| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,205,555 | 5,475,611 | +3,270,056 | 0.27 | 0.82 | +0.56 | buy |
| BlackRock, Inc. | 8,926,656 | 11,212,706 | +2,286,050 | 0.01 | 0.02 | +0.01 | buy |
| Darwin Global Management, Ltd. | 0 | 2,211,018 | +2,211,018 | 0.00 | 5.44 | +5.44 | buy |
| Vestal Point Capital, LP | 295,000 | 2,375,000 | +2,080,000 | 0.86 | 6.46 | +5.60 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 1,749,000 | +1,749,000 | 0.00 | 0.17 | +0.17 | buy |
| Alyeska Investment Group, L.P. | 239,097 | 1,885,821 | +1,646,724 | 0.05 | 0.52 | +0.47 | buy |
| UBS Group AG | 3,087,937 | 4,386,791 | +1,298,854 | 0.05 | 0.08 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 421,735 | 1,558,807 | +1,137,072 | 0.05 | 0.13 | +0.08 | buy |
| Sculptor Capital LP | 178,107 | 958,822 | +780,715 | 0.00 | 0.02 | +0.02 | buy |
| LMR Partners LLP | 3,151,705 | 3,838,024 | +686,319 | 0.03 | 0.06 | +0.03 | buy |
| Nearwater Capital Markets, Ltd | 0 | 678,000 | +678,000 | 0.00 | 1.56 | +1.56 | buy |
| Holocene Advisors, LP | 1,907,948 | 2,468,644 | +560,696 | 0.32 | 0.58 | +0.26 | buy |
| Qube Research & Technologies Ltd | 0 | 553,290 | +553,290 | 0.00 | 0.08 | +0.08 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 94,010 | 622,304 | +528,294 | 0.03 | 0.23 | +0.20 | buy |
| Atle Fund Management AB | 90,184 | 617,245 | +527,061 | 2.29 | 2.93 | +0.64 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 479,080 | +479,080 | 0.00 | 3.95 | +3.95 | buy |
| DEUTSCHE BANK AG\ | 32,217 | 465,758 | +433,541 | 0.00 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 100,000 | 517,685 | +417,685 | 0.00 | 0.04 | +0.04 | buy |
| SAMLYN CAPITAL, LLC | 0 | 371,948 | +371,948 | 0.00 | 0.62 | +0.62 | buy |
| Caligan Partners LP | 1,283,900 | 1,652,808 | +368,908 | 9.36 | 11.37 | +2.01 | buy |
| Duquesne Family Office LLC | 0 | 315,860 | +315,860 | 0.00 | 1.05 | +1.05 | buy |
| Integral Health Asset Management, LLC | 1,200,000 | 1,500,000 | +300,000 | 4.84 | 7.72 | +2.87 | buy |
| STATE STREET CORP | 4,109,290 | 4,402,662 | +293,372 | 0.01 | 0.01 | +0.00 | buy |
| MIC Capital Management UK LLP | 508,569 | 795,733 | +287,164 | 9.18 | 21.95 | +12.77 | buy |
| Melqart Asset Management (UK) Ltd | 0 | 270,363 | +270,363 | 0.00 | 2.59 | +2.59 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 5,498 | 270,972 | +265,474 | 0.00 | 0.02 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 258,600 | +258,600 | 0.00 | 0.50 | +0.50 | buy |
| BARCLAYS PLC | 136,048 | 383,179 | +247,131 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 62,032 | 281,632 | +219,600 | 0.85 | 5.26 | +4.42 | buy |
| Legal & General Group Plc | 153,380 | 341,148 | +187,768 | 0.00 | 0.01 | +0.00 | buy |
| Man Group plc | 97,505 | 275,270 | +177,765 | 0.01 | 0.06 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,161,963 | 3,338,142 | +176,179 | 0.02 | 0.02 | +0.00 | buy |
| Avoro Capital Advisors LLC | 2,170,000 | 2,344,444 | +174,444 | 1.70 | 2.25 | +0.55 | buy |
| Birnam Oak Advisors, LP | 0 | 159,413 | +159,413 | 0.00 | 4.27 | +4.27 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 349,412 | 500,595 | +151,183 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 276,331 | 425,431 | +149,100 | 0.01 | 0.02 | +0.01 | buy |
| TCG Crossover Management, LLC | 436,473 | 576,473 | +140,000 | 1.15 | 1.60 | +0.45 | buy |
| PSquared Asset Management AG | 0 | 138,290 | +138,290 | 0.00 | 4.68 | +4.68 | buy |
| Tidal Investments LLC | 0 | 137,242 | +137,242 | 0.00 | 0.04 | +0.04 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 31,514 | 164,988 | +133,474 | 0.00 | 0.01 | +0.01 | buy |
| LMR Partners LLP | 0 | 130,000 | +130,000 | 0.00 | 0.12 | +0.12 | buy |
| D. E. Shaw & Co., Inc. | 1,454,895 | 1,580,345 | +125,450 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 20,067 | 138,560 | +118,493 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 327,152 | 438,595 | +111,443 | 0.67 | 0.98 | +0.32 | buy |
| VAN ECK ASSOCIATES CORP | 0 | 109,365 | +109,365 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 850,323 | 954,256 | +103,933 | 0.01 | 0.01 | +0.00 | buy |
| ING GROEP NV | 0 | 103,000 | +103,000 | 0.00 | 0.06 | +0.06 | buy |
| Empyrean Capital Partners, LP | 0 | 102,400 | +102,400 | 0.00 | 0.33 | +0.33 | buy |
| BAKER BROS. ADVISORS LP | 9,455,357 | 9,555,357 | +100,000 | 4.41 | 5.34 | +0.93 | buy |
| Boxer Capital Management, LLC | 400,000 | 500,000 | +100,000 | 6.97 | 6.38 | -0.59 | buy |
| Squarepoint Ops LLC | 23,635 | 120,769 | +97,134 | 0.00 | 0.03 | +0.02 | buy |
| Bank of New York Mellon Corp | 542,069 | 635,366 | +93,297 | 0.01 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 91,720 | +91,720 | 0.00 | 0.02 | +0.02 | buy |
| BRAIDWELL LP | 0 | 84,900 | +84,900 | 0.00 | 0.28 | +0.28 | buy |
| HRT FINANCIAL LP | 0 | 79,300 | +79,300 | 0.00 | 0.02 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 1,060,171 | 1,133,546 | +73,375 | 0.02 | 0.03 | +0.01 | buy |
| Edgestream Partners, L.P. | 0 | 69,262 | +69,262 | 0.00 | 0.22 | +0.22 | buy |
| Rangeley Capital, LLC | 0 | 66,700 | +66,700 | 0.00 | 1.33 | +1.33 | buy |
| Korea Investment CORP | 0 | 66,461 | +66,461 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 64,583 | +64,583 | 0.00 | 0.00 | +0.00 | buy |
| Vestcor Inc | 0 | 63,077 | +63,077 | 0.00 | 0.17 | +0.17 | buy |
| Quarry LP | 0 | 59,263 | +59,263 | 0.00 | 1.16 | +1.16 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 0 | 58,774 | +58,774 | 0.00 | 0.01 | +0.01 | buy |
| Asset Management One Co., Ltd. | 0 | 55,816 | +55,816 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 651,732 | 705,793 | +54,061 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,683,729 | 1,735,476 | +51,747 | 0.02 | 0.03 | +0.00 | buy |
| Cinctive Capital Management LP | 42,635 | 93,857 | +51,222 | 0.20 | 0.60 | +0.40 | buy |
| Nantahala Capital Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.30 | +0.30 | buy |
| FJARDE AP-FONDEN /FOURTH SWEDISH NATIONAL PENSION FUND | 0 | 46,900 | +46,900 | 0.00 | 0.02 | +0.02 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 322,289 | 368,325 | +46,036 | 0.09 | 0.14 | +0.05 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 45,920 | +45,920 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 45,702 | 89,742 | +44,040 | 0.00 | 0.01 | +0.00 | buy |
| DIADEMA PARTNERS LP | 37,020 | 80,872 | +43,852 | 1.76 | 3.25 | +1.49 | buy |
| Jump Financial, LLC | 0 | 42,330 | +42,330 | 0.00 | 0.06 | +0.06 | buy |
| Resona Asset Management Co.,Ltd. | 0 | 41,680 | +41,680 | 0.00 | 0.02 | +0.02 | buy |
| Twin Securities, Inc. | 0 | 38,593 | +38,593 | 0.00 | 1.86 | +1.86 | buy |
| Athos Capital Ltd | 0 | 36,900 | +36,900 | 0.00 | 1.11 | +1.11 | buy |
| SG Americas Securities, LLC | 16,723 | 53,426 | +36,703 | 0.00 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,376 | 40,628 | +36,252 | 0.00 | 0.01 | +0.00 | buy |
| DnB Asset Management AS | 0 | 36,187 | +36,187 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 32,463 | 68,609 | +36,146 | 0.02 | 0.05 | +0.03 | buy |
| Alberta Investment Management Corp | 0 | 35,000 | +35,000 | 0.00 | 0.02 | +0.02 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 31,847 | +31,847 | 0.00 | 0.18 | +0.18 | buy |
| FIRST TRUST ADVISORS LP | 39,365 | 70,970 | +31,605 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 31,602 | +31,602 | 0.00 | 0.02 | +0.02 | buy |
| Quantinno Capital Management LP | 32,063 | 63,360 | +31,297 | 0.01 | 0.01 | +0.01 | buy |
| KLP KAPITALFORVALTNING AS | 30,004 | 60,500 | +30,496 | 0.01 | 0.02 | +0.01 | buy |
| HSBC HOLDINGS PLC | 2,838 | 32,791 | +29,953 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 135,390 | 165,277 | +29,887 | 0.01 | 0.02 | +0.01 | buy |
| Quantitative Investment Management, LLC | 0 | 29,291 | +29,291 | 0.00 | 0.30 | +0.30 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 29,130 | +29,130 | 0.00 | 0.16 | +0.16 | buy |
| IFM Investors Pty Ltd | 0 | 28,809 | +28,809 | 0.00 | 0.02 | +0.02 | buy |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 0 | 27,075 | +27,075 | 0.00 | 0.05 | +0.05 | buy |
| ORBIMED ADVISORS LLC | 25,900 | 52,000 | +26,100 | 0.04 | 0.11 | +0.07 | buy |
| Ikarian Capital, LLC | 138,142 | 163,142 | +25,000 | 1.42 | 2.27 | +0.85 | buy |
| Invesco Ltd. | 367,851 | 392,844 | +24,993 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 23,227 | +23,227 | 0.00 | 0.32 | +0.32 | buy |
| AXQ CAPITAL, LP | 0 | 22,946 | +22,946 | 0.00 | 0.29 | +0.29 | buy |
| CANADA LIFE ASSURANCE Co | 16,549 | 39,419 | +22,870 | 0.00 | 0.01 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 45,517 | 68,018 | +22,501 | 0.01 | 0.01 | +0.01 | buy |