| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 908,096 | 5,858,860 | +4,950,764 | 0.04 | 0.41 | +0.37 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,357,719 | 9,703,351 | +4,345,632 | 0.05 | 0.14 | +0.09 | buy |
| MAVERICK CAPITAL LTD | 7,669,361 | 10,047,520 | +2,378,159 | 0.73 | 1.61 | +0.88 | buy |
| Artisan Partners Limited Partnership | 0 | 1,960,470 | +1,960,470 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,439,271 | 3,126,604 | +1,687,333 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 375,000 | 1,400,000 | +1,025,000 | 0.29 | 1.78 | +1.49 | buy |
| FMR LLC | 561,080 | 1,540,190 | +979,110 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 3,975,521 | 4,899,497 | +923,976 | 2.08 | 3.11 | +1.04 | buy |
| CITADEL ADVISORS LLC | 24,716 | 937,586 | +912,870 | 0.00 | 0.01 | +0.01 | buy |
| RTW INVESTMENTS, LP | 0 | 900,000 | +900,000 | 0.00 | 0.11 | +0.11 | buy |
| Maven Securities LTD | 0 | 850,000 | +850,000 | 0.00 | 0.79 | +0.79 | buy |
| MPM BioImpact LLC | 0 | 624,471 | +624,471 | 0.00 | 0.77 | +0.77 | buy |
| Walleye Capital LLC | 0 | 602,441 | +602,441 | 0.00 | 0.05 | +0.05 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 273,272 | 844,617 | +571,345 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 486,023 | +486,023 | 0.00 | 0.10 | +0.10 | buy |
| VANGUARD GROUP INC | 2,417,690 | 2,887,556 | +469,866 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 451,813 | +451,813 | 0.00 | 0.03 | +0.03 | buy |
| EMERALD ADVISERS, LLC | 2,493,230 | 2,881,510 | +388,280 | 0.52 | 0.91 | +0.39 | buy |
| BAKER BROS. ADVISORS LP | 0 | 344,063 | +344,063 | 0.00 | 0.03 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 108,567 | 418,461 | +309,894 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,820,938 | 2,123,466 | +302,528 | 0.48 | 0.90 | +0.43 | buy |
| STEMPOINT CAPITAL LP | 0 | 300,000 | +300,000 | 0.00 | 0.74 | +0.74 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,986,245 | 2,269,664 | +283,419 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 260,000 | +260,000 | 0.00 | 0.23 | +0.23 | buy |
| Cinctive Capital Management LP | 100,162 | 356,308 | +256,146 | 0.03 | 0.17 | +0.14 | buy |
| BANK OF AMERICA CORP /DE/ | 75,073 | 275,076 | +200,003 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 163,196 | +163,196 | 0.00 | 0.02 | +0.02 | buy |
| Ghisallo Capital Management LLC | 0 | 140,000 | +140,000 | 0.00 | 0.06 | +0.06 | buy |
| GOLDMAN SACHS GROUP INC | 234,931 | 374,363 | +139,432 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 0 | 135,260 | +135,260 | 0.00 | 0.06 | +0.06 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 495,471 | 627,552 | +132,081 | 0.61 | 1.16 | +0.55 | buy |
| Alyeska Investment Group, L.P. | 0 | 125,000 | +125,000 | 0.00 | 0.01 | +0.01 | buy |
| MOODY ALDRICH PARTNERS LLC | 179,359 | 303,062 | +123,703 | 0.17 | 0.45 | +0.28 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 104,520 | +104,520 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 58,743 | 159,241 | +100,498 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 100,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,820 | 102,184 | +83,364 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 68,041 | +68,041 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 183,946 | 251,806 | +67,860 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 62,102 | 128,550 | +66,448 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,263,426 | 2,321,248 | +57,822 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 0 | 48,834 | +48,834 | 0.00 | 0.10 | +0.10 | buy |
| NORTHERN TRUST CORP | 751,725 | 799,365 | +47,640 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 26,095 | 68,472 | +42,377 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 27,463 | 69,006 | +41,543 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 40,869 | +40,869 | 0.00 | 0.16 | +0.16 | buy |
| JANE STREET GROUP, LLC | 106,542 | 142,014 | +35,472 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 7,240 | 41,828 | +34,588 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 139,790 | 168,141 | +28,351 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 17,410 | 44,004 | +26,594 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 23,704 | +23,704 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 88,547 | 111,199 | +22,652 | 0.01 | 0.02 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 20,950 | +20,950 | 0.00 | 0.01 | +0.01 | buy |
| Weiss Asset Management LP | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 15,334 | +15,334 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 15,202 | +15,202 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 0 | 14,941 | +14,941 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 12,701 | +12,701 | 0.00 | 0.01 | +0.01 | buy |
| Point72 (DIFC) Ltd | 0 | 11,958 | +11,958 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 33,131 | 44,710 | +11,579 | 0.00 | 0.00 | +0.00 | buy |
| James J. Burns & Company, LLC | 90,000 | 100,111 | +10,111 | 0.09 | 0.15 | +0.06 | buy |
| China Universal Asset Management Co., Ltd. | 14,388 | 23,991 | +9,603 | 0.01 | 0.02 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 12,211 | 20,645 | +8,434 | 0.00 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 55,258 | 63,513 | +8,255 | 0.02 | 0.04 | +0.02 | buy |
| Trexquant Investment LP | 281,060 | 288,814 | +7,754 | 0.02 | 0.03 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 167,556 | 174,112 | +6,556 | 0.03 | 0.04 | +0.02 | buy |
| US BANCORP \DE\ | 11,727 | 18,043 | +6,316 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 669 | 6,384 | +5,715 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 82,111 | 87,461 | +5,350 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,421 | 42,485 | +5,064 | 0.00 | 0.00 | +0.00 | buy |
| Sandia Investment Management LP | 0 | 5,000 | +5,000 | 0.00 | 0.07 | +0.07 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 15,572 | 19,607 | +4,035 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 3,500 | +3,500 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 16,987 | 19,997 | +3,010 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 17,453 | 19,966 | +2,513 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 124,679 | 126,183 | +1,504 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 10,625 | 11,904 | +1,279 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,656 | 4,512 | +856 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 22,251 | 22,923 | +672 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 35,142 | 35,659 | +517 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 13,970 | 14,222 | +252 | 0.03 | 0.05 | +0.02 | buy |
| NISA INVESTMENT ADVISORS, LLC | 172 | 346 | +174 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 34 | 144 | +110 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 25 | 45 | +20 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 17 | +17 | 0.00 | 0.00 | 0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 12,465 | 12,473 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 7,334 | 7,334 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 51,700 | 51,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Amundi | 4,357 | 4,357 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 18,202,009 | 18,202,009 | 0 | 1.20 | 1.72 | +0.52 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 33,491 | 33,491 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TAKEDA PHARMACEUTICAL CO LTD | 1,346,892 | 1,346,892 | 0 | 2.89 | 29.10 | +26.21 | hold |
| MACQUARIE GROUP LTD | 81,955 | 81,955 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 349 | 349 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NJ State Employees Deferred Compensation Plan | 11,700 | 11,700 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MetLife Investment Management, LLC | 43,601 | 43,601 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Swiss National Bank | 156,500 | 156,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Birchview Capital, LP | 40,000 | 40,000 | 0 | 0.18 | 0.28 | +0.10 | hold |