| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 5,736,132 | 8,514,862 | +2,778,730 | 2.39 | 2.15 | -0.24 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 8,853,631 | 11,168,712 | +2,315,081 | 0.05 | 0.04 | -0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 131,970 | 1,574,599 | +1,442,629 | 0.00 | 0.01 | +0.01 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 3,717,667 | 5,026,043 | +1,308,376 | 0.32 | 0.25 | -0.06 | buy |
| First Light Asset Management, LLC | 288,181 | 1,445,305 | +1,157,124 | 0.72 | 2.42 | +1.70 | buy |
| Man Group plc | 49,913 | 1,200,309 | +1,150,396 | 0.00 | 0.06 | +0.06 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,642,568 | 3,739,119 | +1,096,551 | 1.36 | 1.22 | -0.14 | buy |
| Engaged Capital LLC | 3,261,458 | 4,111,458 | +850,000 | 17.33 | 13.46 | -3.87 | buy |
| CITADEL ADVISORS LLC | 154,045 | 843,518 | +689,473 | 0.00 | 0.02 | +0.01 | buy |
| Camber Capital Management LP | 0 | 625,000 | +625,000 | 0.00 | 0.46 | +0.46 | buy |
| JENNISON ASSOCIATES LLC | 0 | 611,816 | +611,816 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 105,690 | 638,164 | +532,474 | 0.01 | 0.02 | +0.02 | buy |
| Granahan Investment Management, LLC | 2,505,464 | 3,031,988 | +526,524 | 2.88 | 2.32 | -0.57 | buy |
| Bank of New York Mellon Corp | 1,641,504 | 2,048,341 | +406,837 | 0.01 | 0.01 | -0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 328,106 | +328,106 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,256,406 | 1,532,582 | +276,176 | 0.08 | 0.05 | -0.02 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 1,052,519 | 1,287,416 | +234,897 | 0.15 | 0.11 | -0.05 | buy |
| MORGAN STANLEY | 588,600 | 791,609 | +203,009 | 0.00 | 0.00 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 20,673 | 213,752 | +193,079 | 0.01 | 0.08 | +0.07 | buy |
| Lombard Odier Asset Management (Europe) Ltd | 13,000 | 200,000 | +187,000 | 0.03 | 0.19 | +0.16 | buy |
| Bellevue Group AG | 1,483,096 | 1,669,835 | +186,739 | 0.74 | 0.52 | -0.22 | buy |
| STATE STREET CORP | 2,519,649 | 2,699,408 | +179,759 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 1,076 | 176,613 | +175,537 | 0.00 | 0.07 | +0.07 | buy |
| Valeo Financial Advisors, LLC | 0 | 141,500 | +141,500 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 10,915,070 | 11,055,882 | +140,812 | 0.01 | 0.00 | -0.00 | buy |
| Rock Point Advisors, LLC | 351,607 | 492,387 | +140,780 | 3.42 | 2.82 | -0.60 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 35,664 | 176,021 | +140,357 | 0.15 | 0.26 | +0.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,469,862 | 2,601,575 | +131,713 | 0.01 | 0.00 | -0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 0 | 126,840 | +126,840 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 6,436 | 130,135 | +123,699 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,246,485 | 2,368,255 | +121,770 | 0.02 | 0.01 | -0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 403,195 | 515,090 | +111,895 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 6,375 | 113,090 | +106,715 | 0.01 | 0.05 | +0.04 | buy |
| SALEM INVESTMENT COUNSELORS INC | 120,121 | 225,901 | +105,780 | 0.13 | 0.14 | +0.01 | buy |
| CONGRESS ASSET MANAGEMENT CO | 0 | 104,929 | +104,929 | 0.00 | 0.01 | +0.01 | buy |
| Forest Hill Capital, LLC | 0 | 104,500 | +104,500 | 0.00 | 1.65 | +1.65 | buy |
| HOLLENCREST CAPITAL MANAGEMENT | 0 | 95,325 | +95,325 | 0.00 | 0.08 | +0.08 | buy |
| GABELLI FUNDS LLC | 638,500 | 732,000 | +93,500 | 0.15 | 0.11 | -0.05 | buy |
| FRANKLIN RESOURCES INC | 553,465 | 645,961 | +92,496 | 0.01 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 3,987,500 | 4,077,500 | +90,000 | 3.32 | 2.35 | -0.97 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 84,000 | +84,000 | 0.00 | 0.65 | +0.65 | buy |
| Caption Management, LLC | 0 | 82,211 | +82,211 | 0.00 | 0.17 | +0.17 | buy |
| LAZARD ASSET MANAGEMENT LLC | 283,458 | 364,048 | +80,590 | 0.01 | 0.01 | -0.00 | buy |
| Dynamic Technology Lab Private Ltd | 39,118 | 113,548 | +74,430 | 0.14 | 0.25 | +0.11 | buy |
| MARSHALL WACE, LLP | 0 | 64,408 | +64,408 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 296,999 | 360,070 | +63,071 | 0.20 | 0.15 | -0.05 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 55,173 | +55,173 | 0.00 | 0.06 | +0.06 | buy |
| Schonfeld Strategic Advisors LLC | 7,600 | 59,470 | +51,870 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 0 | 50,000 | +50,000 | 0.00 | 0.09 | +0.09 | buy |
| Versor Investments LP | 0 | 47,700 | +47,700 | 0.00 | 0.17 | +0.17 | buy |
| NOMURA HOLDINGS INC | 8,934 | 50,513 | +41,579 | 0.00 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 25,105 | 61,178 | +36,073 | 0.01 | 0.01 | +0.00 | buy |
| Aquatic Capital Management LLC | 36,400 | 72,200 | +35,800 | 0.04 | 0.05 | +0.01 | buy |
| Jump Financial, LLC | 20,608 | 56,062 | +35,454 | 0.02 | 0.02 | +0.00 | buy |
| CHOREO, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| GAMCO INVESTORS, INC. ET AL | 97,000 | 131,800 | +34,800 | 0.03 | 0.03 | -0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 303,628 | 337,784 | +34,156 | 0.29 | 0.19 | -0.10 | buy |
| Headlands Technologies LLC | 1,411 | 34,850 | +33,439 | 0.01 | 0.07 | +0.06 | buy |
| DEUTSCHE BANK AG\ | 106,298 | 138,915 | +32,617 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 32,539 | +32,539 | 0.00 | 0.01 | +0.01 | buy |
| Hodges Capital Management Inc. | 474,746 | 505,635 | +30,889 | 0.99 | 0.65 | -0.34 | buy |
| Graham Capital Management, L.P. | 53,518 | 82,423 | +28,905 | 0.05 | 0.05 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 7,133 | 34,783 | +27,650 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 27,364 | +27,364 | 0.00 | 0.02 | +0.02 | buy |
| Redwood Investment Management, LLC | 0 | 27,011 | +27,011 | 0.00 | 0.05 | +0.05 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 86,222 | 112,770 | +26,548 | 0.22 | 0.17 | -0.06 | buy |
| Centiva Capital, LP | 23,402 | 49,946 | +26,544 | 0.04 | 0.05 | +0.00 | buy |
| XTX Topco Ltd | 19,464 | 43,381 | +23,917 | 0.09 | 0.07 | -0.02 | buy |
| Squarepoint Ops LLC | 0 | 22,980 | +22,980 | 0.00 | 0.00 | +0.00 | buy |
| INCEPTIONR LLC | 0 | 21,845 | +21,845 | 0.00 | 0.12 | +0.12 | buy |
| Allianz Asset Management GmbH | 0 | 21,608 | +21,608 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,257 | 22,664 | +21,407 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 936,863 | 958,137 | +21,274 | 0.01 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 21,066 | +21,066 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 95,926 | 109,843 | +13,917 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 166,192 | 180,059 | +13,867 | 0.01 | 0.00 | -0.00 | buy |
| CHOREO, LLC | 0 | 13,829 | +13,829 | 0.00 | 0.00 | +0.00 | buy |
| HAP Trading, LLC | 0 | 12,783 | +12,783 | 0.00 | 0.11 | +0.11 | buy |
| WOLVERINE TRADING, LLC | 0 | 12,627 | +12,627 | 0.00 | 0.00 | +0.00 | buy |
| Parkwood LLC | 0 | 12,362 | +12,362 | 0.00 | 0.03 | +0.03 | buy |
| ALGERT GLOBAL LLC | 0 | 10,455 | +10,455 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 56,723 | 66,730 | +10,007 | 0.01 | 0.01 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 50,410 | 59,998 | +9,588 | 0.00 | 0.00 | -0.00 | buy |
| Bayesian Capital Management, LP | 17,035 | 26,335 | +9,300 | 0.05 | 0.06 | +0.00 | buy |
| Values First Advisors, Inc. | 17,353 | 26,546 | +9,193 | 0.33 | 0.30 | -0.03 | buy |
| Walleye Capital LLC | 0 | 8,448 | +8,448 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 7,725 | +7,725 | 0.00 | 0.01 | +0.01 | buy |
| Annis Gardner Whiting Capital Advisors, LLC | 2,420 | 9,300 | +6,880 | 0.03 | 0.05 | +0.02 | buy |
| CITIGROUP INC | 20,042 | 26,764 | +6,722 | 0.00 | 0.00 | -0.00 | buy |
| Ascent Group, LLC | 20,330 | 26,065 | +5,735 | 0.06 | 0.04 | -0.02 | buy |
| Quantbot Technologies LP | 16,105 | 21,751 | +5,646 | 0.03 | 0.02 | -0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 717,334 | 722,959 | +5,625 | 0.00 | 0.00 | -0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 18,637 | 23,978 | +5,341 | 0.12 | 0.08 | -0.04 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 26,184 | 31,444 | +5,260 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Trading LLC | 0 | 5,099 | +5,099 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 36,870 | 41,919 | +5,049 | 0.00 | 0.00 | -0.00 | buy |
| HB Wealth Management, LLC | 43,139 | 47,740 | +4,601 | 0.02 | 0.01 | -0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 62,927 | 67,499 | +4,572 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 0 | 4,534 | +4,534 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 112,147 | 115,887 | +3,740 | 0.00 | 0.00 | -0.00 | buy |