000 | 7.02 | 6.58 | -0.44 | buy |
| CIBC WORLD MARKETS CORP | 15,664 | 37,786 | +22,122 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 57,246 | 73,752 | +16,506 | 0.93 | 1.00 | +0.07 | buy |
| ProShare Advisors LLC | 55,102 | 45,253 | +9,849 | 0.01 | 0.00 | 0.00 | sell |
| B. Metzler seel. Sohn & Co. AG | 17,199 | 25,821 | +8,622 | 0.01 | 0.01 | +0.00 | buy |
| Granahan Investment Management, LLC | 119,430 | 126,752 | +7,322 | 0.22 | 0.22 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 170,000 | 177,136 | +7,136 | 1.53 | 1.21 | -0.33 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 102,127 | 109,004 | +6,877 | 0.01 | 0.01 | -0.00 | buy |
| MPM BioImpact LLC | 313,817 | 317,083 | +3,266 | 1.95 | 1.93 | -0.02 | buy |
| GUGGENHEIM CAPITAL LLC | 34,961 | 36,647 | +1,686 | 0.01 | 0.01 | 0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 4,900 | 6,240 | +1,340 | 0.14 | 0.17 | +0.03 | buy |
| Woodline Partners LP | 3,885,713 | 3,887,036 | +1,323 | 1.15 | 0.89 | -0.26 | buy |
| CI INVESTMENTS INC. | 4,073 | 2,829 | +1,244 | 0.00 | 0.00 | 0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 3,532 | 4,307 | +775 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 11,224 | 11,811 | +587 | 0.04 | 0.03 | -0.01 | buy |
| Corebridge Financial, Inc. | 83,213 | 83,425 | +212 | 0.02 | 0.02 | 0.00 | buy |
| J.Safra Asset Management Corp | 8 | 51 | +43 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 35,479 | 35,509 | +30 | 0.06 | 0.05 | -0.00 | buy |
| BESSEMER GROUP INC | 243,558 | 243,571 | +13 | 0.02 | 0.02 | -0.00 | buy |
| Beaumont Financial Advisors, LLC | 13,738 | 13,724 | -14 | 0.05 | 0.04 | -0.01 | sell |
| J. Goldman & Co LP | 26,335 | 25,812 | -523 | 0.03 | 0.02 | -0.01 | sell |
| Avanza Fonder AB | 3,950 | 2,877 | -1,073 | 0.01 | 0.00 | -0.00 | sell |
| Casdin Capital, LLC | 3,699,283 | 3,697,933 | -1,350 | 10.77 | 10.68 | -0.08 | sell |
| Candriam S.C.A. | 656,740 | 655,134 | -1,606 | 0.17 | 0.15 | -0.02 | sell |
| Legato Capital Management LLC | 10,713 | 7,734 | -2,979 | 0.06 | 0.04 | -0.02 | sell |
| Atle Fund Management AB | 62,161 | 54,961 | -7,200 | 1.27 | 0.86 | -0.41 | sell |
| Siren, L.L.C. | 571,548 | 563,755 | -7,793 | 1.10 | 1.12 | +0.02 | sell |
| Rafferty Asset Management, LLC | 172,786 | 163,419 | -9,367 | 0.03 | 0.02 | -0.00 | sell |
| Bellevue Group AG | 4,386,900 | 4,374,300 | -12,600 | 3.69 | 3.47 | -0.23 | sell |
| Sandy Cove Advisors, LLC | 42,008 | 27,008 | -15,000 | 0.72 | 0.38 | -0.34 | sell |
| Finepoint Capital LP | 710,260 | 691,260 | -19,000 | 1.90 | 1.86 | -0.03 | sell |
| Cinctive Capital Management LP | 34,790 | 11,343 | -23,447 | 0.08 | 0.03 | -0.05 | sell |
| Nicholas Investment Partners, LP | 84,729 | 61,123 | -23,606 | 0.33 | 0.22 | -0.10 | sell |
| FRED ALGER MANAGEMENT, LLC | 148,126 | 117,399 | -30,727 | 0.03 | 0.02 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 111,700 | 66,662 | -45,038 | 4.92 | 2.73 | -2.18 | sell |
| E Fund Management Co., Ltd. | 71,287 | 15,273 | -56,014 | 0.16 | 0.03 | -0.13 | sell |
| First Turn Management, LLC | 403,915 | 340,109 | -63,806 | 3.16 | 2.42 | -0.74 | sell |
| Soleus Capital Management, L.P. | 201,084 | 84,784 | -116,300 | 0.67 | 0.24 | -0.43 | sell |
| AMERIPRISE FINANCIAL INC | 1,626,848 | 1,490,658 | -136,190 | 0.02 | 0.02 | -0.00 | sell |
| Artia Global Partners LP | 284,190 | 104,190 | -180,000 | 5.01 | 1.08 | -3.93 | sell |
| Avidity Partners Management LP | 446,200 | 213,000 | -233,200 | 1.95 | 1.55 | -0.39 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 650,000 | 394,000 | -256,000 | 0.05 | 0.03 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,865,962 | 5,599,642 | -266,320 | 0.03 | 0.02 | -0.01 | sell |
| Integral Health Asset Management, LLC | 550,000 | 250,000 | -300,000 | 2.05 | 0.94 | -1.11 | sell |
| Paradigm Biocapital Advisors LP | 6,553,111 | 6,178,111 | -375,000 | 9.97 | 10.06 | +0.08 | sell |
| LORD, ABBETT & CO. LLC | 1,978,720 | 367,630 | -1,611,090 | 0.27 | 0.05 | -0.23 | sell |
| Boxer Capital Management, LLC | 4,279,464 | 1,317,977 | -2,961,487 | 15.94 | 14.02 | -1.92 | sell |