| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 2,914,975 | 5,259,089 | +2,344,114 | 3.31 | 7.81 | +4.50 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 7,507,872 | 9,757,692 | +2,249,820 | 1.42 | 2.23 | +0.81 | buy |
| FMR LLC | 4,166,765 | 5,625,856 | +1,459,091 | 0.01 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 0 | 1,200,000 | +1,200,000 | 0.00 | 5.37 | +5.37 | buy |
| Hood River Capital Management LLC | 0 | 914,003 | +914,003 | 0.00 | 0.74 | +0.74 | buy |
| JANUS HENDERSON GROUP PLC | 3,912,119 | 4,640,218 | +728,099 | 0.07 | 0.10 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,654,895 | 2,363,584 | +708,689 | 0.14 | 0.24 | +0.10 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 519,305 | +519,305 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 0 | 455,099 | +455,099 | 0.00 | 1.11 | +1.11 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,814,310 | 5,216,659 | +402,349 | 0.02 | 0.02 | +0.01 | buy |
| First Turn Management, LLC | 0 | 329,519 | +329,519 | 0.00 | 2.08 | +2.08 | buy |
| GOLDMAN SACHS GROUP INC | 1,123,450 | 1,448,095 | +324,645 | 0.01 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 361,000 | 650,826 | +289,826 | 0.18 | 0.43 | +0.25 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,052,691 | 3,335,656 | +282,965 | 0.01 | 0.01 | +0.00 | buy |
| Man Group plc | 29,297 | 282,746 | +253,449 | 0.00 | 0.03 | +0.03 | buy |
| JANE STREET GROUP, LLC | 129,467 | 380,594 | +251,127 | 0.01 | 0.02 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 39,783 | 269,504 | +229,721 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Asset Management, L.P. | 0 | 227,922 | +227,922 | 0.00 | 0.03 | +0.03 | buy |
| TWINBEECH CAPITAL LP | 0 | 220,289 | +220,289 | 0.00 | 0.17 | +0.17 | buy |
| Walleye Capital LLC | 34,957 | 224,143 | +189,186 | 0.01 | 0.09 | +0.08 | buy |
| Nicholas Investment Partners, LP | 0 | 158,132 | +158,132 | 0.00 | 0.64 | +0.64 | buy |
| NORGES BANK | 1,708,276 | 1,848,647 | +140,371 | 0.01 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 728,700 | 856,178 | +127,478 | 2.06 | 2.93 | +0.87 | buy |
| Avidity Partners Management LP | 635,000 | 755,000 | +120,000 | 0.73 | 1.25 | +0.52 | buy |
| Bank of New York Mellon Corp | 529,409 | 645,253 | +115,844 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 133,174 | 241,447 | +108,273 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 106,843 | +106,843 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 101,023 | +101,023 | 0.00 | 0.64 | +0.64 | buy |
| READYSTATE ASSET MANAGEMENT LP | 67,300 | 163,241 | +95,941 | 0.08 | 0.30 | +0.22 | buy |
| Qube Research & Technologies Ltd | 167,480 | 249,188 | +81,708 | 0.01 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 927,070 | 995,489 | +68,419 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,052,263 | 1,109,684 | +57,421 | 0.01 | 0.01 | +0.00 | buy |
| Finepoint Capital LP | 677,100 | 729,464 | +52,364 | 5.60 | 8.04 | +2.44 | buy |
| Engineers Gate Manager LP | 11,208 | 46,159 | +34,951 | 0.01 | 0.04 | +0.03 | buy |
| ALGERT GLOBAL LLC | 6,460 | 40,048 | +33,588 | 0.01 | 0.05 | +0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 60,387 | 89,470 | +29,083 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 16,371 | 45,149 | +28,778 | 0.00 | 0.00 | +0.00 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 0 | 28,562 | +28,562 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 200,131 | 226,831 | +26,700 | 0.00 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 14,325 | 40,083 | +25,758 | 0.16 | 0.57 | +0.40 | buy |
| Tower Research Capital LLC (TRC) | 1,413 | 26,054 | +24,641 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 0 | 23,717 | +23,717 | 0.00 | 0.08 | +0.08 | buy |
| GSA CAPITAL PARTNERS LLP | 7,801 | 31,467 | +23,666 | 0.02 | 0.09 | +0.07 | buy |
| PRUDENTIAL FINANCIAL INC | 14,959 | 37,359 | +22,400 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 206,513 | 228,513 | +22,000 | 0.31 | 0.20 | -0.11 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 21,764 | +21,764 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 20,199 | +20,199 | 0.00 | 0.11 | +0.11 | buy |
| BAKER BROS. ADVISORS LP | 7,549,249 | 7,569,090 | +19,841 | 3.05 | 3.75 | +0.70 | buy |
| Rock Springs Capital Management LP | 923,681 | 943,195 | +19,514 | 0.76 | 1.10 | +0.35 | buy |
| Polar Asset Management Partners Inc. | 0 | 19,500 | +19,500 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 209,310 | 228,567 | +19,257 | 0.01 | 0.01 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 20,225 | 39,070 | +18,845 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 15,384 | 32,303 | +16,919 | 0.03 | 0.05 | +0.02 | buy |
| Alpine Global Management, LLC | 0 | 16,823 | +16,823 | 0.00 | 0.11 | +0.11 | buy |
| MetLife Investment Management, LLC | 71,207 | 87,912 | +16,705 | 0.02 | 0.02 | +0.00 | buy |
| MPM BioImpact LLC | 273,217 | 289,396 | +16,179 | 1.42 | 1.75 | +0.33 | buy |
| Legal & General Group Plc | 106,129 | 119,932 | +13,803 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 199,050 | 212,368 | +13,318 | 0.01 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 12,832 | +12,832 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 43,802 | 55,273 | +11,471 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 16,362 | 27,029 | +10,667 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 6,391 | 16,597 | +10,206 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 0 | 10,097 | +10,097 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 74,112 | 84,090 | +9,978 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 105,373 | 115,281 | +9,908 | 0.00 | 0.01 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 15,646 | 25,528 | +9,882 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 8,660 | +8,660 | 0.00 | 0.07 | +0.07 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 16,568 | 24,562 | +7,994 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 9,649 | 17,344 | +7,695 | 0.01 | 0.02 | +0.01 | buy |
| Mariner, LLC | 0 | 6,317 | +6,317 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 6,112 | +6,112 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 5,966 | +5,966 | 0.00 | 0.05 | +0.05 | buy |
| Parkwood LLC | 0 | 5,845 | +5,845 | 0.00 | 0.03 | +0.03 | buy |
| GROUP ONE TRADING LLC | 0 | 5,841 | +5,841 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 348 | 6,042 | +5,694 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 11,000 | 16,600 | +5,600 | 0.00 | 0.00 | +0.00 | buy |
| Alphabet Inc. | 5,301,512 | 5,307,075 | +5,563 | 6.80 | 10.43 | +3.64 | buy |
| Allianz Asset Management GmbH | 23,720 | 28,111 | +4,391 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 27,924 | 32,273 | +4,349 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 94,431 | 98,551 | +4,120 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 22,615 | 25,318 | +2,703 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 12,532 | 14,787 | +2,255 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 9,129 | 10,730 | +1,601 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 8,476 | 9,651 | +1,175 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 10,188 | 11,224 | +1,036 | 0.03 | 0.04 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 13,911 | 14,928 | +1,017 | 0.02 | 0.02 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 603 | +603 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 2,261 | 2,853 | +592 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 448 | +448 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 2,241 | 2,655 | +414 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 4,907 | 5,272 | +365 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 3,058 | 3,378 | +320 | 0.00 | 0.00 | +0.00 | buy |
| Elequin Capital, LP | 0 | 234 | +234 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 227 | +227 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 2,781 | 2,951 | +170 | 0.00 | 0.00 | +0.00 | buy |
| CSS LLC/IL | 14,856 | 15,003 | +147 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 256 | 398 | +142 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 39 | 173 | +134 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 111 | +111 | 0.00 | 0.00 | +0.00 | buy |