| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 1,673,429 | 4,689,298 | +3,015,869 | 0.04 | 0.11 | +0.07 | buy |
| BAKER BROS. ADVISORS LP | 7,936,972 | 9,364,972 | +1,428,000 | 3.11 | 3.34 | +0.24 | buy |
| CITADEL ADVISORS LLC | 133,067 | 1,477,675 | +1,344,608 | 0.00 | 0.05 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 156,353 | 1,380,841 | +1,224,488 | 0.01 | 0.05 | +0.04 | buy |
| Vestal Point Capital, LP | 0 | 1,200,000 | +1,200,000 | 0.00 | 2.32 | +2.32 | buy |
| JANE STREET GROUP, LLC | 337,402 | 1,290,075 | +952,673 | 0.02 | 0.08 | +0.06 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 13,534,692 | 14,325,692 | +791,000 | 2.58 | 2.40 | -0.18 | buy |
| FMR LLC | 7,535,771 | 8,325,184 | +789,413 | 0.02 | 0.02 | +0.00 | buy |
| HRT FINANCIAL LP | 23,707 | 686,426 | +662,719 | 0.01 | 0.11 | +0.11 | buy |
| D. E. Shaw & Co., Inc. | 0 | 660,132 | +660,132 | 0.00 | 0.02 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 373,754 | 996,124 | +622,370 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 183,140 | 786,017 | +602,877 | 0.01 | 0.04 | +0.03 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,064,046 | 1,649,404 | +585,358 | 0.18 | 0.25 | +0.07 | buy |
| Lunate Capital Ltd | 0 | 450,000 | +450,000 | 0.00 | 0.07 | +0.07 | buy |
| JANUS HENDERSON GROUP PLC | 10,190,071 | 10,590,727 | +400,656 | 0.21 | 0.19 | -0.02 | buy |
| Siren, L.L.C. | 563,755 | 938,755 | +375,000 | 1.12 | 1.79 | +0.66 | buy |
| Weiss Asset Management LP | 0 | 303,772 | +303,772 | 0.00 | 0.18 | +0.18 | buy |
| NORGES BANK | 1,403,528 | 1,701,111 | +297,583 | 0.01 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 747,560 | 1,011,960 | +264,400 | 0.03 | 0.04 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 0 | 251,780 | +251,780 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 92,819 | 338,753 | +245,934 | 0.01 | 0.03 | +0.02 | buy |
| Bellevue Group AG | 4,374,300 | 4,579,300 | +205,000 | 3.47 | 3.71 | +0.25 | buy |
| Brevan Howard Capital Management LP | 0 | 204,120 | +204,120 | 0.00 | 0.08 | +0.08 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 300,196 | 500,697 | +200,501 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 59,214 | 253,335 | +194,121 | 0.02 | 0.11 | +0.08 | buy |
| TD ASSET MANAGEMENT INC | 325,876 | 507,600 | +181,724 | 0.01 | 0.02 | +0.01 | buy |
| Caligan Partners LP | 465,000 | 636,835 | +171,835 | 3.43 | 4.55 | +1.12 | buy |
| BANK OF AMERICA CORP /DE/ | 446,562 | 576,683 | +130,121 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 13,931 | 143,855 | +129,924 | 0.00 | 0.03 | +0.03 | buy |
| Opaleye Management Inc. | 0 | 105,000 | +105,000 | 0.00 | 0.78 | +0.78 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 142,804 | 243,504 | +100,700 | 0.01 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 1,600,000 | 1,700,000 | +100,000 | 10.06 | 8.35 | -1.70 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 98,904 | +98,904 | 0.00 | 0.09 | +0.09 | buy |
| COMERICA BANK | 193,719 | 284,959 | +91,240 | 0.03 | 0.04 | +0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 89,617 | +89,617 | 0.00 | 0.13 | +0.13 | buy |
| DLK Investment Management, LLC | 77,000 | 164,477 | +87,477 | 0.00 | 0.02 | +0.02 | buy |
| Quantessence Capital LLC | 0 | 86,510 | +86,510 | 0.00 | 0.94 | +0.94 | buy |
| ROYAL BANK OF CANADA | 2,425 | 86,171 | +83,746 | 0.00 | 0.00 | +0.00 | buy |
| Treasurer of the State of North Carolina | 0 | 80,960 | +80,960 | 0.00 | 0.01 | +0.01 | buy |
| DIADEMA PARTNERS LP | 0 | 79,079 | +79,079 | 0.00 | 1.81 | +1.81 | buy |
| First Turn Management, LLC | 340,109 | 415,591 | +75,482 | 2.42 | 2.85 | +0.43 | buy |
| Integral Health Asset Management, LLC | 250,000 | 325,000 | +75,000 | 0.98 | 1.12 | +0.14 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,317,332 | 3,384,072 | +66,740 | 2.33 | 2.26 | -0.07 | buy |
| Jain Global LLC | 56,174 | 121,265 | +65,091 | 0.04 | 0.07 | +0.03 | buy |
| Candriam S.C.A. | 655,134 | 719,513 | +64,379 | 0.15 | 0.15 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 10,335 | 71,534 | +61,199 | 0.01 | 0.07 | +0.06 | buy |
| ExodusPoint Capital Management, LP | 10,351 | 71,190 | +60,839 | 0.00 | 0.03 | +0.03 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 12,792 | 69,445 | +56,653 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 53,807 | +53,807 | 0.00 | 0.01 | +0.01 | buy |
| Nicholas Investment Partners, LP | 61,123 | 113,126 | +52,003 | 0.22 | 0.37 | +0.15 | buy |
| Rock Springs Capital Management LP | 1,281,640 | 1,330,960 | +49,320 | 2.59 | 3.05 | +0.46 | buy |
| Engineers Gate Manager LP | 0 | 47,525 | +47,525 | 0.00 | 0.02 | +0.02 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 45,600 | +45,600 | 0.00 | 0.46 | +0.46 | buy |
| MACQUARIE GROUP LTD | 0 | 44,565 | +44,565 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 43,005 | +43,005 | 0.00 | 0.08 | +0.08 | buy |
| LMR Partners LLP | 2,606,720 | 2,646,023 | +39,303 | 0.00 | 0.01 | +0.01 | buy |
| Atom Investors LP | 0 | 36,998 | +36,998 | 0.00 | 0.12 | +0.12 | buy |
| Invesco Ltd. | 190,259 | 227,019 | +36,760 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 35,185 | +35,185 | 0.00 | 0.01 | +0.01 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 91,611 | 126,443 | +34,832 | 0.04 | 0.04 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 0 | 33,750 | +33,750 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 482,107 | 514,753 | +32,646 | 0.00 | 0.00 | +0.00 | buy |
| Neo Ivy Capital Management | 0 | 30,910 | +30,910 | 0.00 | 0.36 | +0.36 | buy |
| Hudson Bay Capital Management LP | 0 | 30,550 | +30,550 | 0.00 | 0.01 | +0.01 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 39,070 | 69,198 | +30,128 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 337,881 | 367,093 | +29,212 | 0.01 | 0.01 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 36,643 | 65,597 | +28,954 | 0.01 | 0.02 | +0.01 | buy |
| Atle Fund Management AB | 54,961 | 82,275 | +27,314 | 0.86 | 1.30 | +0.44 | buy |
| XTX Topco Ltd | 55,488 | 81,928 | +26,440 | 0.10 | 0.12 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 60,322 | 85,986 | +25,664 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 35,417 | 58,323 | +22,906 | 0.06 | 0.09 | +0.03 | buy |
| ALGERT GLOBAL LLC | 46,973 | 68,983 | +22,010 | 0.04 | 0.05 | +0.01 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 21,335 | +21,335 | 0.00 | 0.10 | +0.10 | buy |
| DAFNA Capital Management LLC | 656,176 | 677,176 | +21,000 | 6.58 | 6.88 | +0.30 | buy |
| Aquatic Capital Management LLC | 44,755 | 65,660 | +20,905 | 0.04 | 0.05 | +0.01 | buy |
| Scientech Research LLC | 0 | 20,796 | +20,796 | 0.00 | 0.19 | +0.19 | buy |
| Creative Planning | 45,098 | 65,714 | +20,616 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 0 | 19,747 | +19,747 | 0.00 | 0.08 | +0.08 | buy |
| Allianz Asset Management GmbH | 103,657 | 122,545 | +18,888 | 0.01 | 0.01 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 18,303 | +18,303 | 0.00 | 0.11 | +0.11 | buy |
| Persistent Asset Partners Ltd | 0 | 18,239 | +18,239 | 0.00 | 0.59 | +0.59 | buy |
| Avidity Partners Management LP | 213,000 | 228,600 | +15,600 | 1.55 | 1.69 | +0.13 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 13,648 | +13,648 | 0.00 | 0.11 | +0.11 | buy |
| Qsemble Capital Management, LP | 11,195 | 24,267 | +13,072 | 0.04 | 0.09 | +0.04 | buy |
| Diametric Capital, LP | 0 | 12,225 | +12,225 | 0.00 | 0.24 | +0.24 | buy |
| Erste Asset Management GmbH | 27,400 | 39,400 | +12,000 | 0.01 | 0.01 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 245,997 | 257,814 | +11,817 | 0.02 | 0.02 | -0.00 | buy |
| HSBC HOLDINGS PLC | 220,188 | 231,885 | +11,697 | 0.01 | 0.01 | +0.00 | buy |
| Sterling Capital Management LLC | 1,137 | 11,536 | +10,399 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 175,861 | 185,842 | +9,981 | 0.21 | 0.21 | -0.01 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 17,213 | 26,461 | +9,248 | 0.05 | 0.08 | +0.02 | buy |
| Utah Retirement Systems | 0 | 9,161 | +9,161 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 8,486 | +8,486 | 0.00 | 0.02 | +0.02 | buy |
| Maryland State Retirement & Pension System | 0 | 8,423 | +8,423 | 0.00 | 0.01 | +0.01 | buy |
| Marex Group plc | 0 | 7,706 | +7,706 | 0.00 | 0.01 | +0.01 | buy |
| AXQ CAPITAL, LP | 0 | 7,658 | +7,658 | 0.00 | 0.09 | +0.09 | buy |
| Dynamic Technology Lab Private Ltd | 14,188 | 21,762 | +7,574 | 0.07 | 0.11 | +0.04 | buy |
| Legato Capital Management LLC | 7,734 | 15,017 | +7,283 | 0.04 | 0.07 | +0.03 | buy |
| Jump Financial, LLC | 8,121 | 15,258 | +7,137 | 0.00 | 0.01 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 6,542 | +6,542 | 0.00 | 0.06 | +0.06 | buy |