| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Casdin Capital, LLC | 1,810,000 | 5,714,775 | +3,904,775 | 5.55 | 16.09 | +10.54 | buy |
| BAKER BROS. ADVISORS LP | 2,691,493 | 5,148,657 | +2,457,164 | 0.43 | 1.68 | +1.25 | buy |
| BVF INC/IL | 3,981,212 | 5,981,212 | +2,000,000 | 2.97 | 4.29 | +1.32 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,751,496 | 3,090,073 | +1,338,577 | 1.07 | 1.64 | +0.57 | buy |
| Holocene Advisors, LP | 2,190,722 | 2,882,155 | +691,433 | 0.27 | 0.32 | +0.06 | buy |
| AMERIPRISE FINANCIAL INC | 1,211,856 | 1,623,021 | +411,165 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 962,657 | 567,105 | +395,552 | 0.08 | 0.05 | 0.00 | sell |
| Bellevue Group AG | 4,721,500 | 5,091,000 | +369,500 | 2.11 | 2.23 | +0.13 | buy |
| Finepoint Capital LP | 427,000 | 617,100 | +190,100 | 5.89 | 5.58 | -0.30 | buy |
| Rafferty Asset Management, LLC | 226,942 | 365,095 | +138,153 | 0.04 | 0.04 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 152,290 | 39,719 | +112,571 | 0.06 | 0.01 | 0.00 | sell |
| Logos Global Management LP | 250,000 | 350,000 | +100,000 | 0.99 | 1.12 | +0.13 | buy |
| Candriam S.C.A. | 561,948 | 606,950 | +45,002 | 0.11 | 0.12 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 2,240,739 | 2,199,480 | +41,259 | 0.04 | 0.04 | 0.00 | sell |
| DAFNA Capital Management LLC | 473,394 | 511,894 | +38,500 | 4.08 | 3.52 | -0.56 | buy |
| PROFUND ADVISORS LLC | 39,396 | 61,107 | +21,711 | 0.06 | 0.08 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,802 | 18,941 | +16,139 | 0.02 | 0.11 | +0.08 | buy |
| ProShare Advisors LLC | 20,312 | 34,274 | +13,962 | 0.00 | 0.00 | 0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 18,767 | 29,705 | +10,938 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 17,400 | 27,400 | +10,000 | 0.01 | 0.01 | +0.00 | buy |
| E Fund Management Co., Ltd. | 11,655 | 19,532 | +7,877 | 0.02 | 0.04 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 10,076 | 14,889 | +4,813 | 0.01 | 0.02 | +0.00 | buy |
| HighVista Strategies LLC | 18,005 | 22,650 | +4,645 | 0.23 | 0.24 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 271,824 | 271,760 | -64 | 0.01 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 3,916 | 3,540 | -376 | 0.07 | 0.06 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 142,650 | 13,710 | -128,940 | 0.77 | 0.17 | -0.60 | sell |
| TWINBEECH CAPITAL LP | 186,145 | 7,486 | -178,659 | 0.10 | 0.00 | -0.10 | sell |
| Woodline Partners LP | 3,145,445 | 2,960,040 | -185,405 | 1.02 | 0.93 | -0.10 | sell |
| Integral Health Asset Management, LLC | 525,000 | 200,000 | -325,000 | 2.06 | 0.83 | -1.23 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,094,706 | 4,636,353 | -458,353 | 0.02 | 0.02 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 1,321,795 | 818,882 | -502,913 | 1.22 | 0.52 | -0.70 | sell |
| Avidity Partners Management LP | 657,200 | 60,000 | -597,200 | 0.73 | 0.07 | -0.67 | sell |
| Artal Group S.A. | 2,529,737 | 1,695,949 | -833,788 | 3.00 | 1.62 | -1.39 | sell |
| Column Group LLC | 1,230,641 | 46 | -1,230,595 | 22.62 | 0.00 | -22.62 | sell |
| EcoR1 Capital, LLC | 5,577,863 | 132,579 | -5,445,284 | 5.21 | 0.10 | -5.11 | sell |