| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 18,203,009 | 26,975,505 | +8,772,496 | 3.17 | 2.07 | -1.10 | buy |
| BlackRock, Inc. | 12,648,907 | 14,117,412 | +1,468,505 | 0.00 | 0.00 | -0.00 | buy |
| MAVERICK CAPITAL LTD | 9,280,237 | 10,161,399 | +881,162 | 1.69 | 0.86 | -0.84 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 7,407,372 | 8,704,550 | +1,297,178 | 0.01 | 0.01 | -0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,581,067 | 5,431,021 | -1,150,046 | 0.76 | 0.29 | -0.47 | sell |
| FEDERATED HERMES, INC. | 4,744,520 | 5,317,457 | +572,937 | 0.13 | 0.06 | -0.07 | buy |
| FMR LLC | 15,135,983 | 5,192,761 | -9,943,222 | 0.01 | 0.00 | -0.01 | sell |
| 683 Capital Management, LLC | 4,015,000 | 4,900,000 | +885,000 | 5.68 | 3.30 | -2.38 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 4,095,282 | 4,832,952 | +737,670 | 0.05 | 0.03 | -0.03 | buy |
| M28 Capital Management LP | 5,664,548 | 4,588,284 | -1,076,264 | 70.00 | 61.83 | -8.17 | sell |
| STATE STREET CORP | 2,996,084 | 3,674,033 | +677,949 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,170,110 | 3,579,099 | +408,989 | 0.00 | 0.00 | -0.00 | buy |
| Siren, L.L.C. | 2,450,000 | 2,450,000 | 0 | 1.24 | 0.49 | -0.75 | hold |
| CITADEL ADVISORS LLC | 789,964 | 2,202,856 | +1,412,892 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 749,448 | 1,878,115 | +1,128,667 | 0.02 | 0.01 | -0.01 | buy |
| PFIZER INC | 1,875,000 | 1,875,000 | 0 | 13.48 | 5.00 | -8.48 | hold |
| First Light Asset Management, LLC | 1,853,851 | 1,843,968 | -9,883 | 2.41 | 1.20 | -1.21 | sell |
| MARSHALL WACE, LLP | 0 | 1,789,882 | +1,789,882 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 883,586 | 1,462,390 | +578,804 | 0.03 | 0.02 | -0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,005,984 | 1,441,059 | +435,075 | 0.01 | 0.01 | -0.01 | buy |
| Affinity Asset Advisors, LLC | 2,700,000 | 1,401,727 | -1,298,273 | 3.30 | 0.60 | -2.70 | sell |
| GOLDMAN SACHS GROUP INC | 2,854,082 | 1,383,590 | -1,470,492 | 0.01 | 0.00 | -0.01 | sell |
| MORGAN STANLEY | 409,663 | 1,361,001 | +951,338 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 1,350,000 | 1,350,000 | 0 | 0.23 | 0.10 | -0.13 | hold |
| ALGERT GLOBAL LLC | 122,470 | 1,315,589 | +1,193,119 | 0.03 | 0.14 | +0.11 | buy |
| EMERALD ADVISERS, LLC | 2,455,089 | 1,261,183 | -1,193,906 | 1.29 | 0.29 | -1.00 | sell |
| NORTHERN TRUST CORP | 1,033,068 | 1,189,230 | +156,162 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,191,361 | 1,179,279 | -12,082 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 805,901 | 1,149,127 | +343,226 | 0.01 | 0.01 | -0.00 | buy |
| Trexquant Investment LP | 391,111 | 1,089,642 | +698,531 | 0.06 | 0.06 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 9,786,061 | 1,000,000 | -8,786,061 | 0.25 | 0.01 | -0.24 | sell |
| MILLENNIUM MANAGEMENT LLC | 584,633 | 972,241 | +387,608 | 0.01 | 0.01 | -0.00 | buy |
| Kynam Capital Management, LP | 2,169,105 | 965,193 | -1,203,912 | 2.40 | 0.44 | -1.96 | sell |
| BAKER BROS. ADVISORS LP | 344,063 | 822,638 | +478,575 | 0.03 | 0.03 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,414,665 | 814,529 | -600,136 | 1.17 | 0.29 | -0.89 | sell |
| JPMORGAN CHASE & CO | 892,886 | 670,170 | -222,716 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 332,735 | 657,720 | +324,985 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 69,078 | 624,735 | +555,657 | 0.00 | 0.01 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 600,000 | 600,000 | 0 | 0.50 | 0.22 | -0.28 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 236,420 | 597,220 | +360,800 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 0 | 550,000 | +550,000 | 0.00 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 408,166 | 548,272 | +140,106 | 1.45 | 0.68 | -0.77 | buy |
| UBS Group AG | 268,723 | 538,997 | +270,274 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 492,437 | 519,768 | +27,331 | 0.18 | 0.08 | -0.10 | buy |
| CITIGROUP INC | 46,759 | 501,477 | +454,718 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 378,823 | 493,512 | +114,689 | 0.04 | 0.02 | -0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 202,721 | 451,185 | +248,464 | 0.00 | 0.00 | -0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 411,494 | 415,458 | +3,964 | 0.01 | 0.01 | -0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 365,235 | 373,794 | +8,559 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 321,445 | 361,204 | +39,759 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 313,509 | 360,054 | +46,545 | 0.07 | 0.04 | -0.03 | buy |
| Woodline Partners LP | 350,531 | 350,531 | 0 | 0.02 | 0.01 | -0.01 | hold |
| TD ASSET MANAGEMENT INC | 252,160 | 338,826 | +86,666 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 323,573 | +323,573 | 0.00 | 0.07 | +0.07 | buy |
| HRT FINANCIAL LP | 299,718 | 321,376 | +21,658 | 0.02 | 0.01 | -0.01 | buy |
| Newtyn Management, LLC | 300,000 | 300,000 | 0 | 0.54 | 0.23 | -0.31 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 722,237 | 288,502 | -433,735 | 0.04 | 0.01 | -0.03 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 282,719 | +282,719 | 0.00 | 0.13 | +0.13 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 82,022 | 281,023 | +199,001 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 230,687 | 275,269 | +44,582 | 0.91 | 0.50 | -0.40 | buy |
| MOODY ALDRICH PARTNERS LLC | 274,425 | 272,533 | -1,892 | 0.87 | 0.36 | -0.51 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 378,987 | 259,825 | -119,162 | 0.01 | 0.00 | -0.01 | sell |
| Privium Fund Management B.V. | 193,010 | 241,010 | +48,000 | 0.60 | 0.36 | -0.24 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 182,728 | 240,983 | +58,255 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 182,855 | 236,760 | +53,905 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 164,985 | 225,114 | +60,129 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 219,700 | 219,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 211,074 | +211,074 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 15,573 | 200,331 | +184,758 | 0.17 | 1.21 | +1.05 | buy |
| Invesco Ltd. | 179,932 | 199,740 | +19,808 | 0.00 | 0.00 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 230,512 | 195,840 | -34,672 | 0.06 | 0.02 | -0.04 | sell |
| BARCLAYS PLC | 276,781 | 189,865 | -86,916 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 158,182 | 189,253 | +31,071 | 0.12 | 0.07 | -0.05 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 183,331 | +183,331 | 0.00 | 0.01 | +0.01 | buy |
| Caitong International Asset Management Co., Ltd | 10,357 | 180,980 | +170,623 | 0.04 | 0.24 | +0.20 | buy |
| Duquesne Family Office LLC | 173,000 | 173,000 | 0 | 0.07 | 0.04 | -0.03 | hold |
| RHUMBLINE ADVISERS | 141,895 | 167,528 | +25,633 | 0.00 | 0.00 | -0.00 | buy |
| F/m Investments LLC | 395,894 | 164,921 | -230,973 | 0.26 | 0.08 | -0.18 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 234,799 | 160,311 | -74,488 | 0.10 | 0.03 | -0.08 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 157,013 | +157,013 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 0 | 155,924 | +155,924 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 134,558 | 150,368 | +15,810 | 0.00 | 0.00 | -0.00 | buy |
| Burkehill Global Management, LP | 150,000 | 150,000 | 0 | 0.17 | 0.05 | -0.11 | hold |
| TWINBEECH CAPITAL LP | 0 | 145,825 | +145,825 | 0.00 | 0.11 | +0.11 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 107,680 | 145,206 | +37,526 | 0.00 | 0.00 | -0.00 | buy |
| Advisory Services Network, LLC | 20,900 | 144,950 | +124,050 | 0.01 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 139,218 | +139,218 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 200,890 | 136,173 | -64,717 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 112,030 | 125,096 | +13,066 | 0.00 | 0.00 | +0.00 | buy |
| James J. Burns & Company, LLC | 105,802 | 114,800 | +8,998 | 0.25 | 0.11 | -0.14 | buy |
| DEUTSCHE BANK AG\ | 95,706 | 114,110 | +18,404 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 109,862 | +109,862 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 87,141 | 108,164 | +21,023 | 0.00 | 0.00 | -0.00 | buy |
| Itau Unibanco Holding S.A. | 102,000 | 102,000 | 0 | 0.04 | 0.04 | -0.01 | hold |
| TUDOR INVESTMENT CORP ET AL | 0 | 97,900 | +97,900 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 21,126 | 89,263 | +68,137 | 0.01 | 0.02 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 86,677 | +86,677 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 85,285 | 85,285 | 0 | 0.19 | 0.09 | -0.10 | hold |
| Engineers Gate Manager LP | 0 | 80,217 | +80,217 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 54,457 | 80,161 | +25,704 | 0.00 | 0.00 | -0.00 | buy |