| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 6,137,244 | 9,483,999 | +3,346,755 | 0.14 | 0.21 | 0.00 | buy |
| Paradigm Biocapital Advisors LP | 5,314,089 | 6,553,111 | +1,239,022 | 8.43 | 9.97 | +1.54 | buy |
| Holocene Advisors, LP | 2,149,561 | 2,996,710 | +847,149 | 0.39 | 0.42 | +0.03 | buy |
| BVF INC/IL | 3,478,612 | 4,181,179 | +702,567 | 4.61 | 6.20 | +1.58 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,313,305 | 5,865,962 | +552,657 | 0.03 | 0.03 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,627,025 | 4,086,199 | +459,174 | 0.01 | 0.01 | 0.00 | buy |
| Woodline Partners LP | 3,433,713 | 3,885,713 | +452,000 | 1.32 | 1.15 | -0.17 | buy |
| BAKER BROS. ADVISORS LP | 7,569,090 | 7,936,972 | +367,882 | 3.56 | 3.71 | +0.15 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 290,000 | 650,000 | +360,000 | 0.02 | 0.05 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,651,805 | 1,302,848 | +348,957 | 0.21 | 0.14 | 0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,912,692 | 3,258,332 | +345,640 | 1.97 | 2.70 | +0.73 | buy |
| Hood River Capital Management LLC | 1,332,812 | 1,678,434 | +345,622 | 0.98 | 1.08 | +0.11 | buy |
| Logos Global Management LP | 1,200,000 | 1,450,000 | +250,000 | 6.10 | 7.42 | +1.32 | buy |
| Decheng Capital LLC | 2,000 | 226,000 | +224,000 | 0.02 | 2.12 | +2.10 | buy |
| Rock Springs Capital Management LP | 1,009,945 | 1,213,257 | +203,312 | 1.49 | 2.02 | +0.53 | buy |
| Integral Health Asset Management, LLC | 350,000 | 550,000 | +200,000 | 1.87 | 2.13 | +0.26 | buy |
| Artia Global Partners LP | 95,885 | 284,190 | +188,305 | 1.23 | 5.01 | +3.78 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 26,901 | 208,401 | +181,500 | 0.01 | 0.04 | +0.04 | buy |
| STEMPOINT CAPITAL LP | 16,654 | 193,535 | +176,881 | 0.23 | 2.12 | +1.90 | buy |
| LORD, ABBETT & CO. LLC | 1,832,021 | 1,978,720 | +146,699 | 0.26 | 0.27 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 1,485,422 | 1,626,848 | +141,426 | 0.02 | 0.02 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 44,351 | 170,000 | +125,649 | 0.34 | 1.53 | +1.20 | buy |
| DAFNA Capital Management LLC | 517,994 | 631,176 | +113,182 | 5.55 | 7.02 | +1.47 | buy |
| Walleye Capital LLC | 323,732 | 212,656 | +111,076 | 0.20 | 0.11 | 0.00 | sell |
| Candriam S.C.A. | 554,334 | 656,740 | +102,406 | 0.13 | 0.17 | +0.04 | buy |
| NATIXIS | 84,794 | 1,170 | +83,624 | 0.02 | 0.00 | 0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 577,408 | 641,646 | +64,238 | 0.02 | 0.02 | +0.00 | buy |
| E Fund Management Co., Ltd. | 10,784 | 71,287 | +60,503 | 0.03 | 0.16 | +0.13 | buy |
| TD ASSET MANAGEMENT INC | 243,534 | 281,386 | +37,852 | 0.01 | 0.01 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 37,694 | 72,328 | +34,634 | 0.02 | 0.03 | +0.01 | buy |
| Brevan Howard Capital Management LP | 11,088 | 41,884 | +30,796 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 32,127 | 61,980 | +29,853 | 0.16 | 0.25 | +0.09 | buy |
| Nicholas Investment Partners, LP | 62,300 | 84,729 | +22,429 | 0.26 | 0.33 | +0.07 | buy |
| MPM BioImpact LLC | 291,391 | 313,817 | +22,426 | 1.98 | 1.95 | -0.03 | buy |
| ProShare Advisors LLC | 38,664 | 55,102 | +16,438 | 0.00 | 0.01 | 0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 90,043 | 102,127 | +12,084 | 0.01 | 0.01 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 7,300 | 19,253 | +11,953 | 0.29 | 0.72 | +0.44 | buy |
| Polar Asset Management Partners Inc. | 23,700 | 34,600 | +10,900 | 0.02 | 0.02 | -0.00 | buy |
| NEOS Investment Management LLC | 38,082 | 48,239 | +10,157 | 0.05 | 0.05 | -0.00 | buy |
| CSS LLC/IL | 16,661 | 26,268 | +9,607 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 437,750 | 430,462 | +7,288 | 0.02 | 0.02 | -0.00 | sell |
| ALGERT GLOBAL LLC | 40,048 | 46,973 | +6,925 | 0.05 | 0.05 | 0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 28,965 | 34,632 | +5,667 | 0.01 | 0.01 | -0.00 | buy |
| Rafferty Asset Management, LLC | 167,839 | 172,786 | +4,947 | 0.03 | 0.03 | +0.00 | buy |
| Swiss National Bank | 225,531 | 229,931 | +4,400 | 0.01 | 0.01 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 39,353 | 34,961 | +4,392 | 0.01 | 0.01 | 0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 108,000 | 111,700 | +3,700 | 3.97 | 4.92 | +0.95 | buy |
| Legato Capital Management LLC | 7,546 | 10,713 | +3,167 | 0.04 | 0.06 | +0.02 | buy |
| Ameritas Investment Partners, Inc. | 15,156 | 17,287 | +2,131 | 0.02 | 0.03 | +0.00 | buy |
| Corebridge Financial, Inc. | 81,474 | 83,213 | +1,739 | 0.02 | 0.02 | 0.00 | buy |
| HighVista Strategies LLC | 55,562 | 57,246 | +1,684 | 0.87 | 0.93 | +0.06 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 111,932 | 113,036 | +1,104 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 34,935 | 35,479 | +544 | 0.06 | 0.06 | 0.00 | buy |
| CI INVESTMENTS INC. | 3,652 | 4,073 | +421 | 0.00 | 0.00 | 0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 7,706 | 7,704 | -2 | 0.68 | 0.77 | +0.08 | sell |
| MEEDER ASSET MANAGEMENT INC | 102 | 88 | -14 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,321 | 1,582 | -739 | 0.05 | 0.03 | -0.02 | sell |
| Beaumont Financial Advisors, LLC | 14,924 | 13,738 | -1,186 | 0.05 | 0.05 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 6,430 | 4,900 | -1,530 | 0.17 | 0.14 | -0.03 | sell |
| GREAT LAKES ADVISORS, LLC | 114,034 | 110,973 | -3,061 | 0.04 | 0.04 | -0.00 | sell |
| Wedmont Private Capital | 47,600 | 40,000 | -7,600 | 0.13 | 0.09 | -0.04 | sell |
| Cinctive Capital Management LP | 53,361 | 34,790 | -18,571 | 0.14 | 0.08 | -0.06 | sell |
| Finepoint Capital LP | 731,960 | 710,260 | -21,700 | 2.41 | 1.90 | -0.52 | sell |
| Granahan Investment Management, LLC | 149,359 | 119,430 | -29,929 | 0.27 | 0.22 | -0.05 | sell |
| Edgestream Partners, L.P. | 38,482 | 7,779 | -30,703 | 0.08 | 0.01 | -0.06 | sell |
| Alphabet Inc. | 4,256,175 | 4,133,277 | -122,898 | 10.48 | 10.53 | +0.05 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 523,051 | 372,229 | -150,822 | 0.41 | 0.30 | -0.11 | sell |
| Siren, L.L.C. | 753,601 | 571,548 | -182,053 | 1.71 | 1.10 | -0.61 | sell |
| Avidity Partners Management LP | 790,000 | 446,200 | -343,800 | 1.83 | 1.95 | +0.12 | sell |
| FRED ALGER MANAGEMENT, LLC | 540,673 | 148,126 | -392,547 | 0.12 | 0.03 | -0.09 | sell |
| Casdin Capital, LLC | 4,114,283 | 3,699,283 | -415,000 | 12.44 | 10.77 | -1.67 | sell |
| Bellevue Group AG | 4,871,360 | 4,386,900 | -484,460 | 3.58 | 3.69 | +0.11 | sell |
| Soleus Capital Management, L.P. | 704,584 | 201,084 | -503,500 | 2.66 | 0.67 | -1.99 | sell |