| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EMERALD ADVISERS, LLC | 0 | 2,493,230 | +2,493,230 | 0.00 | 0.52 | +0.52 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 1,820,938 | +1,820,938 | 0.00 | 0.48 | +0.48 | buy |
| STATE STREET CORP | 1,514,419 | 2,263,426 | +749,007 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,834,090 | 2,417,690 | +583,600 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 4,051,400 | 4,566,251 | +514,851 | 0.64 | 0.59 | -0.06 | buy |
| Exome Asset Management LLC | 0 | 488,135 | +488,135 | 0.00 | 2.17 | +2.17 | buy |
| Avidity Partners Management LP | 0 | 350,000 | +350,000 | 0.00 | 0.07 | +0.07 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 559,796 | 908,096 | +348,300 | 0.03 | 0.04 | +0.01 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 179,359 | +179,359 | 0.00 | 0.17 | +0.17 | buy |
| Trexquant Investment LP | 112,632 | 281,060 | +168,428 | 0.01 | 0.02 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,201,389 | 5,357,719 | +156,330 | 0.06 | 0.05 | -0.01 | buy |
| SG Americas Securities, LLC | 0 | 133,827 | +133,827 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 241,860 | 366,601 | +124,741 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 102,635 | +102,635 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 75,053 | 171,049 | +95,996 | 0.00 | 0.00 | +0.00 | buy |
| James J. Burns & Company, LLC | 0 | 90,000 | +90,000 | 0.00 | 0.09 | +0.09 | buy |
| Affinity Asset Advisors, LLC | 286,585 | 375,000 | +88,415 | 0.29 | 0.29 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 78,048 | +78,048 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 13,300 | 89,267 | +75,967 | 0.01 | 0.04 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,912,742 | 1,986,245 | +73,503 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 37,335 | 106,542 | +69,207 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 68,803 | +68,803 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 336,589 | 403,984 | +67,395 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 51,700 | +51,700 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 30,000 | 76,651 | +46,651 | 0.05 | 0.08 | +0.03 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 45,557 | +45,557 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 3,932,082 | 3,975,521 | +43,439 | 2.70 | 2.08 | -0.62 | buy |
| UBS Group AG | 82,321 | 119,913 | +37,592 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 68,406 | 100,162 | +31,756 | 0.02 | 0.03 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 399,099 | 428,311 | +29,212 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,635,610 | 1,664,300 | +28,690 | 0.01 | 0.01 | -0.00 | buy |
| Bank of New York Mellon Corp | 197,878 | 225,402 | +27,524 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 0 | 26,095 | +26,095 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 21,444 | +21,444 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 50,168 | 70,071 | +19,903 | 0.01 | 0.01 | -0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 68,904 | 88,547 | +19,643 | 0.01 | 0.01 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 16,987 | +16,987 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 16,950 | +16,950 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 15,572 | +15,572 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 14,900 | +14,900 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 14,766 | +14,766 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19,120 | 33,491 | +14,371 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 71,300 | 85,300 | +14,000 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 13,970 | +13,970 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 14,076 | 27,463 | +13,387 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 11,459 | +11,459 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 732 | 11,727 | +10,995 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 71,152 | 82,111 | +10,959 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 10,625 | +10,625 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 528 | 7,748 | +7,220 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 26,556 | 33,529 | +6,973 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 38,068 | 43,601 | +5,533 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 134,876 | 139,790 | +4,914 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 28,218 | 33,131 | +4,913 | 0.00 | 0.00 | -0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 4,537 | +4,537 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 4,357 | +4,357 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 121,742 | 125,834 | +4,092 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 22,883 | 26,880 | +3,997 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 3,656 | +3,656 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,007 | 3,325 | +2,318 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 13,982 | 15,887 | +1,905 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 26,079 | 27,569 | +1,490 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,582 | 12,465 | +883 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 21,796 | 22,251 | +455 | 0.00 | 0.00 | -0.00 | buy |
| Global Retirement Partners, LLC | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 12,021 | 12,211 | +190 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,635 | 18,820 | +185 | 0.00 | 0.00 | -0.00 | buy |
| Matisse Capital | 13,913 | 14,063 | +150 | 0.04 | 0.03 | -0.01 | buy |
| Aspire Private Capital, LLC | 0 | 150 | +150 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 38 | 172 | +134 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 7,334 | 7,334 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 18,202,009 | 18,202,009 | 0 | 1.43 | 1.20 | -0.23 | hold |
| TAKEDA PHARMACEUTICAL CO LTD | 1,346,892 | 1,346,892 | 0 | 2.88 | 2.89 | +0.02 | hold |
| MACQUARIE GROUP LTD | 81,955 | 81,955 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 349 | 349 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NJ State Employees Deferred Compensation Plan | 11,700 | 11,700 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Swiss National Bank | 156,500 | 156,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Birchview Capital, LP | 40,000 | 40,000 | 0 | 0.20 | 0.18 | -0.02 | hold |
| QUADRANT CAPITAL GROUP LLC | 2,396 | 2,396 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bellevue Group AG | 4,094,458 | 4,094,458 | 0 | 0.39 | 0.33 | -0.05 | hold |
| Parallel Advisors, LLC | 95 | 95 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 1,200 | 1,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 495,471 | 495,471 | 0 | 0.86 | 0.61 | -0.25 | hold |
| a16z Perennial Management, L.P. | 77,619 | 77,619 | 0 | 0.04 | 0.04 | -0.00 | hold |
| AMALGAMATED BANK | 2,500 | 2,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 2 | 0 | -2 | 0.00 | 0.00 | 0.00 | sell |
| Avior Wealth Management, LLC | 12 | 0 | -12 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 26 | 11 | -15 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 20 | 0 | -20 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 62 | 34 | -28 | 0.00 | 0.00 | -0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 17,656 | 17,453 | -203 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 26,344 | 25,994 | -350 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 493 | 0 | -493 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 1,261 | 669 | -592 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 12,079 | 11,390 | -689 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 78,675 | 77,768 | -907 | 0.00 | 0.00 | -0.00 | sell |
| Hillsdale Investment Management Inc. | 1,100 | 0 | -1,100 | 0.00 | 0.00 | -0.00 | sell |