| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,044,492 | 7,407,372 | +3,362,880 | 0.00 | 0.01 | +0.01 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 1,898,650 | 4,095,282 | +2,196,632 | 0.01 | 0.05 | +0.04 | buy |
| MAVERICK CAPITAL LTD | 8,391,856 | 9,280,237 | +888,381 | 0.82 | 1.69 | +0.87 | buy |
| Affinity Asset Advisors, LLC | 2,100,000 | 2,700,000 | +600,000 | 1.43 | 3.30 | +1.87 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 555,544 | 1,005,984 | +450,440 | 0.00 | 0.01 | +0.01 | buy |
| RTW INVESTMENTS, LP | 900,000 | 1,350,000 | +450,000 | 0.08 | 0.23 | +0.15 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 50,000 | 408,166 | +358,166 | 0.08 | 1.34 | +1.26 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,298,060 | 6,581,067 | +283,007 | 0.33 | 0.76 | +0.43 | buy |
| F/m Investments LLC | 318,087 | 395,894 | +77,807 | 0.09 | 0.26 | +0.17 | buy |
| SIG BROKERAGE, LP | 17,971 | 48,384 | +30,413 | 0.00 | 0.03 | +0.02 | buy |
| Matisse Capital | 13,193 | 42,193 | +29,000 | 0.04 | 0.32 | +0.28 | buy |
| Privium Fund Management B.V. | 170,000 | 193,010 | +23,010 | 0.22 | 0.60 | +0.38 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 18,202,009 | 18,203,009 | +1,000 | 1.64 | 3.17 | +1.53 | buy |
| Virtus Investment Advisers, LLC | 15,804 | 16,064 | +260 | 0.03 | 0.07 | +0.04 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,424 | 3,285 | -139 | 0.00 | 0.00 | +0.00 | sell |
| Ikarian Capital, LLC | 95,955 | 85,285 | -10,670 | 0.14 | 0.19 | +0.05 | sell |
| Sofinnova Investments, Inc. | 170,943 | 158,182 | -12,761 | 0.07 | 0.12 | +0.05 | sell |
| INCEPTIONR LLC | 34,643 | 10,636 | -24,007 | 0.06 | 0.05 | -0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 267,794 | 230,687 | -37,107 | 0.13 | 0.91 | +0.78 | sell |
| China Universal Asset Management Co., Ltd. | 77,895 | 39,742 | -38,153 | 0.05 | 0.05 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 540,437 | 492,437 | -48,000 | 0.09 | 0.18 | +0.09 | sell |
| Cinctive Capital Management LP | 110,537 | 61,831 | -48,706 | 0.04 | 0.06 | +0.02 | sell |
| Susquehanna Portfolio Strategies, LLC | 305,374 | 230,512 | -74,862 | 0.04 | 0.06 | +0.03 | sell |
| MOODY ALDRICH PARTNERS LLC | 350,548 | 274,425 | -76,123 | 0.49 | 0.87 | +0.38 | sell |
| 683 Capital Management, LLC | 4,150,000 | 4,015,000 | -135,000 | 1.59 | 2.97 | +1.38 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 262,577 | 95,068 | -167,509 | 0.07 | 0.07 | +0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,766,062 | 1,414,665 | -351,397 | 0.67 | 1.17 | +0.50 | sell |
| EMERALD ADVISERS, LLC | 2,996,900 | 2,455,089 | -541,811 | 0.70 | 1.29 | +0.58 | sell |
| LOOMIS SAYLES & CO L P | 2,905,466 | 2,040,223 | -865,243 | 0.03 | 0.04 | +0.02 | sell |
| Siren, L.L.C. | 3,696,322 | 2,450,000 | -1,246,322 | 1.06 | 1.24 | +0.18 | sell |
| Kynam Capital Management, LP | 4,560,053 | 2,169,105 | -2,390,948 | 2.49 | 2.40 | -0.08 | sell |
| Bellevue Group AG | 4,094,458 | 1,490,518 | -2,603,940 | 0.62 | 0.48 | -0.14 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 14,567,784 | 9,786,061 | -4,781,723 | 0.17 | 0.25 | +0.08 | sell |