| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 0 | 4,008,244 | +4,008,244 | 0.00 | 0.09 | +0.09 | buy |
| NORGES BANK | 0 | 2,157,479 | +2,157,479 | 0.00 | 0.04 | +0.04 | buy |
| BAKER BROS. ADVISORS LP | 9,555,357 | 11,443,357 | +1,888,000 | 5.34 | 10.74 | +5.40 | buy |
| LMR Partners LLP | 3,838,024 | 5,066,598 | +1,228,574 | 0.06 | 0.35 | +0.29 | buy |
| AQR CAPITAL MANAGEMENT LLC | 116,787 | 1,295,450 | +1,178,663 | 0.01 | 0.08 | +0.08 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,338,142 | 3,942,676 | +604,534 | 0.02 | 0.04 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 258,600 | 527,600 | +269,000 | 0.50 | 1.53 | +1.04 | buy |
| Assenagon Asset Management S.A. | 0 | 200,486 | +200,486 | 0.00 | 0.05 | +0.05 | buy |
| CITADEL ADVISORS LLC | 400,053 | 589,906 | +189,853 | 0.03 | 0.06 | +0.04 | buy |
| NWI MANAGEMENT LP | 0 | 180,000 | +180,000 | 0.00 | 2.15 | +2.15 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,385 | 227,985 | +176,600 | 0.01 | 0.04 | +0.03 | buy |
| Hood River Capital Management LLC | 0 | 170,422 | +170,422 | 0.00 | 0.23 | +0.23 | buy |
| Handelsbanken Fonder AB | 61,775 | 212,275 | +150,500 | 0.02 | 0.11 | +0.09 | buy |
| Amundi | 138,560 | 269,701 | +131,141 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 422,443 | 552,710 | +130,267 | 0.03 | 0.05 | +0.03 | buy |
| Zweig-DiMenna Associates LLC | 8,287 | 120,200 | +111,913 | 0.11 | 2.04 | +1.93 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 47,766 | 156,169 | +108,403 | 0.00 | 0.03 | +0.02 | buy |
| BVF INC/IL | 2,856,782 | 2,965,160 | +108,378 | 8.85 | 14.20 | +5.35 | buy |
| AVIVA PLC | 21,460 | 118,070 | +96,610 | 0.00 | 0.03 | +0.03 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,297,000 | 2,392,000 | +95,000 | 2.64 | 4.67 | +2.04 | buy |
| FEDERATED HERMES, INC. | 0 | 90,878 | +90,878 | 0.00 | 0.02 | +0.02 | buy |
| Neuberger Berman Group LLC | 20,118 | 109,221 | +89,103 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 142,578 | 230,909 | +88,331 | 0.01 | 0.02 | +0.02 | buy |
| Duquesne Family Office LLC | 315,860 | 399,587 | +83,727 | 1.05 | 1.72 | +0.67 | buy |
| BAILLIE GIFFORD & CO | 187,072 | 263,466 | +76,394 | 0.02 | 0.04 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 165,277 | 238,463 | +73,186 | 0.02 | 0.04 | +0.02 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 67,000 | +67,000 | 0.00 | 0.02 | +0.02 | buy |
| AGF MANAGEMENT LTD | 0 | 66,941 | +66,941 | 0.00 | 0.05 | +0.05 | buy |
| CSS LLC/IL | 17,505 | 78,367 | +60,862 | 0.02 | 0.29 | +0.28 | buy |
| RHUMBLINE ADVISERS | 179,942 | 226,008 | +46,066 | 0.01 | 0.03 | +0.02 | buy |
| LPL Financial LLC | 22,619 | 67,500 | +44,881 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 43,794 | +43,794 | 0.00 | 0.01 | +0.01 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 270,972 | 306,300 | +35,328 | 0.02 | 0.03 | +0.02 | buy |
| SHIKIAR ASSET MANAGEMENT INC | 0 | 33,205 | +33,205 | 0.00 | 1.57 | +1.57 | buy |
| Zurich Insurance Group Ltd/FI | 0 | 31,880 | +31,880 | 0.00 | 0.04 | +0.04 | buy |
| Swiss National Bank | 425,431 | 456,331 | +30,900 | 0.02 | 0.04 | +0.02 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 49,509 | 77,402 | +27,893 | 0.02 | 0.04 | +0.03 | buy |
| MARSHALL WACE, LLP | 216,661 | 244,544 | +27,883 | 0.02 | 0.04 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 438,595 | 465,787 | +27,192 | 0.98 | 1.63 | +0.64 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 55,600 | 81,700 | +26,100 | 0.20 | 0.35 | +0.15 | buy |
| Rangeley Capital, LLC | 0 | 25,000 | +25,000 | 0.00 | 4.35 | +4.35 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 164,988 | 186,924 | +21,936 | 0.01 | 0.02 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 8,820 | 30,450 | +21,630 | 0.00 | 0.00 | +0.00 | buy |
| Anson Funds Management LP | 0 | 20,000 | +20,000 | 0.00 | 0.34 | +0.34 | buy |
| Cerity Partners LLC | 17,663 | 37,364 | +19,701 | 0.00 | 0.01 | +0.01 | buy |
| Bronte Capital Management Pty Ltd. | 0 | 18,780 | +18,780 | 0.00 | 0.40 | +0.40 | buy |
| ORBIMED ADVISORS LLC | 52,000 | 70,500 | +18,500 | 0.11 | 0.25 | +0.14 | buy |
| NATIXIS ADVISORS, LLC | 0 | 14,976 | +14,976 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 49,392 | 64,120 | +14,728 | 0.00 | 0.01 | +0.00 | buy |
| CIBC WORLD MARKET INC. | 0 | 14,093 | +14,093 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 15,395 | 28,136 | +12,741 | 0.00 | 0.01 | +0.01 | buy |
| MEITAV INVESTMENT HOUSE LTD | 0 | 11,500 | +11,500 | 0.00 | 0.01 | +0.01 | buy |
| BAMCO INC /NY/ | 2,500 | 12,500 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 0 | 9,505 | +9,505 | 0.00 | 0.01 | +0.01 | buy |
| FJARDE AP-FONDEN /FOURTH SWEDISH NATIONAL PENSION FUND | 46,900 | 56,300 | +9,400 | 0.02 | 0.05 | +0.03 | buy |
| SANDLER CAPITAL MANAGEMENT | 0 | 8,328 | +8,328 | 0.00 | 0.92 | +0.92 | buy |
| HighTower Advisors, LLC | 2,550 | 10,485 | +7,935 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 2,788 | 10,635 | +7,847 | 0.00 | 0.01 | +0.01 | buy |
| DnB Asset Management AS | 36,187 | 43,909 | +7,722 | 0.01 | 0.02 | +0.01 | buy |
| Focus Partners Wealth | 0 | 7,471 | +7,471 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 7,200 | +7,200 | 0.00 | 0.01 | +0.01 | buy |
| Arizona State Retirement System | 39,396 | 46,382 | +6,986 | 0.02 | 0.04 | +0.02 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 58,774 | 65,240 | +6,466 | 0.01 | 0.03 | +0.01 | buy |
| Asset Management One Co., Ltd. | 55,816 | 62,267 | +6,451 | 0.02 | 0.03 | +0.01 | buy |
| ASSETMARK, INC | 185 | 6,589 | +6,404 | 0.00 | 0.00 | +0.00 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 8,894 | 15,274 | +6,380 | 0.00 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 68,018 | 74,284 | +6,266 | 0.01 | 0.03 | +0.01 | buy |
| Blackstone Inc. | 3,539 | 9,635 | +6,096 | 0.00 | 0.01 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 45,920 | 51,993 | +6,073 | 0.01 | 0.02 | +0.01 | buy |
| CAPTRUST FINANCIAL ADVISORS | 10,438 | 16,289 | +5,851 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 39,419 | 45,164 | +5,745 | 0.01 | 0.01 | +0.01 | buy |
| Harvest Investment Services, LLC | 0 | 5,543 | +5,543 | 0.00 | 0.16 | +0.16 | buy |
| NOMURA HOLDINGS INC | 17,359 | 22,796 | +5,437 | 0.01 | 0.02 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 5,384 | +5,384 | 0.00 | 0.01 | +0.01 | buy |
| Equitable Holdings, Inc. | 0 | 5,140 | +5,140 | 0.00 | 0.01 | +0.01 | buy |
| BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp | 19,983 | 24,256 | +4,273 | 0.01 | 0.03 | +0.02 | buy |
| Calamos Advisors LLC | 15,463 | 19,711 | +4,248 | 0.01 | 0.01 | +0.01 | buy |
| Robeco Institutional Asset Management B.V. | 0 | 4,140 | +4,140 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 4,745 | 8,467 | +3,722 | 0.00 | 0.01 | +0.01 | buy |
| &PARTNERS | 0 | 3,474 | +3,474 | 0.00 | 0.00 | +0.00 | buy |
| BRIGHTON JONES LLC | 0 | 3,466 | +3,466 | 0.00 | 0.01 | +0.01 | buy |
| Chicago Partners Investment Group LLC | 0 | 3,116 | +3,116 | 0.00 | 0.01 | +0.01 | buy |
| Atria Investments, Inc | 0 | 3,008 | +3,008 | 0.00 | 0.01 | +0.01 | buy |
| Allianz Asset Management GmbH | 9,379 | 12,282 | +2,903 | 0.00 | 0.00 | +0.00 | buy |
| SIG BROKERAGE, LP | 0 | 2,846 | +2,846 | 0.00 | 0.09 | +0.09 | buy |
| State of New Jersey Common Pension Fund D | 49,551 | 52,307 | +2,756 | 0.02 | 0.03 | +0.01 | buy |
| Arax Advisory Partners | 169 | 2,835 | +2,666 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 19,604 | 22,169 | +2,565 | 0.01 | 0.01 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 14,945 | 17,476 | +2,531 | 0.00 | 0.00 | +0.00 | buy |
| CI INVESTMENTS INC. | 0 | 2,478 | +2,478 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 140,770 | 143,222 | +2,452 | 1.44 | 2.33 | +0.89 | buy |
| GRIMES & COMPANY, INC. | 0 | 2,369 | +2,369 | 0.00 | 0.01 | +0.01 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 2,314 | +2,314 | 0.00 | 0.01 | +0.01 | buy |
| OMERS ADMINISTRATION Corp | 0 | 2,308 | +2,308 | 0.00 | 0.00 | +0.00 | buy |
| Lombard Odier Asset Management (Switzerland) SA | 2,544 | 4,832 | +2,288 | 0.01 | 0.03 | +0.02 | buy |
| Janney Montgomery Scott LLC | 2,472 | 4,717 | +2,245 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 2,204 | +2,204 | 0.00 | 0.00 | +0.00 | buy |
| Baader Bank Aktiengesellschaft | 0 | 2,000 | +2,000 | 0.00 | 0.03 | +0.03 | buy |
| Curi Capital, LLC | 0 | 1,787 | +1,787 | 0.00 | 0.01 | +0.01 | buy |
| Dorsey & Whitney Trust CO LLC | 0 | 1,787 | +1,787 | 0.00 | 0.02 | +0.02 | buy |