| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 18,202,009 | 18,203,009 | +1,000 | 1.64 | 3.17 | +1.53 | buy |
| FMR LLC | 5,130,374 | 15,135,983 | +10,005,609 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 10,430,813 | 12,648,907 | +2,218,094 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 14,567,784 | 9,786,061 | -4,781,723 | 0.17 | 0.25 | +0.08 | sell |
| MAVERICK CAPITAL LTD | 8,391,856 | 9,280,237 | +888,381 | 0.82 | 1.69 | +0.87 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,044,492 | 7,407,372 | +3,362,880 | 0.00 | 0.01 | +0.01 | buy |
| Darwin Global Management, Ltd. | 0 | 7,298,421 | +7,298,421 | 0.00 | 2.53 | +2.53 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,298,060 | 6,581,067 | +283,007 | 0.33 | 0.76 | +0.43 | buy |
| M28 Capital Management LP | 5,664,548 | 5,664,548 | 0 | 60.97 | 70.00 | +9.03 | hold |
| FEDERATED HERMES, INC. | 3,750,693 | 4,744,520 | +993,827 | 0.05 | 0.13 | +0.09 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 1,898,650 | 4,095,282 | +2,196,632 | 0.01 | 0.05 | +0.04 | buy |
| 683 Capital Management, LLC | 4,150,000 | 4,015,000 | -135,000 | 2.76 | 5.68 | +2.92 | sell |
| VANGUARD GROUP INC | 3,139,836 | 3,573,746 | +433,910 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,918,370 | 3,170,110 | +251,740 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,846,366 | 2,996,084 | +149,718 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 2,125,137 | 2,854,082 | +728,945 | 0.00 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 2,100,000 | 2,700,000 | +600,000 | 1.43 | 3.30 | +1.87 | buy |
| EMERALD ADVISERS, LLC | 2,996,900 | 2,455,089 | -541,811 | 0.70 | 1.29 | +0.58 | sell |
| Siren, L.L.C. | 3,696,322 | 2,450,000 | -1,246,322 | 1.06 | 1.24 | +0.18 | sell |
| Kynam Capital Management, LP | 4,560,053 | 2,169,105 | -2,390,948 | 2.49 | 2.40 | -0.08 | sell |
| LOOMIS SAYLES & CO L P | 2,905,466 | 2,040,223 | -865,243 | 0.03 | 0.04 | +0.02 | sell |
| PFIZER INC | 1,875,000 | 1,875,000 | 0 | 3.14 | 13.48 | +10.34 | hold |
| First Light Asset Management, LLC | 0 | 1,853,851 | +1,853,851 | 0.00 | 2.41 | +2.41 | buy |
| Bellevue Group AG | 4,094,458 | 1,490,518 | -2,603,940 | 0.62 | 0.48 | -0.14 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,766,062 | 1,414,665 | -351,397 | 0.67 | 1.17 | +0.50 | sell |
| RTW INVESTMENTS, LP | 900,000 | 1,350,000 | +450,000 | 0.08 | 0.23 | +0.15 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 998,372 | 1,191,361 | +192,989 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,011,750 | 1,033,068 | +21,318 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 555,544 | 1,005,984 | +450,440 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 860,141 | 892,886 | +32,745 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 273,591 | 883,586 | +609,995 | 0.00 | 0.03 | +0.03 | buy |
| Pictet Asset Management Holding SA | 15,726 | 805,901 | +790,175 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 789,964 | +789,964 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 563,004 | 749,448 | +186,444 | 0.01 | 0.02 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 722,237 | +722,237 | 0.00 | 0.04 | +0.04 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 600,000 | +600,000 | 0.00 | 0.50 | +0.50 | buy |
| MILLENNIUM MANAGEMENT LLC | 390,749 | 584,633 | +193,884 | 0.00 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 500,000 | +500,000 | 0.00 | 0.13 | +0.13 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 540,437 | 492,437 | -48,000 | 0.09 | 0.18 | +0.09 | sell |
| Exome Asset Management LLC | 0 | 421,488 | +421,488 | 0.00 | 3.54 | +3.54 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 368,705 | 411,494 | +42,789 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 507,290 | 409,663 | -97,627 | 0.00 | 0.00 | +0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 50,000 | 408,166 | +358,166 | 0.09 | 1.45 | +1.36 | buy |
| AMERIPRISE FINANCIAL INC | 107,865 | 398,416 | +290,551 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 318,087 | 395,894 | +77,807 | 0.09 | 0.26 | +0.17 | buy |
| Trexquant Investment LP | 0 | 391,111 | +391,111 | 0.00 | 0.06 | +0.06 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 196,280 | 378,987 | +182,707 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 730,639 | 378,823 | -351,816 | 0.04 | 0.04 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 429,619 | 365,235 | -64,384 | 0.00 | 0.00 | +0.00 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 352,144 | +352,144 | 0.00 | 1.88 | +1.88 | buy |
| Woodline Partners LP | 0 | 350,531 | +350,531 | 0.00 | 0.02 | +0.02 | buy |
| BAKER BROS. ADVISORS LP | 344,063 | 344,063 | 0 | 0.02 | 0.03 | +0.02 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 338,546 | +338,546 | 0.00 | 0.02 | +0.02 | buy |
| Nuveen, LLC | 249,469 | 332,735 | +83,266 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 328,145 | +328,145 | 0.00 | 0.05 | +0.05 | buy |
| Bank of New York Mellon Corp | 297,856 | 321,445 | +23,589 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 313,509 | +313,509 | 0.00 | 0.07 | +0.07 | buy |
| Newtyn Management, LLC | 300,000 | 300,000 | 0 | 0.27 | 0.54 | +0.27 | hold |
| HRT FINANCIAL LP | 0 | 299,718 | +299,718 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 272,874 | 276,781 | +3,907 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 350,548 | 274,425 | -76,123 | 0.49 | 0.87 | +0.38 | sell |
| UBS Group AG | 705,608 | 268,723 | -436,885 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 266,132 | +266,132 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 142,408 | 252,160 | +109,752 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 248,815 | +248,815 | 0.00 | 0.47 | +0.47 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 236,420 | +236,420 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 121,162 | 234,799 | +113,637 | 0.02 | 0.10 | +0.08 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 267,794 | 230,687 | -37,107 | 0.13 | 0.91 | +0.78 | sell |
| Susquehanna Portfolio Strategies, LLC | 305,374 | 230,512 | -74,862 | 0.04 | 0.06 | +0.03 | sell |
| Swiss National Bank | 211,000 | 219,700 | +8,700 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 10,698 | 202,721 | +192,023 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 73,811 | 200,890 | +127,079 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 170,000 | 193,010 | +23,010 | 0.22 | 0.60 | +0.38 | buy |
| BANK OF AMERICA CORP /DE/ | 665,150 | 182,855 | -482,295 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 125,359 | 182,728 | +57,369 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 141,126 | 179,932 | +38,806 | 0.00 | 0.00 | +0.00 | buy |
| Duquesne Family Office LLC | 0 | 173,000 | +173,000 | 0.00 | 0.07 | +0.07 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 170,170 | +170,170 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 164,985 | +164,985 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 170,943 | 158,182 | -12,761 | 0.08 | 0.12 | +0.04 | sell |
| Burkehill Global Management, LP | 0 | 150,000 | +150,000 | 0.00 | 0.17 | +0.17 | buy |
| RHUMBLINE ADVISERS | 159,173 | 141,895 | -17,278 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 134,276 | 134,558 | +282 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 122,470 | +122,470 | 0.00 | 0.03 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 258,011 | 112,875 | -145,136 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 92,830 | 112,030 | +19,200 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 15,687 | 111,170 | +95,483 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 619,641 | 110,924 | -508,717 | 0.01 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 98,495 | 107,680 | +9,185 | 0.00 | 0.00 | +0.00 | buy |
| James J. Burns & Company, LLC | 105,802 | 105,802 | 0 | 0.12 | 0.25 | +0.13 | hold |
| Itau Unibanco Holding S.A. | 0 | 102,000 | +102,000 | 0.00 | 0.04 | +0.04 | buy |
| LMR Partners LLP | 0 | 100,000 | +100,000 | 0.00 | 0.02 | +0.02 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.13 | +0.13 | buy |
| DEUTSCHE BANK AG\ | 94,265 | 95,706 | +1,441 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 262,577 | 95,068 | -167,509 | 0.05 | 0.07 | +0.02 | sell |
| Legal & General Group Plc | 101,916 | 93,985 | -7,931 | 0.00 | 0.00 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 93,202 | +93,202 | 0.00 | 0.12 | +0.12 | buy |
| PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 0 | 90,000 | +90,000 | 0.00 | 0.14 | +0.14 | buy |
| Knott David M Jr | 90,000 | 90,000 | 0 | 0.28 | 0.71 | +0.43 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 59,131 | 87,141 | +28,010 | 0.00 | 0.00 | +0.00 | buy |