| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 18,202,009 | 18,202,009 | 0 | 1.99 | 1.64 | -0.35 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 15,016,500 | 14,567,784 | -448,716 | 0.16 | 0.17 | +0.00 | sell |
| BlackRock, Inc. | 10,383,716 | 10,430,813 | +47,097 | 0.00 | 0.00 | +0.00 | buy |
| MAVERICK CAPITAL LTD | 8,261,683 | 8,391,856 | +130,173 | 0.82 | 0.82 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,531,519 | 6,298,060 | -233,459 | 0.34 | 0.33 | -0.01 | sell |
| M28 Capital Management LP | 5,664,548 | 5,664,548 | 0 | 62.80 | 60.97 | -1.83 | hold |
| FMR LLC | 619,137 | 5,130,374 | +4,511,237 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 4,560,053 | 4,560,053 | 0 | 3.19 | 2.49 | -0.71 | hold |
| 683 Capital Management, LLC | 4,100,000 | 4,150,000 | +50,000 | 2.70 | 2.76 | +0.06 | buy |
| Bellevue Group AG | 4,094,458 | 4,094,458 | 0 | 0.59 | 0.62 | +0.04 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,190,403 | 4,044,492 | -1,145,911 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 553 | 3,750,693 | +3,750,140 | 0.00 | 0.05 | +0.05 | buy |
| Siren, L.L.C. | 3,696,322 | 3,696,322 | 0 | 1.24 | 1.06 | -0.18 | hold |
| VANGUARD GROUP INC | 3,477,077 | 3,139,836 | -337,241 | 0.00 | 0.00 | -0.00 | sell |
| EMERALD ADVISERS, LLC | 3,257,119 | 2,996,900 | -260,219 | 0.78 | 0.70 | -0.07 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,759,381 | 2,918,370 | +158,989 | 0.00 | 0.00 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 3,295,700 | 2,905,466 | -390,234 | 0.03 | 0.03 | -0.00 | sell |
| STATE STREET CORP | 2,756,755 | 2,846,366 | +89,611 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,007,081 | 2,125,137 | +1,118,056 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 900,338 | 2,110,152 | +1,209,814 | 1.88 | 3.11 | +1.23 | buy |
| Affinity Asset Advisors, LLC | 2,000,308 | 2,100,000 | +99,692 | 1.92 | 1.43 | -0.49 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 2,465,850 | 1,898,650 | -567,200 | 0.01 | 0.01 | -0.00 | sell |
| PFIZER INC | 1,875,000 | 1,875,000 | 0 | 2.12 | 3.14 | +1.02 | hold |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,937,489 | 1,766,062 | -171,427 | 0.77 | 0.67 | -0.10 | sell |
| MPM BioImpact LLC | 1,505,262 | 1,505,262 | 0 | 1.70 | 1.80 | +0.11 | hold |
| Artisan Partners Limited Partnership | 2,264,835 | 1,232,926 | -1,031,909 | 0.02 | 0.01 | -0.01 | sell |
| Polar Capital Holdings Plc | 1,003,500 | 1,062,276 | +58,776 | 0.03 | 0.04 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,008,782 | 1,011,750 | +2,968 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,010,658 | 998,372 | -12,286 | 0.00 | 0.00 | +0.00 | sell |
| RTW INVESTMENTS, LP | 900,000 | 900,000 | 0 | 0.08 | 0.08 | -0.00 | hold |
| JPMORGAN CHASE & CO | 1,569,015 | 860,141 | -708,874 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 467,887 | 730,639 | +262,752 | 0.03 | 0.04 | +0.02 | buy |
| UBS Group AG | 607,272 | 705,608 | +98,336 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 645,560 | 665,150 | +19,590 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 663,967 | +663,967 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 619,641 | +619,641 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 243,167 | 563,004 | +319,837 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 621,378 | 555,544 | -65,834 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 34,000 | 540,437 | +506,437 | 0.01 | 0.09 | +0.08 | buy |
| MORGAN STANLEY | 1,544,038 | 507,290 | -1,036,748 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 297,887 | 429,619 | +131,732 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 692,415 | 390,749 | -301,666 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 358,429 | 368,705 | +10,276 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 421,852 | 350,548 | -71,304 | 0.53 | 0.49 | -0.04 | sell |
| BAKER BROS. ADVISORS LP | 344,063 | 344,063 | 0 | 0.02 | 0.02 | -0.00 | hold |
| F/m Investments LLC | 243,677 | 318,087 | +74,410 | 0.06 | 0.09 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 313,307 | 313,307 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 285,086 | 305,374 | +20,288 | 0.04 | 0.04 | -0.01 | buy |
| Newtyn Management, LLC | 400,000 | 300,000 | -100,000 | 0.39 | 0.27 | -0.13 | sell |
| Bank of New York Mellon Corp | 289,282 | 297,856 | +8,574 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 297,500 | +297,500 | 0.00 | 0.50 | +0.50 | buy |
| Squarepoint Ops LLC | 46,154 | 273,591 | +227,437 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 573,187 | 272,874 | -300,313 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 355,353 | 267,794 | -87,559 | 0.15 | 0.13 | -0.03 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 280,765 | 262,577 | -18,188 | 0.07 | 0.05 | -0.02 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 30,844 | 258,011 | +227,167 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 92,300 | 251,700 | +159,400 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 249,469 | 249,469 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Swiss National Bank | 205,200 | 211,000 | +5,800 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 224,426 | 196,280 | -28,146 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 117,903 | 170,943 | +53,040 | 0.05 | 0.08 | +0.02 | buy |
| ROYAL BANK OF CANADA | 26,835 | 170,498 | +143,663 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 135,550 | 170,000 | +34,450 | 0.19 | 0.22 | +0.03 | buy |
| RHUMBLINE ADVISERS | 162,599 | 159,173 | -3,426 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 179,608 | 142,408 | -37,200 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 114,959 | 141,126 | +26,167 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 145,308 | 134,276 | -11,032 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 59,279 | 132,771 | +73,492 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 591,384 | 127,983 | -463,401 | 0.01 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 163,699 | 125,359 | -38,340 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 132,891 | 121,162 | -11,729 | 0.03 | 0.02 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 114,814 | 119,067 | +4,253 | 0.12 | 0.09 | -0.03 | buy |
| Cinctive Capital Management LP | 277,764 | 110,537 | -167,227 | 0.10 | 0.04 | -0.06 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 107,865 | +107,865 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 150,513 | 107,046 | -43,467 | 0.00 | 0.00 | -0.00 | sell |
| James J. Burns & Company, LLC | 121,913 | 105,802 | -16,111 | 0.13 | 0.12 | -0.01 | sell |
| Legal & General Group Plc | 102,050 | 101,916 | -134 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 98,237 | 98,495 | +258 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 161,137 | 95,955 | -65,182 | 0.35 | 0.14 | -0.20 | sell |
| DEUTSCHE BANK AG\ | 84,531 | 94,265 | +9,734 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 10,264 | 94,080 | +83,816 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 92,830 | 92,830 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Knott David M Jr | 40,000 | 90,000 | +50,000 | 0.12 | 0.28 | +0.16 | buy |
| MACQUARIE GROUP LTD | 266,856 | 81,955 | -184,901 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 93,370 | 77,895 | -15,475 | 0.06 | 0.05 | -0.01 | sell |
| a16z Perennial Management, L.P. | 77,619 | 77,619 | 0 | 0.04 | 0.05 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 124,667 | 73,811 | -50,856 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 88,819 | 72,255 | -16,564 | 0.00 | 0.00 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 163,745 | 65,091 | -98,654 | 0.02 | 0.02 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 61,982 | 62,259 | +277 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 35,958 | 59,261 | +23,303 | 0.09 | 0.11 | +0.02 | buy |
| MetLife Investment Management, LLC | 67,257 | 59,206 | -8,051 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 45,458 | 59,131 | +13,673 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 53,611 | +53,611 | 0.00 | 0.02 | +0.02 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 52,303 | 52,046 | -257 | 0.00 | 0.00 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 51,700 | 51,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GSA CAPITAL PARTNERS LLP | 0 | 51,198 | +51,198 | 0.00 | 0.03 | +0.03 | buy |
| Handelsbanken Fonder AB | 50,800 | 50,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 50,000 | +50,000 | 0.00 | 0.09 | +0.09 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 66,194 | 45,888 | -20,306 | 0.00 | 0.00 | -0.00 | sell |