| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 11,638,819 | 11,781,024 | +142,205 | 0.02 | 0.03 | +0.01 | buy |
| BlackRock, Inc. | 5,522,101 | 5,521,221 | -880 | 0.00 | 0.00 | +0.00 | sell |
| RTW INVESTMENTS, LP | 4,171,996 | 4,171,996 | 0 | 1.37 | 2.09 | +0.72 | hold |
| Fairmount Funds Management LLC | 4,018,101 | 4,018,101 | 0 | 10.02 | 14.64 | +4.62 | hold |
| PERCEPTIVE ADVISORS LLC | 3,069,225 | 3,783,225 | +714,000 | 1.84 | 3.77 | +1.93 | buy |
| VR Adviser, LLC | 3,685,448 | 3,685,448 | 0 | 5.96 | 6.94 | +0.97 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,882,420 | 2,790,785 | -91,635 | 0.64 | 1.03 | +0.39 | sell |
| STATE STREET CORP | 2,262,839 | 2,607,031 | +344,192 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 1,467,266 | 1,957,266 | +490,000 | 1.29 | 2.02 | +0.73 | buy |
| Commodore Capital LP | 2,388,245 | 1,912,380 | -475,865 | 5.21 | 5.58 | +0.37 | sell |
| TCG Crossover Management, LLC | 1,900,582 | 1,900,582 | 0 | 2.06 | 2.74 | +0.68 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,892,200 | 1,892,200 | 0 | 3.06 | 4.85 | +1.79 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 1,549,284 | 1,824,811 | +275,527 | 0.01 | 0.02 | +0.01 | buy |
| Capital International Investors | 3,492,541 | 1,746,129 | -1,746,412 | 0.02 | 0.02 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,659,140 | 1,720,912 | +61,772 | 0.00 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,829,009 | 1,656,164 | -172,845 | 0.03 | 0.04 | +0.01 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,621,620 | 1,621,620 | 0 | 0.54 | 0.87 | +0.32 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,601,882 | 1,598,730 | -3,152 | 0.01 | 0.01 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 1,432,591 | 1,279,134 | -153,457 | 3.37 | 3.78 | +0.41 | sell |
| BANK OF AMERICA CORP /DE/ | 419,727 | 1,228,093 | +808,366 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,000,000 | 1,000,000 | 0 | 0.19 | 0.29 | +0.10 | hold |
| JPMORGAN CHASE & CO | 62,951 | 979,299 | +916,348 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 1,634,615 | 932,823 | -701,792 | 1.71 | 1.57 | -0.14 | sell |
| FRANKLIN RESOURCES INC | 1,109,274 | 882,833 | -226,441 | 0.01 | 0.01 | +0.00 | sell |
| Caligan Partners LP | 0 | 878,127 | +878,127 | 0.00 | 3.13 | +3.13 | buy |
| Siren, L.L.C. | 818,598 | 818,598 | 0 | 0.80 | 1.14 | +0.34 | hold |
| Polar Capital Holdings Plc | 740,326 | 792,847 | +52,521 | 0.11 | 0.17 | +0.06 | buy |
| UBS Group AG | 680,566 | 671,235 | -9,331 | 0.00 | 0.01 | +0.00 | sell |
| Capital World Investors | 200,172 | 666,564 | +466,392 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 636,109 | 613,365 | -22,744 | 0.64 | 0.98 | +0.34 | sell |
| Candriam S.C.A. | 425,534 | 610,282 | +184,748 | 0.07 | 0.16 | +0.09 | buy |
| NORTHERN TRUST CORP | 561,023 | 578,907 | +17,884 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 574,622 | 562,653 | -11,969 | 0.00 | 0.00 | +0.00 | sell |
| Pictet Asset Management Holding SA | 913,960 | 491,649 | -422,311 | 0.03 | 0.03 | -0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 412,371 | 408,113 | -4,258 | 0.66 | 1.00 | +0.34 | sell |
| SAMLYN CAPITAL, LLC | 0 | 396,661 | +396,661 | 0.00 | 0.34 | +0.34 | buy |
| ADAR1 Capital Management, LLC | 34,051 | 338,323 | +304,272 | 0.08 | 1.03 | +0.94 | buy |
| Blackstone Inc. | 500,998 | 292,847 | -208,151 | 0.07 | 0.06 | -0.01 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 146,079 | 292,126 | +146,047 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 275,065 | 269,938 | -5,127 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 265,892 | 265,892 | 0 | 0.03 | 0.05 | +0.02 | hold |
| MORGAN STANLEY | 182,734 | 246,719 | +63,985 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 62,216 | 207,314 | +145,098 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 193,031 | +193,031 | 0.00 | 0.22 | +0.22 | buy |
| Bank of New York Mellon Corp | 192,830 | 191,395 | -1,435 | 0.00 | 0.00 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 187,737 | 186,618 | -1,119 | 0.89 | 1.11 | +0.22 | sell |
| FIRST TRUST ADVISORS LP | 0 | 178,389 | +178,389 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 171,211 | 170,381 | -830 | 0.01 | 0.01 | +0.01 | sell |
| STEMPOINT CAPITAL LP | 32,377 | 167,606 | +135,229 | 0.18 | 1.62 | +1.44 | buy |
| AMERIPRISE FINANCIAL INC | 38,256 | 159,217 | +120,961 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 150,980 | 153,899 | +2,919 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 148,537 | +148,537 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 76,194 | 146,639 | +70,445 | 0.00 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 188,206 | 146,264 | -41,942 | 1.59 | 2.04 | +0.45 | sell |
| MARSHALL WACE, LLP | 0 | 139,259 | +139,259 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 149,822 | 137,390 | -12,432 | 0.00 | 0.01 | +0.00 | sell |
| Invesco Ltd. | 150,934 | 132,390 | -18,544 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 121,941 | 129,242 | +7,301 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 196,426 | 120,931 | -75,495 | 0.16 | 0.20 | +0.04 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 129,013 | 112,841 | -16,172 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 63,904 | 108,135 | +44,231 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 100,000 | 100,000 | 0 | 0.25 | 0.34 | +0.09 | hold |
| B Group, Inc. | 100,000 | 100,000 | 0 | 2.43 | 3.74 | +1.31 | hold |
| F/m Investments LLC | 103,718 | 99,460 | -4,258 | 0.13 | 0.33 | +0.20 | sell |
| Swiss National Bank | 96,500 | 96,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ExodusPoint Capital Management, LP | 37,871 | 87,065 | +49,194 | 0.01 | 0.04 | +0.03 | buy |
| RHUMBLINE ADVISERS | 82,956 | 85,121 | +2,165 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 106,316 | 71,091 | -35,225 | 0.01 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 67,500 | 70,900 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 549 | 64,002 | +63,453 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 63,708 | 63,939 | +231 | 0.01 | 0.02 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 61,574 | 63,684 | +2,110 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 0 | 62,735 | +62,735 | 0.00 | 1.13 | +1.13 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 59,555 | +59,555 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 59,453 | +59,453 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,038 | 59,242 | +11,204 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 53,410 | 56,920 | +3,510 | 0.01 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 73,465 | 55,477 | -17,988 | 0.00 | 0.01 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 27,277 | 53,970 | +26,693 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 53,101 | 53,101 | 0 | 0.03 | 0.04 | +0.01 | hold |
| DIMENSIONAL FUND ADVISORS LP | 77,290 | 47,697 | -29,593 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 182,524 | 45,786 | -136,738 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 56,448 | 44,792 | -11,656 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 38,011 | 38,407 | +396 | 0.01 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,144 | 36,323 | +1,179 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 82,416 | 33,208 | -49,208 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 28,962 | +28,962 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 24,950 | 27,550 | +2,600 | 0.00 | 0.01 | +0.01 | buy |
| Cinctive Capital Management LP | 35,935 | 27,430 | -8,505 | 0.07 | 0.09 | +0.02 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 27,252 | 26,523 | -729 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 20,593 | 26,043 | +5,450 | 0.02 | 0.05 | +0.03 | buy |
| Waverly Advisors, LLC | 25,954 | 25,966 | +12 | 0.01 | 0.01 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 25,799 | 25,799 | 0 | 0.01 | 0.01 | +0.00 | hold |
| XTX Topco Ltd | 0 | 24,435 | +24,435 | 0.00 | 0.02 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 19,165 | 22,265 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| Ellsworth Advisors, LLC | 0 | 21,963 | +21,963 | 0.00 | 0.21 | +0.21 | buy |
| AQR CAPITAL MANAGEMENT LLC | 17,820 | 20,874 | +3,054 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 19,755 | +19,755 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 22,136 | 18,647 | -3,489 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 11,844 | 18,630 | +6,786 | 0.00 | 0.00 | +0.00 | buy |