| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 7,232,383 | 10,677,894 | +3,445,511 | 0.17 | 0.35 | +0.18 | buy |
| VANGUARD GROUP INC | 38,804,928 | 42,059,041 | +3,254,113 | 0.01 | 0.01 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,920,496 | 5,335,125 | +2,414,629 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 3,767,773 | 5,555,017 | +1,787,244 | 0.41 | 0.71 | +0.29 | buy |
| Affinity Asset Advisors, LLC | 800,000 | 1,700,000 | +900,000 | 1.13 | 2.65 | +1.52 | buy |
| Y-Intercept (Hong Kong) Ltd | 873,081 | 67,342 | +805,739 | 0.34 | 0.03 | 0.00 | sell |
| Polar Capital Holdings Plc | 1,958,735 | 2,690,124 | +731,389 | 0.14 | 0.27 | +0.12 | buy |
| PERCEPTIVE ADVISORS LLC | 7,368,461 | 7,985,461 | +617,000 | 3.22 | 3.09 | -0.13 | buy |
| Gotham Asset Management, LLC | 330,475 | 925,193 | +594,718 | 0.02 | 0.07 | +0.05 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,759,880 | 2,294,506 | +534,626 | 0.02 | 0.03 | 0.00 | buy |
| CenterBook Partners LP | 247,443 | 611,833 | +364,390 | 0.18 | 0.65 | +0.46 | buy |
| Candriam S.C.A. | 2,157,995 | 2,490,426 | +332,431 | 0.17 | 0.27 | +0.10 | buy |
| Capricorn Fund Managers Ltd | 198,500 | 445,500 | +247,000 | 1.01 | 2.33 | +1.32 | buy |
| Voleon Capital Management LP | 96,573 | 342,421 | +245,848 | 0.04 | 0.16 | +0.12 | buy |
| TD ASSET MANAGEMENT INC | 316,200 | 551,376 | +235,176 | 0.00 | 0.01 | +0.01 | buy |
| First Turn Management, LLC | 959,703 | 1,186,817 | +227,114 | 2.18 | 2.94 | +0.76 | buy |
| Clearbridge Investments, LLC | 1,831,372 | 1,972,921 | +141,549 | 0.02 | 0.03 | +0.01 | buy |
| Neo Ivy Capital Management | 237,392 | 341,354 | +103,962 | 0.88 | 1.17 | +0.29 | buy |
| Integral Health Asset Management, LLC | 750,000 | 850,000 | +100,000 | 0.83 | 0.93 | +0.11 | buy |
| ADAR1 Capital Management, LLC | 3,347,501 | 3,428,962 | +81,461 | 5.02 | 5.57 | +0.55 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 8,202,594 | 8,153,546 | +49,048 | 0.01 | 0.01 | 0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 81,080 | 120,515 | +39,435 | 0.10 | 0.20 | +0.10 | buy |
| Nicholas Investment Partners, LP | 245,621 | 279,856 | +34,235 | 0.28 | 0.44 | +0.16 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 336,424 | 358,559 | +22,135 | 0.01 | 0.01 | +0.00 | buy |
| BAMCO INC /NY/ | 105,000 | 125,000 | +20,000 | 0.00 | 0.01 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 114,050 | 131,860 | +17,810 | 0.00 | 0.01 | 0.00 | buy |
| AXQ CAPITAL, LP | 12,981 | 27,879 | +14,898 | 0.08 | 0.14 | +0.06 | buy |
| DnB Asset Management AS | 48,831 | 61,407 | +12,576 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 119,699 | 129,330 | +9,631 | 0.15 | 0.22 | +0.07 | buy |
| PROFUND ADVISORS LLC | 106,639 | 113,033 | +6,394 | 0.05 | 0.08 | 0.00 | buy |
| Retirement Systems of Alabama | 520,157 | 525,863 | +5,706 | 0.03 | 0.04 | +0.01 | buy |
| ProShare Advisors LLC | 42,626 | 48,290 | +5,664 | 0.00 | 0.00 | 0.00 | buy |
| HANTZ FINANCIAL SERVICES, INC. | 17,629 | 22,438 | +4,809 | 0.00 | 0.01 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 109,571 | 111,895 | +2,324 | 0.04 | 0.05 | +0.01 | buy |
| Wedmont Private Capital | 13,215 | 15,462 | +2,247 | 0.01 | 0.01 | +0.00 | buy |
| YOUSIF CAPITAL MANAGEMENT, LLC | 138,225 | 139,552 | +1,327 | 0.02 | 0.04 | 0.00 | buy |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 102,400 | 103,500 | +1,100 | 0.01 | 0.01 | +0.00 | buy |
| Rakuten Securities, Inc. | 2 | 872 | +870 | 0.00 | 0.01 | +0.01 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 110,414 | 109,646 | +768 | 0.01 | 0.01 | +0.00 | sell |
| Clearstead Trust, LLC | 104 | 228 | +124 | 0.00 | 0.00 | +0.00 | buy |
| Miracle Mile Advisors, LLC | 14,192 | 14,292 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Meiji Yasuda Asset Management Co Ltd. | 10,191 | 10,054 | -137 | 0.01 | 0.01 | +0.00 | sell |
| SECURIAN ASSET MANAGEMENT, INC | 32,148 | 31,932 | -216 | 0.01 | 0.03 | +0.01 | sell |
| T. Rowe Price Investment Management, Inc. | 2,629 | 2,048 | -581 | 0.00 | 0.00 | +0.00 | sell |
| FIRST MANHATTAN CO. LLC. | 12,100 | 11,146 | -954 | 0.00 | 0.00 | +0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 14,692 | 13,668 | -1,024 | 0.00 | 0.01 | +0.00 | sell |
| Pier Capital, LLC | 394,684 | 391,061 | -3,623 | 0.93 | 1.35 | +0.42 | sell |
| PENN DAVIS MCFARLAND INC | 1,862,088 | 1,858,289 | -3,799 | 2.91 | 3.86 | +0.95 | sell |
| SECTORAL ASSET MANAGEMENT INC | 50,007 | 45,347 | -4,660 | 0.47 | 0.79 | +0.32 | sell |
| CREDIT INDUSTRIEL ET COMMERCIAL | 155,000 | 150,000 | -5,000 | 0.37 | 0.48 | +0.10 | sell |
| Inspire Investing, LLC | 20,361 | 15,246 | -5,115 | 0.03 | 0.03 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 38,744 | 30,922 | -7,822 | 0.17 | 0.18 | +0.01 | sell |
| FNY Investment Advisers, LLC | 9,582 | 60 | -9,522 | 0.05 | 0.00 | -0.05 | sell |
| GILDER GAGNON HOWE & CO LLC | 495,957 | 483,117 | -12,840 | 0.08 | 0.11 | +0.03 | sell |
| Persistent Asset Partners Ltd | 27,667 | 14,121 | -13,546 | 0.30 | 0.15 | -0.16 | sell |
| INCEPTIONR LLC | 66,059 | 40,410 | -25,649 | 0.24 | 0.24 | +0.00 | sell |
| Elevate Capital Advisors, LLC | 113,781 | 77,545 | -36,236 | 1.20 | 1.11 | -0.09 | sell |
| Anfield Capital Management, LLC | 155,644 | 118,951 | -36,693 | 0.69 | 0.81 | +0.12 | sell |
| SummitTX Capital, L.P. | 105,083 | 65,887 | -39,196 | 0.07 | 0.04 | -0.02 | sell |
| CITIGROUP INC | 1,759,635 | 1,711,744 | -47,891 | 0.02 | 0.03 | +0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 239,420 | 189,146 | -50,274 | 0.23 | 0.95 | +0.71 | sell |
| Te Ahumairangi Investment Management Ltd | 163,207 | 108,407 | -54,800 | 0.42 | 0.42 | +0.00 | sell |
| PDT Partners, LLC | 617,462 | 464,944 | -152,518 | 0.59 | 0.65 | +0.07 | sell |
| Rafferty Asset Management, LLC | 475,873 | 294,783 | -181,090 | 0.02 | 0.02 | -0.00 | sell |
| DME Capital Management, LP | 2,275,529 | 2,069,309 | -206,220 | 1.35 | 1.58 | +0.22 | sell |
| WINTON GROUP Ltd | 543,333 | 326,362 | -216,971 | 0.31 | 0.24 | -0.06 | sell |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 329,935 | 76,161 | -253,774 | 0.02 | 0.01 | -0.02 | sell |
| ORBIMED ADVISORS LLC | 2,714,798 | 2,190,907 | -523,891 | 0.99 | 0.97 | -0.01 | sell |
| Prosight Management, LP | 1,335,500 | 627,162 | -708,338 | 4.71 | 2.81 | -1.90 | sell |
| Blue Owl Capital Holdings LP | 988,249 | 263,249 | -725,000 | 4.64 | 1.76 | -2.88 | sell |
| Impax Asset Management Group plc | 1,800,000 | 550,000 | -1,250,000 | 0.16 | 0.07 | -0.08 | sell |
| BlackBarn Capital Partners LP | 4,400,000 | 3,084,300 | -1,315,700 | 21.72 | 24.00 | +2.27 | sell |
| Whitefort Capital Management, LP | 3,532,000 | 2,120,000 | -1,412,000 | 17.69 | 13.92 | -3.77 | sell |
| Two Seas Capital LP | 11,754,164 | 9,791,891 | -1,962,273 | 10.69 | 12.45 | +1.76 | sell |
| Sofinnova Investments, Inc. | 3,149,270 | 734,582 | -2,414,688 | 2.61 | 0.69 | -1.92 | sell |
| QVT Financial LP | 29,381,635 | 26,387,021 | -2,994,614 | 31.37 | 49.10 | +17.73 | sell |
| STEMPOINT CAPITAL LP | 4,197,187 | 966,698 | -3,230,489 | 12.81 | 3.60 | -9.21 | sell |
| Patient Square Capital LP | 12,480,000 | 8,166,047 | -4,313,953 | 50.51 | 37.93 | -12.57 | sell |
| Rubric Capital Management LP | 20,000,000 | 9,000,000 | -11,000,000 | 3.41 | 2.34 | -1.08 | sell |
| VIKING GLOBAL INVESTORS LP | 23,594,831 | 6,443,191 | -17,151,640 | 0.93 | 0.37 | -0.56 | sell |
| SB INVESTMENT ADVISERS (UK) LTD | 40,315,127 | 16,413,603 | -23,901,524 | 4.60 | 3.56 | -1.04 | sell |