| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 14,757,112 | 14,378,297 | -378,815 | 0.01 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 14,714,726 | 13,660,196 | -1,054,530 | 0.08 | 0.09 | +0.01 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 7,507,872 | 9,757,692 | +2,249,820 | 1.42 | 2.23 | +0.81 | buy |
| BAKER BROS. ADVISORS LP | 7,549,249 | 7,569,090 | +19,841 | 3.05 | 3.75 | +0.70 | buy |
| BVF INC/IL | 5,981,212 | 5,981,212 | 0 | 5.30 | 6.51 | +1.21 | hold |
| FMR LLC | 4,166,765 | 5,625,856 | +1,459,091 | 0.01 | 0.01 | +0.00 | buy |
| Alphabet Inc. | 5,301,512 | 5,307,075 | +5,563 | 6.80 | 10.43 | +3.64 | buy |
| Paradigm Biocapital Advisors LP | 2,914,975 | 5,259,089 | +2,344,114 | 3.31 | 7.81 | +4.50 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,814,310 | 5,216,659 | +402,349 | 0.02 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 5,386,020 | 5,071,068 | -314,952 | 0.01 | 0.01 | +0.00 | sell |
| Bellevue Group AG | 5,073,600 | 5,029,100 | -44,500 | 2.49 | 3.17 | +0.68 | sell |
| JANUS HENDERSON GROUP PLC | 3,912,119 | 4,640,218 | +728,099 | 0.07 | 0.10 | +0.03 | buy |
| Casdin Capital, LLC | 5,617,599 | 4,406,875 | -1,210,724 | 13.47 | 13.06 | -0.41 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,052,691 | 3,335,656 | +282,965 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 3,797,148 | 3,290,791 | -506,357 | 1.13 | 1.22 | +0.09 | sell |
| JPMORGAN CHASE & CO | 3,509,104 | 3,115,575 | -393,529 | 0.01 | 0.01 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,090,073 | 3,090,073 | 0 | 1.73 | 2.00 | +0.26 | hold |
| AH Capital Management, L.L.C. | 2,748,523 | 2,748,523 | 0 | 6.41 | 9.10 | +2.69 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 1,654,895 | 2,363,584 | +708,689 | 0.14 | 0.24 | +0.10 | buy |
| Holocene Advisors, LP | 2,422,411 | 2,203,474 | -218,937 | 0.29 | 0.36 | +0.07 | sell |
| LMR Partners LLP | 2,185,658 | 2,185,658 | 0 | 0.01 | 0.00 | -0.01 | hold |
| NORGES BANK | 1,708,276 | 1,848,647 | +140,371 | 0.01 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 1,694,501 | 1,472,290 | -222,211 | 0.02 | 0.02 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,123,450 | 1,448,095 | +324,645 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,347,439 | 1,347,439 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Logos Global Management LP | 0 | 1,200,000 | +1,200,000 | 0.00 | 5.37 | +5.37 | buy |
| NORTHERN TRUST CORP | 1,214,271 | 1,180,016 | -34,255 | 0.01 | 0.01 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,052,263 | 1,109,684 | +57,421 | 0.01 | 0.01 | +0.00 | buy |
| Artal Group S.A. | 1,318,649 | 1,015,776 | -302,873 | 1.10 | 1.01 | -0.08 | sell |
| Frazier Life Sciences Management, L.P. | 997,455 | 997,455 | 0 | 1.36 | 1.81 | +0.45 | hold |
| MORGAN STANLEY | 927,070 | 995,489 | +68,419 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 923,681 | 943,195 | +19,514 | 0.76 | 1.10 | +0.35 | buy |
| Hood River Capital Management LLC | 0 | 914,003 | +914,003 | 0.00 | 0.74 | +0.74 | buy |
| Soleus Capital Management, L.P. | 728,700 | 856,178 | +127,478 | 2.06 | 2.93 | +0.87 | buy |
| MARSHALL WACE, LLP | 1,535,940 | 816,055 | -719,885 | 0.08 | 0.04 | -0.04 | sell |
| Avidity Partners Management LP | 635,000 | 755,000 | +120,000 | 0.73 | 1.25 | +0.52 | buy |
| Finepoint Capital LP | 677,100 | 729,464 | +52,364 | 5.60 | 8.04 | +2.44 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 361,000 | 650,826 | +289,826 | 0.18 | 0.43 | +0.25 | buy |
| Bank of New York Mellon Corp | 529,409 | 645,253 | +115,844 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 607,436 | 606,180 | -1,256 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 583,950 | 554,334 | -29,616 | 0.12 | 0.13 | +0.01 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 600,581 | 542,601 | -57,980 | 0.02 | 0.02 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 0 | 519,305 | +519,305 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 511,894 | 511,894 | 0 | 3.76 | 4.75 | +0.99 | hold |
| MIC Capital Management UK LLP | 508,569 | 508,569 | 0 | 3.11 | 4.29 | +1.18 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 500,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sofinnova Investments, Inc. | 0 | 455,099 | +455,099 | 0.00 | 1.11 | +1.11 | buy |
| CITADEL ADVISORS LLC | 588,088 | 408,842 | -179,246 | 0.02 | 0.02 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 544,086 | 400,567 | -143,519 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,331,259 | 390,583 | -940,676 | 0.01 | 0.00 | -0.01 | sell |
| JANE STREET GROUP, LLC | 129,467 | 380,594 | +251,127 | 0.01 | 0.02 | +0.01 | buy |
| SOROS CAPITAL MANAGEMENT LLC | 364,824 | 364,824 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Walleye Capital LLC | 356,667 | 352,667 | -4,000 | 0.00 | 0.00 | -0.00 | sell |
| First Turn Management, LLC | 0 | 329,519 | +329,519 | 0.00 | 2.08 | +2.08 | buy |
| Integral Health Asset Management, LLC | 420,000 | 325,000 | -95,000 | 1.33 | 1.26 | -0.07 | sell |
| ALLIANCEBERNSTEIN L.P. | 323,364 | 319,618 | -3,746 | 0.00 | 0.00 | +0.00 | sell |
| MPM BioImpact LLC | 273,217 | 289,396 | +16,179 | 1.42 | 1.75 | +0.33 | buy |
| Man Group plc | 29,297 | 282,746 | +253,449 | 0.00 | 0.03 | +0.03 | buy |
| Mubadala Investment Co PJSC | 278,000 | 278,000 | 0 | 0.04 | 0.04 | +0.01 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 291,465 | 271,197 | -20,268 | 0.01 | 0.01 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 39,783 | 269,504 | +229,721 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 254,594 | 250,194 | -4,400 | 0.01 | 0.01 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 250,000 | 250,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qube Research & Technologies Ltd | 167,480 | 249,188 | +81,708 | 0.01 | 0.02 | +0.01 | buy |
| BESSEMER GROUP INC | 243,442 | 243,442 | 0 | 0.01 | 0.02 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 133,174 | 241,447 | +108,273 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 209,310 | 228,567 | +19,257 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 206,513 | 228,513 | +22,000 | 0.31 | 0.20 | -0.11 | buy |
| Point72 Asset Management, L.P. | 0 | 227,922 | +227,922 | 0.00 | 0.03 | +0.03 | buy |
| Swiss National Bank | 200,131 | 226,831 | +26,700 | 0.00 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 34,957 | 224,143 | +189,186 | 0.01 | 0.09 | +0.08 | buy |
| TWINBEECH CAPITAL LP | 0 | 220,289 | +220,289 | 0.00 | 0.17 | +0.17 | buy |
| UBS Group AG | 304,979 | 217,763 | -87,216 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 199,050 | 212,368 | +13,318 | 0.01 | 0.01 | +0.00 | buy |
| Bleichroeder LP | 200,000 | 200,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Rafferty Asset Management, LLC | 284,352 | 185,637 | -98,715 | 0.03 | 0.03 | -0.01 | sell |
| Sculptor Capital LP | 178,107 | 178,107 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000 | 170,000 | -30,000 | 0.01 | 0.01 | +0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 67,300 | 163,241 | +95,941 | 0.08 | 0.30 | +0.22 | buy |
| Nicholas Investment Partners, LP | 0 | 158,132 | +158,132 | 0.00 | 0.64 | +0.64 | buy |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 150,000 | 150,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Neuberger Berman Group LLC | 143,359 | 142,087 | -1,272 | 0.00 | 0.00 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 143,777 | 133,000 | -10,777 | 3.01 | 4.35 | +1.34 | sell |
| GREAT LAKES ADVISORS, LLC | 288,820 | 120,867 | -167,953 | 0.08 | 0.04 | -0.04 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 120,085 | 120,085 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 106,129 | 119,932 | +13,803 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 119,289 | 119,289 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 105,373 | 115,281 | +9,908 | 0.00 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 106,843 | +106,843 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 135,416 | 102,643 | -32,773 | 0.00 | 0.00 | -0.00 | sell |
| Informed Momentum Co LLC | 0 | 101,023 | +101,023 | 0.00 | 0.64 | +0.64 | buy |
| Invesco Ltd. | 94,431 | 98,551 | +4,120 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 96,861 | 91,533 | -5,328 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 60,387 | 89,470 | +29,083 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 71,207 | 87,912 | +16,705 | 0.02 | 0.02 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 74,112 | 84,090 | +9,978 | 0.01 | 0.01 | +0.00 | buy |
| DLK Investment Management, LLC | 77,000 | 77,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Weiss Asset Management LP | 73,640 | 73,640 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 70,349 | 70,349 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 277,675 | 58,367 | -219,308 | 0.01 | 0.00 | -0.01 | sell |