| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NORGES BANK | 0 | 2,455,347 | +2,455,347 | 0.00 | 0.02 | +0.02 | buy |
| Avoro Capital Advisors LLC | 0 | 2,170,000 | +2,170,000 | 0.00 | 1.70 | +1.70 | buy |
| UBS Group AG | 1,088,965 | 3,087,937 | +1,998,972 | 0.01 | 0.05 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 738,026 | 2,491,583 | +1,753,557 | 0.00 | 0.03 | +0.02 | buy |
| Polar Capital Holdings Plc | 478,105 | 2,013,791 | +1,535,686 | 0.11 | 0.73 | +0.63 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 742,400 | 2,205,555 | +1,463,155 | 0.05 | 0.27 | +0.21 | buy |
| Jefferies Financial Group Inc. | 13,000 | 1,141,195 | +1,128,195 | 0.01 | 0.74 | +0.74 | buy |
| VANGUARD GROUP INC | 15,663,094 | 16,719,886 | +1,056,792 | 0.01 | 0.02 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 11,356,054 | 12,303,502 | +947,448 | 0.24 | 0.44 | +0.20 | buy |
| AMERIPRISE FINANCIAL INC | 1,224,759 | 2,056,857 | +832,098 | 0.01 | 0.04 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 812,279 | 1,613,730 | +801,451 | 0.03 | 0.10 | +0.07 | buy |
| Integral Health Asset Management, LLC | 400,000 | 1,200,000 | +800,000 | 1.36 | 4.84 | +3.48 | buy |
| BlackRock, Inc. | 8,327,758 | 8,926,656 | +598,898 | 0.01 | 0.01 | +0.01 | buy |
| LMR Partners LLP | 2,646,023 | 3,151,705 | +505,682 | 0.01 | 0.03 | +0.02 | buy |
| JANE STREET GROUP, LLC | 597,455 | 1,090,416 | +492,961 | 0.03 | 0.10 | +0.07 | buy |
| Point72 Asset Management, L.P. | 0 | 446,616 | +446,616 | 0.00 | 0.06 | +0.06 | buy |
| Paradigm Biocapital Advisors LP | 6,223,291 | 6,644,403 | +421,112 | 8.60 | 14.17 | +5.57 | buy |
| TWO SIGMA INVESTMENTS, LP | 9,107 | 421,735 | +412,628 | 0.00 | 0.05 | +0.05 | buy |
| LORD, ABBETT & CO. LLC | 0 | 399,484 | +399,484 | 0.00 | 0.10 | +0.10 | buy |
| MILLENNIUM MANAGEMENT LLC | 428,309 | 800,118 | +371,809 | 0.02 | 0.05 | +0.03 | buy |
| GENERAL ATLANTIC, L.P. | 2,474,428 | 2,812,928 | +338,500 | 3.47 | 7.80 | +4.33 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 2,513,967 | 2,845,013 | +331,046 | 0.49 | 0.94 | +0.45 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 95,596 | 415,207 | +319,611 | 0.01 | 0.06 | +0.05 | buy |
| ROYAL BANK OF CANADA | 192,329 | 503,721 | +311,392 | 0.00 | 0.01 | +0.01 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 122,780 | 430,768 | +307,988 | 0.05 | 0.36 | +0.31 | buy |
| JENNISON ASSOCIATES LLC | 0 | 305,260 | +305,260 | 0.00 | 0.01 | +0.01 | buy |
| Siren, L.L.C. | 1,043,720 | 1,335,075 | +291,355 | 1.91 | 3.17 | +1.27 | buy |
| Logos Global Management LP | 1,750,000 | 2,000,000 | +250,000 | 8.07 | 10.62 | +2.54 | buy |
| TWO SIGMA ADVISERS, LP | 38,991 | 287,646 | +248,655 | 0.00 | 0.04 | +0.04 | buy |
| Alyeska Investment Group, L.P. | 0 | 239,097 | +239,097 | 0.00 | 0.05 | +0.05 | buy |
| Fisher Asset Management, LLC | 7,305 | 241,057 | +233,752 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 161,096 | 386,191 | +225,095 | 0.01 | 0.03 | +0.02 | buy |
| Caligan Partners LP | 1,064,249 | 1,283,900 | +219,651 | 6.90 | 9.36 | +2.46 | buy |
| MARSICO CAPITAL MANAGEMENT LLC | 0 | 219,460 | +219,460 | 0.00 | 0.49 | +0.49 | buy |
| BAILLIE GIFFORD & CO | 0 | 194,959 | +194,959 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 424,681 | 619,387 | +194,706 | 0.02 | 0.03 | +0.02 | buy |
| ARISTEIA CAPITAL, L.L.C. | 430,939 | 624,935 | +193,996 | 0.00 | 0.02 | +0.01 | buy |
| MPM BioImpact LLC | 315,722 | 505,672 | +189,950 | 2.41 | 4.61 | +2.19 | buy |
| a16z Perennial Management, L.P. | 0 | 182,918 | +182,918 | 0.00 | 1.16 | +1.16 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 149,145 | 322,289 | +173,144 | 0.02 | 0.09 | +0.07 | buy |
| Invesco Ltd. | 200,942 | 367,851 | +166,909 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 868,724 | 1,030,992 | +162,268 | 0.21 | 0.41 | +0.20 | buy |
| Ikarian Capital, LLC | 0 | 138,142 | +138,142 | 0.00 | 1.42 | +1.42 | buy |
| BANK OF AMERICA CORP /DE/ | 753,867 | 879,845 | +125,978 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF NOVA SCOTIA | 0 | 125,913 | +125,913 | 0.00 | 0.01 | +0.01 | buy |
| MUFG Securities EMEA plc | 0 | 123,000 | +123,000 | 0.00 | 0.11 | +0.11 | buy |
| CITADEL ADVISORS LLC | 1,180,085 | 1,302,361 | +122,276 | 0.04 | 0.07 | +0.03 | buy |
| Eagle Health Investments LP | 0 | 115,900 | +115,900 | 0.00 | 2.03 | +2.03 | buy |
| Aberdeen Group plc | 0 | 113,268 | +113,268 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 951,490 | 1,060,171 | +108,681 | 0.01 | 0.02 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 108,675 | +108,675 | 0.00 | 0.01 | +0.01 | buy |
| Zweig-DiMenna Associates LLC | 0 | 104,600 | +104,600 | 0.00 | 0.59 | +0.59 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,276 | 103,552 | +102,276 | 0.00 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 92,391 | +92,391 | 0.00 | 0.04 | +0.04 | buy |
| Man Group plc | 5,994 | 97,505 | +91,511 | 0.00 | 0.01 | +0.01 | buy |
| M&G Plc | 0 | 88,952 | +88,952 | 0.00 | 0.04 | +0.04 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 70,349 | 154,869 | +84,520 | 0.00 | 0.00 | +0.00 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 9,991 | 94,010 | +84,019 | 0.00 | 0.03 | +0.03 | buy |
| Nuveen, LLC | 337,474 | 406,241 | +68,767 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 118,208 | 183,221 | +65,013 | 0.01 | 0.02 | +0.01 | buy |
| Informed Momentum Co LLC | 0 | 64,236 | +64,236 | 0.00 | 0.57 | +0.57 | buy |
| GENERAL AMERICAN INVESTORS CO INC | 0 | 64,045 | +64,045 | 0.00 | 0.32 | +0.32 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 265,008 | 327,152 | +62,144 | 0.31 | 0.67 | +0.36 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 230,974 | 291,006 | +60,032 | 0.01 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 70,289 | 127,170 | +56,881 | 0.00 | 0.01 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 54,879 | +54,879 | 0.00 | 2.34 | +2.34 | buy |
| Verition Fund Management LLC | 135,449 | 189,333 | +53,884 | 0.04 | 0.08 | +0.05 | buy |
| Nicholas Investment Partners, LP | 267,911 | 317,711 | +49,800 | 0.96 | 1.84 | +0.89 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,635,395 | 1,683,729 | +48,334 | 0.01 | 0.02 | +0.01 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 85,576 | 130,936 | +45,360 | 0.01 | 0.02 | +0.01 | buy |
| Cinctive Capital Management LP | 0 | 42,635 | +42,635 | 0.00 | 0.20 | +0.20 | buy |
| IEQ CAPITAL, LLC | 5,500 | 47,412 | +41,912 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 0 | 39,365 | +39,365 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 4,280 | 40,145 | +35,865 | 0.01 | 0.09 | +0.09 | buy |
| Weiss Asset Management LP | 0 | 30,022 | +30,022 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 17,300 | 45,702 | +28,402 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 25,900 | +25,900 | 0.00 | 0.04 | +0.04 | buy |
| Amundi | 0 | 20,067 | +20,067 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 18,845 | +18,845 | 0.00 | 0.10 | +0.10 | buy |
| Hood River Capital Management LLC | 928,123 | 945,585 | +17,462 | 0.51 | 0.83 | +0.31 | buy |
| BIT Capital GmbH | 1,522 | 18,400 | +16,878 | 0.00 | 0.06 | +0.06 | buy |
| AMERICAN CENTURY COMPANIES INC | 451,014 | 467,360 | +16,346 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,145,640 | 3,161,963 | +16,323 | 0.01 | 0.02 | +0.01 | buy |
| Bridgefront Capital, LLC | 0 | 15,556 | +15,556 | 0.00 | 0.31 | +0.31 | buy |
| Gotham Asset Management, LLC | 99,114 | 113,829 | +14,715 | 0.02 | 0.03 | +0.01 | buy |
| Jasper Ridge Partners, L.P. | 0 | 14,368 | +14,368 | 0.00 | 0.03 | +0.03 | buy |
| Legato Capital Management LLC | 34,654 | 48,751 | +14,097 | 0.18 | 0.33 | +0.16 | buy |
| Mirae Asset Global Investments Co., Ltd. | 7,227 | 21,289 | +14,062 | 0.00 | 0.00 | +0.00 | buy |
| Ground Swell Capital, LLC | 0 | 13,613 | +13,613 | 0.00 | 0.03 | +0.03 | buy |
| Catalyst Funds Management Pty Ltd | 210,169 | 223,569 | +13,400 | 1.49 | 4.13 | +2.64 | buy |
| Squarepoint Ops LLC | 10,379 | 23,635 | +13,256 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 529,270 | 542,069 | +12,799 | 0.00 | 0.01 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 12,783 | +12,783 | 0.00 | 0.04 | +0.04 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 47,534 | 60,237 | +12,703 | 0.00 | 0.00 | +0.00 | buy |
| Calamos Advisors LLC | 0 | 12,460 | +12,460 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 12,459 | +12,459 | 0.00 | 0.00 | +0.00 | buy |
| S&CO INC | 22,171 | 34,171 | +12,000 | 0.06 | 0.17 | +0.11 | buy |
| FORA Capital, LLC | 6,369 | 17,357 | +10,988 | 0.05 | 0.17 | +0.11 | buy |
| SEI INVESTMENTS CO | 51,930 | 62,489 | +10,559 | 0.00 | 0.00 | +0.00 | buy |