| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,317,842 | 2,240,739 | +922,897 | 0.02 | 0.04 | 0.00 | buy |
| Integral Health Asset Management, LLC | 356,000 | 525,000 | +169,000 | 1.25 | 2.06 | +0.81 | buy |
| Frazier Life Sciences Management, L.P. | 854,484 | 997,455 | +142,971 | 1.37 | 1.84 | +0.47 | buy |
| TD ASSET MANAGEMENT INC | 131,812 | 271,824 | +140,012 | 0.00 | 0.01 | +0.01 | buy |
| Artal Group S.A. | 2,401,617 | 2,529,737 | +128,120 | 2.06 | 3.05 | +1.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,018,765 | 5,094,706 | +75,941 | 0.02 | 0.02 | +0.00 | buy |
| Rock Springs Capital Management LP | 702,712 | 725,152 | +22,440 | 0.45 | 0.54 | +0.09 | buy |
| Holocene Advisors, LP | 2,178,060 | 2,190,722 | +12,662 | 0.25 | 0.27 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 1,393 | 2,802 | +1,409 | 0.01 | 0.02 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 360,635 | 361,000 | +365 | 0.16 | 0.18 | +0.02 | buy |
| ProShare Advisors LLC | 20,069 | 20,312 | +243 | 0.00 | 0.00 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,306 | 3,916 | -390 | 0.07 | 0.07 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 218,643 | 218,153 | -490 | 0.07 | 0.08 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 14,627 | 10,662 | -3,965 | 0.01 | 0.01 | -0.00 | sell |
| E Fund Management Co., Ltd. | 17,469 | 11,655 | -5,814 | 0.04 | 0.02 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 1,223,725 | 1,211,856 | -11,869 | 0.01 | 0.01 | +0.00 | sell |
| Candriam S.C.A. | 579,948 | 561,948 | -18,000 | 0.11 | 0.11 | -0.00 | sell |
| PROFUND ADVISORS LLC | 59,708 | 39,396 | -20,312 | 0.09 | 0.06 | -0.03 | sell |
| Bellevue Group AG | 4,746,000 | 4,721,500 | -24,500 | 1.81 | 2.11 | +0.29 | sell |
| DAFNA Capital Management LLC | 512,285 | 473,394 | -38,891 | 3.75 | 4.08 | +0.33 | sell |
| Rafferty Asset Management, LLC | 324,943 | 226,942 | -98,001 | 0.05 | 0.04 | -0.01 | sell |
| Hudson Bay Capital Management LP | 242,000 | 43,095 | -198,905 | 0.07 | 0.01 | -0.05 | sell |
| BESSEMER GROUP INC | 442,442 | 243,442 | -199,000 | 0.03 | 0.01 | -0.01 | sell |
| Avidity Partners Management LP | 1,075,000 | 657,200 | -417,800 | 1.00 | 0.73 | -0.27 | sell |
| Woodline Partners LP | 3,761,375 | 3,145,445 | -615,930 | 1.20 | 1.02 | -0.17 | sell |
| Column Group LLC | 2,577,220 | 1,230,641 | -1,346,579 | 26.76 | 22.62 | -4.14 | sell |
| EcoR1 Capital, LLC | 7,198,700 | 5,577,863 | -1,620,837 | 5.07 | 5.26 | +0.18 | sell |
| BVF INC/IL | 6,255,588 | 3,981,212 | -2,274,376 | 4.66 | 2.97 | -1.69 | sell |