| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital International Investors | 0 | 2,392,541 | +2,392,541 | 0.00 | 0.01 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 2,050,000 | +2,050,000 | 0.00 | 1.83 | +1.83 | buy |
| Paradigm Biocapital Advisors LP | 1,527,205 | 2,127,205 | +600,000 | 1.24 | 1.58 | +0.34 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 427,075 | +427,075 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 8,801,266 | 9,038,553 | +237,287 | 0.01 | 0.01 | -0.00 | buy |
| BlackRock, Inc. | 3,399,591 | 3,572,674 | +173,083 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 392,197 | 552,243 | +160,046 | 0.00 | 0.00 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 115,470 | 257,432 | +141,962 | 0.01 | 0.02 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 0 | 136,139 | +136,139 | 0.00 | 0.70 | +0.70 | buy |
| Woodline Partners LP | 352,680 | 464,808 | +112,128 | 0.06 | 0.05 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 966,129 | 1,059,563 | +93,434 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 123,071 | 214,606 | +91,535 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 255,256 | 335,467 | +80,211 | 0.00 | 0.00 | -0.00 | buy |
| Polar Capital Holdings Plc | 750,000 | 825,000 | +75,000 | 0.10 | 0.08 | -0.02 | buy |
| Squarepoint Ops LLC | 15,231 | 72,011 | +56,780 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,846,473 | 2,898,267 | +51,794 | 0.00 | 0.00 | -0.00 | buy |
| Blackstone Inc. | 449,201 | 489,248 | +40,047 | 0.05 | 0.03 | -0.01 | buy |
| WEXFORD CAPITAL LP | 0 | 38,292 | +38,292 | 0.00 | 0.16 | +0.16 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 18,784 | 55,833 | +37,049 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,089 | 58,696 | +35,607 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 1,216,954 | 1,248,854 | +31,900 | 0.32 | 0.35 | +0.03 | buy |
| NORTHERN TRUST CORP | 348,983 | 379,875 | +30,892 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 28,499 | +28,499 | 0.00 | 0.02 | +0.02 | buy |
| B Group, Inc. | 50,000 | 70,000 | +20,000 | 0.71 | 0.98 | +0.27 | buy |
| Waverly Advisors, LLC | 0 | 19,430 | +19,430 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,680,936 | 1,697,115 | +16,179 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 15,033 | +15,033 | 0.00 | 0.05 | +0.05 | buy |
| Bank of New York Mellon Corp | 103,688 | 114,240 | +10,552 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 73,752 | 83,464 | +9,712 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 7,122 | +7,122 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 6,861 | +6,861 | 0.00 | 0.03 | +0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 14,043 | 20,428 | +6,385 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 35,248 | 41,556 | +6,308 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 19,663 | 25,207 | +5,544 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 24,718 | 30,035 | +5,317 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,741 | 27,018 | +4,277 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 31,484 | 34,901 | +3,417 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 48,981 | 52,138 | +3,157 | 0.00 | 0.00 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 386,384 | 389,422 | +3,038 | 0.55 | 0.45 | -0.10 | buy |
| F/m Investments LLC | 48,806 | 51,844 | +3,038 | 0.04 | 0.03 | -0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 379,650 | 382,636 | +2,986 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 17,213 | 19,595 | +2,382 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 21,382 | 23,733 | +2,351 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 7,378 | 8,767 | +1,389 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 52,762 | 53,901 | +1,139 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 11,767 | 12,903 | +1,136 | 0.01 | 0.01 | -0.00 | buy |
| EMERALD ADVISERS, LLC | 546,791 | 547,827 | +1,036 | 0.49 | 0.40 | -0.10 | buy |
| AlphaQuest LLC | 2,198 | 3,191 | +993 | 0.01 | 0.01 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,392 | 4,046 | +654 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 8 | 374 | +366 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 37,490 | 37,844 | +354 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 0 | 270 | +270 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,232 | 1,502 | +270 | 0.00 | 0.00 | -0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 206 | +206 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,198 | 1,379 | +181 | 0.00 | 0.00 | -0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 133 | +133 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 126 | +126 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 22,652 | 22,726 | +74 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 120 | 184 | +64 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,955 | 2,016 | +61 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 0 | 44 | +44 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Stephens Consulting, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 8 | 24 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 14 | 28 | +14 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 40 | 50 | +10 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 9 | 13 | +4 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 450,000 | 450,000 | 0 | 0.20 | 0.14 | -0.06 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,598 | 32,598 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 36,230 | 36,230 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 95,159 | 95,159 | 0 | 0.82 | 0.59 | -0.23 | hold |
| RTW INVESTMENTS, LP | 3,621,996 | 3,621,996 | 0 | 1.28 | 0.89 | -0.38 | hold |
| Global Endowment Management, LP | 18,184 | 18,184 | 0 | 0.05 | 0.04 | -0.02 | hold |
| NBW CAPITAL LLC | 19,430 | 19,430 | 0 | 0.08 | 0.07 | -0.01 | hold |
| Swiss National Bank | 68,600 | 68,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ARMISTICE CAPITAL, LLC | 200,000 | 200,000 | 0 | 0.11 | 0.09 | -0.02 | hold |
| VR Adviser, LLC | 2,685,448 | 2,685,448 | 0 | 4.29 | 3.69 | -0.60 | hold |
| IFP Advisors, Inc | 109 | 109 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 7,800 | 7,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fairmount Funds Management LLC | 4,018,101 | 4,018,101 | 0 | 9.30 | 10.06 | +0.76 | hold |
| Commodore Capital LP | 1,988,084 | 1,988,084 | 0 | 3.39 | 2.36 | -1.03 | hold |
| SBI Securities Co., Ltd. | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Deep Track Capital, LP | 219,015 | 219,015 | 0 | 0.19 | 0.11 | -0.08 | hold |
| Covestor Ltd | 4 | 4 | 0 | 0.00 | 0.00 | 0.00 | hold |
| BRAIDWELL LP | 2,578,404 | 2,578,404 | 0 | 1.78 | 1.46 | -0.32 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 1,589 | 1,589 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1,470 | 1,470 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 25,799 | 25,799 | 0 | 0.01 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,265 | 10,265 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pacific Capital Wealth Advisors, Inc. | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 760,642 | 760,628 | -14 | 0.00 | 0.00 | -0.00 | sell |
| Amundi | 32 | 5 | -27 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 55 | 0 | -55 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 68 | 0 | -68 | 0.00 | 0.00 | -0.00 | sell |
| Arizona State Retirement System | 10,115 | 10,017 | -98 | 0.00 | 0.00 | -0.00 | sell |
| Brooklyn Investment Group | 120 | 0 | -120 | 0.00 | 0.00 | -0.00 | sell |