| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 3,785,877 | 6,583,755 | +2,797,878 | 0.01 | 0.02 | +0.01 | buy |
| Darwin Global Management, Ltd. | 0 | 473,200 | +473,200 | 0.00 | 2.39 | +2.39 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 466,000 | +466,000 | 0.00 | 0.10 | +0.10 | buy |
| First Turn Management, LLC | 0 | 464,435 | +464,435 | 0.00 | 2.64 | +2.64 | buy |
| VANGUARD GROUP INC | 39,446 | 497,181 | +457,735 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 30,326 | 330,225 | +299,899 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 239,915 | +239,915 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 108,486 | 319,563 | +211,077 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 188,053 | +188,053 | 0.00 | 0.03 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 635,455 | 812,860 | +177,405 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 0 | 152,578 | +152,578 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 20,252 | 161,921 | +141,669 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 0 | 134,426 | +134,426 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 576,711 | 707,590 | +130,879 | 0.01 | 0.03 | +0.01 | buy |
| Walleye Capital LLC | 0 | 111,478 | +111,478 | 0.00 | 0.05 | +0.05 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,000 | 1,105,200 | +105,200 | 0.04 | 0.08 | +0.03 | buy |
| Candriam S.C.A. | 0 | 105,000 | +105,000 | 0.00 | 0.03 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 101,503 | +101,503 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 0 | 100,527 | +100,527 | 0.00 | 0.04 | +0.04 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.37 | +0.37 | buy |
| Logos Global Management LP | 150,000 | 250,000 | +100,000 | 0.36 | 1.00 | +0.64 | buy |
| Nicholas Investment Partners, LP | 0 | 89,962 | +89,962 | 0.00 | 0.35 | +0.35 | buy |
| HRT FINANCIAL LP | 0 | 78,996 | +78,996 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 78,529 | +78,529 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 66,340 | +66,340 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 0 | 64,400 | +64,400 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 0 | 60,968 | +60,968 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 57,678 | +57,678 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 687,090 | 741,904 | +54,814 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 0 | 51,188 | +51,188 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 6,440 | 49,500 | +43,060 | 0.06 | 0.51 | +0.45 | buy |
| Swiss National Bank | 0 | 39,100 | +39,100 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 36,332 | +36,332 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 35,500 | +35,500 | 0.00 | 0.01 | +0.01 | buy |
| NBW CAPITAL LLC | 0 | 34,360 | +34,360 | 0.00 | 0.27 | +0.27 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 32,397 | +32,397 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 31,800 | +31,800 | 0.00 | 0.00 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 30,038 | +30,038 | 0.00 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 24,657 | +24,657 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 26,150 | 49,303 | +23,153 | 0.01 | 0.02 | +0.01 | buy |
| Jump Financial, LLC | 0 | 22,800 | +22,800 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 10,297 | 31,757 | +21,460 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 18,158 | +18,158 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 17,938 | +17,938 | 0.00 | 0.11 | +0.11 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 17,803 | +17,803 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 17,032 | +17,032 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 16,213 | +16,213 | 0.00 | 0.05 | +0.05 | buy |
| Engineers Gate Manager LP | 0 | 15,653 | +15,653 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 14,632 | +14,632 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 365 | 14,670 | +14,305 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 13,977 | +13,977 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 13,143 | +13,143 | 0.00 | 0.26 | +0.26 | buy |
| EFG Asset Management (North America) Corp. | 0 | 11,151 | +11,151 | 0.00 | 0.07 | +0.07 | buy |
| LMR Partners LLP | 0 | 11,093 | +11,093 | 0.00 | 0.01 | +0.01 | buy |
| Polymer Capital Management (HK) LTD | 0 | 10,520 | +10,520 | 0.00 | 0.10 | +0.10 | buy |
| Squarepoint Ops LLC | 0 | 8,161 | +8,161 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 8,075 | +8,075 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 7,210 | +7,210 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 6,050 | +6,050 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 5,445 | +5,445 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 2,523 | +2,523 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 2,242 | +2,242 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,580 | 3,828 | +1,248 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 48,536 | 49,468 | +932 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 45,498 | 45,962 | +464 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 298 | +298 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 125,000 | 125,000 | 0 | 0.46 | 0.74 | +0.28 | hold |
| Blackstone Inc. | 19,991 | 19,991 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 2,232,760 | 2,232,760 | 0 | 0.75 | 1.25 | +0.50 | hold |
| Carlyle Group Inc. | 9,620 | 9,620 | 0 | 0.01 | 0.02 | +0.01 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 162,395 | 162,395 | 0 | 0.16 | 0.26 | +0.10 | hold |
| Avoro Capital Advisors LLC | 1,839,138 | 1,839,138 | 0 | 0.55 | 0.81 | +0.27 | hold |
| IFP Advisors, Inc | 114 | 114 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fairmount Funds Management LLC | 378,421 | 378,421 | 0 | 0.86 | 1.56 | +0.70 | hold |
| Pacific Capital Wealth Advisors, Inc. | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Commodore Capital LP | 1,884,084 | 1,884,084 | 0 | 3.54 | 4.78 | +1.24 | hold |
| Polar Capital Holdings Plc | 500,000 | 500,000 | 0 | 0.07 | 0.10 | +0.03 | hold |
| BRAIDWELL LP | 515,000 | 515,000 | 0 | 0.41 | 0.63 | +0.22 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Parallel Advisors, LLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 6,239 | 5,838 | -401 | 0.09 | 0.12 | +0.03 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,169 | 0 | -1,169 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 26,210 | 24,472 | -1,738 | 0.01 | 0.01 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 28,095 | 13,355 | -14,740 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 2,606,679 | 2,556,679 | -50,000 | 1.25 | 1.71 | +0.46 | sell |
| Prosight Management, LP | 55,000 | 0 | -55,000 | 0.48 | 0.00 | -0.48 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 771,902 | 687,080 | -84,822 | 0.20 | 0.26 | +0.06 | sell |
| Affinity Asset Advisors, LLC | 517,554 | 410,000 | -107,554 | 2.22 | 2.53 | +0.31 | sell |
| VR Adviser, LLC | 2,372,714 | 2,171,782 | -200,932 | 3.50 | 3.92 | +0.42 | sell |
| STEMPOINT CAPITAL LP | 378,766 | 62,253 | -316,513 | 2.20 | 0.63 | -1.57 | sell |
| HighVista Strategies LLC | 577,616 | 154,381 | -423,235 | 4.51 | 2.09 | -2.42 | sell |
| Global Endowment Management, LP | 513,436 | 18,184 | -495,252 | 1.23 | 0.07 | -1.16 | sell |
| BVF INC/IL | 687,080 | 0 | -687,080 | 0.37 | 0.00 | -0.37 | sell |
| Cormorant Asset Management, LP | 937,080 | 250,000 | -687,080 | 0.97 | 0.42 | -0.55 | sell |
| Deep Track Capital, LP | 1,952,760 | 1,213,420 | -739,340 | 1.47 | 1.32 | -0.15 | sell |
| EcoR1 Capital, LLC | 887,076 | 0 | -887,076 | 0.50 | 0.00 | -0.50 | sell |