| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 55,509,281 | 60,766,984 | +5,257,703 | 0.04 | 0.05 | +0.01 | buy |
| MORGAN STANLEY | 44,693,966 | 44,322,857 | -371,109 | 0.03 | 0.04 | +0.01 | sell |
| SB INVESTMENT ADVISERS (UK) LTD | 59,952,652 | 40,315,127 | -19,637,525 | 5.36 | 4.60 | -0.75 | sell |
| BlackRock, Inc. | 40,316,307 | 39,724,879 | -591,428 | 0.01 | 0.01 | +0.00 | sell |
| VANGUARD GROUP INC | 39,326,336 | 38,804,928 | -521,408 | 0.01 | 0.01 | +0.00 | sell |
| QVT Financial LP | 29,381,635 | 29,381,635 | 0 | 46.25 | 49.35 | +3.10 | hold |
| VIKING GLOBAL INVESTORS LP | 34,237,779 | 23,594,831 | -10,642,948 | 1.12 | 0.93 | -0.19 | sell |
| Rubric Capital Management LP | 20,370,336 | 20,000,000 | -370,336 | 3.69 | 4.06 | +0.37 | sell |
| STATE STREET CORP | 19,773,480 | 18,700,144 | -1,073,336 | 0.01 | 0.01 | +0.00 | sell |
| Patient Square Capital LP | 12,480,000 | 12,480,000 | 0 | 50.71 | 50.51 | -0.20 | hold |
| Two Seas Capital LP | 10,598,040 | 11,754,164 | +1,156,124 | 11.71 | 10.69 | -1.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 7,885,636 | 9,308,710 | +1,423,074 | 0.02 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 7,750,399 | 8,202,594 | +452,195 | 0.01 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 3,331,465 | 7,368,461 | +4,036,996 | 1.41 | 3.22 | +1.81 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,082,383 | 7,232,383 | +5,150,000 | 0.04 | 0.17 | +0.13 | buy |
| Bank of New York Mellon Corp | 4,506,400 | 4,630,948 | +124,548 | 0.01 | 0.01 | +0.00 | buy |
| BlackBarn Capital Partners LP | 4,625,000 | 4,400,000 | -225,000 | 17.27 | 21.72 | +4.45 | sell |
| STEMPOINT CAPITAL LP | 601,781 | 4,197,187 | +3,595,406 | 2.18 | 12.81 | +10.62 | buy |
| MARSHALL WACE, LLP | 955,150 | 3,978,001 | +3,022,851 | 0.01 | 0.07 | +0.05 | buy |
| BAKER BROS. ADVISORS LP | 3,767,773 | 3,767,773 | 0 | 0.41 | 0.41 | -0.00 | hold |
| Whitefort Capital Management, LP | 3,882,000 | 3,532,000 | -350,000 | 16.92 | 17.69 | +0.77 | sell |
| ADAR1 Capital Management, LLC | 1,940,797 | 3,347,501 | +1,406,704 | 3.55 | 5.02 | +1.46 | buy |
| NORTHERN TRUST CORP | 3,233,214 | 3,283,061 | +49,847 | 0.01 | 0.01 | +0.00 | buy |
| Sofinnova Investments, Inc. | 3,088,814 | 3,149,270 | +60,456 | 2.37 | 2.92 | +0.55 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,889,082 | 3,117,731 | +228,649 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 4,000,033 | 3,065,590 | -934,443 | 0.24 | 0.22 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,471,223 | 2,920,496 | +1,449,273 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 1,221,750 | 2,745,772 | +1,524,022 | 0.02 | 0.05 | +0.03 | buy |
| UBS Group AG | 5,093,068 | 2,744,956 | -2,348,112 | 0.01 | 0.01 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 2,779,427 | 2,714,798 | -64,629 | 0.79 | 0.99 | +0.20 | sell |
| BANK OF AMERICA CORP /DE/ | 2,652,043 | 2,687,805 | +35,762 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 2,951,132 | 2,608,294 | -342,838 | 0.08 | 0.09 | +0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 965,967 | 2,588,098 | +1,622,131 | 0.01 | 0.03 | +0.02 | buy |
| ROYAL BANK OF CANADA | 1,679,810 | 2,523,069 | +843,259 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 2,937,367 | 2,361,066 | -576,301 | 0.01 | 0.01 | -0.00 | sell |
| Nuveen, LLC | 2,281,526 | 2,292,986 | +11,460 | 0.01 | 0.01 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 2,281,123 | +2,281,123 | 0.00 | 0.12 | +0.12 | buy |
| DME Capital Management, LP | 4,551,057 | 2,275,529 | -2,275,528 | 2.21 | 1.35 | -0.85 | sell |
| Candriam S.C.A. | 1,503,994 | 2,157,995 | +654,001 | 0.10 | 0.17 | +0.07 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,775,349 | 2,123,617 | -651,732 | 0.01 | 0.01 | +0.00 | sell |
| Polar Capital Holdings Plc | 1,225,000 | 1,958,735 | +733,735 | 0.07 | 0.14 | +0.07 | buy |
| PENN DAVIS MCFARLAND INC | 1,691,632 | 1,862,088 | +170,456 | 2.15 | 2.91 | +0.76 | buy |
| Clearbridge Investments, LLC | 1,860,540 | 1,831,372 | -29,168 | 0.02 | 0.02 | +0.00 | sell |
| Impax Asset Management Group plc | 2,000,000 | 1,800,000 | -200,000 | 0.13 | 0.16 | +0.03 | sell |
| PointState Capital LP | 2,426,563 | 1,791,440 | -635,123 | 0.59 | 0.49 | -0.10 | sell |
| Invesco Ltd. | 1,684,099 | 1,769,358 | +85,259 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 156,345 | 1,759,880 | +1,603,535 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 1,486,699 | 1,759,635 | +272,936 | 0.01 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 2,211,675 | 1,433,029 | -778,646 | 0.05 | 0.05 | -0.01 | sell |
| Prosight Management, LP | 1,808,539 | 1,335,500 | -473,039 | 4.97 | 4.85 | -0.12 | sell |
| JPMORGAN CHASE & CO | 783,927 | 1,229,197 | +445,270 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 2,114,867 | 1,208,755 | -906,112 | 0.01 | 0.01 | -0.00 | sell |
| RHUMBLINE ADVISERS | 1,029,698 | 1,028,262 | -1,436 | 0.01 | 0.01 | +0.00 | sell |
| Blue Owl Capital Holdings LP | 0 | 988,249 | +988,249 | 0.00 | 4.64 | +4.64 | buy |
| CITADEL ADVISORS LLC | 492,132 | 968,203 | +476,071 | 0.00 | 0.01 | +0.01 | buy |
| First Turn Management, LLC | 0 | 959,703 | +959,703 | 0.00 | 2.18 | +2.18 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 972,335 | 953,933 | -18,402 | 0.01 | 0.01 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 0 | 943,163 | +943,163 | 0.00 | 0.20 | +0.20 | buy |
| FOURSIXTHREE CAPITAL LP | 900,000 | 938,175 | +38,175 | 4.65 | 4.98 | +0.33 | buy |
| Y-Intercept (Hong Kong) Ltd | 271,903 | 873,081 | +601,178 | 0.07 | 0.32 | +0.24 | buy |
| Affinity Asset Advisors, LLC | 400,000 | 800,000 | +400,000 | 0.67 | 1.13 | +0.46 | buy |
| Integral Health Asset Management, LLC | 600,000 | 750,000 | +150,000 | 0.63 | 0.83 | +0.20 | buy |
| Parkside Financial Bank & Trust | 1,309,541 | 698,520 | -611,021 | 1.59 | 0.82 | -0.77 | sell |
| ExodusPoint Capital Management, LP | 404,744 | 632,908 | +228,164 | 0.06 | 0.13 | +0.08 | buy |
| Verition Fund Management LLC | 498,570 | 629,497 | +130,927 | 0.03 | 0.05 | +0.02 | buy |
| PDT Partners, LLC | 795,426 | 617,462 | -177,964 | 0.51 | 0.59 | +0.08 | sell |
| Swiss National Bank | 681,646 | 593,246 | -88,400 | 0.00 | 0.01 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 542,185 | 556,803 | +14,618 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 611,156 | 549,329 | -61,827 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 83,684 | 548,059 | +464,375 | 0.00 | 0.01 | +0.01 | buy |
| WINTON GROUP Ltd | 208,064 | 543,333 | +335,269 | 0.12 | 0.31 | +0.19 | buy |
| Retirement Systems of Alabama | 514,551 | 520,157 | +5,606 | 0.02 | 0.03 | +0.01 | buy |
| Tejara Capital Ltd | 463,013 | 506,095 | +43,082 | 2.42 | 4.20 | +1.78 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 42,326 | 497,823 | +455,497 | 0.00 | 0.01 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 547,840 | 495,957 | -51,883 | 0.07 | 0.08 | +0.01 | sell |
| Alyeska Investment Group, L.P. | 115,866 | 494,455 | +378,589 | 0.00 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 119,775 | 486,244 | +366,469 | 0.01 | 0.03 | +0.02 | buy |
| Man Group plc | 152,512 | 484,154 | +331,642 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 598,231 | 475,873 | -122,358 | 0.02 | 0.02 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 385,949 | 467,199 | +81,250 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 133,707 | 458,589 | +324,882 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 463,169 | 448,361 | -14,808 | 0.00 | 0.00 | +0.00 | sell |
| Brandywine Global Investment Management, LLC | 443,896 | 443,469 | -427 | 0.04 | 0.05 | +0.01 | sell |
| Pier Capital, LLC | 396,304 | 394,684 | -1,620 | 0.68 | 0.93 | +0.25 | sell |
| DekaBank Deutsche Girozentrale | 350,000 | 350,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 336,407 | 336,424 | +17 | 0.00 | 0.01 | +0.00 | buy |
| Gotham Asset Management, LLC | 39,149 | 330,475 | +291,326 | 0.00 | 0.02 | +0.02 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 0 | 329,935 | +329,935 | 0.00 | 0.02 | +0.02 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 330,414 | 325,757 | -4,657 | 0.01 | 0.01 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 162,400 | 316,200 | +153,800 | 0.00 | 0.00 | +0.00 | buy |
| THOMPSON SIEGEL & WALMSLEY LLC | 527,074 | 282,624 | -244,450 | 0.10 | 0.07 | -0.03 | sell |
| Pine Ridge Advisers LLC | 276,530 | 276,530 | 0 | 0.20 | 0.29 | +0.09 | hold |
| Pictet Asset Management Holding SA | 273,298 | 259,743 | -13,555 | 0.00 | 0.00 | +0.00 | sell |
| LMR Partners LLP | 444,444 | 256,750 | -187,694 | 0.08 | 0.05 | -0.03 | sell |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 221,921 | 255,921 | +34,000 | 0.01 | 0.01 | +0.00 | buy |
| CenterBook Partners LP | 99,990 | 247,443 | +147,453 | 0.06 | 0.18 | +0.12 | buy |
| Nicholas Investment Partners, LP | 0 | 245,621 | +245,621 | 0.00 | 0.28 | +0.28 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 481,335 | 239,420 | -241,915 | 0.36 | 0.23 | -0.13 | sell |
| Neo Ivy Capital Management | 72,030 | 237,392 | +165,362 | 0.26 | 0.88 | +0.62 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 182,693 | 229,037 | +46,344 | 0.00 | 0.00 | +0.00 | buy |