| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 65,779,464 | 77,981,253 | +12,201,789 | 0.07 | 0.11 | +0.04 | buy |
| MORGAN STANLEY | 58,359,553 | 51,828,325 | -6,531,228 | 0.08 | 0.09 | +0.01 | sell |
| BlackRock, Inc. | 41,170,475 | 44,254,260 | +3,083,785 | 0.02 | 0.02 | +0.01 | buy |
| QVT Financial LP | 26,387,021 | 25,161,237 | -1,225,784 | 54.38 | 55.05 | +0.68 | sell |
| UBS Group AG | 18,390,792 | 22,619,472 | +4,228,680 | 0.08 | 0.11 | +0.03 | buy |
| STATE STREET CORP | 17,361,465 | 16,186,613 | -1,174,852 | 0.01 | 0.02 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 10,677,894 | 12,794,097 | +2,116,203 | 0.35 | 0.55 | +0.20 | buy |
| GOLDMAN SACHS GROUP INC | 10,982,683 | 11,111,591 | +128,908 | 0.03 | 0.04 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 8,153,546 | 10,182,477 | +2,028,931 | 0.01 | 0.02 | +0.01 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 37,000 | 9,675,000 | +9,638,000 | 0.00 | 1.59 | +1.58 | buy |
| Two Seas Capital LP | 9,791,891 | 9,328,291 | -463,600 | 12.45 | 11.93 | -0.52 | sell |
| PERCEPTIVE ADVISORS LLC | 7,985,461 | 8,285,461 | +300,000 | 3.17 | 4.53 | +1.36 | buy |
| Patient Square Capital LP | 8,166,047 | 8,166,047 | 0 | 37.93 | 40.13 | +2.20 | hold |
| DIMENSIONAL FUND ADVISORS LP | 9,247,468 | 7,475,866 | -1,771,602 | 0.04 | 0.04 | +0.00 | sell |
| Assenagon Asset Management S.A. | 6,937,112 | 7,076,488 | +139,376 | 0.23 | 0.31 | +0.09 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,335,125 | 6,992,136 | +1,657,011 | 0.01 | 0.02 | +0.01 | buy |
| Darwin Global Management, Ltd. | 0 | 6,797,300 | +6,797,300 | 0.00 | 4.76 | +4.76 | buy |
| VIKING GLOBAL INVESTORS LP | 6,443,191 | 6,652,448 | +209,257 | 0.37 | 0.52 | +0.14 | buy |
| Invesco Ltd. | 2,281,487 | 6,439,145 | +4,157,658 | 0.01 | 0.02 | +0.02 | buy |
| NATIONAL BANK OF CANADA /FI/ | 2,040,000 | 6,298,000 | +4,258,000 | 0.05 | 0.18 | +0.13 | buy |
| AQR CAPITAL MANAGEMENT LLC | 880,773 | 5,946,858 | +5,066,085 | 0.01 | 0.07 | +0.06 | buy |
| Rubric Capital Management LP | 9,000,000 | 5,000,000 | -4,000,000 | 2.34 | 1.70 | -0.64 | sell |
| BAKER BROS. ADVISORS LP | 5,555,017 | 4,867,723 | -687,294 | 0.71 | 0.77 | +0.07 | sell |
| NORTHERN TRUST CORP | 3,285,928 | 3,520,452 | +234,524 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 3,239,696 | 3,457,448 | +217,752 | 0.01 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 759,219 | 3,450,904 | +2,691,685 | 0.02 | 0.14 | +0.11 | buy |
| ADAR1 Capital Management, LLC | 3,428,962 | 3,285,906 | -143,056 | 5.57 | 5.47 | -0.10 | sell |
| BANK OF AMERICA CORP /DE/ | 2,928,328 | 3,163,821 | +235,493 | 0.00 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 2,918,109 | 3,095,448 | +177,339 | 0.03 | 0.04 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 2,353,386 | 2,982,799 | +629,413 | 0.03 | 0.06 | +0.03 | buy |
| Affinity Asset Advisors, LLC | 1,700,000 | 2,800,000 | +1,100,000 | 2.65 | 4.55 | +1.90 | buy |
| Bank of New York Mellon Corp | 2,903,129 | 2,735,824 | -167,305 | 0.01 | 0.01 | +0.00 | sell |
| Pictet Asset Management Holding SA | 2,312,436 | 2,673,233 | +360,797 | 0.05 | 0.08 | +0.03 | buy |
| SB INVESTMENT ADVISERS (UK) LTD | 16,413,603 | 2,671,732 | -13,741,871 | 3.56 | 0.96 | -2.61 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 2,294,506 | 2,516,353 | +221,847 | 0.03 | 0.05 | +0.01 | buy |
| CITADEL ADVISORS LLC | 2,286,001 | 2,515,998 | +229,997 | 0.03 | 0.05 | +0.02 | buy |
| BlackBarn Capital Partners LP | 3,084,300 | 2,285,117 | -799,183 | 24.00 | 19.04 | -4.95 | sell |
| MARSHALL WACE, LLP | 3,458,926 | 2,246,943 | -1,211,983 | 0.07 | 0.07 | -0.01 | sell |
| DME Capital Management, LP | 2,069,309 | 2,152,669 | +83,360 | 1.58 | 1.87 | +0.29 | buy |
| Clearbridge Investments, LLC | 1,972,921 | 2,005,565 | +32,644 | 0.03 | 0.05 | +0.01 | buy |
| Candriam S.C.A. | 2,490,426 | 2,001,976 | -488,450 | 0.27 | 0.29 | +0.02 | sell |
| Integral Health Asset Management, LLC | 850,000 | 2,000,000 | +1,150,000 | 0.93 | 2.93 | +2.00 | buy |
| Nuveen, LLC | 2,249,867 | 1,955,046 | -294,821 | 0.01 | 0.01 | +0.00 | sell |
| Woodline Partners LP | 1,750,017 | 1,750,017 | 0 | 0.15 | 0.18 | +0.04 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,084,609 | 1,741,480 | -343,129 | 0.01 | 0.01 | +0.00 | sell |
| MAVERICK CAPITAL LTD | 0 | 1,626,940 | +1,626,940 | 0.00 | 0.52 | +0.52 | buy |
| PENN DAVIS MCFARLAND INC | 1,858,289 | 1,592,623 | -265,666 | 3.86 | 4.32 | +0.45 | sell |
| Polar Capital Holdings Plc | 2,690,124 | 1,578,308 | -1,111,816 | 0.27 | 0.19 | -0.08 | sell |
| JPMORGAN CHASE & CO | 934,533 | 1,537,519 | +602,986 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,711,744 | 1,536,110 | -175,634 | 0.03 | 0.03 | +0.00 | sell |
| Amundi | 1,043,464 | 1,480,970 | +437,506 | 0.01 | 0.01 | +0.01 | buy |
| Whitefort Capital Management, LP | 2,120,000 | 1,419,000 | -701,000 | 13.92 | 11.96 | -1.96 | sell |
| Gotham Asset Management, LLC | 925,193 | 1,416,091 | +490,898 | 0.07 | 0.12 | +0.05 | buy |
| BARCLAYS PLC | 839,279 | 1,415,848 | +576,569 | 0.01 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 395,404 | 1,392,748 | +997,344 | 0.01 | 0.03 | +0.02 | buy |
| Parkside Financial Bank & Trust | 1,166,756 | 1,329,164 | +162,408 | 1.90 | 2.83 | +0.93 | buy |
| BANK OF NOVA SCOTIA | 1,423,000 | 1,310,387 | -112,613 | 0.05 | 0.06 | +0.02 | sell |
| First Turn Management, LLC | 1,186,817 | 1,190,118 | +3,301 | 2.94 | 3.68 | +0.74 | buy |
| RHUMBLINE ADVISERS | 1,037,631 | 1,113,266 | +75,635 | 0.02 | 0.03 | +0.01 | buy |
| JANE STREET GROUP, LLC | 1,311,585 | 1,020,707 | -290,878 | 0.03 | 0.03 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 34,489 | 1,018,842 | +984,353 | 0.00 | 0.05 | +0.05 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 941,222 | 1,005,533 | +64,311 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 963,282 | +963,282 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 111,872 | 925,186 | +813,314 | 0.01 | 0.11 | +0.10 | buy |
| Point72 Asset Management, L.P. | 0 | 890,900 | +890,900 | 0.00 | 0.04 | +0.04 | buy |
| Man Group plc | 1,457,127 | 852,204 | -604,923 | 0.06 | 0.05 | -0.01 | sell |
| ALGERT GLOBAL LLC | 706,554 | 827,454 | +120,900 | 0.24 | 0.34 | +0.11 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,197,592 | 803,801 | -393,791 | 0.02 | 0.02 | -0.00 | sell |
| Cormorant Asset Management, LP | 0 | 750,000 | +750,000 | 0.00 | 1.05 | +1.05 | buy |
| Swiss National Bank | 740,646 | 743,446 | +2,800 | 0.01 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 551,376 | 715,282 | +163,906 | 0.01 | 0.02 | +0.01 | buy |
| Russell Investments Group, Ltd. | 89,830 | 707,171 | +617,341 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 598,515 | 699,137 | +100,622 | 0.01 | 0.02 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 0 | 691,463 | +691,463 | 0.00 | 0.01 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 641,461 | 678,518 | +37,057 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 542,047 | 676,344 | +134,297 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 23,294 | 640,923 | +617,629 | 0.00 | 0.02 | +0.02 | buy |
| Dorsey Wright & Associates | 376,106 | 577,147 | +201,041 | 1.76 | 1.98 | +0.22 | buy |
| Legal & General Group Plc | 589,673 | 561,307 | -28,366 | 0.00 | 0.00 | +0.00 | sell |
| Retirement Systems of Alabama | 525,863 | 552,771 | +26,908 | 0.04 | 0.05 | +0.01 | buy |
| Sofinnova Investments, Inc. | 734,582 | 477,995 | -256,587 | 0.69 | 0.66 | -0.02 | sell |
| FIRST TRUST ADVISORS LP | 260,764 | 455,865 | +195,101 | 0.00 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 358,559 | 440,634 | +82,075 | 0.01 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 645,448 | 438,565 | -206,883 | 0.00 | 0.00 | -0.00 | sell |
| ING GROEP NV | 588,400 | 391,500 | -196,900 | 0.08 | 0.07 | -0.01 | sell |
| STEMPOINT CAPITAL LP | 966,698 | 385,800 | -580,898 | 3.60 | 2.05 | -1.55 | sell |
| LPL Financial LLC | 351,467 | 378,656 | +27,189 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 464,944 | 376,509 | -88,435 | 0.65 | 0.62 | -0.04 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 325,757 | 325,757 | 0 | 0.01 | 0.02 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 261,937 | 314,440 | +52,503 | 0.01 | 0.01 | +0.00 | buy |
| Impax Asset Management Group plc | 550,000 | 300,000 | -250,000 | 0.07 | 0.06 | -0.02 | sell |
| Empowered Funds, LLC | 18,229 | 285,915 | +267,686 | 0.00 | 0.05 | +0.05 | buy |
| Nicholas Investment Partners, LP | 279,856 | 278,425 | -1,431 | 0.44 | 0.56 | +0.11 | sell |
| Pine Ridge Advisers LLC | 276,530 | 276,530 | 0 | 0.41 | 0.54 | +0.13 | hold |
| Consolidated Portfolio Review Corp | 276,530 | 276,530 | 0 | 0.52 | 0.70 | +0.18 | hold |
| Cinctive Capital Management LP | 0 | 274,521 | +274,521 | 0.00 | 0.50 | +0.50 | buy |
| WELLS FARGO & COMPANY/MN | 13,768 | 263,965 | +250,197 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 38,312 | 256,447 | +218,135 | 0.01 | 0.09 | +0.08 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 270,221 | 255,908 | -14,313 | 0.01 | 0.01 | +0.00 | sell |
| XTX Topco Ltd | 0 | 255,431 | +255,431 | 0.00 | 0.12 | +0.12 | buy |