| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 478,105 | 2,013,791 | +1,535,686 | 0.11 | 0.73 | +0.63 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 742,400 | 2,205,555 | +1,463,155 | 0.05 | 0.27 | +0.21 | buy |
| VANGUARD GROUP INC | 15,663,094 | 16,719,886 | +1,056,792 | 0.01 | 0.02 | 0.00 | buy |
| AMERIPRISE FINANCIAL INC | 1,224,759 | 2,056,857 | +832,098 | 0.01 | 0.04 | +0.03 | buy |
| Integral Health Asset Management, LLC | 400,000 | 1,200,000 | +800,000 | 1.36 | 4.84 | +3.48 | buy |
| LMR Partners LLP | 2,646,023 | 3,151,705 | +505,682 | 0.01 | 0.03 | +0.02 | buy |
| Paradigm Biocapital Advisors LP | 6,223,291 | 6,644,403 | +421,112 | 8.60 | 14.17 | +5.57 | buy |
| GENERAL ATLANTIC, L.P. | 2,474,428 | 2,812,928 | +338,500 | 3.47 | 7.80 | +4.33 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 2,513,967 | 2,845,013 | +331,046 | 0.49 | 0.94 | +0.45 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 122,780 | 430,768 | +307,988 | 0.05 | 0.36 | +0.31 | buy |
| Siren, L.L.C. | 1,043,720 | 1,335,075 | +291,355 | 1.91 | 3.17 | +1.27 | buy |
| Logos Global Management LP | 1,750,000 | 2,000,000 | +250,000 | 8.07 | 10.62 | +2.54 | buy |
| Caligan Partners LP | 1,064,249 | 1,283,900 | +219,651 | 6.51 | 8.42 | +1.91 | buy |
| ARISTEIA CAPITAL, L.L.C. | 430,939 | 624,935 | +193,996 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 315,722 | 505,672 | +189,950 | 2.41 | 4.61 | +2.19 | buy |
| Candriam S.C.A. | 868,724 | 1,030,992 | +162,268 | 0.21 | 0.41 | +0.20 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 9,991 | 94,010 | +84,019 | 0.00 | 0.03 | +0.03 | buy |
| Nicholas Investment Partners, LP | 267,911 | 317,711 | +49,800 | 0.96 | 1.84 | +0.89 | buy |
| Hood River Capital Management LLC | 928,123 | 945,585 | +17,462 | 0.51 | 0.83 | +0.31 | buy |
| BIT Capital GmbH | 1,522 | 18,400 | +16,878 | 0.00 | 0.05 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,145,640 | 3,161,963 | +16,323 | 0.01 | 0.02 | 0.00 | buy |
| Gotham Asset Management, LLC | 99,114 | 113,829 | +14,715 | 0.02 | 0.03 | +0.01 | buy |
| Legato Capital Management LLC | 34,654 | 48,751 | +14,097 | 0.18 | 0.33 | +0.16 | buy |
| Catalyst Funds Management Pty Ltd | 210,169 | 223,569 | +13,400 | 1.49 | 4.13 | +2.64 | buy |
| S&CO INC | 22,171 | 34,171 | +12,000 | 0.06 | 0.17 | +0.11 | buy |
| FORA Capital, LLC | 6,369 | 17,357 | +10,988 | 0.05 | 0.17 | +0.11 | buy |
| PROFUND ADVISORS LLC | 37,079 | 26,929 | +10,150 | 0.06 | 0.07 | 0.00 | sell |
| Raiffeisen Bank International AG | 20,000 | 29,000 | +9,000 | 0.01 | 0.03 | +0.02 | buy |
| AlphaQuest LLC | 11,913 | 20,664 | +8,751 | 0.04 | 0.10 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 139,136 | 145,079 | +5,943 | 0.64 | 0.86 | +0.22 | buy |
| Swiss National Bank | 270,831 | 276,331 | +5,500 | 0.01 | 0.01 | +0.01 | buy |
| Atle Fund Management AB | 85,355 | 90,184 | +4,829 | 1.57 | 2.29 | +0.72 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 140,085 | 135,390 | +4,695 | 0.01 | 0.01 | +0.00 | sell |
| Persistent Asset Partners Ltd | 13,627 | 17,537 | +3,910 | 0.46 | 0.67 | +0.21 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 41,801 | 45,517 | +3,716 | 0.00 | 0.01 | 0.00 | buy |
| Virtus Investment Advisers, LLC | 2,768 | 3,371 | +603 | 0.04 | 0.07 | +0.04 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 21,590 | 21,076 | +514 | 0.08 | 0.13 | 0.00 | sell |
| Wedmont Private Capital | 40,006 | 40,056 | +50 | 0.07 | 0.14 | +0.07 | buy |
| Clearstead Trust, LLC | 53 | 80 | +27 | 0.00 | 0.00 | +0.00 | buy |
| FIDUCIARY TRUST CO | 23,095 | 23,098 | +3 | 0.01 | 0.02 | +0.01 | buy |
| Quaker Wealth Management, LLC | 8 | 10 | +2 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 96 | 71 | -25 | 0.00 | 0.00 | +0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 4,022 | 3,798 | -224 | 0.00 | 0.01 | +0.00 | sell |
| Knights of Columbus Asset Advisors LLC | 12,573 | 12,114 | -459 | 0.03 | 0.05 | +0.02 | sell |
| Avior Wealth Management, LLC | 8,498 | 7,325 | -1,173 | 0.01 | 0.02 | +0.01 | sell |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 4,389 | 3,200 | -1,189 | 0.30 | 0.04 | -0.26 | sell |
| Avanza Fonder AB | 4,335 | 3,036 | -1,299 | 0.01 | 0.01 | +0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 20,576 | 18,652 | -1,924 | 0.06 | 0.34 | +0.28 | sell |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 17,909 | 15,700 | -2,209 | 0.01 | 0.01 | +0.00 | sell |
| J. Goldman & Co LP | 14,366 | 10,179 | -4,187 | 0.02 | 0.02 | +0.00 | sell |
| First Turn Management, LLC | 643,050 | 638,385 | -4,665 | 4.51 | 5.81 | +1.30 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 60,000 | 52,500 | -7,500 | 0.59 | 0.81 | +0.22 | sell |
| B. Metzler seel. Sohn & Co. AG | 25,821 | 17,440 | -8,381 | 0.01 | 0.01 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 42,767 | 34,001 | -8,766 | 0.17 | 0.21 | +0.04 | sell |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 21,421 | 12,624 | -8,797 | 0.06 | 0.06 | +0.00 | sell |
| Headlands Technologies LLC | 37,200 | 27,275 | -9,925 | 0.14 | 0.18 | +0.04 | sell |
| Decheng Capital LLC | 210,000 | 200,000 | -10,000 | 1.71 | 2.14 | +0.43 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 19,246 | 8,129 | -11,117 | 0.14 | 0.15 | +0.01 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 34,324 | 20,820 | -13,504 | 0.01 | 0.01 | -0.00 | sell |
| Neo Ivy Capital Management | 27,262 | 13,498 | -13,764 | 0.31 | 0.17 | -0.14 | sell |
| Granahan Investment Management, LLC | 118,692 | 99,194 | -19,498 | 0.23 | 0.34 | +0.11 | sell |
| DIADEMA PARTNERS LP | 59,079 | 37,020 | -22,059 | 1.92 | 1.76 | -0.17 | sell |
| Shay Capital LLC | 46,000 | 22,260 | -23,740 | 0.19 | 0.18 | -0.00 | sell |
| NEOS Investment Management LLC | 126,921 | 101,888 | -25,033 | 0.04 | 0.05 | +0.00 | sell |
| TEMA ETFS LLC | 126,921 | 100,603 | -26,318 | 0.49 | 0.62 | +0.13 | sell |
| DAFNA Capital Management LLC | 657,176 | 604,514 | -52,662 | 7.58 | 11.18 | +3.60 | sell |
| HighVista Strategies LLC | 175,448 | 120,240 | -55,208 | 2.01 | 2.47 | +0.46 | sell |
| Casdin Capital, LLC | 2,647,333 | 2,577,333 | -70,000 | 10.31 | 12.75 | +2.44 | sell |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 15,640 | -84,360 | 0.18 | 0.06 | -0.12 | sell |
| FRED ALGER MANAGEMENT, LLC | 116,780 | 16,250 | -100,530 | 0.02 | 0.01 | -0.02 | sell |
| Rafferty Asset Management, LLC | 179,833 | 74,698 | -105,135 | 0.03 | 0.02 | -0.01 | sell |
| Checkpoint Capital L.P. | 492,300 | 370,000 | -122,300 | 7.70 | 9.34 | +1.63 | sell |
| STEMPOINT CAPITAL LP | 185,380 | 62,032 | -123,348 | 1.75 | 0.85 | -0.90 | sell |
| BESSEMER GROUP INC | 243,867 | 117,662 | -126,205 | 0.02 | 0.01 | -0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 253,377 | 117,215 | -136,162 | 0.02 | 0.02 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 535,604 | 370,520 | -165,084 | 0.02 | 0.02 | +0.00 | sell |
| PFM Health Sciences, LP | 331,069 | 151,453 | -179,616 | 1.19 | 1.20 | +0.01 | sell |
| Frazier Life Sciences Management, L.P. | 997,455 | 797,455 | -200,000 | 1.40 | 1.71 | +0.31 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 595,038 | 378,261 | -216,777 | 0.46 | 0.47 | +0.01 | sell |
| Vestal Point Capital, LP | 630,000 | 295,000 | -335,000 | 1.33 | 0.86 | -0.47 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,873,706 | 3,404,717 | -468,989 | 0.02 | 0.03 | +0.01 | sell |
| Bellevue Group AG | 5,573,838 | 5,005,719 | -568,119 | 5.41 | 7.56 | +2.15 | sell |
| BVF INC/IL | 3,974,913 | 3,356,782 | -618,131 | 7.52 | 9.00 | +1.48 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,650,342 | 2,894,613 | -755,729 | 2.60 | 2.94 | +0.34 | sell |
| Alphabet Inc. | 4,133,277 | 3,345,102 | -788,175 | 8.01 | 10.33 | +2.31 | sell |
| Holocene Advisors, LP | 3,437,283 | 1,907,948 | -1,529,335 | 0.37 | 0.32 | -0.05 | sell |
| AH Capital Management, L.L.C. | 2,748,523 | 921,099 | -1,827,424 | 9.20 | 4.64 | -4.56 | sell |
| T. Rowe Price Investment Management, Inc. | 4,782,318 | 2,200,376 | -2,581,942 | 0.14 | 0.11 | -0.03 | sell |