| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Artal Group S.A. | 4,051,400 | 4,566,251 | +514,851 | 0.64 | 0.58 | -0.06 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 559,796 | 908,096 | +348,300 | 0.03 | 0.04 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,201,389 | 5,357,719 | +156,330 | 0.06 | 0.05 | -0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 241,860 | 366,601 | +124,741 | 0.01 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 462,582 | 339,749 | +122,833 | 0.01 | 0.01 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 286,585 | 375,000 | +88,415 | 0.29 | 0.29 | +0.01 | buy |
| PDT Partners, LLC | 13,300 | 89,267 | +75,967 | 0.01 | 0.04 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 30,000 | 76,651 | +46,651 | 0.05 | 0.08 | +0.03 | buy |
| Kynam Capital Management, LP | 3,932,082 | 3,975,521 | +43,439 | 2.70 | 2.08 | -0.62 | buy |
| Cinctive Capital Management LP | 68,406 | 100,162 | +31,756 | 0.02 | 0.03 | +0.01 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 68,904 | 88,547 | +19,643 | 0.01 | 0.01 | +0.00 | buy |
| Matisse Capital | 13,913 | 14,063 | +150 | 0.04 | 0.03 | -0.01 | buy |
| KRAEMATON INVESTMENT ADVISORS, INC | 22,000 | 19,000 | -3,000 | 0.14 | 0.10 | -0.04 | sell |
| China Universal Asset Management Co., Ltd. | 23,473 | 14,388 | -9,085 | 0.02 | 0.01 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 144,300 | 135,200 | -9,100 | 0.06 | 0.06 | -0.01 | sell |
| Ikarian Capital, LLC | 590,088 | 575,088 | -15,000 | 0.99 | 0.90 | -0.09 | sell |
| MAVERICK CAPITAL LTD | 7,688,079 | 7,669,361 | -18,718 | 0.92 | 0.73 | -0.19 | sell |
| 683 Capital Management, LLC | 5,350,000 | 5,325,000 | -25,000 | 2.42 | 2.01 | -0.41 | sell |
| Newtyn Management, LLC | 500,000 | 475,000 | -25,000 | 0.61 | 0.44 | -0.17 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 65,565 | 18,744 | -46,821 | 0.02 | 0.00 | -0.02 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 600,155 | 537,345 | -62,810 | 0.15 | 0.11 | -0.04 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 2,876,440 | 2,664,216 | -212,224 | 0.01 | 0.01 | -0.00 | sell |
| Laurion Capital Management LP | 871,500 | 516,473 | -355,027 | 0.05 | 0.03 | -0.02 | sell |
| M28 Capital Management LP | 7,000,000 | 6,164,548 | -835,452 | 31.91 | 39.88 | +7.96 | sell |