| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 14,582,796 | 13,604,796 | -978,000 | 6.04 | 7.84 | +1.81 | sell |
| BlackRock, Inc. | 8,926,656 | 11,212,706 | +2,286,050 | 0.01 | 0.02 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 12,303,502 | 9,766,496 | -2,537,006 | 0.44 | 0.45 | +0.01 | sell |
| BAKER BROS. ADVISORS LP | 9,455,357 | 9,555,357 | +100,000 | 4.41 | 5.34 | +0.93 | buy |
| FMR LLC | 8,587,981 | 8,464,314 | -123,667 | 0.03 | 0.04 | +0.01 | sell |
| Nextech Invest, Ltd. | 7,601,087 | 7,601,087 | 0 | 58.53 | 52.02 | -6.51 | hold |
| Paradigm Biocapital Advisors LP | 6,644,403 | 6,655,703 | +11,300 | 14.17 | 13.23 | -0.94 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 6,987,639 | 6,027,819 | -959,820 | 0.10 | 0.11 | +0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,205,555 | 5,475,611 | +3,270,056 | 0.27 | 0.82 | +0.56 | buy |
| STATE STREET CORP | 4,109,290 | 4,402,662 | +293,372 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 3,087,937 | 4,386,791 | +1,298,854 | 0.05 | 0.08 | +0.03 | buy |
| LMR Partners LLP | 3,151,705 | 3,838,024 | +686,319 | 0.03 | 0.06 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,161,963 | 3,338,142 | +176,179 | 0.02 | 0.02 | +0.00 | buy |
| Alphabet Inc. | 3,345,102 | 3,292,525 | -52,577 | 10.33 | 7.97 | -2.35 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,404,717 | 3,232,213 | -172,504 | 0.03 | 0.04 | +0.01 | sell |
| BVF INC/IL | 3,356,782 | 2,856,782 | -500,000 | 9.00 | 8.85 | -0.15 | sell |
| Casdin Capital, LLC | 2,577,333 | 2,577,333 | 0 | 12.75 | 18.98 | +6.23 | hold |
| Woodline Partners LP | 2,500,895 | 2,506,570 | +5,675 | 0.77 | 0.92 | +0.15 | buy |
| Holocene Advisors, LP | 1,907,948 | 2,468,644 | +560,696 | 0.32 | 0.58 | +0.26 | buy |
| Vestal Point Capital, LP | 295,000 | 2,375,000 | +2,080,000 | 0.86 | 6.46 | +5.60 | buy |
| Avoro Capital Advisors LLC | 2,170,000 | 2,344,444 | +174,444 | 1.70 | 2.25 | +0.55 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,894,613 | 2,297,000 | -597,613 | 2.96 | 2.64 | -0.32 | sell |
| Darwin Global Management, Ltd. | 0 | 2,211,018 | +2,211,018 | 0.00 | 5.44 | +5.44 | buy |
| GOLDMAN SACHS GROUP INC | 2,491,583 | 2,185,500 | -306,083 | 0.03 | 0.03 | -0.00 | sell |
| Logos Global Management LP | 2,000,000 | 2,000,000 | 0 | 10.62 | 10.02 | -0.60 | hold |
| Alyeska Investment Group, L.P. | 239,097 | 1,885,821 | +1,646,724 | 0.05 | 0.52 | +0.47 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 1,749,000 | +1,749,000 | 0.00 | 0.17 | +0.17 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,683,729 | 1,735,476 | +51,747 | 0.02 | 0.03 | +0.00 | buy |
| Caligan Partners LP | 1,283,900 | 1,652,808 | +368,908 | 9.36 | 11.37 | +2.01 | buy |
| D. E. Shaw & Co., Inc. | 1,454,895 | 1,580,345 | +125,450 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 2,056,857 | 1,579,793 | -477,064 | 0.04 | 0.04 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 421,735 | 1,558,807 | +1,137,072 | 0.05 | 0.13 | +0.08 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 2,845,013 | 1,556,578 | -1,288,435 | 0.94 | 0.64 | -0.31 | sell |
| Bellevue Group AG | 5,005,719 | 1,544,456 | -3,461,263 | 7.56 | 3.57 | -3.98 | sell |
| Integral Health Asset Management, LLC | 1,200,000 | 1,500,000 | +300,000 | 4.84 | 7.72 | +2.87 | buy |
| Rock Springs Capital Management LP | 1,335,270 | 1,209,465 | -125,805 | 5.46 | 6.93 | +1.48 | sell |
| Polar Capital Holdings Plc | 2,013,791 | 1,133,930 | -879,861 | 0.73 | 0.48 | -0.25 | sell |
| FRANKLIN RESOURCES INC | 1,060,171 | 1,133,546 | +73,375 | 0.02 | 0.03 | +0.01 | buy |
| Siren, L.L.C. | 1,335,075 | 1,110,980 | -224,095 | 3.17 | 3.00 | -0.18 | sell |
| D. E. Shaw & Co., Inc. | 1,613,730 | 1,022,298 | -591,432 | 0.10 | 0.08 | -0.02 | sell |
| Sculptor Capital LP | 178,107 | 958,822 | +780,715 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 850,323 | 954,256 | +103,933 | 0.01 | 0.01 | +0.00 | buy |
| AH Capital Management, L.L.C. | 921,099 | 921,099 | 0 | 4.64 | 6.94 | +2.30 | hold |
| DIMENSIONAL FUND ADVISORS LP | 1,161,646 | 844,614 | -317,032 | 0.02 | 0.02 | -0.00 | sell |
| MIC Capital Management UK LLP | 508,569 | 795,733 | +287,164 | 9.18 | 21.95 | +12.77 | buy |
| GENERAL ATLANTIC, L.P. | 2,812,928 | 707,791 | -2,105,137 | 7.80 | 3.20 | -4.60 | sell |
| MORGAN STANLEY | 651,732 | 705,793 | +54,061 | 0.00 | 0.00 | +0.00 | buy |
| Nearwater Capital Markets, Ltd | 0 | 678,000 | +678,000 | 0.00 | 1.56 | +1.56 | buy |
| Frazier Life Sciences Management, L.P. | 797,455 | 675,686 | -121,769 | 1.71 | 1.69 | -0.02 | sell |
| T. Rowe Price Investment Management, Inc. | 2,200,376 | 664,047 | -1,536,329 | 0.11 | 0.04 | -0.07 | sell |
| Bank of New York Mellon Corp | 542,069 | 635,366 | +93,297 | 0.01 | 0.01 | +0.00 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 94,010 | 622,304 | +528,294 | 0.03 | 0.23 | +0.20 | buy |
| Atle Fund Management AB | 90,184 | 617,245 | +527,061 | 2.29 | 2.93 | +0.64 | buy |
| BANK OF AMERICA CORP /DE/ | 879,845 | 614,157 | -265,688 | 0.01 | 0.00 | -0.00 | sell |
| ARISTEIA CAPITAL, L.L.C. | 624,935 | 583,615 | -41,320 | 0.02 | 0.02 | +0.01 | sell |
| DAFNA Capital Management LLC | 604,514 | 580,678 | -23,836 | 11.18 | 12.85 | +1.66 | sell |
| Candriam S.C.A. | 1,030,992 | 580,677 | -450,315 | 0.41 | 0.29 | -0.12 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 595,934 | 579,550 | -16,384 | 0.00 | 0.00 | +0.00 | sell |
| TCG Crossover Management, LLC | 436,473 | 576,473 | +140,000 | 1.15 | 1.60 | +0.45 | buy |
| Pictet Asset Management Holding SA | 1,137,121 | 557,560 | -579,561 | 0.09 | 0.06 | -0.03 | sell |
| Qube Research & Technologies Ltd | 0 | 553,290 | +553,290 | 0.00 | 0.08 | +0.08 | buy |
| Lunate Capital Ltd | 2,196,200 | 549,050 | -1,647,150 | 66.20 | 44.36 | -21.84 | sell |
| Caption Management, LLC | 100,000 | 517,685 | +417,685 | 0.00 | 0.04 | +0.04 | buy |
| MPM BioImpact LLC | 505,672 | 506,776 | +1,104 | 4.61 | 3.81 | -0.80 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 349,412 | 500,595 | +151,183 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 500,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Boxer Capital Management, LLC | 400,000 | 500,000 | +100,000 | 6.97 | 6.38 | -0.59 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 479,080 | +479,080 | 0.00 | 3.95 | +3.95 | buy |
| First Turn Management, LLC | 638,385 | 468,376 | -170,009 | 5.81 | 5.09 | -0.72 | sell |
| DEUTSCHE BANK AG\ | 32,217 | 465,758 | +433,541 | 0.00 | 0.01 | +0.01 | buy |
| Lunate Capital Ltd | 450,000 | 450,000 | 0 | 0.16 | 0.67 | +0.51 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 327,152 | 438,595 | +111,443 | 0.67 | 0.98 | +0.32 | buy |
| Swiss National Bank | 276,331 | 425,431 | +149,100 | 0.01 | 0.02 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 619,387 | 422,443 | -196,944 | 0.03 | 0.03 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,302,361 | 400,053 | -902,308 | 0.07 | 0.03 | -0.04 | sell |
| Invesco Ltd. | 367,851 | 392,844 | +24,993 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 136,048 | 383,179 | +247,131 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 800,118 | 377,332 | -422,786 | 0.05 | 0.03 | -0.02 | sell |
| SAMLYN CAPITAL, LLC | 0 | 371,948 | +371,948 | 0.00 | 0.62 | +0.62 | buy |
| ROYAL BANK OF CANADA | 503,721 | 371,743 | -131,978 | 0.01 | 0.01 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 322,289 | 368,325 | +46,036 | 0.09 | 0.14 | +0.05 | buy |
| Legal & General Group Plc | 153,380 | 341,148 | +187,768 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 406,241 | 340,611 | -65,630 | 0.01 | 0.01 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 467,360 | 335,528 | -131,832 | 0.02 | 0.02 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 370,520 | 317,811 | -52,709 | 0.02 | 0.03 | +0.00 | sell |
| Duquesne Family Office LLC | 0 | 315,860 | +315,860 | 0.00 | 1.05 | +1.05 | buy |
| JENNISON ASSOCIATES LLC | 305,260 | 307,377 | +2,117 | 0.01 | 0.02 | +0.01 | buy |
| JPMORGAN CHASE & CO | 421,627 | 301,393 | -120,234 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 291,006 | 281,960 | -9,046 | 0.01 | 0.02 | +0.00 | sell |
| STEMPOINT CAPITAL LP | 62,032 | 281,632 | +219,600 | 0.85 | 5.26 | +4.42 | buy |
| Man Group plc | 97,505 | 275,270 | +177,765 | 0.01 | 0.06 | +0.04 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 5,498 | 270,972 | +265,474 | 0.00 | 0.02 | +0.02 | buy |
| Melqart Asset Management (UK) Ltd | 0 | 270,363 | +270,363 | 0.00 | 2.59 | +2.59 | buy |
| Checkpoint Capital L.P. | 370,000 | 262,539 | -107,461 | 9.34 | 9.16 | -0.17 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 378,261 | 261,425 | -116,836 | 0.47 | 0.42 | -0.05 | sell |
| Nicholas Investment Partners, LP | 317,711 | 261,166 | -56,545 | 1.84 | 1.83 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 0 | 258,600 | +258,600 | 0.00 | 0.50 | +0.50 | buy |
| PERCEPTIVE ADVISORS LLC | 250,000 | 250,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 430,768 | 243,804 | -186,964 | 0.36 | 0.24 | -0.12 | sell |
| Ensign Peak Advisors, Inc | 235,808 | 227,940 | -7,868 | 0.03 | 0.04 | +0.01 | sell |