| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 1,673,429 | 4,689,298 | +3,015,869 | 0.04 | 0.11 | +0.07 | buy |
| BAKER BROS. ADVISORS LP | 7,936,972 | 9,364,972 | +1,428,000 | 3.11 | 3.34 | +0.24 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,142,414 | 2,993,866 | +1,148,548 | 0.01 | 0.01 | 0.00 | sell |
| VANGUARD GROUP INC | 16,612,035 | 15,761,691 | +850,344 | 0.01 | 0.01 | 0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,064,046 | 1,649,404 | +585,358 | 0.18 | 0.25 | +0.07 | buy |
| JANUS HENDERSON GROUP PLC | 10,190,071 | 10,590,727 | +400,656 | 0.21 | 0.19 | 0.00 | buy |
| Siren, L.L.C. | 563,755 | 938,755 | +375,000 | 1.12 | 1.79 | +0.66 | buy |
| Bellevue Group AG | 4,374,300 | 4,579,300 | +205,000 | 3.47 | 3.71 | +0.25 | buy |
| TD ASSET MANAGEMENT INC | 325,876 | 507,600 | +181,724 | 0.01 | 0.02 | +0.01 | buy |
| Caligan Partners LP | 465,000 | 636,835 | +171,835 | 3.43 | 4.50 | +1.07 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 179,762 | 32,695 | +147,067 | 0.03 | 0.00 | -0.02 | sell |
| Logos Global Management LP | 1,600,000 | 1,700,000 | +100,000 | 10.06 | 8.35 | -1.70 | buy |
| DLK Investment Management, LLC | 77,000 | 164,477 | +87,477 | 0.00 | 0.02 | +0.02 | buy |
| First Turn Management, LLC | 340,109 | 415,591 | +75,482 | 2.42 | 2.85 | +0.43 | buy |
| Integral Health Asset Management, LLC | 250,000 | 325,000 | +75,000 | 0.98 | 1.12 | +0.14 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,317,332 | 3,384,072 | +66,740 | 2.32 | 2.26 | -0.06 | buy |
| Candriam S.C.A. | 655,134 | 719,513 | +64,379 | 0.15 | 0.15 | +0.01 | buy |
| Nicholas Investment Partners, LP | 61,123 | 113,126 | +52,003 | 0.22 | 0.37 | +0.15 | buy |
| Rock Springs Capital Management LP | 1,281,640 | 1,330,960 | +49,320 | 2.59 | 3.05 | +0.46 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 91,611 | 126,443 | +34,832 | 0.04 | 0.04 | +0.01 | buy |
| Atle Fund Management AB | 54,961 | 82,275 | +27,314 | 0.86 | 1.30 | +0.44 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 35,417 | 58,323 | +22,906 | 0.06 | 0.09 | 0.00 | buy |
| ALGERT GLOBAL LLC | 46,973 | 68,983 | +22,010 | 0.04 | 0.05 | 0.00 | buy |
| DAFNA Capital Management LLC | 656,176 | 677,176 | +21,000 | 6.58 | 6.88 | +0.30 | buy |
| Avidity Partners Management LP | 213,000 | 228,600 | +15,600 | 1.55 | 1.69 | +0.13 | buy |
| Qsemble Capital Management, LP | 11,195 | 24,267 | +13,072 | 0.04 | 0.09 | +0.04 | buy |
| Erste Asset Management GmbH | 27,400 | 39,400 | +12,000 | 0.01 | 0.01 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 245,997 | 257,814 | +11,817 | 0.02 | 0.02 | -0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 17,213 | 26,461 | +9,248 | 0.05 | 0.08 | +0.02 | buy |
| Dynamic Technology Lab Private Ltd | 14,188 | 21,762 | +7,574 | 0.07 | 0.11 | +0.04 | buy |
| Legato Capital Management LLC | 7,734 | 15,017 | +7,283 | 0.04 | 0.07 | +0.03 | buy |
| SIG BROKERAGE, LP | 8,306 | 13,411 | +5,105 | 0.01 | 0.01 | -0.00 | buy |
| S&CO INC | 9,171 | 14,171 | +5,000 | 0.02 | 0.03 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 394,000 | 397,400 | +3,400 | 0.03 | 0.02 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 36,647 | 33,663 | +2,984 | 0.01 | 0.01 | 0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 11,924 | 14,625 | +2,701 | 0.07 | 0.07 | +0.01 | buy |
| Clear Harbor Asset Management, LLC | 11,811 | 13,716 | +1,905 | 0.03 | 0.04 | +0.00 | buy |
| E Fund Management Co., Ltd. | 15,273 | 17,075 | +1,802 | 0.03 | 0.03 | +0.00 | buy |
| Polar Capital Holdings Plc | 750,665 | 751,655 | +990 | 0.16 | 0.15 | -0.02 | buy |
| Avanza Fonder AB | 2,877 | 3,688 | +811 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 139,640 | 140,077 | +437 | 0.01 | 0.01 | -0.00 | buy |
| CI INVESTMENTS INC. | 2,829 | 2,689 | +140 | 0.00 | 0.00 | 0.00 | sell |
| CITIZENS FINANCIAL GROUP INC/RI | 26,792 | 26,831 | +39 | 0.02 | 0.02 | -0.00 | buy |
| Kestra Investment Management, LLC | 168 | 184 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Wedmont Private Capital | 40,000 | 40,015 | +15 | 0.07 | 0.07 | -0.01 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 18,764 | 18,452 | -312 | 0.01 | 0.01 | -0.00 | sell |
| NEOS Investment Management LLC | 94,578 | 94,227 | -351 | 0.06 | 0.04 | -0.02 | sell |
| TEMA ETFS LLC | 94,578 | 94,227 | -351 | 1.00 | 0.92 | -0.08 | sell |
| FRED ALGER MANAGEMENT, LLC | 117,399 | 116,645 | -754 | 0.02 | 0.02 | -0.00 | sell |
| MPM BioImpact LLC | 317,083 | 315,722 | -1,361 | 1.93 | 2.01 | +0.09 | sell |
| Virtus Investment Advisers, LLC | 3,652 | 2,287 | -1,365 | 0.04 | 0.03 | -0.01 | sell |
| BIT Capital GmbH | 5,044 | 1,955 | -3,089 | 0.02 | 0.00 | -0.01 | sell |
| Granahan Investment Management, LLC | 126,752 | 121,780 | -4,972 | 0.22 | 0.18 | -0.04 | sell |
| PROFUND ADVISORS LLC | 35,509 | 30,494 | -5,015 | 0.05 | 0.04 | -0.01 | sell |
| J. Goldman & Co LP | 25,812 | 20,743 | -5,069 | 0.02 | 0.02 | -0.00 | sell |
| HighVista Strategies LLC | 73,752 | 68,048 | -5,704 | 1.00 | 0.92 | -0.08 | sell |
| ARISTEIA CAPITAL, L.L.C. | 319,131 | 313,031 | -6,100 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 276,531 | 266,431 | -10,100 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 163,419 | 152,978 | -10,441 | 0.02 | 0.02 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 66,662 | 55,693 | -10,969 | 2.73 | 2.86 | +0.13 | sell |
| Edgestream Partners, L.P. | 215,717 | 204,313 | -11,404 | 0.26 | 0.21 | -0.05 | sell |
| China Universal Asset Management Co., Ltd. | 89,962 | 77,411 | -12,551 | 0.30 | 0.27 | -0.03 | sell |
| CSS LLC/IL | 51,388 | 35,847 | -15,541 | 0.00 | 0.00 | +0.00 | sell |
| Magnetar Financial LLC | 32,972 | 12,447 | -20,525 | 0.02 | 0.00 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 177,136 | 134,136 | -43,000 | 1.21 | 0.80 | -0.40 | sell |
| Holocene Advisors, LP | 3,691,744 | 3,632,952 | -58,792 | 0.38 | 0.33 | -0.05 | sell |
| Soleus Capital Management, L.P. | 84,784 | 10,000 | -74,784 | 0.24 | 0.03 | -0.21 | sell |
| Paradigm Biocapital Advisors LP | 6,178,111 | 6,093,291 | -84,820 | 10.06 | 9.57 | -0.48 | sell |
| Checkpoint Capital L.P. | 392,011 | 280,000 | -112,011 | 7.61 | 4.80 | -2.80 | sell |
| AMERIPRISE FINANCIAL INC | 1,490,658 | 1,344,460 | -146,198 | 0.02 | 0.01 | -0.00 | sell |
| Boxer Capital Management, LLC | 1,317,977 | 792,977 | -525,000 | 14.02 | 14.69 | +0.67 | sell |
| Hood River Capital Management LLC | 1,717,048 | 1,126,020 | -591,028 | 1.04 | 0.58 | -0.46 | sell |
| Casdin Capital, LLC | 3,697,933 | 2,887,933 | -810,000 | 10.68 | 9.68 | -1.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,599,642 | 4,701,962 | -897,680 | 0.02 | 0.02 | -0.00 | sell |
| Woodline Partners LP | 3,887,036 | 2,915,572 | -971,464 | 0.89 | 0.57 | -0.33 | sell |