| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 60,766,984 | 65,779,464 | +5,012,480 | 0.05 | 0.07 | +0.02 | buy |
| MORGAN STANLEY | 44,322,857 | 58,359,553 | +14,036,696 | 0.04 | 0.08 | +0.04 | buy |
| VANGUARD GROUP INC | 38,804,928 | 42,059,041 | +3,254,113 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 39,724,879 | 41,170,475 | +1,445,596 | 0.01 | 0.02 | +0.00 | buy |
| QVT Financial LP | 29,381,635 | 26,387,021 | -2,994,614 | 49.35 | 54.38 | +5.03 | sell |
| UBS Group AG | 2,744,956 | 18,390,792 | +15,645,836 | 0.01 | 0.08 | +0.07 | buy |
| STATE STREET CORP | 18,700,144 | 17,361,465 | -1,338,679 | 0.01 | 0.01 | +0.00 | sell |
| SB INVESTMENT ADVISERS (UK) LTD | 40,315,127 | 16,413,603 | -23,901,524 | 4.60 | 3.56 | -1.04 | sell |
| GOLDMAN SACHS GROUP INC | 2,361,066 | 10,982,683 | +8,621,617 | 0.01 | 0.03 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 7,232,383 | 10,677,894 | +3,445,511 | 0.17 | 0.35 | +0.18 | buy |
| Two Seas Capital LP | 11,754,164 | 9,791,891 | -1,962,273 | 10.69 | 12.45 | +1.76 | sell |
| DIMENSIONAL FUND ADVISORS LP | 9,308,710 | 9,247,468 | -61,242 | 0.03 | 0.04 | +0.01 | sell |
| Rubric Capital Management LP | 20,000,000 | 9,000,000 | -11,000,000 | 4.06 | 2.34 | -1.73 | sell |
| Patient Square Capital LP | 12,480,000 | 8,166,047 | -4,313,953 | 50.51 | 37.93 | -12.57 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 8,202,594 | 8,153,546 | -49,048 | 0.01 | 0.01 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 7,368,461 | 7,985,461 | +617,000 | 3.22 | 3.17 | -0.05 | buy |
| Assenagon Asset Management S.A. | 59,764 | 6,937,112 | +6,877,348 | 0.00 | 0.23 | +0.22 | buy |
| VIKING GLOBAL INVESTORS LP | 23,594,831 | 6,443,191 | -17,151,640 | 0.93 | 0.37 | -0.56 | sell |
| BAKER BROS. ADVISORS LP | 3,767,773 | 5,555,017 | +1,787,244 | 0.41 | 0.71 | +0.29 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,920,496 | 5,335,125 | +2,414,629 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 0 | 5,195,859 | +5,195,859 | 0.00 | 0.01 | +0.01 | buy |
| Jefferies Financial Group Inc. | 0 | 3,514,833 | +3,514,833 | 0.00 | 0.62 | +0.62 | buy |
| MARSHALL WACE, LLP | 3,978,001 | 3,458,926 | -519,075 | 0.07 | 0.07 | +0.01 | sell |
| ADAR1 Capital Management, LLC | 3,347,501 | 3,428,962 | +81,461 | 5.02 | 5.57 | +0.55 | buy |
| NORTHERN TRUST CORP | 3,283,061 | 3,285,928 | +2,867 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 3,117,731 | 3,239,696 | +121,965 | 0.01 | 0.01 | +0.00 | buy |
| BlackBarn Capital Partners LP | 4,400,000 | 3,084,300 | -1,315,700 | 21.72 | 24.00 | +2.27 | sell |
| BANK OF AMERICA CORP /DE/ | 2,687,805 | 2,928,328 | +240,523 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 142,778 | 2,918,109 | +2,775,331 | 0.00 | 0.03 | +0.03 | buy |
| Bank of New York Mellon Corp | 4,630,948 | 2,903,129 | -1,727,819 | 0.01 | 0.01 | -0.00 | sell |
| Polar Capital Holdings Plc | 1,958,735 | 2,690,124 | +731,389 | 0.14 | 0.27 | +0.12 | buy |
| Candriam S.C.A. | 2,157,995 | 2,490,426 | +332,431 | 0.17 | 0.27 | +0.10 | buy |
| JENNISON ASSOCIATES LLC | 0 | 2,353,386 | +2,353,386 | 0.00 | 0.03 | +0.03 | buy |
| Pictet Asset Management Holding SA | 259,743 | 2,312,436 | +2,052,693 | 0.00 | 0.05 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,759,880 | 2,294,506 | +534,626 | 0.02 | 0.03 | +0.01 | buy |
| CITADEL ADVISORS LLC | 968,203 | 2,286,001 | +1,317,798 | 0.01 | 0.03 | +0.02 | buy |
| Invesco Ltd. | 1,769,358 | 2,281,487 | +512,129 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 2,292,986 | 2,249,867 | -43,119 | 0.01 | 0.01 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 2,714,798 | 2,190,907 | -523,891 | 0.99 | 0.97 | -0.01 | sell |
| Whitefort Capital Management, LP | 3,532,000 | 2,120,000 | -1,412,000 | 17.69 | 13.92 | -3.77 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,123,617 | 2,084,609 | -39,008 | 0.01 | 0.01 | +0.00 | sell |
| DME Capital Management, LP | 2,275,529 | 2,069,309 | -206,220 | 1.35 | 1.58 | +0.22 | sell |
| NATIONAL BANK OF CANADA /FI/ | 0 | 2,040,000 | +2,040,000 | 0.00 | 0.05 | +0.05 | buy |
| Clearbridge Investments, LLC | 1,831,372 | 1,972,921 | +141,549 | 0.02 | 0.03 | +0.01 | buy |
| PENN DAVIS MCFARLAND INC | 1,862,088 | 1,858,289 | -3,799 | 2.91 | 3.86 | +0.95 | sell |
| Woodline Partners LP | 3,065,590 | 1,750,017 | -1,315,573 | 0.22 | 0.15 | -0.07 | sell |
| CITIGROUP INC | 1,759,635 | 1,711,744 | -47,891 | 0.02 | 0.03 | +0.01 | sell |
| Affinity Asset Advisors, LLC | 800,000 | 1,700,000 | +900,000 | 1.13 | 2.65 | +1.52 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 2,281,123 | 1,672,720 | -608,403 | 0.12 | 0.13 | +0.01 | sell |
| Man Group plc | 484,154 | 1,457,127 | +972,973 | 0.01 | 0.06 | +0.05 | buy |
| BANK OF NOVA SCOTIA | 0 | 1,423,000 | +1,423,000 | 0.00 | 0.05 | +0.05 | buy |
| JANE STREET GROUP, LLC | 2,745,772 | 1,311,585 | -1,434,187 | 0.05 | 0.03 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 458,589 | 1,286,197 | +827,608 | 0.01 | 0.04 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,588,098 | 1,197,592 | -1,390,506 | 0.03 | 0.02 | -0.01 | sell |
| First Turn Management, LLC | 959,703 | 1,186,817 | +227,114 | 2.18 | 2.94 | +0.76 | buy |
| Parkside Financial Bank & Trust | 698,520 | 1,166,756 | +468,236 | 0.82 | 1.90 | +1.08 | buy |
| Amundi | 32,416 | 1,043,464 | +1,011,048 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 1,028,262 | 1,037,631 | +9,369 | 0.01 | 0.02 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 4,197,187 | 966,698 | -3,230,489 | 12.81 | 3.60 | -9.21 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 953,933 | 941,222 | -12,711 | 0.01 | 0.01 | +0.00 | sell |
| JPMORGAN CHASE & CO | 1,229,197 | 934,533 | -294,664 | 0.00 | 0.00 | +0.00 | sell |
| Gotham Asset Management, LLC | 330,475 | 925,193 | +594,718 | 0.02 | 0.07 | +0.05 | buy |
| AQR CAPITAL MANAGEMENT LLC | 70,371 | 880,773 | +810,402 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 750,000 | 850,000 | +100,000 | 0.83 | 0.93 | +0.11 | buy |
| BARCLAYS PLC | 1,208,755 | 839,279 | -369,476 | 0.01 | 0.01 | +0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 759,219 | +759,219 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 593,246 | 740,646 | +147,400 | 0.01 | 0.01 | +0.00 | buy |
| Sofinnova Investments, Inc. | 3,149,270 | 734,582 | -2,414,688 | 2.92 | 0.69 | -2.24 | sell |
| Verition Fund Management LLC | 629,497 | 728,997 | +99,500 | 0.05 | 0.09 | +0.03 | buy |
| ALGERT GLOBAL LLC | 0 | 706,554 | +706,554 | 0.00 | 0.24 | +0.24 | buy |
| AMERIPRISE FINANCIAL INC | 448,361 | 645,448 | +197,087 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 38,289 | 641,461 | +603,172 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 0 | 631,004 | +631,004 | 0.00 | 0.02 | +0.02 | buy |
| Prosight Management, LP | 1,335,500 | 627,162 | -708,338 | 4.85 | 2.81 | -2.04 | sell |
| ROYAL BANK OF CANADA | 2,523,069 | 613,609 | -1,909,460 | 0.01 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 247,443 | 611,833 | +364,390 | 0.18 | 0.65 | +0.46 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 467,199 | 598,515 | +131,316 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 549,329 | 589,673 | +40,344 | 0.00 | 0.00 | +0.00 | buy |
| ING GROEP NV | 0 | 588,400 | +588,400 | 0.00 | 0.08 | +0.08 | buy |
| TD ASSET MANAGEMENT INC | 316,200 | 551,376 | +235,176 | 0.00 | 0.01 | +0.01 | buy |
| Impax Asset Management Group plc | 1,800,000 | 550,000 | -1,250,000 | 0.16 | 0.07 | -0.08 | sell |
| ALLIANCEBERNSTEIN L.P. | 556,803 | 542,047 | -14,756 | 0.00 | 0.00 | +0.00 | sell |
| Retirement Systems of Alabama | 520,157 | 525,863 | +5,706 | 0.03 | 0.04 | +0.01 | buy |
| Squarepoint Ops LLC | 1,433,029 | 516,955 | -916,074 | 0.05 | 0.02 | -0.02 | sell |
| MUFG Securities EMEA plc | 0 | 492,000 | +492,000 | 0.00 | 0.12 | +0.12 | buy |
| GILDER GAGNON HOWE & CO LLC | 495,957 | 483,117 | -12,840 | 0.08 | 0.11 | +0.03 | sell |
| PDT Partners, LLC | 617,462 | 464,944 | -152,518 | 0.59 | 0.65 | +0.07 | sell |
| Capricorn Fund Managers Ltd | 198,500 | 445,500 | +247,000 | 1.01 | 2.33 | +1.32 | buy |
| Weiss Asset Management LP | 49,410 | 425,565 | +376,155 | 0.01 | 0.13 | +0.12 | buy |
| D. E. Shaw & Co., Inc. | 548,059 | 395,404 | -152,655 | 0.01 | 0.01 | -0.00 | sell |
| Pier Capital, LLC | 394,684 | 391,061 | -3,623 | 0.93 | 1.35 | +0.42 | sell |
| Dorsey Wright & Associates | 0 | 376,106 | +376,106 | 0.00 | 1.76 | +1.76 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 336,424 | 358,559 | +22,135 | 0.01 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 112,220 | 351,467 | +239,247 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 350,000 | 350,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Voleon Capital Management LP | 96,573 | 342,421 | +245,848 | 0.04 | 0.16 | +0.12 | buy |
| Neo Ivy Capital Management | 237,392 | 341,354 | +103,962 | 0.88 | 1.17 | +0.29 | buy |
| WINTON GROUP Ltd | 543,333 | 326,362 | -216,971 | 0.31 | 0.24 | -0.06 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 325,757 | 325,757 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Rafferty Asset Management, LLC | 475,873 | 294,783 | -181,090 | 0.02 | 0.02 | -0.00 | sell |