| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GENERAL ATLANTIC, L.P. | 0 | 2,474,428 | +2,474,428 | 0.00 | 3.47 | +3.47 | buy |
| FMR LLC | 8,325,184 | 9,401,687 | +1,076,503 | 0.02 | 0.02 | +0.01 | buy |
| Bellevue Group AG | 4,579,300 | 5,573,838 | +994,538 | 3.71 | 5.41 | +1.70 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,649,404 | 2,513,967 | +864,563 | 0.25 | 0.49 | +0.24 | buy |
| JANUS HENDERSON GROUP PLC | 10,590,727 | 11,356,054 | +765,327 | 0.19 | 0.24 | +0.05 | buy |
| FRANKLIN RESOURCES INC | 251,780 | 951,490 | +699,710 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 514,753 | 1,088,965 | +574,212 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 4,718,906 | 5,254,639 | +535,733 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 996,124 | 1,440,818 | +444,694 | 0.01 | 0.01 | +0.01 | buy |
| TCG Crossover Management, LLC | 0 | 436,473 | +436,473 | 0.00 | 1.00 | +1.00 | buy |
| Caligan Partners LP | 636,835 | 1,064,249 | +427,414 | 4.55 | 6.90 | +2.35 | buy |
| MORGAN STANLEY | 1,051,037 | 1,434,642 | +383,605 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 397,400 | 742,400 | +345,000 | 0.02 | 0.05 | +0.03 | buy |
| PFM Health Sciences, LP | 0 | 331,069 | +331,069 | 0.00 | 1.32 | +1.32 | buy |
| Caption Management, LLC | 0 | 314,836 | +314,836 | 0.00 | 0.85 | +0.85 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 14,325,692 | 14,625,692 | +300,000 | 2.40 | 3.86 | +1.46 | buy |
| Pictet Asset Management Holding SA | 1,011,960 | 1,311,741 | +299,781 | 0.04 | 0.06 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,384,072 | 3,650,342 | +266,270 | 2.26 | 2.61 | +0.35 | buy |
| First Turn Management, LLC | 415,591 | 643,050 | +227,459 | 2.85 | 4.51 | +1.66 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 372,229 | 595,038 | +222,809 | 0.24 | 0.46 | +0.22 | buy |
| Checkpoint Capital L.P. | 280,000 | 492,300 | +212,300 | 4.80 | 7.70 | +2.90 | buy |
| COMERICA BANK | 284,959 | 490,216 | +205,257 | 0.04 | 0.09 | +0.05 | buy |
| STEMPOINT CAPITAL LP | 0 | 185,380 | +185,380 | 0.00 | 1.75 | +1.75 | buy |
| BANK OF AMERICA CORP /DE/ | 576,683 | 753,867 | +177,184 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 45,600 | 210,169 | +164,569 | 0.46 | 1.49 | +1.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 32,695 | 191,327 | +158,632 | 0.00 | 0.03 | +0.02 | buy |
| Nicholas Investment Partners, LP | 113,126 | 267,911 | +154,785 | 0.37 | 0.96 | +0.59 | buy |
| D. E. Shaw & Co., Inc. | 660,132 | 812,279 | +152,147 | 0.02 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,993,866 | 3,145,640 | +151,774 | 0.01 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 719,513 | 868,724 | +149,211 | 0.15 | 0.21 | +0.06 | buy |
| MARSHALL WACE, LLP | 27,681 | 161,096 | +133,415 | 0.00 | 0.01 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 6,093,291 | 6,223,291 | +130,000 | 9.57 | 8.60 | -0.97 | buy |
| ARISTEIA CAPITAL, L.L.C. | 313,031 | 430,939 | +117,908 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 34,966 | 149,145 | +114,179 | 0.00 | 0.02 | +0.02 | buy |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 0 | 108,400 | +108,400 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 68,048 | 175,448 | +107,400 | 0.92 | 2.01 | +1.09 | buy |
| ROYAL BANK OF CANADA | 86,171 | 192,329 | +106,158 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 938,755 | 1,043,720 | +104,965 | 1.79 | 1.91 | +0.12 | buy |
| Affinity Asset Advisors, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.43 | +0.43 | buy |
| Gotham Asset Management, LLC | 0 | 99,114 | +99,114 | 0.00 | 0.02 | +0.02 | buy |
| ALGERT GLOBAL LLC | 68,983 | 166,315 | +97,332 | 0.05 | 0.13 | +0.08 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 95,596 | +95,596 | 0.00 | 0.01 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 4,689,298 | 4,782,318 | +93,020 | 0.11 | 0.14 | +0.03 | buy |
| BAKER BROS. ADVISORS LP | 9,364,972 | 9,455,357 | +90,385 | 3.34 | 3.19 | -0.15 | buy |
| Nuveen, LLC | 257,502 | 337,474 | +79,972 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 185,842 | 265,008 | +79,166 | 0.21 | 0.31 | +0.10 | buy |
| Integral Health Asset Management, LLC | 325,000 | 400,000 | +75,000 | 1.12 | 1.36 | +0.24 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 60,000 | +60,000 | 0.00 | 0.66 | +0.66 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 367,345 | 424,681 | +57,336 | 0.01 | 0.02 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 15,016 | 70,289 | +55,273 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 1,700,000 | 1,750,000 | +50,000 | 8.35 | 8.07 | -0.28 | buy |
| Shay Capital LLC | 0 | 46,000 | +46,000 | 0.00 | 0.39 | +0.39 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 38,991 | +38,991 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,600,693 | 1,635,395 | +34,702 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 494,613 | 529,270 | +34,657 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 256,384 | 290,449 | +34,065 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 85,986 | 119,807 | +33,821 | 0.00 | 0.01 | +0.00 | buy |
| NEOS Investment Management LLC | 94,227 | 126,921 | +32,694 | 0.04 | 0.04 | +0.00 | buy |
| TEMA ETFS LLC | 94,227 | 126,921 | +32,694 | 0.92 | 0.49 | -0.43 | buy |
| TD ASSET MANAGEMENT INC | 507,600 | 535,604 | +28,004 | 0.02 | 0.02 | +0.00 | buy |
| Headlands Technologies LLC | 10,262 | 37,200 | +26,938 | 0.05 | 0.14 | +0.09 | buy |
| Rafferty Asset Management, LLC | 152,978 | 179,833 | +26,855 | 0.02 | 0.03 | +0.01 | buy |
| Quantinno Capital Management LP | 0 | 24,715 | +24,715 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 13,023 | 34,575 | +21,552 | 0.00 | 0.01 | +0.01 | buy |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 0 | 21,421 | +21,421 | 0.00 | 0.06 | +0.06 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 20,576 | +20,576 | 0.00 | 0.06 | +0.06 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.07 | +0.07 | buy |
| Raiffeisen Bank International AG | 0 | 20,000 | +20,000 | 0.00 | 0.01 | +0.01 | buy |
| Legato Capital Management LLC | 15,017 | 34,654 | +19,637 | 0.07 | 0.18 | +0.11 | buy |
| OSAIC HOLDINGS, INC. | 3,487 | 22,135 | +18,648 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 17,874 | +17,874 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 214,430 | 230,974 | +16,544 | 0.01 | 0.01 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 69,198 | 85,576 | +16,378 | 0.00 | 0.01 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 0 | 12,573 | +12,573 | 0.00 | 0.03 | +0.03 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 98,536 | 110,597 | +12,061 | 0.01 | 0.01 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 11,847 | +11,847 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 46,675 | 58,375 | +11,700 | 0.01 | 0.01 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 65,597 | 76,929 | +11,332 | 0.02 | 0.03 | +0.01 | buy |
| Private Advisor Group, LLC | 0 | 11,243 | +11,243 | 0.00 | 0.00 | +0.00 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 0 | 9,991 | +9,991 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 1,997 | 11,913 | +9,916 | 0.01 | 0.04 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 243,504 | 253,104 | +9,600 | 0.01 | 0.02 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 9,107 | +9,107 | 0.00 | 0.00 | +0.00 | buy |
| Sender Co & Partners, Inc. | 0 | 8,637 | +8,637 | 0.00 | 0.16 | +0.16 | buy |
| Avior Wealth Management, LLC | 0 | 8,498 | +8,498 | 0.00 | 0.01 | +0.01 | buy |
| Clear Harbor Asset Management, LLC | 13,716 | 22,110 | +8,394 | 0.04 | 0.07 | +0.03 | buy |
| S&CO INC | 14,171 | 22,171 | +8,000 | 0.03 | 0.06 | +0.03 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 71,311 | 78,732 | +7,421 | 0.00 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 0 | 7,305 | +7,305 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 7,030 | +7,030 | 0.00 | 0.81 | +0.81 | buy |
| PROFUND ADVISORS LLC | 30,494 | 37,079 | +6,585 | 0.04 | 0.06 | +0.02 | buy |
| SG Americas Securities, LLC | 4,278 | 10,714 | +6,436 | 0.00 | 0.00 | +0.00 | buy |
| FORA Capital, LLC | 0 | 6,369 | +6,369 | 0.00 | 0.05 | +0.05 | buy |
| Jump Financial, LLC | 15,258 | 21,495 | +6,237 | 0.01 | 0.02 | +0.01 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 6,002 | +6,002 | 0.00 | 0.00 | +0.00 | buy |
| SMITH, MOORE & CO. | 0 | 6,000 | +6,000 | 0.00 | 0.02 | +0.02 | buy |
| LPL Financial LLC | 0 | 5,859 | +5,859 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 5,534 | +5,534 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 5,500 | +5,500 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 52,830 | 58,308 | +5,478 | 0.01 | 0.01 | +0.00 | buy |