| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 4,640,218 | 6,137,244 | +1,497,026 | 0.10 | 0.14 | 0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 2,363,584 | 1,651,805 | +711,779 | 0.25 | 0.21 | 0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 21,764 | 540,673 | +518,909 | 0.00 | 0.12 | +0.11 | buy |
| Hood River Capital Management LLC | 914,003 | 1,332,812 | +418,809 | 0.74 | 0.98 | +0.24 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,335,656 | 3,627,025 | +291,369 | 0.01 | 0.01 | 0.00 | buy |
| Woodline Partners LP | 3,290,791 | 3,433,713 | +142,922 | 1.22 | 1.32 | +0.09 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 170,000 | 290,000 | +120,000 | 0.01 | 0.02 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 542,601 | 437,750 | +104,851 | 0.02 | 0.02 | -0.00 | sell |
| Walleye Capital LLC | 224,143 | 323,732 | +99,589 | 0.12 | 0.20 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,216,659 | 5,313,305 | +96,646 | 0.02 | 0.03 | +0.00 | buy |
| NATIXIS | 1,469 | 84,794 | +83,325 | 0.00 | 0.02 | +0.02 | buy |
| Rock Springs Capital Management LP | 943,195 | 1,009,945 | +66,750 | 1.10 | 1.49 | +0.39 | buy |
| AMERICAN CENTURY COMPANIES INC | 519,305 | 577,408 | +58,103 | 0.01 | 0.02 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 5,259,089 | 5,314,089 | +55,000 | 7.81 | 8.43 | +0.62 | buy |
| Avidity Partners Management LP | 755,000 | 790,000 | +35,000 | 1.25 | 1.83 | +0.58 | buy |
| Cinctive Capital Management LP | 22,931 | 53,361 | +30,430 | 0.05 | 0.14 | +0.09 | buy |
| Integral Health Asset Management, LLC | 325,000 | 350,000 | +25,000 | 1.26 | 1.87 | +0.61 | buy |
| HighVista Strategies LLC | 40,083 | 55,562 | +15,479 | 0.57 | 0.87 | +0.30 | buy |
| AMERIPRISE FINANCIAL INC | 1,472,290 | 1,485,422 | +13,132 | 0.02 | 0.02 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 76,950 | 90,043 | +13,093 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 19,383 | 32,127 | +12,744 | 0.11 | 0.16 | +0.05 | buy |
| ProShare Advisors LLC | 28,868 | 38,664 | +9,796 | 0.00 | 0.00 | 0.00 | buy |
| Candriam S.C.A. | 554,334 | 563,782 | +9,448 | 0.13 | 0.15 | +0.02 | buy |
| DAFNA Capital Management LLC | 511,894 | 517,994 | +6,100 | 4.75 | 5.55 | +0.80 | buy |
| NEOS Investment Management LLC | 32,303 | 38,082 | +5,779 | 0.05 | 0.05 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 19,500 | 23,700 | +4,200 | 0.02 | 0.02 | +0.01 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 25,318 | 28,965 | +3,647 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 115,281 | 111,932 | +3,349 | 0.01 | 0.01 | +0.00 | sell |
| Finepoint Capital LP | 729,464 | 731,960 | +2,496 | 8.04 | 2.41 | -5.62 | buy |
| MPM BioImpact LLC | 289,396 | 291,391 | +1,995 | 1.75 | 1.98 | +0.24 | buy |
| CSS LLC/IL | 15,003 | 16,661 | +1,658 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 40,614 | 39,353 | +1,261 | 0.01 | 0.01 | 0.00 | sell |
| PROFUND ADVISORS LLC | 35,999 | 34,935 | +1,064 | 0.05 | 0.06 | 0.00 | sell |
| Corebridge Financial, Inc. | 81,977 | 81,474 | +503 | 0.02 | 0.02 | 0.00 | sell |
| Ameritas Investment Partners, Inc. | 14,928 | 15,156 | +228 | 0.02 | 0.02 | +0.00 | buy |
| BESSEMER GROUP INC | 243,442 | 243,558 | +116 | 0.02 | 0.02 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,278 | 2,321 | +43 | 0.04 | 0.05 | +0.01 | buy |
| MEEDER ASSET MANAGEMENT INC | 72 | 102 | +30 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 6,600 | 6,430 | -170 | 0.10 | 0.17 | +0.07 | sell |
| E Fund Management Co., Ltd. | 11,274 | 10,784 | -490 | 0.02 | 0.03 | +0.00 | sell |
| NOMURA ASSET MANAGEMENT CO LTD | 2,655 | 2,064 | -591 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 226,831 | 225,531 | -1,300 | 0.01 | 0.01 | +0.00 | sell |
| CITIZENS FINANCIAL GROUP INC/RI | 28,562 | 26,792 | -1,770 | 0.02 | 0.02 | -0.00 | sell |
| Wedmont Private Capital | 49,600 | 47,600 | -2,000 | 0.14 | 0.13 | -0.01 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 5,966 | 3,430 | -2,536 | 0.05 | 0.03 | -0.02 | sell |
| TD ASSET MANAGEMENT INC | 250,194 | 243,534 | -6,660 | 0.01 | 0.01 | +0.00 | sell |
| GREAT LAKES ADVISORS, LLC | 120,867 | 114,034 | -6,833 | 0.04 | 0.04 | +0.00 | sell |
| Legato Capital Management LLC | 20,199 | 7,546 | -12,653 | 0.11 | 0.04 | -0.06 | sell |
| Rafferty Asset Management, LLC | 185,637 | 167,839 | -17,798 | 0.03 | 0.03 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 133,000 | 108,000 | -25,000 | 4.35 | 3.97 | -0.38 | sell |
| Informed Momentum Co LLC | 101,023 | 71,210 | -29,813 | 0.64 | 0.48 | -0.15 | sell |
| Holocene Advisors, LP | 2,203,474 | 2,149,561 | -53,913 | 0.36 | 0.39 | +0.04 | sell |
| Nicholas Investment Partners, LP | 158,132 | 62,300 | -95,832 | 0.64 | 0.26 | -0.38 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 650,826 | 523,051 | -127,775 | 0.43 | 0.41 | -0.02 | sell |
| Soleus Capital Management, L.P. | 856,178 | 704,584 | -151,594 | 2.93 | 2.66 | -0.27 | sell |
| Bellevue Group AG | 5,029,100 | 4,871,360 | -157,740 | 3.17 | 3.58 | +0.41 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,090,073 | 2,912,692 | -177,381 | 2.00 | 1.97 | -0.02 | sell |
| Sofinnova Investments, Inc. | 455,099 | 203,271 | -251,828 | 0.92 | 0.73 | -0.19 | sell |
| Alphabet Inc. | 5,307,075 | 4,256,175 | -1,050,900 | 10.43 | 10.48 | +0.05 | sell |
| Casdin Capital, LLC | 5,617,599 | 4,114,283 | -1,503,316 | 13.46 | 12.44 | -1.02 | sell |
| BVF INC/IL | 5,981,212 | 3,478,612 | -2,502,600 | 6.51 | 4.61 | -1.89 | sell |