| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LORD, ABBETT & CO. LLC | 0 | 1,832,021 | +1,832,021 | 0.00 | 0.26 | +0.26 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 9,757,692 | 11,317,692 | +1,560,000 | 2.23 | 2.82 | +0.58 | buy |
| JANUS HENDERSON GROUP PLC | 4,640,218 | 6,137,244 | +1,497,026 | 0.10 | 0.14 | +0.05 | buy |
| JPMORGAN CHASE & CO | 3,115,575 | 4,137,920 | +1,022,345 | 0.01 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,448,095 | 2,354,602 | +906,507 | 0.01 | 0.02 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,109,684 | 1,763,117 | +653,433 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 14,378,297 | 14,911,373 | +533,076 | 0.01 | 0.01 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 21,764 | 540,673 | +518,909 | 0.00 | 0.12 | +0.11 | buy |
| Hood River Capital Management LLC | 914,003 | 1,332,812 | +418,809 | 0.74 | 0.98 | +0.24 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,335,656 | 3,627,025 | +291,369 | 0.01 | 0.01 | +0.00 | buy |
| HSBC HOLDINGS PLC | 14,913 | 280,622 | +265,709 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 5,625,856 | 5,875,893 | +250,037 | 0.01 | 0.02 | +0.00 | buy |
| MARSHALL WACE, LLP | 816,055 | 1,064,999 | +248,944 | 0.04 | 0.06 | +0.02 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 0 | 228,814 | +228,814 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 5,071,068 | 5,279,584 | +208,516 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 102,643 | 294,664 | +192,021 | 0.00 | 0.01 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 0 | 163,500 | +163,500 | 0.00 | 3.97 | +3.97 | buy |
| Granahan Investment Management, LLC | 0 | 149,359 | +149,359 | 0.00 | 0.27 | +0.27 | buy |
| Woodline Partners LP | 3,290,791 | 3,433,713 | +142,922 | 1.22 | 1.32 | +0.09 | buy |
| NORTHERN TRUST CORP | 1,180,016 | 1,311,288 | +131,272 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 170,000 | 290,000 | +120,000 | 0.01 | 0.02 | +0.01 | buy |
| Walleye Capital LLC | 224,143 | 323,732 | +99,589 | 0.09 | 0.16 | +0.06 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,216,659 | 5,313,305 | +96,646 | 0.02 | 0.03 | +0.00 | buy |
| Artia Global Partners LP | 0 | 95,885 | +95,885 | 0.00 | 1.23 | +1.23 | buy |
| NATIXIS | 1,469 | 84,794 | +83,325 | 0.00 | 0.02 | +0.02 | buy |
| Rock Springs Capital Management LP | 943,195 | 1,009,945 | +66,750 | 1.10 | 1.49 | +0.39 | buy |
| Allianz Asset Management GmbH | 28,111 | 90,363 | +62,252 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 58,367 | 117,938 | +59,571 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 519,305 | 577,408 | +58,103 | 0.01 | 0.02 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 5,259,089 | 5,314,089 | +55,000 | 7.81 | 8.43 | +0.62 | buy |
| SEI INVESTMENTS CO | 45,149 | 98,691 | +53,542 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 98,551 | 147,246 | +48,695 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 106,843 | 155,189 | +48,346 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 44,351 | +44,351 | 0.00 | 0.34 | +0.34 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 271,197 | 312,127 | +40,930 | 0.01 | 0.01 | +0.00 | buy |
| Edgestream Partners, L.P. | 0 | 38,482 | +38,482 | 0.00 | 0.08 | +0.08 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 38,306 | +38,306 | 0.00 | 0.02 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 37,694 | +37,694 | 0.00 | 0.02 | +0.02 | buy |
| Allspring Global Investments Holdings, LLC | 3,190 | 38,589 | +35,399 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 755,000 | 790,000 | +35,000 | 1.25 | 1.83 | +0.58 | buy |
| Aquatic Capital Management LLC | 200 | 34,800 | +34,600 | 0.00 | 0.04 | +0.04 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 31,514 | +31,514 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 22,931 | 53,361 | +30,430 | 0.05 | 0.14 | +0.09 | buy |
| BANK OF AMERICA CORP /DE/ | 400,567 | 428,118 | +27,551 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 26,901 | +26,901 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 325,000 | 350,000 | +25,000 | 1.26 | 1.87 | +0.61 | buy |
| DEUTSCHE BANK AG\ | 91,533 | 112,386 | +20,853 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 10,730 | 31,454 | +20,724 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 0 | 17,791 | +17,791 | 0.00 | 0.01 | +0.01 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 17,667 | +17,667 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 37,764 | 54,670 | +16,906 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 16,654 | +16,654 | 0.00 | 0.23 | +0.23 | buy |
| Headlands Technologies LLC | 0 | 16,442 | +16,442 | 0.00 | 0.09 | +0.09 | buy |
| HighVista Strategies LLC | 40,083 | 55,562 | +15,479 | 0.57 | 0.87 | +0.30 | buy |
| Verition Fund Management LLC | 0 | 14,226 | +14,226 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 16,597 | 29,940 | +13,343 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 13,200 | +13,200 | 0.00 | 0.07 | +0.07 | buy |
| AMERIPRISE FINANCIAL INC | 1,472,290 | 1,485,422 | +13,132 | 0.02 | 0.02 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 76,950 | 90,043 | +13,093 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 19,383 | 32,127 | +12,744 | 0.11 | 0.16 | +0.05 | buy |
| Cubist Systematic Strategies, LLC | 0 | 11,326 | +11,326 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 27,029 | 37,868 | +10,839 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 29,294 | 40,009 | +10,715 | 0.00 | 0.00 | +0.00 | buy |
| Advantage Alpha Capital Partners LP | 0 | 10,164 | +10,164 | 0.00 | 0.10 | +0.10 | buy |
| Handelsbanken Fonder AB | 36,675 | 46,775 | +10,100 | 0.01 | 0.01 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 9,929 | +9,929 | 0.00 | 0.01 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 0 | 9,926 | +9,926 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 28,868 | 38,664 | +9,796 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 554,334 | 563,782 | +9,448 | 0.13 | 0.15 | +0.02 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 9,384 | +9,384 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 9,312 | +9,312 | 0.00 | 0.03 | +0.03 | buy |
| LPL Financial LLC | 6,112 | 14,530 | +8,418 | 0.00 | 0.00 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 0 | 7,706 | +7,706 | 0.00 | 0.68 | +0.68 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 7,421 | +7,421 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 6,794 | +6,794 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 511,894 | 517,994 | +6,100 | 4.75 | 5.55 | +0.80 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 6,011 | +6,011 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 32,303 | 38,082 | +5,779 | 0.05 | 0.05 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 5,444 | +5,444 | 0.00 | 0.02 | +0.02 | buy |
| Vontobel Holding Ltd. | 0 | 5,432 | +5,432 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 5,170 | +5,170 | 0.00 | 0.00 | +0.00 | buy |
| FISHMAN JAY A LTD/MI | 0 | 5,000 | +5,000 | 0.00 | 0.02 | +0.02 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 0 | 4,988 | +4,988 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 37,359 | 42,214 | +4,855 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Asset Management Inc | 0 | 4,767 | +4,767 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 4,700 | +4,700 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 19,500 | 23,700 | +4,200 | 0.02 | 0.03 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 390,583 | 394,473 | +3,890 | 0.00 | 0.00 | +0.00 | buy |
| CI INVESTMENTS INC. | 0 | 3,652 | +3,652 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 25,318 | 28,965 | +3,647 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 55,273 | 58,172 | +2,899 | 0.00 | 0.00 | +0.00 | buy |
| Finepoint Capital LP | 729,464 | 731,960 | +2,496 | 8.04 | 4.04 | -4.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 12,832 | 15,247 | +2,415 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 6,317 | 8,728 | +2,411 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 119,932 | 121,998 | +2,066 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 0 | 2,043 | +2,043 | 0.00 | 0.05 | +0.05 | buy |
| Decheng Capital LLC | 0 | 2,000 | +2,000 | 0.00 | 0.02 | +0.02 | buy |
| MPM BioImpact LLC | 289,396 | 291,391 | +1,995 | 1.75 | 1.98 | +0.24 | buy |
| Quarry LP | 0 | 1,800 | +1,800 | 0.00 | 0.02 | +0.02 | buy |
| CSS LLC/IL | 15,003 | 16,661 | +1,658 | 0.00 | 0.00 | +0.00 | buy |