| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 4,777,430 | 9,428,592 | +4,651,162 | 0.19 | 0.55 | 0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 14,880,925 | 11,090,300 | +3,790,625 | 0.25 | 0.24 | 0.00 | sell |
| Artal Group S.A. | 600,000 | 1,625,000 | +1,025,000 | 0.26 | 0.52 | +0.26 | buy |
| PERCEPTIVE ADVISORS LLC | 2,692,136 | 3,131,736 | +439,600 | 0.52 | 0.92 | 0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,750,000 | 1,354,974 | +395,026 | 0.29 | 0.29 | 0.00 | sell |
| JANUS HENDERSON GROUP PLC | 4,761,438 | 4,449,421 | +312,017 | 0.02 | 0.03 | 0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,219,917 | 1,051,236 | +168,681 | 0.03 | 0.03 | 0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 622,578 | 758,575 | +135,997 | 0.16 | 0.27 | 0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 161,825 | 190,211 | +28,386 | 0.05 | 0.07 | 0.00 | buy |
| PROFUND ADVISORS LLC | 135,581 | 127,878 | +7,703 | 0.06 | 0.07 | 0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 21,000 | 25,427 | +4,427 | 0.03 | 0.04 | 0.00 | buy |
| Itau Unibanco Holding S.A. | 3,005 | 2,123 | +882 | 0.00 | 0.00 | 0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 48,653 | 48,215 | +438 | 0.04 | 0.05 | 0.00 | sell |