| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Alphabet Inc. | 0 | 5,301,512 | +5,301,512 | 0.00 | 7.05 | +7.05 | buy |
| VANGUARD GROUP INC | 9,643,591 | 14,634,391 | +4,990,800 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 10,572,475 | 14,882,086 | +4,309,611 | 0.06 | 0.08 | +0.02 | buy |
| Casdin Capital, LLC | 1,810,000 | 5,714,775 | +3,904,775 | 5.59 | 16.16 | +10.57 | buy |
| FMR LLC | 698,818 | 4,164,150 | +3,465,332 | 0.00 | 0.01 | +0.01 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 3,325,480 | 6,736,854 | +3,411,374 | 0.52 | 1.21 | +0.69 | buy |
| ARCH Venture Management, LLC | 0 | 3,233,490 | +3,233,490 | 0.00 | 56.72 | +56.72 | buy |
| BAKER BROS. ADVISORS LP | 2,691,493 | 5,148,657 | +2,457,164 | 0.43 | 1.68 | +1.25 | buy |
| STATE STREET CORP | 3,867,610 | 6,253,361 | +2,385,751 | 0.01 | 0.01 | +0.00 | buy |
| BVF INC/IL | 3,981,212 | 5,981,212 | +2,000,000 | 2.97 | 4.29 | +1.32 | buy |
| D. E. Shaw & Co., Inc. | 0 | 1,347,439 | +1,347,439 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,751,496 | 3,090,073 | +1,338,577 | 1.07 | 1.64 | +0.57 | buy |
| MARSHALL WACE, LLP | 86,088 | 1,208,929 | +1,122,841 | 0.01 | 0.07 | +0.06 | buy |
| Bain Capital Life Sciences Investors, LLC | 0 | 1,112,396 | +1,112,396 | 0.00 | 3.06 | +3.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,072,732 | 2,978,784 | +906,052 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 801,973 | 1,653,174 | +851,201 | 0.00 | 0.00 | +0.00 | buy |
| Holocene Advisors, LP | 2,190,722 | 2,882,155 | +691,433 | 0.27 | 0.32 | +0.05 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 679,630 | +679,630 | 0.00 | 1.80 | +1.80 | buy |
| CITADEL ADVISORS LLC | 246,458 | 904,029 | +657,571 | 0.01 | 0.03 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 608,474 | +608,474 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 595,986 | +595,986 | 0.00 | 0.00 | +0.00 | buy |
| MIC Capital Management UK LLP | 0 | 508,569 | +508,569 | 0.00 | 2.83 | +2.83 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 500,000 | +500,000 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 627,445 | 1,053,257 | +425,812 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 1,211,856 | 1,623,021 | +411,165 | 0.01 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 4,721,500 | 5,091,000 | +369,500 | 2.11 | 2.23 | +0.13 | buy |
| SOROS CAPITAL MANAGEMENT LLC | 0 | 364,824 | +364,824 | 0.00 | 0.09 | +0.09 | buy |
| NORTHERN TRUST CORP | 933,125 | 1,270,795 | +337,670 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 766,669 | 1,042,967 | +276,298 | 0.01 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 252,000 | +252,000 | 0.00 | 0.80 | +0.80 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 250,000 | +250,000 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 342,359 | 558,369 | +216,010 | 0.01 | 0.02 | +0.01 | buy |
| UBS Group AG | 97,159 | 306,558 | +209,399 | 0.00 | 0.00 | +0.00 | buy |
| Bleichroeder LP | 0 | 200,000 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| Finepoint Capital LP | 427,000 | 617,100 | +190,100 | 5.89 | 6.12 | +0.24 | buy |
| Sculptor Capital LP | 0 | 178,107 | +178,107 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 420,366 | 581,216 | +160,850 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 160,000 | +160,000 | 0.00 | 2.58 | +2.58 | buy |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 0 | 150,000 | +150,000 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 40,438 | 183,181 | +142,743 | 0.00 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 226,942 | 365,095 | +138,153 | 0.04 | 0.04 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,661,863 | 1,795,421 | +133,558 | 0.02 | 0.02 | -0.00 | buy |
| BARCLAYS PLC | 228,661 | 353,785 | +125,124 | 0.00 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 120,085 | +120,085 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 119,289 | +119,289 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 4,279,919 | 4,391,629 | +111,710 | 0.01 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 0 | 111,204 | +111,204 | 0.00 | 0.03 | +0.03 | buy |
| Logos Global Management LP | 250,000 | 350,000 | +100,000 | 0.99 | 1.12 | +0.13 | buy |
| Neuberger Berman Group LLC | 0 | 85,782 | +85,782 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 168,775 | 246,007 | +77,232 | 0.00 | 0.00 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 73,640 | +73,640 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 73,354 | +73,354 | 0.00 | 0.03 | +0.03 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 70,349 | +70,349 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 65,108 | +65,108 | 0.00 | 0.13 | +0.13 | buy |
| DEUTSCHE BANK AG\ | 53,001 | 117,835 | +64,834 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 256,043 | 320,245 | +64,202 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 97,234 | 161,041 | +63,807 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 145,572 | 205,358 | +59,786 | 0.00 | 0.01 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 55,600 | +55,600 | 0.00 | 0.04 | +0.04 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 51,647 | +51,647 | 0.00 | 0.01 | +0.01 | buy |
| Wedmont Private Capital | 0 | 49,600 | +49,600 | 0.00 | 0.12 | +0.12 | buy |
| Candriam S.C.A. | 561,948 | 606,950 | +45,002 | 0.11 | 0.12 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 0 | 40,636 | +40,636 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 473,394 | 511,894 | +38,500 | 4.08 | 3.52 | -0.56 | buy |
| State of New Jersey Common Pension Fund D | 75,027 | 113,390 | +38,363 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 163,600 | 200,131 | +36,531 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 35,362 | +35,362 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 76,447 | 108,682 | +32,235 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 14,899 | 45,563 | +30,664 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 104,238 | 133,174 | +28,936 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 14,200 | 40,175 | +25,975 | 0.00 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 88,156 | 114,105 | +25,949 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 55,245 | 80,405 | +25,160 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 24,500 | +24,500 | 0.00 | 0.28 | +0.28 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 155,536 | 178,987 | +23,451 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 53,461 | 75,397 | +21,936 | 0.01 | 0.02 | +0.00 | buy |
| PROFUND ADVISORS LLC | 39,396 | 61,107 | +21,711 | 0.06 | 0.08 | +0.01 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 50,613 | 71,494 | +20,881 | 0.01 | 0.01 | -0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 20,600 | +20,600 | 0.00 | 0.02 | +0.02 | buy |
| WOLVERINE TRADING, LLC | 0 | 20,151 | +20,151 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 42,278 | 60,842 | +18,564 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,802 | 18,941 | +16,139 | 0.02 | 0.11 | +0.08 | buy |
| TWO SIGMA INVESTMENTS, LP | 74,314 | 89,957 | +15,643 | 0.01 | 0.01 | +0.00 | buy |
| Beaumont Financial Advisors, LLC | 0 | 14,924 | +14,924 | 0.00 | 0.04 | +0.04 | buy |
| ProShare Advisors LLC | 20,312 | 34,274 | +13,962 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 53,100 | 65,791 | +12,691 | 0.00 | 0.00 | +0.00 | buy |
| CSS LLC/IL | 0 | 11,881 | +11,881 | 0.00 | 0.00 | +0.00 | buy |
| Corvex Management LP | 0 | 11,698 | +11,698 | 0.00 | 0.02 | +0.02 | buy |
| Pale Fire Capital SE | 0 | 11,142 | +11,142 | 0.00 | 0.05 | +0.05 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 18,767 | 29,705 | +10,938 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 10,904 | +10,904 | 0.00 | 0.03 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 9,601 | 19,985 | +10,384 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 10,334 | +10,334 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 28,945 | 39,070 | +10,125 | 0.00 | 0.00 | +0.00 | buy |
| Texas Yale Capital Corp. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 17,400 | 27,400 | +10,000 | 0.01 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 8,801 | +8,801 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 8,728 | +8,728 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 8,652 | +8,652 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 8,502 | +8,502 | 0.00 | 0.01 | +0.01 | buy |