| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 2,914,975 | 5,259,089 | +2,344,114 | 3.31 | 7.81 | +4.50 | buy |
| JANUS HENDERSON GROUP PLC | 3,912,119 | 4,640,218 | +728,099 | 0.07 | 0.10 | 0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,654,895 | 2,363,584 | +708,689 | 0.14 | 0.25 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,814,310 | 5,216,659 | +402,349 | 0.02 | 0.02 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 361,000 | 650,826 | +289,826 | 0.18 | 0.43 | +0.25 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,052,691 | 3,335,656 | +282,965 | 0.01 | 0.01 | 0.00 | buy |
| Soleus Capital Management, L.P. | 728,700 | 856,178 | +127,478 | 2.06 | 2.93 | +0.87 | buy |
| Avidity Partners Management LP | 635,000 | 755,000 | +120,000 | 0.73 | 1.25 | +0.52 | buy |
| READYSTATE ASSET MANAGEMENT LP | 67,300 | 163,241 | +95,941 | 0.08 | 0.30 | +0.22 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 600,581 | 542,601 | +57,980 | 0.02 | 0.02 | +0.00 | sell |
| Finepoint Capital LP | 677,100 | 729,464 | +52,364 | 5.60 | 8.04 | +2.44 | buy |
| ALGERT GLOBAL LLC | 6,460 | 40,048 | +33,588 | 0.01 | 0.05 | 0.00 | buy |
| HighVista Strategies LLC | 14,325 | 40,083 | +25,758 | 0.16 | 0.57 | +0.40 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 206,513 | 228,513 | +22,000 | 0.31 | 0.20 | -0.11 | buy |
| BAKER BROS. ADVISORS LP | 7,549,249 | 7,569,090 | +19,841 | 3.05 | 3.75 | +0.70 | buy |
| Rock Springs Capital Management LP | 923,681 | 943,195 | +19,514 | 0.76 | 1.10 | +0.35 | buy |
| NEOS Investment Management LLC | 15,384 | 32,303 | +16,919 | 0.03 | 0.05 | +0.02 | buy |
| MPM BioImpact LLC | 273,217 | 289,396 | +16,179 | 1.42 | 1.75 | +0.33 | buy |
| PROFUND ADVISORS LLC | 46,114 | 35,999 | +10,115 | 0.06 | 0.05 | 0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 48,590 | 40,614 | +7,976 | 0.01 | 0.01 | 0.00 | sell |
| ProShare Advisors LLC | 36,605 | 28,868 | +7,737 | 0.00 | 0.00 | 0.00 | sell |
| Alphabet Inc. | 5,301,512 | 5,307,075 | +5,563 | 6.80 | 10.43 | +3.64 | buy |
| Clear Harbor Asset Management, LLC | 10,188 | 11,224 | +1,036 | 0.03 | 0.04 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 13,911 | 14,928 | +1,017 | 0.02 | 0.02 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 2,241 | 2,655 | +414 | 0.00 | 0.00 | +0.00 | buy |
| CSS LLC/IL | 14,856 | 15,003 | +147 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,311 | 2,278 | -1,033 | 0.06 | 0.04 | -0.01 | sell |
| E Fund Management Co., Ltd. | 13,438 | 11,274 | -2,164 | 0.03 | 0.02 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 254,594 | 250,194 | -4,400 | 0.01 | 0.01 | +0.00 | sell |
| NATIXIS | 6,075 | 1,469 | -4,606 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 12,910 | 6,600 | -6,310 | 0.16 | 0.10 | -0.06 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 143,777 | 133,000 | -10,777 | 3.01 | 4.35 | +1.34 | sell |
| China Universal Asset Management Co., Ltd. | 31,637 | 19,383 | -12,254 | 0.13 | 0.11 | -0.02 | sell |
| Cinctive Capital Management LP | 38,161 | 22,931 | -15,230 | 0.06 | 0.05 | -0.02 | sell |
| Candriam S.C.A. | 583,950 | 554,334 | -29,616 | 0.12 | 0.13 | +0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000 | 170,000 | -30,000 | 0.01 | 0.01 | +0.00 | sell |
| Bellevue Group AG | 5,073,600 | 5,029,100 | -44,500 | 2.49 | 3.17 | +0.68 | sell |
| Integral Health Asset Management, LLC | 420,000 | 325,000 | -95,000 | 1.33 | 1.26 | -0.07 | sell |
| Rafferty Asset Management, LLC | 284,352 | 185,637 | -98,715 | 0.03 | 0.03 | -0.01 | sell |
| GREAT LAKES ADVISORS, LLC | 288,820 | 120,867 | -167,953 | 0.08 | 0.04 | -0.04 | sell |
| Holocene Advisors, LP | 2,422,411 | 2,203,474 | -218,937 | 0.29 | 0.36 | +0.07 | sell |
| AMERIPRISE FINANCIAL INC | 1,694,501 | 1,472,290 | -222,211 | 0.02 | 0.02 | +0.00 | sell |
| Artal Group S.A. | 1,318,649 | 1,015,776 | -302,873 | 1.08 | 1.01 | -0.08 | sell |
| Woodline Partners LP | 3,797,148 | 3,290,791 | -506,357 | 1.13 | 1.22 | +0.09 | sell |
| Casdin Capital, LLC | 5,617,599 | 4,406,875 | -1,210,724 | 13.47 | 13.06 | -0.41 | sell |