| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD | 73,031,667 | 71,361,388 | -1,670,279 | 7.60 | 6.97 | -0.63 | sell |
| VIKING GLOBAL INVESTORS LP | 69,368,961 | 69,155,846 | -213,115 | 2.72 | 2.81 | +0.09 | sell |
| QVT Financial LP | 66,719,779 | 66,719,779 | 0 | 65.50 | 66.35 | +0.85 | hold |
| FMR LLC | 35,340,563 | 46,551,146 | +11,210,583 | 0.03 | 0.03 | +0.01 | buy |
| MORGAN STANLEY | 35,635,501 | 29,330,139 | -6,305,362 | 0.03 | 0.02 | -0.01 | sell |
| Rubric Capital Management LP | 20,000,000 | 23,000,000 | +3,000,000 | 6.23 | 6.41 | +0.18 | buy |
| STATE STREET CORP | 17,153,134 | 18,442,688 | +1,289,554 | 0.01 | 0.01 | +0.00 | buy |
| Patient Square Capital LP | 12,228,465 | 12,228,465 | 0 | 54.89 | 59.99 | +5.11 | hold |
| Two Seas Capital LP | 7,930,349 | 10,318,764 | +2,388,415 | 16.37 | 17.80 | +1.43 | buy |
| VANGUARD GROUP INC | 8,106,332 | 8,191,824 | +85,492 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 11,172,306 | 8,000,939 | -3,171,367 | 1.09 | 0.81 | -0.28 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 6,046,846 | 6,284,899 | +238,053 | 0.01 | 0.01 | -0.00 | buy |
| Invesco Ltd. | 503,569 | 5,908,065 | +5,404,496 | 0.00 | 0.01 | +0.01 | buy |
| Anchorage Capital Group, L.L.C. | 4,832,642 | 4,832,642 | 0 | 13.26 | 15.77 | +2.51 | hold |
| DME Capital Management, LP | 4,190,490 | 4,810,960 | +620,470 | 2.02 | 2.49 | +0.47 | buy |
| PointState Capital LP | 4,046,485 | 4,484,698 | +438,213 | 1.28 | 1.35 | +0.07 | buy |
| NORGES BANK | 4,266,692 | 4,240,777 | -25,915 | 0.01 | 0.01 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,498,916 | 4,201,335 | +2,702,419 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 2,791,870 | 4,150,009 | +1,358,139 | 8.03 | 8.83 | +0.80 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,934,752 | 3,934,752 | 0 | 0.08 | 0.08 | -0.00 | hold |
| LOOMIS SAYLES & CO L P | 3,193,342 | 3,453,604 | +260,262 | 0.05 | 0.05 | +0.00 | buy |
| BlackBarn Capital Partners LP | 1,900,594 | 3,100,000 | +1,199,406 | 11.58 | 16.89 | +5.31 | buy |
| FIRST TRUST ADVISORS LP | 1,716,558 | 3,007,142 | +1,290,584 | 0.02 | 0.03 | +0.01 | buy |
| Troluce Capital Advisors LLC | 0 | 2,950,000 | +2,950,000 | 0.00 | 6.51 | +6.51 | buy |
| BAKER BROS. ADVISORS LP | 7,413,834 | 2,798,716 | -4,615,118 | 0.98 | 0.38 | -0.60 | sell |
| BVF INC/IL | 2,742,409 | 2,742,409 | 0 | 0.79 | 0.81 | +0.02 | hold |
| STEMPOINT CAPITAL LP | 3,553,844 | 2,712,741 | -841,103 | 10.01 | 8.44 | -1.57 | sell |
| Bank of New York Mellon Corp | 2,627,997 | 2,686,538 | +58,541 | 0.01 | 0.01 | +0.00 | buy |
| Pertento Partners LLP | 1,828,063 | 2,652,562 | +824,499 | 3.88 | 3.55 | -0.33 | buy |
| BANK OF AMERICA CORP /DE/ | 2,250,177 | 2,643,717 | +393,540 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 701,277 | 2,507,783 | +1,806,506 | 0.01 | 0.03 | +0.02 | buy |
| NORTHERN TRUST CORP | 1,665,335 | 2,393,141 | +727,806 | 0.00 | 0.00 | +0.00 | buy |
| Whitefort Capital Management, LP | 2,391,000 | 2,391,000 | 0 | 15.35 | 15.58 | +0.23 | hold |
| Tejara Capital Ltd | 2,600,295 | 2,183,943 | -416,352 | 10.15 | 8.40 | -1.75 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,112,411 | 2,120,785 | +8,374 | 0.01 | 0.00 | -0.00 | buy |
| Prosight Management, LP | 1,860,000 | 2,000,000 | +140,000 | 5.45 | 6.32 | +0.86 | buy |
| CITADEL ADVISORS LLC | 3,139,579 | 1,924,037 | -1,215,542 | 0.03 | 0.02 | -0.01 | sell |
| Sofinnova Investments, Inc. | 1,001,704 | 1,868,412 | +866,708 | 0.62 | 1.24 | +0.62 | buy |
| Clearbridge Investments, LLC | 1,229,824 | 1,860,536 | +630,712 | 0.01 | 0.02 | +0.01 | buy |
| LAKEWOOD CAPITAL MANAGEMENT, LP | 1,744,800 | 1,744,800 | 0 | 1.61 | 1.59 | -0.02 | hold |
| Tyro Capital Management LLC | 1,495,594 | 1,744,327 | +248,733 | 9.10 | 8.36 | -0.75 | buy |
| PENN DAVIS MCFARLAND INC | 1,640,125 | 1,631,919 | -8,206 | 2.68 | 2.67 | -0.02 | sell |
| Impax Asset Management Group plc | 1,600,000 | 1,600,000 | 0 | 0.06 | 0.07 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,144,428 | 1,544,225 | +399,797 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,500,000 | 1,500,000 | 0 | 0.08 | 0.09 | +0.01 | hold |
| RTW INVESTMENTS, LP | 1,454,273 | 1,454,273 | 0 | 0.23 | 0.24 | +0.01 | hold |
| J. Goldman & Co LP | 0 | 1,307,543 | +1,307,543 | 0.00 | 0.51 | +0.51 | buy |
| Melqart Asset Management (UK) Ltd | 0 | 1,265,609 | +1,265,609 | 0.00 | 1.26 | +1.26 | buy |
| Pictet Asset Management Holding SA | 3,708,086 | 1,221,929 | -2,486,157 | 0.04 | 0.01 | -0.03 | sell |
| LMR Partners LLP | 451,006 | 1,205,168 | +754,162 | 0.12 | 0.27 | +0.15 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,274,737 | 1,155,372 | -119,365 | 0.01 | 0.01 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 1,139,245 | 1,145,203 | +5,958 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 1,126,987 | 1,126,987 | 0 | 0.02 | 0.02 | -0.00 | hold |
| TIFF ADVISORY SERVICES, LLC | 1,147,752 | 1,032,752 | -115,000 | 5.28 | 3.76 | -1.51 | sell |
| Alyeska Investment Group, L.P. | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.06 | +0.06 | buy |
| RHUMBLINE ADVISERS | 957,349 | 886,493 | -70,856 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 912,193 | 877,709 | -34,484 | 0.04 | 0.03 | -0.00 | sell |
| JPMORGAN CHASE & CO | 923,802 | 788,129 | -135,673 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 54,100 | 714,760 | +660,660 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 555,546 | 714,146 | +158,600 | 0.00 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 898,600 | 673,000 | -225,600 | 0.06 | 0.04 | -0.01 | sell |
| Point72 Asset Management, L.P. | 461,900 | 647,126 | +185,226 | 0.01 | 0.02 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 669,047 | 569,745 | -99,302 | 0.28 | 0.24 | -0.04 | sell |
| Legal & General Group Plc | 434,340 | 533,290 | +98,950 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 537,597 | 494,349 | -43,248 | 0.00 | 0.00 | -0.00 | sell |
| Pearl River Capital, LLC | 0 | 490,436 | +490,436 | 0.00 | 0.82 | +0.82 | buy |
| Privium Fund Management B.V. | 567,795 | 484,500 | -83,295 | 1.60 | 1.30 | -0.29 | sell |
| ALLIANCEBERNSTEIN L.P. | 468,280 | 448,233 | -20,047 | 0.00 | 0.00 | -0.00 | sell |
| Pier Capital, LLC | 328,182 | 425,087 | +96,905 | 0.48 | 0.67 | +0.19 | buy |
| Retirement Systems of Alabama | 423,486 | 417,736 | -5,750 | 0.02 | 0.02 | -0.00 | sell |
| 683 Capital Management, LLC | 270,134 | 410,000 | +139,866 | 0.29 | 0.45 | +0.16 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 599,798 | 409,656 | -190,142 | 0.02 | 0.02 | -0.01 | sell |
| Atika Capital Management LLC | 534,980 | 400,000 | -134,980 | 0.63 | 0.49 | -0.14 | sell |
| Integral Health Asset Management, LLC | 600,000 | 400,000 | -200,000 | 0.62 | 0.42 | -0.20 | sell |
| BARCLAYS PLC | 446,962 | 383,912 | -63,050 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 377,411 | 383,297 | +5,886 | 0.00 | 0.00 | +0.00 | buy |
| CLOUGH CAPITAL PARTNERS L P | 668,555 | 376,937 | -291,618 | 0.77 | 0.44 | -0.34 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 375,411 | +375,411 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 290,459 | 353,792 | +63,333 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 500,000 | 351,587 | -148,413 | 0.86 | 0.59 | -0.27 | sell |
| DekaBank Deutsche Girozentrale | 350,000 | 350,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| EFG Asset Management (North America) Corp. | 296,824 | 331,072 | +34,248 | 0.54 | 0.61 | +0.07 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 325,937 | 327,079 | +1,142 | 0.04 | 0.04 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 399,884 | 321,959 | -77,925 | 0.00 | 0.00 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 323,366 | 306,051 | -17,315 | 0.07 | 0.06 | -0.01 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 304,214 | +304,214 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 304,207 | +304,207 | 0.00 | 0.04 | +0.04 | buy |
| Monashee Investment Management LLC | 350,000 | 303,575 | -46,425 | 0.44 | 0.41 | -0.02 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 604,062 | 294,425 | -309,637 | 0.01 | 0.01 | -0.00 | sell |
| DAVENPORT & Co LLC | 306,700 | 292,300 | -14,400 | 0.02 | 0.02 | -0.00 | sell |
| CastleKnight Management LP | 227,300 | 289,900 | +62,600 | 0.35 | 0.41 | +0.06 | buy |
| Pine Ridge Advisers LLC | 0 | 276,530 | +276,530 | 0.00 | 0.31 | +0.31 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 266,756 | 262,278 | -4,478 | 0.19 | 0.23 | +0.04 | sell |
| TEXAS PERMANENT SCHOOL FUND CORP | 295,505 | 252,721 | -42,784 | 0.02 | 0.02 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 0 | 252,721 | +252,721 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 202,661 | 249,262 | +46,601 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 600,869 | 247,224 | -353,645 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 246,000 | 246,000 | 0 | 0.04 | 0.03 | -0.00 | hold |
| NORDEA INVESTMENT MANAGEMENT AB | 271,539 | 240,044 | -31,495 | 0.00 | 0.00 | -0.00 | sell |
| Integrated Wealth Concepts LLC | 188,684 | 237,373 | +48,689 | 0.03 | 0.03 | +0.01 | buy |