| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 6,137,244 | 9,483,999 | +3,346,755 | 0.14 | 0.21 | +0.07 | buy |
| LMR Partners LLP | 0 | 2,595,245 | +2,595,245 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 14,911,373 | 17,096,455 | +2,185,082 | 0.01 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 11,317,692 | 13,248,692 | +1,931,000 | 2.82 | 3.05 | +0.24 | buy |
| Paradigm Biocapital Advisors LP | 5,314,089 | 6,553,111 | +1,239,022 | 8.43 | 9.97 | +1.54 | buy |
| FMR LLC | 5,875,893 | 6,742,083 | +866,190 | 0.02 | 0.02 | +0.00 | buy |
| BlackRock, Inc. | 13,866,858 | 14,719,548 | +852,690 | 0.01 | 0.01 | -0.00 | buy |
| Holocene Advisors, LP | 2,149,561 | 2,996,710 | +847,149 | 0.39 | 0.43 | +0.03 | buy |
| Polar Capital Holdings Plc | 0 | 750,665 | +750,665 | 0.00 | 0.18 | +0.18 | buy |
| BVF INC/IL | 3,478,612 | 4,181,179 | +702,567 | 4.61 | 6.20 | +1.58 | buy |
| Pictet Asset Management Holding SA | 15,837 | 712,596 | +696,759 | 0.00 | 0.03 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,313,305 | 5,865,962 | +552,657 | 0.03 | 0.03 | +0.00 | buy |
| STATE STREET CORP | 5,279,584 | 5,791,752 | +512,168 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,627,025 | 4,086,199 | +459,174 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 3,433,713 | 3,885,713 | +452,000 | 1.32 | 1.15 | -0.17 | buy |
| MARSHALL WACE, LLP | 1,064,999 | 1,504,801 | +439,802 | 0.06 | 0.08 | +0.02 | buy |
| First Turn Management, LLC | 0 | 403,915 | +403,915 | 0.00 | 3.16 | +3.16 | buy |
| BAKER BROS. ADVISORS LP | 7,569,090 | 7,936,972 | +367,882 | 3.56 | 3.71 | +0.15 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 290,000 | 650,000 | +360,000 | 0.02 | 0.05 | +0.03 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,912,692 | 3,258,332 | +345,640 | 1.97 | 2.71 | +0.74 | buy |
| Hood River Capital Management LLC | 1,332,812 | 1,678,434 | +345,622 | 0.98 | 1.08 | +0.11 | buy |
| ARISTEIA CAPITAL, L.L.C. | 0 | 319,131 | +319,131 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 2,354,602 | 2,630,152 | +275,550 | 0.02 | 0.02 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 39,783 | 305,172 | +265,389 | 0.00 | 0.02 | +0.02 | buy |
| Ghisallo Capital Management LLC | 0 | 257,100 | +257,100 | 0.00 | 0.66 | +0.66 | buy |
| Logos Global Management LP | 1,200,000 | 1,450,000 | +250,000 | 6.10 | 7.42 | +1.32 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 248,326 | +248,326 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,311,288 | 1,540,078 | +228,790 | 0.01 | 0.01 | -0.00 | buy |
| Decheng Capital LLC | 2,000 | 226,000 | +224,000 | 0.02 | 2.12 | +2.10 | buy |
| Checkpoint Capital L.P. | 0 | 210,000 | +210,000 | 0.00 | 4.67 | +4.67 | buy |
| MORGAN STANLEY | 652,818 | 858,278 | +205,460 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,009,945 | 1,213,257 | +203,312 | 1.49 | 2.02 | +0.53 | buy |
| Integral Health Asset Management, LLC | 350,000 | 550,000 | +200,000 | 1.87 | 2.13 | +0.26 | buy |
| Artia Global Partners LP | 95,885 | 284,190 | +188,305 | 1.23 | 5.01 | +3.78 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 26,901 | 208,401 | +181,500 | 0.01 | 0.04 | +0.04 | buy |
| STEMPOINT CAPITAL LP | 16,654 | 193,535 | +176,881 | 0.23 | 2.12 | +1.90 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,763,117 | 1,931,114 | +167,997 | 0.02 | 0.02 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 157,477 | +157,477 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 117,938 | 268,454 | +150,516 | 0.00 | 0.01 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 1,832,021 | 1,978,720 | +146,699 | 0.26 | 0.27 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 1,485,422 | 1,626,848 | +141,426 | 0.02 | 0.02 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 135,000 | +135,000 | 0.00 | 0.00 | +0.00 | buy |
| Empowered Funds, LLC | 0 | 132,679 | +132,679 | 0.00 | 0.08 | +0.08 | buy |
| ADAR1 Capital Management, LLC | 44,351 | 170,000 | +125,649 | 0.34 | 1.53 | +1.20 | buy |
| ExodusPoint Capital Management, LP | 0 | 123,315 | +123,315 | 0.00 | 0.06 | +0.06 | buy |
| BARCLAYS PLC | 294,664 | 408,614 | +113,950 | 0.01 | 0.01 | +0.00 | buy |
| DAFNA Capital Management LLC | 517,994 | 631,176 | +113,182 | 5.55 | 7.02 | +1.47 | buy |
| D. E. Shaw & Co., Inc. | 1,347,439 | 1,454,895 | +107,456 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 193,079 | 299,783 | +106,704 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 100,000 | +100,000 | 0.00 | 0.29 | +0.29 | buy |
| Candriam S.C.A. | 563,782 | 656,740 | +92,958 | 0.15 | 0.17 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,670 | 146,188 | +91,518 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 143,074 | 230,845 | +87,771 | 0.01 | 0.02 | +0.00 | buy |
| Aquatic Capital Management LLC | 34,800 | 113,405 | +78,605 | 0.04 | 0.13 | +0.09 | buy |
| Caption Management, LLC | 0 | 72,795 | +72,795 | 0.00 | 0.13 | +0.13 | buy |
| Man Group plc | 256,106 | 321,673 | +65,567 | 0.03 | 0.04 | +0.01 | buy |
| Maven Securities LTD | 0 | 65,000 | +65,000 | 0.00 | 0.46 | +0.46 | buy |
| DEUTSCHE BANK AG\ | 112,386 | 177,383 | +64,997 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 577,408 | 641,646 | +64,238 | 0.02 | 0.02 | +0.00 | buy |
| Atle Fund Management AB | 0 | 62,161 | +62,161 | 0.00 | 1.27 | +1.27 | buy |
| E Fund Management Co., Ltd. | 10,784 | 71,287 | +60,503 | 0.03 | 0.16 | +0.13 | buy |
| Altium Capital Management LLC | 0 | 60,000 | +60,000 | 0.00 | 0.82 | +0.82 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 216,026 | 262,851 | +46,825 | 0.00 | 0.00 | +0.00 | buy |
| Sandy Cove Advisors, LLC | 0 | 42,008 | +42,008 | 0.00 | 0.72 | +0.72 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 228,814 | 268,289 | +39,475 | 0.01 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 243,534 | 281,386 | +37,852 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 532,310 | 569,015 | +36,705 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 37,694 | 72,328 | +34,634 | 0.02 | 0.03 | +0.01 | buy |
| Brevan Howard Capital Management LP | 11,088 | 41,884 | +30,796 | 0.02 | 0.05 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 58,172 | 88,327 | +30,155 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 32,127 | 61,980 | +29,853 | 0.16 | 0.25 | +0.09 | buy |
| J. Goldman & Co LP | 0 | 26,335 | +26,335 | 0.00 | 0.04 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 212,841 | 237,539 | +24,698 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 226,992 | 251,465 | +24,473 | 0.01 | 0.01 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 22,725 | +22,725 | 0.00 | 0.01 | +0.01 | buy |
| Nicholas Investment Partners, LP | 62,300 | 84,729 | +22,429 | 0.26 | 0.33 | +0.07 | buy |
| MPM BioImpact LLC | 291,391 | 313,817 | +22,426 | 1.98 | 1.95 | -0.03 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 26,514 | 47,851 | +21,337 | 0.00 | 0.01 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 38,589 | 59,743 | +21,154 | 0.00 | 0.00 | +0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 0 | 17,199 | +17,199 | 0.00 | 0.01 | +0.01 | buy |
| Allianz Asset Management GmbH | 90,363 | 107,550 | +17,187 | 0.01 | 0.01 | +0.00 | buy |
| Proficio Capital Partners LLC | 0 | 17,146 | +17,146 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 16,687 | +16,687 | 0.00 | 0.33 | +0.33 | buy |
| ProShare Advisors LLC | 38,664 | 55,102 | +16,438 | 0.00 | 0.01 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,392 | 18,479 | +16,087 | 0.00 | 0.02 | +0.01 | buy |
| CIBC WORLD MARKETS CORP | 0 | 15,664 | +15,664 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 86,411 | 100,329 | +13,918 | 0.02 | 0.02 | +0.00 | buy |
| Neuberger Berman Group LLC | 133,453 | 146,657 | +13,204 | 0.00 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 7,421 | 20,000 | +12,579 | 0.00 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 90,043 | 102,127 | +12,084 | 0.01 | 0.01 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 7,300 | 19,253 | +11,953 | 0.29 | 0.72 | +0.44 | buy |
| Polar Asset Management Partners Inc. | 23,700 | 34,600 | +10,900 | 0.03 | 0.02 | -0.00 | buy |
| NEOS Investment Management LLC | 38,082 | 48,239 | +10,157 | 0.05 | 0.05 | -0.00 | buy |
| CSS LLC/IL | 16,661 | 26,268 | +9,607 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 121,998 | 130,658 | +8,660 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 8,358 | +8,358 | 0.00 | 0.00 | +0.00 | buy |
| SYON CAPITAL LLC | 0 | 7,306 | +7,306 | 0.00 | 0.03 | +0.03 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 56,357 | 63,601 | +7,244 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 40,048 | 46,973 | +6,925 | 0.05 | 0.05 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 24,562 | 30,846 | +6,284 | 0.00 | 0.00 | +0.00 | buy |