| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 0 | 1,673,429 | +1,673,429 | 0.00 | 0.04 | +0.04 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5,799 | 1,064,046 | +1,058,247 | 0.00 | 0.18 | +0.18 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 10,821,691 | 11,787,921 | +966,230 | 0.09 | 0.08 | -0.01 | buy |
| BVF INC/IL | 4,181,179 | 4,982,384 | +801,205 | 6.20 | 7.18 | +0.98 | buy |
| FMR LLC | 6,742,083 | 7,535,771 | +793,688 | 0.02 | 0.02 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 9,483,999 | 10,190,071 | +706,072 | 0.21 | 0.21 | -0.00 | buy |
| Holocene Advisors, LP | 2,996,710 | 3,691,744 | +695,034 | 0.43 | 0.39 | -0.04 | buy |
| Caligan Partners LP | 0 | 465,000 | +465,000 | 0.00 | 3.43 | +3.43 | buy |
| MORGAN STANLEY | 858,278 | 1,255,687 | +397,409 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 268,454 | 609,388 | +340,934 | 0.01 | 0.02 | +0.01 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 13,248,692 | 13,534,692 | +286,000 | 3.05 | 2.58 | -0.47 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 248,326 | 524,428 | +276,102 | 0.01 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 63,931 | 337,402 | +273,471 | 0.00 | 0.02 | +0.02 | buy |
| Russell Investments Group, Ltd. | 4,243 | 276,230 | +271,987 | 0.00 | 0.01 | +0.01 | buy |
| TORONTO DOMINION BANK | 0 | 221,663 | +221,663 | 0.00 | 0.00 | +0.00 | buy |
| Edgestream Partners, L.P. | 7,779 | 215,717 | +207,938 | 0.01 | 0.26 | +0.24 | buy |
| COMERICA BANK | 452 | 193,719 | +193,267 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 299,783 | 482,107 | +182,324 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 210,000 | 392,011 | +182,011 | 4.67 | 7.61 | +2.93 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 175,861 | +175,861 | 0.00 | 0.21 | +0.21 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 156,353 | +156,353 | 0.00 | 0.01 | +0.01 | buy |
| Logos Global Management LP | 1,450,000 | 1,600,000 | +150,000 | 7.42 | 10.06 | +2.64 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 142,804 | +142,804 | 0.00 | 0.01 | +0.01 | buy |
| Jefferies Financial Group Inc. | 22,725 | 163,297 | +140,572 | 0.01 | 0.10 | +0.09 | buy |
| STEMPOINT CAPITAL LP | 193,535 | 318,782 | +125,247 | 2.12 | 3.60 | +1.48 | buy |
| Ensign Peak Advisors, Inc | 305,172 | 427,466 | +122,294 | 0.02 | 0.03 | +0.01 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 109,617 | +109,617 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 641,646 | 741,860 | +100,214 | 0.02 | 0.02 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 146,188 | 244,053 | +97,865 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 92,819 | +92,819 | 0.00 | 0.01 | +0.01 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 91,611 | +91,611 | 0.00 | 0.04 | +0.04 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 157,477 | 245,997 | +88,520 | 0.02 | 0.02 | +0.01 | buy |
| Invesco Ltd. | 117,652 | 190,259 | +72,607 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,213,257 | 1,281,640 | +68,383 | 2.02 | 2.59 | +0.57 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 66,251 | +66,251 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 59,214 | +59,214 | 0.00 | 0.02 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,258,332 | 3,317,332 | +59,000 | 2.71 | 2.33 | -0.39 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,086,199 | 4,142,414 | +56,215 | 0.01 | 0.01 | -0.00 | buy |
| Jain Global LLC | 0 | 56,174 | +56,174 | 0.00 | 0.04 | +0.04 | buy |
| XTX Topco Ltd | 0 | 55,488 | +55,488 | 0.00 | 0.10 | +0.10 | buy |
| TEMA ETFS LLC | 45,522 | 94,578 | +49,056 | 0.83 | 1.00 | +0.17 | buy |
| Swiss National Bank | 229,931 | 276,531 | +46,600 | 0.01 | 0.01 | +0.00 | buy |
| NEOS Investment Management LLC | 48,239 | 94,578 | +46,339 | 0.05 | 0.06 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 401,043 | 446,562 | +45,519 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 281,386 | 325,876 | +44,490 | 0.01 | 0.01 | -0.00 | buy |
| Hood River Capital Management LLC | 1,678,434 | 1,717,048 | +38,614 | 1.08 | 1.04 | -0.05 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 262,851 | 300,196 | +37,345 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 130,658 | 166,738 | +36,080 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 35,417 | +35,417 | 0.00 | 0.06 | +0.06 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 72,328 | 107,628 | +35,300 | 0.03 | 0.04 | +0.01 | buy |
| Pictet Asset Management Holding SA | 712,596 | 747,560 | +34,964 | 0.03 | 0.03 | -0.00 | buy |
| Magnetar Financial LLC | 90 | 32,972 | +32,882 | 0.00 | 0.02 | +0.02 | buy |
| Neuberger Berman Group LLC | 146,657 | 178,082 | +31,425 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 61,980 | 89,962 | +27,982 | 0.25 | 0.30 | +0.04 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 113,036 | 139,640 | +26,604 | 0.01 | 0.01 | +0.00 | buy |
| CSS LLC/IL | 26,268 | 51,388 | +25,120 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 631,176 | 656,176 | +25,000 | 7.02 | 6.58 | -0.44 | buy |
| HRT FINANCIAL LP | 0 | 23,707 | +23,707 | 0.00 | 0.01 | +0.01 | buy |
| CIBC WORLD MARKETS CORP | 15,664 | 37,786 | +22,122 | 0.00 | 0.01 | +0.01 | buy |
| CANADA LIFE ASSURANCE Co | 11,398 | 30,380 | +18,982 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 0 | 18,764 | +18,764 | 0.00 | 0.01 | +0.01 | buy |
| CW Advisors, LLC | 0 | 18,505 | +18,505 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 79,985 | 98,069 | +18,084 | 0.01 | 0.01 | -0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 17,213 | +17,213 | 0.00 | 0.05 | +0.05 | buy |
| HighVista Strategies LLC | 57,246 | 73,752 | +16,506 | 0.93 | 1.00 | +0.07 | buy |
| SG Americas Securities, LLC | 2,939 | 18,103 | +15,164 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 14,188 | +14,188 | 0.00 | 0.07 | +0.07 | buy |
| Verition Fund Management LLC | 0 | 13,931 | +13,931 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 569,015 | 582,721 | +13,706 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 5,791,752 | 5,804,919 | +13,167 | 0.01 | 0.01 | -0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 11,924 | +11,924 | 0.00 | 0.07 | +0.07 | buy |
| SIH Partners, LLLP | 0 | 11,702 | +11,702 | 0.00 | 0.04 | +0.04 | buy |
| LMR Partners LLP | 2,595,245 | 2,606,720 | +11,475 | 0.01 | 0.00 | -0.01 | buy |
| Qsemble Capital Management, LP | 0 | 11,195 | +11,195 | 0.00 | 0.04 | +0.04 | buy |
| S&CO INC | 0 | 9,171 | +9,171 | 0.00 | 0.02 | +0.02 | buy |
| B. Metzler seel. Sohn & Co. AG | 17,199 | 25,821 | +8,622 | 0.01 | 0.01 | +0.00 | buy |
| SIG BROKERAGE, LP | 0 | 8,306 | +8,306 | 0.00 | 0.09 | +0.09 | buy |
| Jump Financial, LLC | 0 | 8,121 | +8,121 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 119,430 | 126,752 | +7,322 | 0.22 | 0.22 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 170,000 | 177,136 | +7,136 | 1.53 | 1.21 | -0.33 | buy |
| Arizona State Retirement System | 33,905 | 40,894 | +6,989 | 0.01 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 102,127 | 109,004 | +6,877 | 0.01 | 0.01 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 30,846 | 37,108 | +6,262 | 0.00 | 0.00 | -0.00 | buy |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 0 | 6,117 | +6,117 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 5,729 | +5,729 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 251,465 | 257,150 | +5,685 | 0.01 | 0.01 | -0.00 | buy |
| BIT Capital GmbH | 0 | 5,044 | +5,044 | 0.00 | 0.02 | +0.02 | buy |
| Headlands Technologies LLC | 8,318 | 12,638 | +4,320 | 0.04 | 0.05 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 88,327 | 92,470 | +4,143 | 0.00 | 0.00 | -0.00 | buy |
| KLP KAPITALFORVALTNING AS | 23,504 | 27,604 | +4,100 | 0.00 | 0.00 | -0.00 | buy |
| State of New Jersey Common Pension Fund D | 49,807 | 53,655 | +3,848 | 0.01 | 0.01 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 34,632 | 38,426 | +3,794 | 0.01 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 3,652 | +3,652 | 0.00 | 0.04 | +0.04 | buy |
| Goodman Advisory Group, LLC | 0 | 3,596 | +3,596 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 1,006 | 4,524 | +3,518 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 316,028 | 319,491 | +3,463 | 0.01 | 0.01 | -0.00 | buy |
| Cerity Partners LLC | 5,699 | 9,069 | +3,370 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 313,817 | 317,083 | +3,266 | 1.95 | 1.93 | -0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 237,539 | 240,095 | +2,556 | 0.01 | 0.01 | -0.00 | buy |
| MACKENZIE FINANCIAL CORP | 6,055 | 8,321 | +2,266 | 0.00 | 0.00 | +0.00 | buy |