| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 16,612,035 | 15,761,691 | -850,344 | 0.01 | 0.01 | -0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 13,534,692 | 14,325,692 | +791,000 | 2.58 | 2.40 | -0.18 | buy |
| JANUS HENDERSON GROUP PLC | 10,190,071 | 10,590,727 | +400,656 | 0.21 | 0.19 | -0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 11,787,921 | 10,259,738 | -1,528,183 | 0.08 | 0.07 | -0.01 | sell |
| BAKER BROS. ADVISORS LP | 7,936,972 | 9,364,972 | +1,428,000 | 3.11 | 3.34 | +0.24 | buy |
| BlackRock, Inc. | 14,692,392 | 8,661,393 | -6,030,999 | 0.01 | 0.01 | -0.00 | sell |
| FMR LLC | 7,535,771 | 8,325,184 | +789,413 | 0.02 | 0.02 | +0.00 | buy |
| Nextech Invest, Ltd. | 7,601,087 | 7,601,087 | 0 | 62.46 | 52.92 | -9.54 | hold |
| Paradigm Biocapital Advisors LP | 6,178,111 | 6,093,291 | -84,820 | 10.06 | 9.57 | -0.48 | sell |
| BVF INC/IL | 4,982,384 | 4,982,384 | 0 | 7.18 | 6.55 | -0.63 | hold |
| STATE STREET CORP | 5,804,919 | 4,718,906 | -1,086,013 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,599,642 | 4,701,962 | -897,680 | 0.02 | 0.02 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 1,673,429 | 4,689,298 | +3,015,869 | 0.04 | 0.11 | +0.07 | buy |
| Bellevue Group AG | 4,374,300 | 4,579,300 | +205,000 | 3.47 | 3.71 | +0.25 | buy |
| Alphabet Inc. | 4,133,277 | 4,133,277 | 0 | 9.27 | 7.12 | -2.15 | hold |
| Holocene Advisors, LP | 3,691,744 | 3,632,952 | -58,792 | 0.39 | 0.33 | -0.06 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,317,332 | 3,384,072 | +66,740 | 2.33 | 2.26 | -0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,142,414 | 2,993,866 | -1,148,548 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 3,887,036 | 2,915,572 | -971,464 | 0.89 | 0.57 | -0.33 | sell |
| Casdin Capital, LLC | 3,697,933 | 2,887,933 | -810,000 | 10.68 | 9.68 | -1.01 | sell |
| JPMORGAN CHASE & CO | 3,702,909 | 2,837,228 | -865,681 | 0.01 | 0.01 | -0.00 | sell |
| AH Capital Management, L.L.C. | 2,748,523 | 2,748,523 | 0 | 13.87 | 32.32 | +18.45 | hold |
| LMR Partners LLP | 2,606,720 | 2,646,023 | +39,303 | 0.00 | 0.01 | +0.01 | buy |
| Lunate Capital Ltd | 2,196,200 | 2,196,200 | 0 | 45.36 | 45.37 | +0.02 | hold |
| GOLDMAN SACHS GROUP INC | 2,164,501 | 2,153,397 | -11,104 | 0.01 | 0.01 | -0.00 | sell |
| NORGES BANK | 1,403,528 | 1,701,111 | +297,583 | 0.01 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 1,600,000 | 1,700,000 | +100,000 | 10.06 | 8.35 | -1.70 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,064,046 | 1,649,404 | +585,358 | 0.18 | 0.25 | +0.07 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,930,468 | 1,600,693 | -329,775 | 0.01 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 133,067 | 1,477,675 | +1,344,608 | 0.00 | 0.05 | +0.04 | buy |
| D. E. Shaw & Co., Inc. | 1,454,895 | 1,454,895 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 156,353 | 1,380,841 | +1,224,488 | 0.01 | 0.05 | +0.04 | buy |
| AMERIPRISE FINANCIAL INC | 1,490,658 | 1,344,460 | -146,198 | 0.01 | 0.01 | -0.00 | sell |
| Rock Springs Capital Management LP | 1,281,640 | 1,330,960 | +49,320 | 2.59 | 3.05 | +0.46 | buy |
| JANE STREET GROUP, LLC | 337,402 | 1,290,075 | +952,673 | 0.02 | 0.08 | +0.06 | buy |
| Vestal Point Capital, LP | 0 | 1,200,000 | +1,200,000 | 0.00 | 2.32 | +2.32 | buy |
| Hood River Capital Management LLC | 1,717,048 | 1,126,020 | -591,028 | 1.04 | 0.58 | -0.46 | sell |
| MORGAN STANLEY | 1,255,687 | 1,051,037 | -204,650 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 747,560 | 1,011,960 | +264,400 | 0.03 | 0.04 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 997,455 | 997,455 | 0 | 1.61 | 1.47 | -0.14 | hold |
| DIMENSIONAL FUND ADVISORS LP | 373,754 | 996,124 | +622,370 | 0.00 | 0.01 | +0.01 | buy |
| Siren, L.L.C. | 563,755 | 938,755 | +375,000 | 1.12 | 1.79 | +0.66 | buy |
| NORTHERN TRUST CORP | 1,534,757 | 856,623 | -678,134 | 0.01 | 0.00 | -0.00 | sell |
| Boxer Capital Management, LLC | 1,317,977 | 792,977 | -525,000 | 14.02 | 14.69 | +0.67 | sell |
| Qube Research & Technologies Ltd | 183,140 | 786,017 | +602,877 | 0.01 | 0.04 | +0.03 | buy |
| Polar Capital Holdings Plc | 750,665 | 751,655 | +990 | 0.16 | 0.15 | -0.02 | buy |
| Candriam S.C.A. | 655,134 | 719,513 | +64,379 | 0.15 | 0.15 | +0.01 | buy |
| HRT FINANCIAL LP | 23,707 | 686,426 | +662,719 | 0.01 | 0.11 | +0.11 | buy |
| DAFNA Capital Management LLC | 656,176 | 677,176 | +21,000 | 6.58 | 6.88 | +0.30 | buy |
| D. E. Shaw & Co., Inc. | 0 | 660,132 | +660,132 | 0.00 | 0.02 | +0.02 | buy |
| Caligan Partners LP | 465,000 | 636,835 | +171,835 | 3.43 | 4.55 | +1.12 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 599,301 | 599,301 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 446,562 | 576,683 | +130,121 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 482,107 | 514,753 | +32,646 | 0.00 | 0.00 | +0.00 | buy |
| MIC Capital Management UK LLP | 508,569 | 508,569 | 0 | 3.66 | 3.67 | +0.01 | hold |
| TD ASSET MANAGEMENT INC | 325,876 | 507,600 | +181,724 | 0.01 | 0.02 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 300,196 | 500,697 | +200,501 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 500,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bank of New York Mellon Corp | 582,721 | 494,613 | -88,108 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 741,860 | 454,572 | -287,288 | 0.02 | 0.01 | -0.01 | sell |
| Lunate Capital Ltd | 0 | 450,000 | +450,000 | 0.00 | 0.07 | +0.07 | buy |
| First Turn Management, LLC | 340,109 | 415,591 | +75,482 | 2.42 | 2.85 | +0.43 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 394,000 | 397,400 | +3,400 | 0.03 | 0.02 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 372,229 | 372,229 | 0 | 0.26 | 0.24 | -0.02 | hold |
| Ensign Peak Advisors, Inc | 427,466 | 371,857 | -55,609 | 0.03 | 0.02 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 524,428 | 367,345 | -157,083 | 0.01 | 0.01 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 337,881 | 367,093 | +29,212 | 0.01 | 0.01 | -0.00 | buy |
| SOROS CAPITAL MANAGEMENT LLC | 364,824 | 364,824 | 0 | 0.00 | 0.03 | +0.03 | hold |
| Squarepoint Ops LLC | 92,819 | 338,753 | +245,934 | 0.01 | 0.03 | +0.02 | buy |
| Integral Health Asset Management, LLC | 250,000 | 325,000 | +75,000 | 0.98 | 1.12 | +0.14 | buy |
| MPM BioImpact LLC | 317,083 | 315,722 | -1,361 | 1.93 | 2.01 | +0.09 | sell |
| CITIGROUP INC | 609,388 | 315,662 | -293,726 | 0.02 | 0.01 | -0.01 | sell |
| ARISTEIA CAPITAL, L.L.C. | 319,131 | 313,031 | -6,100 | 0.00 | 0.00 | +0.00 | sell |
| Weiss Asset Management LP | 0 | 303,772 | +303,772 | 0.00 | 0.18 | +0.18 | buy |
| RAYMOND JAMES FINANCIAL INC | 303,617 | 295,219 | -8,398 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 193,719 | 284,959 | +91,240 | 0.03 | 0.04 | +0.01 | buy |
| Checkpoint Capital L.P. | 392,011 | 280,000 | -112,011 | 7.61 | 4.80 | -2.80 | sell |
| Swiss National Bank | 276,531 | 266,431 | -10,100 | 0.01 | 0.01 | -0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 245,997 | 257,814 | +11,817 | 0.02 | 0.02 | -0.00 | buy |
| Nuveen, LLC | 477,860 | 257,502 | -220,358 | 0.01 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 278,451 | 256,384 | -22,067 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 59,214 | 253,335 | +194,121 | 0.02 | 0.11 | +0.08 | buy |
| FRANKLIN RESOURCES INC | 0 | 251,780 | +251,780 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 250,000 | 250,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BESSEMER GROUP INC | 243,571 | 243,571 | 0 | 0.02 | 0.01 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 142,804 | 243,504 | +100,700 | 0.01 | 0.01 | +0.00 | buy |
| HSBC HOLDINGS PLC | 220,188 | 231,885 | +11,697 | 0.01 | 0.01 | +0.00 | buy |
| Avidity Partners Management LP | 213,000 | 228,600 | +15,600 | 1.55 | 1.69 | +0.13 | buy |
| Invesco Ltd. | 190,259 | 227,019 | +36,760 | 0.00 | 0.00 | +0.00 | buy |
| Decheng Capital LLC | 226,000 | 226,000 | 0 | 2.24 | 2.10 | -0.14 | hold |
| TORONTO DOMINION BANK | 221,663 | 221,363 | -300 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 212,915 | 214,430 | +1,515 | 0.01 | 0.01 | -0.00 | buy |
| Edgestream Partners, L.P. | 215,717 | 204,313 | -11,404 | 0.26 | 0.21 | -0.05 | sell |
| Brevan Howard Capital Management LP | 0 | 204,120 | +204,120 | 0.00 | 0.08 | +0.08 | buy |
| Bleichroeder LP | 200,000 | 200,000 | 0 | 0.00 | 0.01 | +0.01 | hold |
| Russell Investments Group, Ltd. | 276,230 | 190,196 | -86,034 | 0.01 | 0.01 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 175,861 | 185,842 | +9,981 | 0.21 | 0.21 | -0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 244,053 | 185,669 | -58,384 | 0.01 | 0.01 | -0.00 | sell |
| Sculptor Capital LP | 178,107 | 178,107 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 240,095 | 166,386 | -73,709 | 0.01 | 0.01 | -0.00 | sell |