| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 26,975,505 | 26,975,505 | 0 | 2.07 | 1.36 | -0.71 | hold |
| BlackRock, Inc. | 14,117,412 | 19,202,461 | +5,085,049 | 0.00 | 0.00 | -0.00 | buy |
| MAVERICK CAPITAL LTD | 10,161,399 | 10,278,115 | +116,716 | 0.86 | 0.54 | -0.32 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 5,431,021 | 5,443,143 | +12,122 | 0.29 | 0.18 | -0.11 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 4,832,952 | 5,354,622 | +521,670 | 0.03 | 0.02 | -0.01 | buy |
| 683 Capital Management, LLC | 4,900,000 | 4,950,000 | +50,000 | 3.30 | 2.64 | -0.65 | buy |
| FMR LLC | 5,192,761 | 4,922,477 | -270,284 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 3,674,033 | 4,839,317 | +1,165,284 | 0.00 | 0.00 | -0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 4,727,139 | +4,727,139 | 0.00 | 1.12 | +1.12 | buy |
| M28 Capital Management LP | 4,588,284 | 4,588,284 | 0 | 61.83 | 56.53 | -5.30 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 3,579,099 | 3,869,998 | +290,899 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,878,115 | 3,707,686 | +1,829,571 | 0.01 | 0.02 | +0.00 | buy |
| ALGERT GLOBAL LLC | 1,315,589 | 2,817,615 | +1,502,026 | 0.14 | 0.19 | +0.05 | buy |
| Qube Research & Technologies Ltd | 155,924 | 2,776,000 | +2,620,076 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 1,462,390 | 2,541,442 | +1,079,052 | 0.02 | 0.03 | +0.01 | buy |
| MORGAN STANLEY | 1,361,001 | 2,422,705 | +1,061,704 | 0.00 | 0.00 | +0.00 | buy |
| PFIZER INC | 1,875,000 | 1,875,000 | 0 | 5.00 | 6.42 | +1.42 | hold |
| MILLENNIUM MANAGEMENT LLC | 972,241 | 1,811,282 | +839,041 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,704,550 | 1,806,467 | -6,898,083 | 0.01 | 0.00 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 72,305 | 1,772,228 | +1,699,923 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,441,059 | 1,746,643 | +305,584 | 0.01 | 0.01 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 1,707,809 | +1,707,809 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 597,220 | 1,704,520 | +1,107,300 | 0.01 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 451,185 | 1,648,045 | +1,196,860 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,383,590 | 1,622,342 | +238,752 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 1,484,989 | +1,484,989 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 5,317,457 | 1,466,234 | -3,851,223 | 0.06 | 0.01 | -0.05 | sell |
| RTW INVESTMENTS, LP | 1,350,000 | 1,350,000 | 0 | 0.10 | 0.07 | -0.03 | hold |
| NORTHERN TRUST CORP | 1,189,230 | 1,253,500 | +64,270 | 0.00 | 0.00 | -0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,224,445 | +1,224,445 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,179,279 | 1,224,445 | +45,166 | 0.00 | 0.00 | -0.00 | buy |
| EMERALD ADVISERS, LLC | 1,261,183 | 1,223,965 | -37,218 | 0.29 | 0.17 | -0.12 | sell |
| MARSHALL WACE, LLP | 1,789,882 | 999,533 | -790,349 | 0.01 | 0.00 | -0.01 | sell |
| Pictet Asset Management Holding SA | 1,149,127 | 917,409 | -231,718 | 0.01 | 0.01 | -0.00 | sell |
| Aberdeen Group plc | 550,000 | 876,458 | +326,458 | 0.01 | 0.01 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 814,529 | 847,999 | +33,470 | 0.29 | 0.17 | -0.11 | buy |
| BAKER BROS. ADVISORS LP | 822,638 | 822,638 | 0 | 0.03 | 0.02 | -0.01 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 281,023 | 811,057 | +530,034 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 183,331 | 734,746 | +551,415 | 0.01 | 0.03 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 548,272 | 638,272 | +90,000 | 0.68 | 0.53 | -0.15 | buy |
| JPMORGAN CHASE & CO | 670,170 | 618,172 | -51,998 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 157,013 | 610,094 | +453,081 | 0.02 | 0.07 | +0.05 | buy |
| Susquehanna Portfolio Strategies, LLC | 195,840 | 608,194 | +412,354 | 0.02 | 0.06 | +0.04 | buy |
| TANG CAPITAL MANAGEMENT LLC | 600,000 | 600,000 | 0 | 0.22 | 0.16 | -0.06 | hold |
| Walleye Capital LLC | 493,512 | 585,453 | +91,941 | 0.02 | 0.02 | -0.01 | buy |
| Nuveen, LLC | 657,720 | 549,282 | -108,438 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 236,760 | 517,054 | +280,294 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 64,036 | 505,456 | +441,420 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 538,997 | 505,237 | -33,760 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 2,202,856 | 480,154 | -1,722,702 | 0.01 | 0.00 | -0.01 | sell |
| Jump Financial, LLC | 360,054 | 452,502 | +92,448 | 0.04 | 0.02 | -0.02 | buy |
| XTX Topco Ltd | 109,862 | 439,933 | +330,071 | 0.01 | 0.03 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 373,794 | 423,005 | +49,211 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 361,204 | 416,579 | +55,375 | 0.00 | 0.00 | -0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 415,458 | 408,894 | -6,564 | 0.01 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 624,735 | 406,478 | -218,257 | 0.01 | 0.00 | -0.01 | sell |
| Trexquant Investment LP | 1,089,642 | 380,169 | -709,473 | 0.06 | 0.01 | -0.04 | sell |
| HSBC HOLDINGS PLC | 0 | 370,449 | +370,449 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 350,531 | 350,531 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BARCLAYS PLC | 189,865 | 309,580 | +119,715 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 259,825 | 299,400 | +39,575 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 58,052 | 276,013 | +217,961 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 275,269 | 275,269 | 0 | 0.50 | 0.39 | -0.11 | hold |
| Swiss National Bank | 219,700 | 260,600 | +40,900 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 251,072 | +251,072 | 0.00 | 0.01 | +0.01 | buy |
| Privium Fund Management B.V. | 241,010 | 241,010 | 0 | 0.36 | 0.26 | -0.11 | hold |
| F/m Investments LLC | 164,921 | 235,085 | +70,164 | 0.08 | 0.07 | -0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 150,368 | 230,484 | +80,116 | 0.00 | 0.00 | +0.00 | buy |
| Newtyn Management, LLC | 300,000 | 215,000 | -85,000 | 0.23 | 0.16 | -0.08 | sell |
| Invesco Ltd. | 199,740 | 200,306 | +566 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 338,826 | 194,026 | -144,800 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 0 | 193,766 | +193,766 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 167,528 | 193,667 | +26,139 | 0.00 | 0.00 | -0.00 | buy |
| Sofinnova Investments, Inc. | 189,253 | 189,253 | 0 | 0.07 | 0.06 | -0.01 | hold |
| GSA CAPITAL PARTNERS LLP | 282,719 | 185,959 | -96,760 | 0.13 | 0.07 | -0.06 | sell |
| Duquesne Family Office LLC | 173,000 | 173,000 | 0 | 0.04 | 0.02 | -0.02 | hold |
| ADAR1 Capital Management, LLC | 44,900 | 160,000 | +115,100 | 0.02 | 0.04 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 136,173 | 154,211 | +18,038 | 0.00 | 0.00 | -0.00 | buy |
| Burkehill Global Management, LP | 150,000 | 150,000 | 0 | 0.05 | 0.03 | -0.02 | hold |
| DEUTSCHE BANK AG\ | 114,110 | 147,101 | +32,991 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 160,311 | 145,000 | -15,311 | 0.03 | 0.02 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 240,983 | 144,009 | -96,974 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 108,164 | 143,026 | +34,862 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 145,206 | 140,752 | -4,454 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 501,477 | 125,051 | -376,426 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 125,096 | 124,730 | -366 | 0.00 | 0.00 | -0.00 | sell |
| James J. Burns & Company, LLC | 114,800 | 114,800 | 0 | 0.11 | 0.07 | -0.04 | hold |
| IEQ CAPITAL, LLC | 22,532 | 106,446 | +83,914 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 104,878 | +104,878 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 104,705 | +104,705 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 20,891 | 102,195 | +81,304 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 12,146 | 101,454 | +89,308 | 0.02 | 0.16 | +0.13 | buy |
| Jackson Creek Investment Advisors LLC | 0 | 92,662 | +92,662 | 0.00 | 0.17 | +0.17 | buy |
| Legal & General Group Plc | 79,054 | 89,531 | +10,477 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 76,265 | 88,397 | +12,132 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 85,285 | 85,285 | 0 | 0.09 | 0.08 | -0.01 | hold |
| Handelsbanken Fonder AB | 65,500 | 81,900 | +16,400 | 0.00 | 0.00 | -0.00 | buy |
| Entropy Technologies, LP | 28,348 | 80,449 | +52,101 | 0.01 | 0.02 | +0.01 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 32,778 | 80,432 | +47,654 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 86,677 | 79,065 | -7,612 | 0.01 | 0.00 | -0.00 | sell |