| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 15,761,691 | 15,663,094 | -98,597 | 0.01 | 0.01 | +0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 14,325,692 | 14,625,692 | +300,000 | 2.40 | 3.86 | +1.46 | buy |
| JANUS HENDERSON GROUP PLC | 10,590,727 | 11,356,054 | +765,327 | 0.19 | 0.24 | +0.05 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 10,259,738 | 9,813,436 | -446,302 | 0.07 | 0.08 | +0.01 | sell |
| BAKER BROS. ADVISORS LP | 9,364,972 | 9,455,357 | +90,385 | 3.34 | 3.19 | -0.15 | buy |
| FMR LLC | 8,325,184 | 9,401,687 | +1,076,503 | 0.02 | 0.02 | +0.01 | buy |
| BlackRock, Inc. | 8,661,393 | 8,327,758 | -333,635 | 0.01 | 0.01 | +0.00 | sell |
| Nextech Invest, Ltd. | 7,601,087 | 7,601,087 | 0 | 52.92 | 54.03 | +1.11 | hold |
| Paradigm Biocapital Advisors LP | 6,093,291 | 6,223,291 | +130,000 | 9.57 | 8.60 | -0.97 | buy |
| Bellevue Group AG | 4,579,300 | 5,573,838 | +994,538 | 3.71 | 5.41 | +1.70 | buy |
| STATE STREET CORP | 4,718,906 | 5,254,639 | +535,733 | 0.01 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 4,689,298 | 4,782,318 | +93,020 | 0.11 | 0.14 | +0.03 | buy |
| Alphabet Inc. | 4,133,277 | 4,133,277 | 0 | 7.12 | 8.01 | +0.89 | hold |
| BVF INC/IL | 4,982,384 | 3,974,913 | -1,007,471 | 6.55 | 7.52 | +0.98 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,701,962 | 3,873,706 | -828,256 | 0.02 | 0.02 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,384,072 | 3,650,342 | +266,270 | 2.26 | 2.61 | +0.35 | buy |
| Holocene Advisors, LP | 3,632,952 | 3,437,283 | -195,669 | 0.33 | 0.37 | +0.04 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,993,866 | 3,145,640 | +151,774 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 2,915,572 | 2,915,883 | +311 | 0.57 | 0.64 | +0.07 | buy |
| AH Capital Management, L.L.C. | 2,748,523 | 2,748,523 | 0 | 32.32 | 9.20 | -23.11 | hold |
| Casdin Capital, LLC | 2,887,933 | 2,647,333 | -240,600 | 9.68 | 10.31 | +0.63 | sell |
| LMR Partners LLP | 2,646,023 | 2,646,023 | 0 | 0.01 | 0.01 | -0.00 | hold |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,649,404 | 2,513,967 | +864,563 | 0.25 | 0.49 | +0.24 | buy |
| JPMORGAN CHASE & CO | 2,837,228 | 2,498,327 | -338,901 | 0.01 | 0.01 | +0.00 | sell |
| GENERAL ATLANTIC, L.P. | 0 | 2,474,428 | +2,474,428 | 0.00 | 3.47 | +3.47 | buy |
| Lunate Capital Ltd | 2,196,200 | 2,196,200 | 0 | 45.37 | 15.46 | -29.92 | hold |
| Logos Global Management LP | 1,700,000 | 1,750,000 | +50,000 | 8.35 | 8.07 | -0.28 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,600,693 | 1,635,395 | +34,702 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,454,895 | 1,454,895 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 996,124 | 1,440,818 | +444,694 | 0.01 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 1,051,037 | 1,434,642 | +383,605 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,330,960 | 1,335,270 | +4,310 | 3.05 | 3.65 | +0.59 | buy |
| Pictet Asset Management Holding SA | 1,011,960 | 1,311,741 | +299,781 | 0.04 | 0.06 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 1,344,460 | 1,224,759 | -119,701 | 0.01 | 0.01 | +0.00 | sell |
| CITADEL ADVISORS LLC | 1,477,675 | 1,180,085 | -297,590 | 0.05 | 0.04 | -0.00 | sell |
| UBS Group AG | 514,753 | 1,088,965 | +574,212 | 0.00 | 0.01 | +0.01 | buy |
| Caligan Partners LP | 636,835 | 1,064,249 | +427,414 | 4.55 | 6.90 | +2.35 | buy |
| Siren, L.L.C. | 938,755 | 1,043,720 | +104,965 | 1.79 | 1.91 | +0.12 | buy |
| Frazier Life Sciences Management, L.P. | 997,455 | 997,455 | 0 | 1.47 | 1.40 | -0.07 | hold |
| FRANKLIN RESOURCES INC | 251,780 | 951,490 | +699,710 | 0.00 | 0.01 | +0.01 | buy |
| Hood River Capital Management LLC | 1,126,020 | 928,123 | -197,897 | 0.58 | 0.51 | -0.07 | sell |
| Candriam S.C.A. | 719,513 | 868,724 | +149,211 | 0.15 | 0.21 | +0.06 | buy |
| NORTHERN TRUST CORP | 856,623 | 859,548 | +2,925 | 0.00 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 660,132 | 812,279 | +152,147 | 0.02 | 0.03 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 576,683 | 753,867 | +177,184 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 397,400 | 742,400 | +345,000 | 0.02 | 0.05 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 2,153,397 | 738,026 | -1,415,371 | 0.01 | 0.00 | -0.01 | sell |
| DAFNA Capital Management LLC | 677,176 | 657,176 | -20,000 | 6.88 | 7.58 | +0.70 | sell |
| First Turn Management, LLC | 415,591 | 643,050 | +227,459 | 2.85 | 4.51 | +1.66 | buy |
| Vestal Point Capital, LP | 1,200,000 | 630,000 | -570,000 | 2.32 | 1.33 | -0.99 | sell |
| JANE STREET GROUP, LLC | 1,290,075 | 597,455 | -692,620 | 0.08 | 0.03 | -0.04 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 599,301 | 595,935 | -3,366 | 0.00 | 0.00 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 372,229 | 595,038 | +222,809 | 0.24 | 0.46 | +0.22 | buy |
| TD ASSET MANAGEMENT INC | 507,600 | 535,604 | +28,004 | 0.02 | 0.02 | +0.00 | buy |
| Bank of New York Mellon Corp | 494,613 | 529,270 | +34,657 | 0.00 | 0.00 | +0.00 | buy |
| MIC Capital Management UK LLP | 508,569 | 508,569 | 0 | 3.67 | 4.75 | +1.07 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 500,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Checkpoint Capital L.P. | 280,000 | 492,300 | +212,300 | 4.80 | 7.70 | +2.90 | buy |
| COMERICA BANK | 284,959 | 490,216 | +205,257 | 0.04 | 0.09 | +0.05 | buy |
| Polar Capital Holdings Plc | 751,655 | 478,105 | -273,550 | 0.15 | 0.11 | -0.04 | sell |
| AMERICAN CENTURY COMPANIES INC | 454,572 | 451,014 | -3,558 | 0.01 | 0.01 | +0.00 | sell |
| Lunate Capital Ltd | 450,000 | 450,000 | 0 | 0.07 | 0.02 | -0.05 | hold |
| TCG Crossover Management, LLC | 0 | 436,473 | +436,473 | 0.00 | 1.00 | +1.00 | buy |
| ARISTEIA CAPITAL, L.L.C. | 313,031 | 430,939 | +117,908 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,380,841 | 428,309 | -952,532 | 0.05 | 0.02 | -0.03 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 367,345 | 424,681 | +57,336 | 0.01 | 0.02 | +0.00 | buy |
| Integral Health Asset Management, LLC | 325,000 | 400,000 | +75,000 | 1.12 | 1.36 | +0.24 | buy |
| Boxer Capital Management, LLC | 792,977 | 400,000 | -392,977 | 14.69 | 5.95 | -8.73 | sell |
| SOROS CAPITAL MANAGEMENT LLC | 364,824 | 364,824 | 0 | 0.03 | 0.03 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 500,697 | 341,367 | -159,330 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 257,502 | 337,474 | +79,972 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 331,069 | +331,069 | 0.00 | 1.32 | +1.32 | buy |
| MPM BioImpact LLC | 315,722 | 315,722 | 0 | 2.01 | 2.41 | +0.40 | hold |
| Caption Management, LLC | 0 | 314,836 | +314,836 | 0.00 | 0.85 | +0.85 | buy |
| BARCLAYS PLC | 256,384 | 290,449 | +34,065 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 295,219 | 278,160 | -17,059 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 266,431 | 270,831 | +4,400 | 0.01 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 113,126 | 267,911 | +154,785 | 0.37 | 0.96 | +0.59 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 185,842 | 265,008 | +79,166 | 0.21 | 0.31 | +0.10 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 257,814 | 253,377 | -4,437 | 0.02 | 0.02 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 243,504 | 253,104 | +9,600 | 0.01 | 0.02 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 367,093 | 251,810 | -115,283 | 0.01 | 0.01 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 250,000 | 250,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 371,857 | 248,478 | -123,379 | 0.02 | 0.02 | -0.00 | sell |
| BESSEMER GROUP INC | 243,571 | 243,867 | +296 | 0.01 | 0.02 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 214,430 | 230,974 | +16,544 | 0.01 | 0.01 | +0.00 | buy |
| TORONTO DOMINION BANK | 221,363 | 221,363 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Catalyst Funds Management Pty Ltd | 45,600 | 210,169 | +164,569 | 0.46 | 1.49 | +1.03 | buy |
| Decheng Capital LLC | 226,000 | 210,000 | -16,000 | 2.10 | 1.71 | -0.39 | sell |
| Invesco Ltd. | 227,019 | 200,942 | -26,077 | 0.00 | 0.00 | +0.00 | sell |
| Bleichroeder LP | 200,000 | 200,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ROYAL BANK OF CANADA | 86,171 | 192,329 | +106,158 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 32,695 | 191,327 | +158,632 | 0.00 | 0.03 | +0.02 | buy |
| HSBC HOLDINGS PLC | 231,885 | 188,197 | -43,688 | 0.01 | 0.01 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 0 | 185,380 | +185,380 | 0.00 | 1.75 | +1.75 | buy |
| Rafferty Asset Management, LLC | 152,978 | 179,833 | +26,855 | 0.02 | 0.03 | +0.01 | buy |
| Sculptor Capital LP | 178,107 | 178,107 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighVista Strategies LLC | 68,048 | 175,448 | +107,400 | 0.92 | 2.01 | +1.09 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 166,386 | 169,410 | +3,024 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 68,983 | 166,315 | +97,332 | 0.05 | 0.13 | +0.08 | buy |