| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD | 73,031,667 | 73,031,667 | 0 | 7.30 | 7.60 | +0.30 | hold |
| VIKING GLOBAL INVESTORS LP | 69,368,961 | 69,368,961 | 0 | 2.85 | 2.72 | -0.13 | hold |
| QVT Financial LP | 112,541,536 | 66,719,779 | -45,821,757 | 76.36 | 65.50 | -10.86 | sell |
| MORGAN STANLEY | 21,927,044 | 35,635,501 | +13,708,457 | 0.02 | 0.03 | +0.01 | buy |
| FMR LLC | 36,976,248 | 35,340,563 | -1,635,685 | 0.03 | 0.03 | -0.01 | sell |
| Rubric Capital Management LP | 19,000,000 | 20,000,000 | +1,000,000 | 7.96 | 6.23 | -1.73 | buy |
| STATE STREET CORP | 13,727,418 | 17,153,134 | +3,425,716 | 0.01 | 0.01 | +0.00 | buy |
| Patient Square Capital LP | 12,639,920 | 12,228,465 | -411,455 | 77.60 | 54.89 | -22.71 | sell |
| Woodline Partners LP | 6,151,767 | 11,172,306 | +5,020,539 | 0.75 | 1.09 | +0.34 | buy |
| VANGUARD GROUP INC | 7,075,651 | 8,106,332 | +1,030,681 | 0.00 | 0.00 | -0.00 | buy |
| Two Seas Capital LP | 8,508,223 | 7,930,349 | -577,874 | 23.54 | 16.37 | -7.17 | sell |
| BAKER BROS. ADVISORS LP | 7,593,024 | 7,413,834 | -179,190 | 0.97 | 0.98 | +0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 5,524,576 | 6,046,846 | +522,270 | 0.01 | 0.01 | -0.00 | buy |
| Anchorage Capital Group, L.L.C. | 4,832,642 | 4,832,642 | 0 | 6.46 | 13.26 | +6.80 | hold |
| Avoro Capital Advisors LLC | 4,651,162 | 4,651,162 | 0 | 0.72 | 0.57 | -0.15 | hold |
| NORGES BANK | 3,695,967 | 4,266,692 | +570,725 | 0.01 | 0.01 | -0.00 | buy |
| PointState Capital LP | 0 | 4,046,485 | +4,046,485 | 0.00 | 1.28 | +1.28 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,275,000 | 3,934,752 | -1,340,248 | 0.12 | 0.08 | -0.04 | sell |
| Pictet Asset Management Holding SA | 2,716,218 | 3,708,086 | +991,868 | 0.03 | 0.04 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 2,169,116 | 3,553,844 | +1,384,728 | 6.56 | 10.01 | +3.44 | buy |
| LOOMIS SAYLES & CO L P | 2,553,630 | 3,193,342 | +639,712 | 0.04 | 0.05 | +0.00 | buy |
| CITADEL ADVISORS LLC | 3,481,703 | 3,139,579 | -342,124 | 0.04 | 0.03 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 1,256,591 | 2,791,870 | +1,535,279 | 6.31 | 8.03 | +1.72 | buy |
| BVF INC/IL | 2,742,409 | 2,742,409 | 0 | 0.77 | 0.79 | +0.02 | hold |
| Bank of New York Mellon Corp | 1,318,514 | 2,627,997 | +1,309,483 | 0.00 | 0.01 | +0.00 | buy |
| Tejara Capital Ltd | 2,134,895 | 2,600,295 | +465,400 | 10.04 | 10.15 | +0.11 | buy |
| Whitefort Capital Management, LP | 1,591,000 | 2,391,000 | +800,000 | 11.39 | 15.35 | +3.96 | buy |
| BANK OF AMERICA CORP /DE/ | 761,372 | 2,250,177 | +1,488,805 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,023,027 | 2,112,411 | +89,384 | 0.01 | 0.01 | -0.00 | buy |
| BlackBarn Capital Partners LP | 1,550,000 | 1,900,594 | +350,594 | 11.49 | 11.58 | +0.09 | buy |
| Prosight Management, LP | 0 | 1,860,000 | +1,860,000 | 0.00 | 5.45 | +5.45 | buy |
| Pertento Partners LLP | 879,214 | 1,828,063 | +948,849 | 1.87 | 3.88 | +2.01 | buy |
| LAKEWOOD CAPITAL MANAGEMENT, LP | 1,084,000 | 1,744,800 | +660,800 | 1.11 | 1.61 | +0.50 | buy |
| FIRST TRUST ADVISORS LP | 2,739,438 | 1,716,558 | -1,022,880 | 0.03 | 0.02 | -0.02 | sell |
| NORTHERN TRUST CORP | 1,479,544 | 1,665,335 | +185,791 | 0.00 | 0.00 | +0.00 | buy |
| PENN DAVIS MCFARLAND INC | 0 | 1,640,125 | +1,640,125 | 0.00 | 2.68 | +2.68 | buy |
| Impax Asset Management Group plc | 0 | 1,600,000 | +1,600,000 | 0.00 | 0.06 | +0.06 | buy |
| Polar Capital Holdings Plc | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.08 | +0.08 | buy |
| GOLDMAN SACHS GROUP INC | 413,095 | 1,498,916 | +1,085,821 | 0.00 | 0.00 | +0.00 | buy |
| Tyro Capital Management LLC | 1,345,981 | 1,495,594 | +149,613 | 10.65 | 9.10 | -1.55 | buy |
| RTW INVESTMENTS, LP | 1,454,273 | 1,454,273 | 0 | 0.26 | 0.23 | -0.03 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 36,277 | 1,274,737 | +1,238,460 | 0.00 | 0.01 | +0.01 | buy |
| Philosophy Capital Management LLC | 808,638 | 1,230,000 | +421,362 | 1.83 | 2.54 | +0.70 | buy |
| Clearbridge Investments, LLC | 0 | 1,229,824 | +1,229,824 | 0.00 | 0.01 | +0.01 | buy |
| TIFF ADVISORY SERVICES, LLC | 0 | 1,147,752 | +1,147,752 | 0.00 | 5.28 | +5.28 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,146,632 | 1,144,428 | -2,204 | 0.01 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 0 | 1,139,245 | +1,139,245 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 1,126,987 | 1,126,987 | 0 | 0.03 | 0.02 | -0.00 | hold |
| Assenagon Asset Management S.A. | 1,063,392 | 1,018,899 | -44,493 | 0.04 | 0.03 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 1,008,600 | +1,008,600 | 0.00 | 0.02 | +0.02 | buy |
| Sofinnova Investments, Inc. | 0 | 1,001,704 | +1,001,704 | 0.00 | 0.62 | +0.62 | buy |
| RHUMBLINE ADVISERS | 421,641 | 957,349 | +535,708 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 422,440 | 923,802 | +501,362 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 973,134 | 912,193 | -60,941 | 0.05 | 0.04 | -0.01 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 7,336,000 | 898,600 | -6,437,400 | 0.52 | 0.06 | -0.46 | sell |
| CITIGROUP INC | 367,906 | 849,045 | +481,139 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 84,540 | 783,767 | +699,227 | 0.01 | 0.07 | +0.06 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 936,974 | 762,536 | -174,438 | 0.06 | 0.04 | -0.02 | sell |
| JANE STREET GROUP, LLC | 314,848 | 701,277 | +386,429 | 0.00 | 0.01 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 669,047 | 669,047 | 0 | 0.31 | 0.28 | -0.02 | hold |
| CLOUGH CAPITAL PARTNERS L P | 678,660 | 668,555 | -10,105 | 0.84 | 0.77 | -0.07 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 604,062 | +604,062 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,786,613 | 600,869 | -3,185,744 | 0.01 | 0.00 | -0.00 | sell |
| Integral Health Asset Management, LLC | 0 | 600,000 | +600,000 | 0.00 | 0.62 | +0.62 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 599,798 | +599,798 | 0.00 | 0.02 | +0.02 | buy |
| Privium Fund Management B.V. | 277,795 | 567,795 | +290,000 | 0.88 | 1.60 | +0.72 | buy |
| Swiss National Bank | 546,746 | 555,546 | +8,800 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 233,889 | 537,597 | +303,708 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 739,980 | 534,980 | -205,000 | 1.18 | 0.63 | -0.55 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 326,161 | 531,019 | +204,858 | 2.61 | 3.70 | +1.09 | buy |
| Invesco Ltd. | 928,048 | 503,569 | -424,479 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 500,000 | 500,000 | 0 | 1.12 | 0.86 | -0.26 | hold |
| ALLIANCEBERNSTEIN L.P. | 96,089 | 468,280 | +372,191 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 433,700 | 461,900 | +28,200 | 0.01 | 0.01 | -0.00 | buy |
| LMR Partners LLP | 0 | 451,006 | +451,006 | 0.00 | 0.12 | +0.12 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 5,853 | 450,065 | +444,212 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 394,370 | 446,962 | +52,592 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 492,912 | 438,155 | -54,757 | 0.01 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 293,965 | 434,340 | +140,375 | 0.00 | 0.00 | +0.00 | buy |
| Retirement Systems of Alabama | 0 | 423,486 | +423,486 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 289,811 | 399,884 | +110,073 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,109,179 | 388,062 | -721,117 | 0.01 | 0.00 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 377,411 | +377,411 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 898,966 | 372,556 | -526,410 | 0.05 | 0.02 | -0.03 | sell |
| DekaBank Deutsche Girozentrale | 350,000 | 350,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Monashee Investment Management LLC | 350,000 | 350,000 | 0 | 0.69 | 0.44 | -0.26 | hold |
| Pier Capital, LLC | 331,267 | 328,182 | -3,085 | 0.53 | 0.48 | -0.06 | sell |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 150,363 | 325,937 | +175,574 | 0.02 | 0.04 | +0.02 | buy |
| TWINBEECH CAPITAL LP | 13,952 | 323,366 | +309,414 | 0.00 | 0.07 | +0.07 | buy |
| DAVENPORT & Co LLC | 283,080 | 306,700 | +23,620 | 0.02 | 0.02 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 86,944 | 301,828 | +214,884 | 0.00 | 0.01 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 151,170 | 296,824 | +145,654 | 0.32 | 0.54 | +0.22 | buy |
| TEXAS PERMANENT SCHOOL FUND CORP | 0 | 295,505 | +295,505 | 0.00 | 0.02 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 306,548 | 290,459 | -16,089 | 0.00 | 0.00 | -0.00 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 0 | 271,539 | +271,539 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 261,000 | 270,134 | +9,134 | 0.29 | 0.29 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18,201 | 266,756 | +248,555 | 0.02 | 0.19 | +0.17 | buy |
| Tower Research Capital LLC (TRC) | 9,671 | 263,048 | +253,377 | 0.00 | 0.07 | +0.07 | buy |
| Erste Asset Management GmbH | 246,000 | 246,000 | 0 | 0.04 | 0.04 | -0.00 | hold |
| State of New Jersey Common Pension Fund D | 275,303 | 238,300 | -37,003 | 0.01 | 0.01 | -0.00 | sell |