| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 11,212,706 | 13,695,790 | +2,483,084 | 0.02 | 0.04 | +0.02 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 13,604,796 | 13,550,796 | -54,000 | 7.84 | 14.86 | +7.01 | sell |
| FMR LLC | 8,464,314 | 12,200,422 | +3,736,108 | 0.04 | 0.10 | +0.06 | buy |
| BAKER BROS. ADVISORS LP | 9,555,357 | 11,443,357 | +1,888,000 | 5.34 | 10.74 | +5.40 | buy |
| Darwin Global Management, Ltd. | 2,211,018 | 10,629,822 | +8,418,804 | 5.44 | 54.45 | +49.02 | buy |
| Nextech Invest, Ltd. | 7,601,087 | 7,601,087 | 0 | 52.02 | 67.55 | +15.53 | hold |
| Paradigm Biocapital Advisors LP | 6,655,703 | 6,361,323 | -294,380 | 13.23 | 22.31 | +9.08 | sell |
| UBS Group AG | 4,386,791 | 5,448,364 | +1,061,573 | 0.08 | 0.16 | +0.09 | buy |
| LMR Partners LLP | 3,838,024 | 5,066,598 | +1,228,574 | 0.06 | 0.35 | +0.29 | buy |
| STATE STREET CORP | 4,402,662 | 4,897,051 | +494,389 | 0.01 | 0.03 | +0.01 | buy |
| Capital World Investors | 0 | 4,008,244 | +4,008,244 | 0.00 | 0.09 | +0.09 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,338,142 | 3,942,676 | +604,534 | 0.02 | 0.04 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 6,027,819 | 3,843,415 | -2,184,404 | 0.11 | 0.12 | +0.01 | sell |
| JPMORGAN CHASE & CO | 301,393 | 3,298,066 | +2,996,673 | 0.00 | 0.04 | +0.04 | buy |
| BVF INC/IL | 2,856,782 | 2,965,160 | +108,378 | 8.85 | 14.20 | +5.35 | buy |
| Alphabet Inc. | 3,292,525 | 2,946,619 | -345,906 | 7.97 | 0.56 | -7.42 | sell |
| Casdin Capital, LLC | 2,577,333 | 2,577,333 | 0 | 18.98 | 24.16 | +5.18 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,297,000 | 2,392,000 | +95,000 | 2.64 | 4.67 | +2.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,232,213 | 2,390,303 | -841,910 | 0.04 | 0.04 | +0.01 | sell |
| Avoro Capital Advisors LLC | 2,344,444 | 2,297,000 | -47,444 | 2.25 | 3.86 | +1.62 | sell |
| NORGES BANK | 0 | 2,157,479 | +2,157,479 | 0.00 | 0.04 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 2,185,500 | 2,133,101 | -52,399 | 0.03 | 0.04 | +0.01 | sell |
| Nearwater Capital Markets, Ltd | 678,000 | 2,097,000 | +1,419,000 | 1.56 | 6.77 | +5.22 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 2,012,317 | +2,012,317 | 0.00 | 0.12 | +0.12 | buy |
| Woodline Partners LP | 2,506,570 | 2,002,863 | -503,707 | 0.92 | 1.16 | +0.24 | sell |
| Caligan Partners LP | 1,652,808 | 1,961,795 | +308,987 | 11.37 | 17.73 | +6.36 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,917,025 | +1,917,025 | 0.00 | 0.05 | +0.05 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,735,476 | 1,917,025 | +181,549 | 0.03 | 0.05 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 1,580,345 | 1,580,345 | 0 | 0.00 | 0.01 | +0.01 | hold |
| Integral Health Asset Management, LLC | 1,500,000 | 1,500,000 | 0 | 7.72 | 11.53 | +3.81 | hold |
| FRANKLIN RESOURCES INC | 1,133,546 | 1,488,394 | +354,848 | 0.03 | 0.06 | +0.03 | buy |
| Holocene Advisors, LP | 2,468,644 | 1,359,269 | -1,109,375 | 0.58 | 0.58 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 116,787 | 1,295,450 | +1,178,663 | 0.01 | 0.08 | +0.08 | buy |
| NORTHERN TRUST CORP | 954,256 | 1,117,110 | +162,854 | 0.01 | 0.02 | +0.01 | buy |
| Rock Springs Capital Management LP | 1,209,465 | 1,105,210 | -104,255 | 6.93 | 10.10 | +3.17 | sell |
| NATIONAL BANK OF CANADA /FI/ | 1,749,000 | 1,096,025 | -652,975 | 0.17 | 0.18 | +0.01 | sell |
| Bellevue Group AG | 1,544,456 | 1,048,014 | -496,442 | 3.57 | 4.13 | +0.56 | sell |
| AMERIPRISE FINANCIAL INC | 1,579,793 | 1,039,702 | -540,091 | 0.04 | 0.04 | +0.00 | sell |
| Pictet Asset Management Holding SA | 557,560 | 1,014,894 | +457,334 | 0.06 | 0.18 | +0.13 | buy |
| BANK OF AMERICA CORP /DE/ | 614,157 | 983,911 | +369,754 | 0.00 | 0.01 | +0.01 | buy |
| AH Capital Management, L.L.C. | 921,099 | 921,099 | 0 | 6.94 | 1.21 | -5.73 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 500,595 | 912,335 | +411,740 | 0.01 | 0.03 | +0.02 | buy |
| Siren, L.L.C. | 1,110,980 | 900,000 | -210,980 | 3.00 | 3.42 | +0.43 | sell |
| DEUTSCHE BANK AG\ | 465,758 | 888,019 | +422,261 | 0.01 | 0.05 | +0.03 | buy |
| MORGAN STANLEY | 705,793 | 838,249 | +132,456 | 0.00 | 0.01 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 134,233 | 789,241 | +655,008 | 0.04 | 0.42 | +0.38 | buy |
| DIMENSIONAL FUND ADVISORS LP | 844,614 | 763,434 | -81,180 | 0.02 | 0.03 | +0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,558,807 | 737,697 | -821,110 | 0.13 | 0.10 | -0.02 | sell |
| Sculptor Capital LP | 958,822 | 709,670 | -249,152 | 0.02 | 0.07 | +0.05 | sell |
| Logos Global Management LP | 2,000,000 | 700,000 | -1,300,000 | 10.02 | 5.64 | -4.37 | sell |
| Polar Capital Holdings Plc | 1,133,930 | 690,316 | -443,614 | 0.48 | 0.37 | -0.12 | sell |
| Alyeska Investment Group, L.P. | 1,885,821 | 659,279 | -1,226,542 | 0.52 | 0.32 | -0.20 | sell |
| Bank of New York Mellon Corp | 635,366 | 601,056 | -34,310 | 0.01 | 0.02 | +0.01 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,556,578 | 600,821 | -955,757 | 0.64 | 0.37 | -0.27 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,475,611 | 597,226 | -4,878,385 | 0.82 | 0.16 | -0.67 | sell |
| CITADEL ADVISORS LLC | 400,053 | 589,906 | +189,853 | 0.03 | 0.06 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 579,550 | 579,550 | 0 | 0.00 | 0.00 | +0.00 | hold |
| T. Rowe Price Investment Management, Inc. | 664,047 | 579,382 | -84,665 | 0.04 | 0.07 | +0.03 | sell |
| Invesco Ltd. | 392,844 | 578,287 | +185,443 | 0.00 | 0.01 | +0.00 | buy |
| DAFNA Capital Management LLC | 580,678 | 562,630 | -18,048 | 12.85 | 20.09 | +7.25 | sell |
| Candriam S.C.A. | 580,677 | 556,392 | -24,285 | 0.29 | 0.47 | +0.18 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 422,443 | 552,710 | +130,267 | 0.03 | 0.05 | +0.03 | buy |
| MIC Capital Management UK LLP | 795,733 | 531,733 | -264,000 | 21.95 | 25.25 | +3.30 | sell |
| PERCEPTIVE ADVISORS LLC | 258,600 | 527,600 | +269,000 | 0.50 | 1.53 | +1.04 | buy |
| Caption Management, LLC | 517,685 | 517,685 | 0 | 0.04 | 0.17 | +0.13 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 500,000 | 0 | 0.00 | 0.01 | +0.01 | hold |
| Boxer Capital Management, LLC | 500,000 | 500,000 | 0 | 6.38 | 7.05 | +0.67 | hold |
| MPM BioImpact LLC | 506,776 | 492,483 | -14,293 | 3.81 | 5.62 | +1.82 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 479,080 | 479,080 | 0 | 3.95 | 4.91 | +0.96 | hold |
| Nuveen, LLC | 340,611 | 475,231 | +134,620 | 0.01 | 0.02 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 438,595 | 465,787 | +27,192 | 0.98 | 1.63 | +0.64 | buy |
| Swiss National Bank | 425,431 | 456,331 | +30,900 | 0.02 | 0.04 | +0.02 | buy |
| Vestal Point Capital, LP | 2,375,000 | 450,000 | -1,925,000 | 6.46 | 1.97 | -4.49 | sell |
| First Turn Management, LLC | 468,376 | 415,307 | -53,069 | 5.09 | 8.32 | +3.23 | sell |
| Checkpoint Capital L.P. | 262,539 | 410,353 | +147,814 | 9.16 | 19.72 | +10.55 | buy |
| Duquesne Family Office LLC | 315,860 | 399,587 | +83,727 | 1.05 | 1.72 | +0.67 | buy |
| Legal & General Group Plc | 341,148 | 381,366 | +40,218 | 0.01 | 0.01 | +0.01 | buy |
| GENERAL ATLANTIC, L.P. | 707,791 | 357,791 | -350,000 | 3.20 | 2.31 | -0.90 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 281,960 | 349,929 | +67,969 | 0.02 | 0.04 | +0.02 | buy |
| TCG Crossover Management, LLC | 576,473 | 340,899 | -235,574 | 1.60 | 1.53 | -0.07 | sell |
| Qube Research & Technologies Ltd | 553,290 | 314,365 | -238,925 | 0.08 | 0.07 | -0.01 | sell |
| 1832 Asset Management L.P. | 0 | 309,200 | +309,200 | 0.00 | 0.07 | +0.07 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 270,972 | 306,300 | +35,328 | 0.02 | 0.03 | +0.02 | buy |
| JENNISON ASSOCIATES LLC | 307,377 | 280,933 | -26,444 | 0.02 | 0.03 | +0.01 | sell |
| Patient Square Capital LP | 0 | 276,000 | +276,000 | 0.00 | 8.01 | +8.01 | buy |
| National Pension Service | 0 | 273,604 | +273,604 | 0.00 | 0.03 | +0.03 | buy |
| Amundi | 138,560 | 269,701 | +131,141 | 0.00 | 0.01 | +0.01 | buy |
| BAILLIE GIFFORD & CO | 187,072 | 263,466 | +76,394 | 0.02 | 0.04 | +0.03 | buy |
| FRED ALGER MANAGEMENT, LLC | 21,374 | 259,468 | +238,094 | 0.01 | 0.16 | +0.15 | buy |
| Chicago Capital, LLC | 0 | 251,847 | +251,847 | 0.00 | 1.14 | +1.14 | buy |
| PERCEPTIVE ADVISORS LLC | 250,000 | 250,000 | 0 | 0.01 | 0.04 | +0.03 | hold |
| Affinity Asset Advisors, LLC | 100,000 | 250,000 | +150,000 | 0.57 | 2.29 | +1.72 | buy |
| CITIGROUP INC | 89,742 | 247,052 | +157,310 | 0.01 | 0.02 | +0.02 | buy |
| Nicholas Investment Partners, LP | 261,166 | 244,594 | -16,572 | 1.83 | 2.58 | +0.75 | sell |
| MARSHALL WACE, LLP | 216,661 | 244,544 | +27,883 | 0.02 | 0.04 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 165,277 | 238,463 | +73,186 | 0.02 | 0.04 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 142,578 | 230,909 | +88,331 | 0.01 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,385 | 227,985 | +176,600 | 0.01 | 0.04 | +0.03 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 261,425 | 227,845 | -33,580 | 0.42 | 0.57 | +0.15 | sell |
| ROYAL BANK OF CANADA | 371,743 | 226,210 | -145,533 | 0.01 | 0.01 | +0.00 | sell |