| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Fairmount Funds Management LLC | 378,421 | 4,018,101 | +3,639,680 | 1.56 | 10.67 | +9.11 | buy |
| BRAIDWELL LP | 515,000 | 2,514,538 | +1,999,538 | 0.63 | 1.85 | +1.22 | buy |
| RTW INVESTMENTS, LP | 2,232,760 | 3,258,360 | +1,025,600 | 1.25 | 1.19 | -0.06 | buy |
| Deep Track Capital, LP | 1,213,420 | 1,756,667 | +543,247 | 1.32 | 1.23 | -0.09 | buy |
| VR Adviser, LLC | 2,171,782 | 2,685,448 | +513,666 | 3.92 | 4.02 | +0.10 | buy |
| PERCEPTIVE ADVISORS LLC | 2,556,679 | 3,031,018 | +474,339 | 1.70 | 1.72 | +0.02 | buy |
| Logos Global Management LP | 250,000 | 575,000 | +325,000 | 1.00 | 1.56 | +0.56 | buy |
| Blackstone Inc. | 19,991 | 292,995 | +273,004 | 0.00 | 0.03 | +0.03 | buy |
| Woodline Partners LP | 100,527 | 262,616 | +162,089 | 0.04 | 0.06 | +0.02 | buy |
| SOROS FUND MANAGEMENT LLC | 30,038 | 145,000 | +114,962 | 0.02 | 0.06 | +0.04 | buy |
| Commodore Capital LP | 1,884,084 | 1,988,084 | +104,000 | 4.78 | 3.19 | -1.59 | buy |
| Affinity Asset Advisors, LLC | 410,000 | 513,420 | +103,420 | 2.53 | 1.90 | -0.63 | buy |
| STEMPOINT CAPITAL LP | 62,253 | 150,450 | +88,197 | 0.63 | 1.04 | +0.41 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,105,200 | 1,152,411 | +47,211 | 0.08 | 0.05 | -0.03 | buy |
| EFG Asset Management (North America) Corp. | 11,151 | 36,781 | +25,630 | 0.07 | 0.15 | +0.08 | buy |
| GREAT POINT PARTNERS LLC | 125,000 | 134,612 | +9,612 | 0.74 | 0.61 | -0.13 | buy |
| VIRTUS ADVISERS, LLC | 5,838 | 2,797 | -3,041 | 0.12 | 0.03 | -0.09 | sell |
| ADAR1 Capital Management, LLC | 49,500 | 35,180 | -14,320 | 0.51 | 0.17 | -0.35 | sell |
| Darwin Global Management, Ltd. | 473,200 | 452,040 | -21,160 | 2.39 | 1.19 | -1.19 | sell |
| HighVista Strategies LLC | 154,381 | 113,550 | -40,831 | 2.09 | 0.98 | -1.11 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 162,395 | 107,310 | -55,085 | 0.23 | 0.09 | -0.14 | sell |