| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 18,202,009 | 18,202,009 | 0 | 2.46 | 1.99 | -0.46 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 12,516,500 | 15,016,500 | +2,500,000 | 0.19 | 0.16 | -0.02 | buy |
| BlackRock, Inc. | 9,628,612 | 10,383,716 | +755,104 | 0.00 | 0.00 | -0.00 | buy |
| MAVERICK CAPITAL LTD | 8,261,683 | 8,261,683 | 0 | 1.20 | 0.82 | -0.38 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,358,599 | 6,531,519 | +172,920 | 0.50 | 0.34 | -0.16 | buy |
| M28 Capital Management LP | 5,664,548 | 5,664,548 | 0 | 62.72 | 62.80 | +0.09 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,125,291 | 5,190,403 | +1,065,112 | 0.00 | 0.00 | -0.00 | buy |
| Kynam Capital Management, LP | 4,899,497 | 4,560,053 | -339,444 | 3.39 | 3.19 | -0.20 | sell |
| 683 Capital Management, LLC | 3,925,000 | 4,100,000 | +175,000 | 3.22 | 2.70 | -0.51 | buy |
| Bellevue Group AG | 4,094,458 | 4,094,458 | 0 | 0.74 | 0.59 | -0.15 | hold |
| Siren, L.L.C. | 3,696,322 | 3,696,322 | 0 | 1.68 | 1.24 | -0.44 | hold |
| VANGUARD GROUP INC | 3,206,403 | 3,477,077 | +270,674 | 0.00 | 0.00 | -0.00 | buy |
| LOOMIS SAYLES & CO L P | 2,436,540 | 3,295,700 | +859,160 | 0.03 | 0.03 | -0.00 | buy |
| EMERALD ADVISERS, LLC | 3,133,558 | 3,257,119 | +123,561 | 1.14 | 0.78 | -0.36 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,592,399 | 2,759,381 | +166,982 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 2,417,963 | 2,756,755 | +338,792 | 0.00 | 0.00 | -0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 2,507,520 | 2,465,850 | -41,670 | 0.02 | 0.01 | -0.00 | sell |
| Artisan Partners Limited Partnership | 2,370,153 | 2,264,835 | -105,318 | 0.03 | 0.02 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 1,825,000 | 2,000,308 | +175,308 | 2.31 | 1.92 | -0.39 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,930,820 | 1,937,489 | +6,669 | 1.11 | 0.77 | -0.34 | buy |
| PFIZER INC | 1,875,000 | 1,875,000 | 0 | 3.02 | 2.12 | -0.91 | hold |
| JPMORGAN CHASE & CO | 1,178,937 | 1,569,015 | +390,078 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 1,179,927 | 1,544,038 | +364,111 | 0.00 | 0.00 | -0.00 | buy |
| MPM BioImpact LLC | 1,509,580 | 1,505,262 | -4,318 | 2.10 | 1.70 | -0.40 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 963,125 | 1,010,658 | +47,533 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 971,746 | 1,008,782 | +37,036 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 557,644 | 1,007,081 | +449,437 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,003,500 | 1,003,500 | 0 | 0.05 | 0.03 | -0.02 | hold |
| STEMPOINT CAPITAL LP | 89,833 | 900,338 | +810,505 | 0.23 | 1.88 | +1.65 | buy |
| RTW INVESTMENTS, LP | 900,000 | 900,000 | 0 | 0.11 | 0.08 | -0.03 | hold |
| MILLENNIUM MANAGEMENT LLC | 26,222 | 692,415 | +666,193 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 770,707 | 683,193 | -87,514 | 0.02 | 0.02 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 535,265 | 645,560 | +110,295 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 479,269 | 621,378 | +142,109 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 2,144,827 | 619,137 | -1,525,690 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 168,289 | 607,272 | +438,983 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 374,864 | 591,384 | +216,520 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 261,214 | 573,187 | +311,973 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 390,840 | 467,887 | +77,047 | 0.03 | 0.03 | -0.01 | buy |
| Woodline Partners LP | 452,060 | 452,060 | 0 | 0.02 | 0.02 | -0.01 | hold |
| MOODY ALDRICH PARTNERS LLC | 439,827 | 421,852 | -17,975 | 0.74 | 0.53 | -0.21 | sell |
| Newtyn Management, LLC | 400,000 | 400,000 | 0 | 0.51 | 0.39 | -0.12 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 362,558 | 358,429 | -4,129 | 0.01 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 311,992 | 355,353 | +43,361 | 0.15 | 0.15 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 344,063 | 344,063 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Ensign Peak Advisors, Inc | 0 | 313,307 | +313,307 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 308,044 | 302,276 | -5,768 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 299,669 | 297,887 | -1,782 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 183,402 | 295,061 | +111,659 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 247,251 | 289,282 | +42,031 | 0.00 | 0.00 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 14,328 | 285,086 | +270,758 | 0.05 | 0.04 | -0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 197,216 | 280,765 | +83,549 | 0.07 | 0.07 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 277,764 | +277,764 | 0.00 | 0.10 | +0.10 | buy |
| D. E. Shaw & Co., Inc. | 106,554 | 271,474 | +164,920 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 272,326 | 266,856 | -5,470 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 50,203 | 249,469 | +199,266 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 240,418 | 243,677 | +3,259 | 0.08 | 0.06 | -0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 241,714 | 243,167 | +1,453 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 117,089 | 224,426 | +107,337 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 192,000 | 205,200 | +13,200 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 154,408 | 179,608 | +25,200 | 0.00 | 0.00 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 396,048 | 163,745 | -232,303 | 0.06 | 0.02 | -0.03 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 155,786 | 163,699 | +7,913 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 132,700 | 162,599 | +29,899 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 0 | 161,137 | +161,137 | 0.00 | 0.35 | +0.35 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 150,513 | 150,513 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 57,349 | 145,308 | +87,959 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 113,550 | 135,550 | +22,000 | 0.24 | 0.19 | -0.05 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 46,746 | 132,891 | +86,145 | 0.01 | 0.03 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 222,962 | 124,667 | -98,295 | 0.00 | 0.00 | -0.00 | sell |
| James J. Burns & Company, LLC | 121,913 | 121,913 | 0 | 0.18 | 0.13 | -0.05 | hold |
| Sofinnova Investments, Inc. | 0 | 117,903 | +117,903 | 0.00 | 0.05 | +0.05 | buy |
| Invesco Ltd. | 78,880 | 114,959 | +36,079 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 23,100 | 114,814 | +91,714 | 0.04 | 0.12 | +0.09 | buy |
| Legal & General Group Plc | 116,012 | 102,050 | -13,962 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 100,000 | 100,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Compass Rose Asset Management, LP | 0 | 100,000 | +100,000 | 0.00 | 0.24 | +0.24 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 98,237 | 98,237 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 91,161 | 98,075 | +6,914 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 52,520 | 93,370 | +40,850 | 0.04 | 0.06 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 93,565 | 92,830 | -735 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 29,600 | 92,300 | +62,700 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 92,611 | 88,819 | -3,792 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 70,910 | 84,531 | +13,621 | 0.00 | 0.00 | -0.00 | buy |
| a16z Perennial Management, L.P. | 77,619 | 77,619 | 0 | 0.08 | 0.04 | -0.04 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 233,653 | 72,459 | -161,194 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 70,242 | +70,242 | 0.00 | 0.57 | +0.57 | buy |
| MetLife Investment Management, LLC | 55,403 | 67,257 | +11,854 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 76,693 | 66,194 | -10,499 | 0.01 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 45,516 | 61,982 | +16,466 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 59,279 | +59,279 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 154,757 | 52,728 | -102,029 | 0.01 | 0.00 | -0.01 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 41,974 | 52,303 | +10,329 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 51,700 | 51,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Handelsbanken Fonder AB | 0 | 50,800 | +50,800 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 11,514 | 46,230 | +34,716 | 0.00 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 45,284 | 46,154 | +870 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 105,902 | 45,458 | -60,444 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 115,668 | 44,413 | -71,255 | 0.02 | 0.00 | -0.01 | sell |
| Birchview Capital, LP | 40,300 | 40,300 | 0 | 0.28 | 0.26 | -0.02 | hold |