SPYRE THERAPEUTICS INC
| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 3,069,225 | 3,783,225 | +714,000 | 1.84 | 3.77 | +1.93 | buy |
| Paradigm Biocapital Advisors LP | 1,467,266 | 1,957,266 | +490,000 | 1.29 | 2.02 | +0.73 | buy |
| Capital World Investors | 200,172 | 666,564 | +466,392 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 34,051 | 338,323 | +304,272 | 0.08 | 1.03 | +0.94 | buy |
| Candriam S.C.A. | 425,534 | 610,282 | +184,748 | 0.07 | 0.16 | +0.09 | buy |
| STEMPOINT CAPITAL LP | 32,377 | 167,606 | +135,229 | 0.18 | 1.62 | +1.44 | buy |
| Polar Capital Holdings Plc | 740,326 | 792,847 | +52,521 | 0.11 | 0.17 | +0.06 | buy |
| Persistent Asset Partners Ltd | 2,246 | 4,803 | +2,557 | 0.04 | 0.09 | +0.06 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 6,930 | 9,080 | +2,150 | 0.01 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 12,644 | 13,938 | +1,294 | 0.03 | 0.05 | +0.02 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,523 | 1,743 | +220 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 7,913 | 8,110 | +197 | 0.07 | 0.11 | +0.04 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 187,737 | 186,618 | -1,119 | 0.89 | 1.11 | +0.22 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 412,371 | 408,113 | -4,258 | 0.66 | 1.00 | +0.34 | sell |
| F/m Investments LLC | 103,718 | 99,460 | -4,258 | 0.13 | 0.33 | +0.20 | sell |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 13,724 | 6,140 | -7,584 | 0.07 | 0.45 | +0.38 | sell |
| Cinctive Capital Management LP | 35,935 | 27,430 | -8,505 | 0.07 | 0.09 | +0.02 | sell |
| Neo Ivy Capital Management | 18,261 | 598 | -17,663 | 0.09 | 0.01 | -0.09 | sell |
| EMERALD ADVISERS, LLC | 636,109 | 613,365 | -22,744 | 0.64 | 0.98 | +0.34 | sell |
| HighVista Strategies LLC | 188,206 | 146,264 | -41,942 | 1.59 | 2.04 | +0.45 | sell |
| ARMISTICE CAPITAL, LLC | 196,426 | 120,931 | -75,495 | 0.16 | 0.20 | +0.04 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,882,420 | 2,790,785 | -91,635 | 0.64 | 1.03 | +0.39 | sell |
| Patient Square Capital LP | 150,000 | 1,000 | -149,000 | 1.05 | 0.01 | -1.04 | sell |
| Affinity Asset Advisors, LLC | 1,432,591 | 1,279,134 | -153,457 | 3.37 | 3.78 | +0.41 | sell |
| Commodore Capital LP | 2,388,245 | 1,912,380 | -475,865 | 5.21 | 5.58 | +0.37 | sell |
| BRAIDWELL LP | 1,634,615 | 932,823 | -701,792 | 1.71 | 1.57 | -0.14 | sell |
| Capital International Investors | 3,492,541 | 1,746,129 | -1,746,412 | 0.02 | 0.02 | +0.00 | sell |