| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 9,622,104 | 12,516,500 | +2,894,396 | 0.21 | 0.19 | -0.02 | buy |
| LOOMIS SAYLES & CO L P | 1,660,866 | 2,436,540 | +775,674 | 0.03 | 0.03 | +0.00 | buy |
| Artisan Partners Limited Partnership | 1,906,790 | 2,370,153 | +463,363 | 0.04 | 0.03 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 608,897 | 1,050,374 | +441,477 | 1.68 | 1.77 | +0.09 | buy |
| Affinity Asset Advisors, LLC | 1,500,000 | 1,825,000 | +325,000 | 2.90 | 2.31 | -0.59 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 387,871 | 126,046 | +261,825 | 0.02 | 0.00 | -0.02 | sell |
| 683 Capital Management, LLC | 3,785,000 | 3,925,000 | +140,000 | 2.90 | 2.19 | -0.71 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 42,000 | 105,000 | +63,000 | 0.15 | 0.21 | +0.05 | buy |
| MOODY ALDRICH PARTNERS LLC | 398,475 | 439,827 | +41,352 | 0.91 | 0.74 | -0.17 | buy |
| Privium Fund Management B.V. | 88,000 | 113,550 | +25,550 | 0.25 | 0.24 | -0.01 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 10,300 | 35,712 | +25,412 | 0.00 | 0.01 | +0.00 | buy |
| Atom Investors LP | 77,325 | 98,798 | +21,473 | 0.12 | 0.10 | -0.02 | buy |
| MPM BioImpact LLC | 1,489,237 | 1,509,580 | +20,343 | 2.62 | 2.10 | -0.52 | buy |
| PROFUND ADVISORS LLC | 16,011 | 33,245 | +17,234 | 0.01 | 0.01 | +0.01 | buy |
| F/m Investments LLC | 226,034 | 240,418 | +14,384 | 0.10 | 0.08 | -0.03 | buy |
| Y-Intercept (Hong Kong) Ltd | 22,684 | 35,691 | +13,007 | 0.02 | 0.02 | 0.00 | buy |
| James J. Burns & Company, LLC | 111,111 | 121,913 | +10,802 | 0.24 | 0.18 | -0.06 | buy |
| Nebula Research & Development LLC | 27,137 | 31,594 | +4,457 | 0.04 | 0.02 | -0.02 | buy |
| Polar Capital Holdings Plc | 1,000,000 | 1,003,500 | +3,500 | 0.07 | 0.05 | -0.02 | buy |
| ADAR1 Capital Management, LLC | 21,700 | 23,100 | +1,400 | 0.06 | 0.04 | -0.02 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,202 | 3,905 | +703 | 0.00 | 0.00 | -0.00 | buy |
| MAVERICK CAPITAL LTD | 8,261,242 | 8,261,683 | +441 | 1.84 | 1.20 | -0.64 | buy |
| Birchview Capital, LP | 40,000 | 40,300 | +300 | 0.40 | 0.28 | -0.12 | buy |
| Woodline Partners LP | 451,813 | 452,060 | +247 | 0.04 | 0.02 | -0.01 | buy |
| Matisse Capital | 12,643 | 12,633 | -10 | 0.08 | 0.05 | -0.03 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,931,034 | 1,930,820 | -214 | 1.45 | 1.11 | -0.35 | sell |
| Informed Momentum Co LLC | 214,717 | 213,848 | -869 | 0.38 | 0.30 | -0.08 | sell |
| KRAEMATON INVESTMENT ADVISORS, INC | 19,885 | 18,885 | -1,000 | 0.24 | 0.16 | -0.09 | sell |
| China Universal Asset Management Co., Ltd. | 54,267 | 52,520 | -1,747 | 0.06 | 0.04 | -0.02 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 21,854 | 12,151 | -9,703 | 0.05 | 0.02 | -0.03 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 2,519,520 | 2,507,520 | -12,000 | 0.02 | 0.02 | -0.01 | sell |
| PDT Partners, LLC | 69,220 | 55,918 | -13,302 | 0.08 | 0.03 | -0.04 | sell |
| Newtyn Management, LLC | 425,000 | 400,000 | -25,000 | 0.92 | 0.51 | -0.40 | sell |
| EMERALD ADVISERS, LLC | 3,162,369 | 3,133,558 | -28,811 | 1.52 | 1.14 | -0.38 | sell |
| Siren, L.L.C. | 3,750,491 | 3,696,322 | -54,169 | 2.05 | 1.68 | -0.37 | sell |
| Maven Securities LTD | 170,000 | 35,000 | -135,000 | 0.05 | 0.01 | -0.04 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,712,449 | 6,358,599 | -353,850 | 0.69 | 0.50 | -0.19 | sell |
| Polar Asset Management Partners Inc. | 557,323 | 27,380 | -529,943 | 0.08 | 0.01 | -0.08 | sell |
| STEMPOINT CAPITAL LP | 721,209 | 89,833 | -631,376 | 2.24 | 0.23 | -2.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,098,866 | 4,125,291 | -973,575 | 0.01 | 0.00 | -0.00 | sell |