| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rubric Capital Management LP | 3,536,438 | 10,500,000 | +6,963,562 | 1.53 | 5.16 | +3.63 | buy |
| Woodline Partners LP | 3,796,871 | 7,174,253 | +3,377,382 | 0.45 | 0.98 | +0.53 | buy |
| BAKER BROS. ADVISORS LP | 9,428,592 | 11,877,171 | +2,448,579 | 0.55 | 0.80 | +0.25 | buy |
| HHLR ADVISORS, LTD. | 523,461 | 2,448,579 | +1,925,118 | 0.11 | 0.64 | +0.53 | buy |
| PFM Health Sciences, LP | 384,991 | 1,215,033 | +830,042 | 0.16 | 0.68 | +0.52 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 130,207 | 936,974 | +806,767 | 0.01 | 0.07 | +0.06 | buy |
| Nicholas Investment Partners, LP | 2,265,323 | 2,998,135 | +732,812 | 1.56 | 2.62 | +1.05 | buy |
| PERCEPTIVE ADVISORS LLC | 3,131,736 | 3,819,456 | +687,720 | 0.92 | 1.50 | +0.58 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 135,622 | 778,965 | +643,343 | 0.01 | 0.05 | +0.04 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,051,236 | 554,464 | +496,772 | 0.03 | 0.02 | 0.00 | sell |
| JANUS HENDERSON GROUP PLC | 4,449,421 | 3,978,497 | +470,924 | 0.03 | 0.03 | 0.00 | sell |
| Octagon Capital Advisors LP | 3,904,000 | 4,367,000 | +463,000 | 5.49 | 8.98 | +3.49 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,354,974 | 1,604,487 | +249,513 | 0.29 | 0.41 | +0.12 | buy |
| CLOUGH CAPITAL PARTNERS L P | 507,500 | 722,800 | +215,300 | 0.51 | 0.91 | +0.39 | buy |
| Monashee Investment Management LLC | 400,000 | 550,000 | +150,000 | 0.96 | 2.68 | +1.72 | buy |
| Ghisallo Capital Management LLC | 250,000 | 400,000 | +150,000 | 0.30 | 0.48 | +0.18 | buy |
| Atika Capital Management LLC | 398,500 | 545,000 | +146,500 | 0.50 | 0.91 | +0.40 | buy |
| Tejara Capital Ltd | 239,907 | 358,572 | +118,665 | 1.19 | 2.38 | +1.19 | buy |
| Artia Global Partners LP | 824,363 | 914,023 | +89,660 | 2.86 | 4.44 | +1.57 | buy |
| ArrowMark Colorado Holdings LLC | 92,000 | 166,260 | +74,260 | 0.01 | 0.02 | +0.01 | buy |
| Treasurer of the State of North Carolina | 106,610 | 152,640 | +46,030 | 0.01 | 0.01 | 0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 190,211 | 164,211 | +26,000 | 0.07 | 0.05 | 0.00 | sell |
| LOOMIS SAYLES & CO L P | 1,960,507 | 1,984,935 | +24,428 | 0.03 | 0.04 | +0.01 | buy |
| Corton Capital Inc. | 14,551 | 27,236 | +12,685 | 0.07 | 0.16 | +0.09 | buy |
| China Universal Asset Management Co., Ltd. | 9,941 | 19,797 | +9,856 | 0.03 | 0.07 | +0.04 | buy |
| VELA Investment Management, LLC | 22,200 | 29,765 | +7,565 | 0.10 | 0.15 | +0.05 | buy |
| Utah Retirement Systems | 13,200 | 18,900 | +5,700 | 0.00 | 0.00 | +0.00 | buy |
| Two Seas Capital LP | 7,909,591 | 7,915,232 | +5,641 | 17.43 | 18.71 | +1.29 | buy |
| SECTORAL ASSET MANAGEMENT INC | 25,427 | 30,447 | +5,020 | 0.04 | 0.07 | +0.03 | buy |
| ProShare Advisors LLC | 49,073 | 50,452 | +1,379 | 0.00 | 0.00 | 0.00 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 33,221 | 34,583 | +1,362 | 0.04 | 0.06 | +0.02 | buy |
| Itau Unibanco Holding S.A. | 2,123 | 2,809 | +686 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 38,725 | 36,291 | -2,434 | 0.03 | 0.03 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 35,389 | 31,338 | -4,051 | 0.21 | 0.22 | +0.01 | sell |
| DnB Asset Management AS | 57,443 | 46,140 | -11,303 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 127,878 | 116,009 | -11,869 | 0.07 | 0.07 | +0.01 | sell |
| Rafferty Asset Management, LLC | 792,631 | 777,998 | -14,633 | 0.05 | 0.05 | +0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 49,300 | 22,280 | -27,020 | 0.04 | 0.02 | -0.02 | sell |
| ADVISORY RESEARCH INC | 108,952 | 79,694 | -29,258 | 0.14 | 0.13 | -0.01 | sell |
| Edge Wealth Management LLC | 175,532 | 134,528 | -41,004 | 0.39 | 0.37 | -0.02 | sell |
| ARDSLEY ADVISORY PARTNERS LP | 554,000 | 450,000 | -104,000 | 1.26 | 1.42 | +0.16 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 758,575 | 598,732 | -159,843 | 0.27 | 0.27 | +0.01 | sell |
| Avidity Partners Management LP | 1,687,500 | 1,503,302 | -184,198 | 0.59 | 0.71 | +0.11 | sell |
| Ikarian Capital, LLC | 225,000 | 1,821 | -223,179 | 0.80 | 0.01 | -0.79 | sell |
| Pier Capital, LLC | 614,935 | 335,003 | -279,932 | 0.89 | 0.63 | -0.26 | sell |
| Artal Group S.A. | 1,625,000 | 1,000,000 | -625,000 | 0.52 | 0.51 | -0.02 | sell |
| Laurion Capital Management LP | 1,702,662 | 1,035,447 | -667,215 | 0.74 | 0.32 | -0.42 | sell |
| Avoro Capital Advisors LLC | 5,806,162 | 4,651,162 | -1,155,000 | 0.79 | 0.85 | +0.05 | sell |
| HSG Holding Ltd | 2,595,838 | 1,345,839 | -1,249,999 | 2.99 | 1.69 | -1.31 | sell |
| VIKING GLOBAL INVESTORS LP | 75,238,700 | 73,434,301 | -1,804,399 | 3.10 | 3.48 | +0.38 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 11,090,300 | 6,200,000 | -4,890,300 | 0.24 | 0.16 | -0.08 | sell |
| QVT Financial LP | 122,541,536 | 112,541,536 | -10,000,000 | 72.44 | 78.50 | +6.07 | sell |
| SB INVESTMENT ADVISERS (UK) LTD | 83,031,667 | 73,031,667 | -10,000,000 | 6.38 | 7.03 | +0.65 | sell |