| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Fairmount Funds Management LLC | 378,421 | 4,018,101 | +3,639,680 | 1.56 | 10.67 | +9.11 | buy |
| BRAIDWELL LP | 515,000 | 2,514,538 | +1,999,538 | 0.63 | 1.85 | +1.22 | buy |
| VANGUARD GROUP INC | 497,181 | 1,911,566 | +1,414,385 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 134,426 | 1,409,659 | +1,275,233 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 2,232,760 | 3,258,360 | +1,025,600 | 1.25 | 1.19 | -0.06 | buy |
| FMR LLC | 6,583,755 | 7,507,983 | +924,228 | 0.02 | 0.01 | -0.01 | buy |
| JANUS HENDERSON GROUP PLC | 13,977 | 673,867 | +659,890 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 239,915 | 893,083 | +653,168 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 1,213,420 | 1,756,667 | +543,247 | 1.32 | 1.23 | -0.09 | buy |
| VR Adviser, LLC | 2,171,782 | 2,685,448 | +513,666 | 3.92 | 4.02 | +0.10 | buy |
| PERCEPTIVE ADVISORS LLC | 2,556,679 | 3,031,018 | +474,339 | 1.71 | 1.72 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 330,225 | 765,834 | +435,609 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 386,617 | +386,617 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 51,188 | 408,853 | +357,665 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 250,000 | 575,000 | +325,000 | 1.00 | 1.56 | +0.56 | buy |
| Blackstone Inc. | 19,991 | 292,995 | +273,004 | 0.00 | 0.03 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 32,397 | 272,636 | +240,239 | 0.00 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 78,529 | 307,976 | +229,447 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 466,000 | 666,000 | +200,000 | 0.10 | 0.09 | -0.01 | buy |
| Avidity Partners Management LP | 0 | 195,000 | +195,000 | 0.00 | 0.19 | +0.19 | buy |
| Woodline Partners LP | 100,527 | 262,616 | +162,089 | 0.04 | 0.06 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 36,332 | 191,169 | +154,837 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 136,000 | +136,000 | 0.00 | 0.08 | +0.08 | buy |
| SOROS FUND MANAGEMENT LLC | 30,038 | 145,000 | +114,962 | 0.03 | 0.08 | +0.05 | buy |
| Bank of New York Mellon Corp | 6,050 | 117,686 | +111,636 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 1,884,084 | 1,988,084 | +104,000 | 4.78 | 3.19 | -1.59 | buy |
| Affinity Asset Advisors, LLC | 410,000 | 513,420 | +103,420 | 2.53 | 1.90 | -0.63 | buy |
| Jefferies Financial Group Inc. | 0 | 97,573 | +97,573 | 0.00 | 0.05 | +0.05 | buy |
| STEMPOINT CAPITAL LP | 62,253 | 150,450 | +88,197 | 0.63 | 1.04 | +0.41 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 188,053 | 275,226 | +87,173 | 0.03 | 0.02 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15,000 | 98,181 | +83,181 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 82,475 | +82,475 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 70,843 | +70,843 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 67,109 | +67,109 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 0 | 51,896 | +51,896 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,105,200 | 1,152,411 | +47,211 | 0.08 | 0.05 | -0.03 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 45,571 | +45,571 | 0.00 | 1.35 | +1.35 | buy |
| UBS Group AG | 0 | 44,504 | +44,504 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 35,500 | 78,500 | +43,000 | 0.01 | 0.01 | +0.00 | buy |
| Jump Financial, LLC | 22,800 | 64,900 | +42,100 | 0.02 | 0.03 | +0.01 | buy |
| Walleye Capital LLC | 111,478 | 150,820 | +39,342 | 0.05 | 0.04 | -0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 36,230 | +36,230 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 36,100 | +36,100 | 0.00 | 0.02 | +0.02 | buy |
| Alpine Global Management, LLC | 0 | 33,858 | +33,858 | 0.00 | 0.14 | +0.14 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 30,121 | +30,121 | 0.00 | 0.00 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 11,151 | 36,781 | +25,630 | 0.07 | 0.15 | +0.08 | buy |
| JPMORGAN CHASE & CO | 0 | 22,772 | +22,772 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 66,340 | 85,588 | +19,248 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 45,962 | 64,043 | +18,081 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 298 | 16,245 | +15,947 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 2,242 | 17,175 | +14,933 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,657 | 37,782 | +13,125 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 12,606 | +12,606 | 0.00 | 0.01 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 11,800 | +11,800 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 11,607 | +11,607 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 125,000 | 134,612 | +9,612 | 0.74 | 0.61 | -0.13 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 9,030 | +9,030 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 8,788 | +8,788 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 17,032 | 23,263 | +6,231 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 5,545 | +5,545 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 3,392 | +3,392 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 1,523 | +1,523 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,803 | 19,105 | +1,302 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 0 | 1,198 | +1,198 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 382 | +382 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 64 | +64 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 1 | +1 | 0.00 | 0.00 | 0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Informed Momentum Co LLC | 17,938 | 17,938 | 0 | 0.11 | 0.07 | -0.04 | hold |
| Global Endowment Management, LP | 18,184 | 18,184 | 0 | 0.07 | 0.05 | -0.03 | hold |
| NBW CAPITAL LLC | 34,360 | 34,360 | 0 | 0.27 | 0.16 | -0.11 | hold |
| Carlyle Group Inc. | 9,620 | 9,620 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Candriam S.C.A. | 105,000 | 105,000 | 0 | 0.03 | 0.01 | -0.01 | hold |
| Avoro Capital Advisors LLC | 1,839,138 | 1,839,138 | 0 | 0.81 | 0.58 | -0.24 | hold |
| IFP Advisors, Inc | 114 | 114 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Integral Health Asset Management, LLC | 100,000 | 100,000 | 0 | 0.37 | 0.23 | -0.14 | hold |
| Pacific Capital Wealth Advisors, Inc. | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Polar Capital Holdings Plc | 500,000 | 500,000 | 0 | 0.10 | 0.07 | -0.03 | hold |
| First Turn Management, LLC | 464,435 | 464,435 | 0 | 2.64 | 1.78 | -0.86 | hold |
| FRANKLIN RESOURCES INC | 741,904 | 741,904 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 687,080 | 687,080 | 0 | 0.26 | 0.16 | -0.10 | hold |
| CITADEL ADVISORS LLC | 707,590 | 707,586 | -4 | 0.03 | 0.02 | -0.01 | sell |
| Point72 (DIFC) Ltd | 22 | 0 | -22 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 14,670 | 14,365 | -305 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,828 | 3,384 | -444 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 14,632 | 13,932 | -700 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 2,523 | 0 | -2,523 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 39,100 | 36,100 | -3,000 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 5,838 | 2,797 | -3,041 | 0.12 | 0.03 | -0.09 | sell |
| TWO SIGMA INVESTMENTS, LP | 13,355 | 9,842 | -3,513 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 16,213 | 11,016 | -5,197 | 0.05 | 0.02 | -0.03 | sell |
| Arizona State Retirement System | 5,445 | 0 | -5,445 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 7,210 | 0 | -7,210 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 8,075 | 0 | -8,075 | 0.01 | 0.00 | -0.01 | sell |
| Squarepoint Ops LLC | 8,161 | 0 | -8,161 | 0.00 | 0.00 | -0.00 | sell |
| Polymer Capital Management (HK) LTD | 10,520 | 0 | -10,520 | 0.10 | 0.00 | -0.10 | sell |
| LMR Partners LLP | 11,093 | 0 | -11,093 | 0.01 | 0.00 | -0.01 | sell |
| CITIGROUP INC | 31,757 | 19,320 | -12,437 | 0.00 | 0.00 | -0.00 | sell |