| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 18,202,009 | 18,202,009 | 0 | 1.44 | 1.43 | -0.01 | hold |
| MAVERICK CAPITAL LTD | 8,447,804 | 7,688,079 | -759,725 | 0.88 | 0.92 | +0.04 | sell |
| M28 Capital Management LP | 7,373,413 | 7,000,000 | -373,413 | 30.85 | 31.91 | +1.07 | sell |
| 683 Capital Management, LLC | 5,600,000 | 5,350,000 | -250,000 | 2.83 | 3.37 | +0.54 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,987,730 | 5,201,389 | -786,341 | 0.06 | 0.06 | -0.00 | sell |
| Bellevue Group AG | 4,494,458 | 4,094,458 | -400,000 | 0.35 | 0.39 | +0.04 | sell |
| Artal Group S.A. | 3,007,400 | 4,051,400 | +1,044,000 | 0.52 | 0.64 | +0.13 | buy |
| Kynam Capital Management, LP | 3,932,082 | 3,932,082 | 0 | 2.25 | 2.70 | +0.45 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 3,759,408 | 2,876,440 | -882,968 | 0.02 | 0.01 | -0.00 | sell |
| Point72 Asset Management, L.P. | 3,213,500 | 1,974,737 | -1,238,763 | 0.05 | 0.04 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,459,764 | 1,912,742 | +452,978 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,627,363 | 1,861,254 | +233,891 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,312,425 | 1,834,090 | +521,665 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 514,581 | 1,635,610 | +1,121,029 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 1,263,729 | 1,514,419 | +250,690 | 0.00 | 0.00 | +0.00 | buy |
| TAKEDA PHARMACEUTICAL CO LTD | 1,346,892 | 1,346,892 | 0 | 2.31 | 2.88 | +0.56 | hold |
| FMR LLC | 1,202,215 | 1,168,773 | -33,442 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 1,391,561 | 948,444 | -443,117 | 0.08 | 0.05 | -0.02 | sell |
| MORGAN STANLEY | 190,328 | 945,120 | +754,792 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 1,071,500 | 871,500 | -200,000 | 0.19 | 0.15 | -0.04 | sell |
| NORTHERN TRUST CORP | 626,450 | 757,291 | +130,841 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 655,331 | 600,155 | -55,176 | 0.13 | 0.15 | +0.01 | sell |
| Ikarian Capital, LLC | 0 | 590,088 | +590,088 | 0.00 | 0.99 | +0.99 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 587,575 | 559,796 | -27,779 | 0.04 | 0.03 | -0.00 | sell |
| Newtyn Management, LLC | 510,000 | 500,000 | -10,000 | 0.51 | 0.61 | +0.11 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 495,471 | +495,471 | 0.00 | 0.86 | +0.86 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 462,582 | +462,582 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 462,717 | 455,811 | -6,906 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 169,693 | 433,577 | +263,884 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 26,543 | 416,725 | +390,182 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 274,093 | 399,099 | +125,006 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 391,132 | 340,678 | -50,454 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 11,900 | 336,589 | +324,689 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 500,209 | 313,405 | -186,804 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 0 | 286,585 | +286,585 | 0.00 | 0.29 | +0.29 | buy |
| D. E. Shaw & Co., Inc. | 0 | 285,092 | +285,092 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 205,746 | 251,946 | +46,200 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 212,377 | 241,860 | +29,483 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 180,418 | 197,878 | +17,460 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 171,926 | +171,926 | 0.00 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 14,700 | 164,620 | +149,920 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 152,400 | 156,500 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 144,300 | +144,300 | 0.00 | 0.06 | +0.06 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 133,406 | 134,876 | +1,470 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 114,595 | 121,742 | +7,147 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 113,840 | +113,840 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 32,119 | 112,632 | +80,513 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 0 | 97,142 | +97,142 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 95,037 | +95,037 | 0.00 | 0.05 | +0.05 | buy |
| BARCLAYS PLC | 181,267 | 93,794 | -87,473 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 62,226 | 93,486 | +31,260 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 86,100 | +86,100 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,982,252 | 84,629 | -1,897,623 | 0.01 | 0.00 | -0.01 | sell |
| UBS Group AG | 81,584 | 82,321 | +737 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 81,955 | 81,955 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 78,661 | 78,675 | +14 | 0.00 | 0.00 | +0.00 | buy |
| a16z Perennial Management, L.P. | 77,619 | 77,619 | 0 | 0.07 | 0.04 | -0.02 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 57,026 | 75,053 | +18,027 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 75,800 | 71,300 | -4,500 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 49,356 | 71,152 | +21,796 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 68,807 | 68,904 | +97 | 0.01 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 250 | 68,538 | +68,288 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 25,000 | 68,406 | +43,406 | 0.01 | 0.02 | +0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 65,565 | +65,565 | 0.00 | 0.02 | +0.02 | buy |
| Jump Financial, LLC | 0 | 59,082 | +59,082 | 0.00 | 0.01 | +0.01 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 0 | 56,051 | +56,051 | 0.00 | 0.05 | +0.05 | buy |
| Walleye Capital LLC | 432,933 | 55,129 | -377,804 | 0.03 | 0.00 | -0.03 | sell |
| CAPSTONE INVESTMENT ADVISORS, LLC | 50,000 | 54,500 | +4,500 | 0.00 | 0.01 | +0.00 | buy |
| Engineers Gate Manager LP | 26,820 | 50,168 | +23,348 | 0.00 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 0 | 46,837 | +46,837 | 0.00 | 0.04 | +0.04 | buy |
| Invesco Ltd. | 37,777 | 43,993 | +6,216 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 42,223 | +42,223 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 41,234 | 41,466 | +232 | 0.00 | 0.00 | -0.00 | buy |
| Birchview Capital, LP | 40,000 | 40,000 | 0 | 0.16 | 0.20 | +0.04 | hold |
| MetLife Investment Management, LLC | 31,423 | 38,068 | +6,645 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 79,438 | 37,335 | -42,103 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 29,390 | 36,241 | +6,851 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 17,292 | 34,199 | +16,907 | 0.00 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 34,149 | +34,149 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 32,957 | +32,957 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.05 | +0.05 | buy |
| DEUTSCHE BANK AG\ | 27,457 | 28,218 | +761 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 88,970 | 27,541 | -61,429 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 11,168 | 26,556 | +15,388 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 25,999 | 26,344 | +345 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 18,259 | 26,079 | +7,820 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,456 | 23,473 | +12,017 | 0.01 | 0.02 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 24,792 | 22,883 | -1,909 | 0.00 | 0.00 | +0.00 | sell |
| KRAEMATON INVESTMENT ADVISORS, INC | 47,000 | 22,000 | -25,000 | 0.26 | 0.14 | -0.12 | sell |
| Arizona State Retirement System | 17,943 | 21,796 | +3,853 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 16,116 | 21,764 | +5,648 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 20,640 | +20,640 | 0.00 | 0.02 | +0.02 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 32,250 | 19,120 | -13,130 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,803 | 18,635 | +10,832 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 11,303 | 18,559 | +7,256 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 17,105 | 17,656 | +551 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 10,353 | 14,076 | +3,723 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 13,982 | +13,982 | 0.00 | 0.00 | +0.00 | buy |
| Matisse Capital | 12,013 | 13,913 | +1,900 | 0.03 | 0.04 | +0.01 | buy |
| PDT Partners, LLC | 0 | 13,300 | +13,300 | 0.00 | 0.01 | +0.01 | buy |