| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 2,050,000 | 3,200,000 | +1,150,000 | 1.83 | 2.42 | +0.59 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 450,000 | 613,665 | +163,665 | 0.14 | 0.17 | +0.02 | buy |
| Affinity Asset Advisors, LLC | 481,678 | 606,678 | +125,000 | 0.74 | 1.24 | +0.50 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 108,504 | 129,558 | +21,054 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 15,033 | 34,051 | +19,018 | 0.05 | 0.08 | +0.04 | buy |
| EMERALD ADVISERS, LLC | 547,827 | 565,863 | +18,036 | 0.40 | 0.31 | -0.09 | buy |
| HighVista Strategies LLC | 95,159 | 112,805 | +17,646 | 0.59 | 0.62 | +0.03 | buy |
| B Group, Inc. | 70,000 | 80,000 | +10,000 | 0.98 | 1.03 | +0.05 | buy |
| F/m Investments LLC | 51,844 | 52,546 | +702 | 0.03 | 0.03 | -0.00 | buy |
| Woodline Partners LP | 464,808 | 465,152 | +344 | 0.05 | 0.04 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 12,087 | 12,122 | +35 | 0.02 | 0.02 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 6,861 | 5,310 | -1,551 | 0.03 | 0.03 | -0.00 | sell |
| PROFUND ADVISORS LLC | 14,662 | 11,043 | -3,619 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 70,323 | 50,957 | -19,366 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 200,000 | 172,000 | -28,000 | 0.05 | 0.04 | -0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 389,422 | 329,430 | -59,992 | 0.45 | 0.30 | -0.15 | sell |
| Polar Capital Holdings Plc | 825,000 | 745,000 | -80,000 | 0.08 | 0.06 | -0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 803,200 | 610,200 | -193,000 | 0.02 | 0.02 | -0.01 | sell |
| Paradigm Biocapital Advisors LP | 2,127,205 | 1,870,445 | -256,760 | 1.58 | 1.20 | -0.38 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,717,312 | 2,085,590 | -631,722 | 0.42 | 0.25 | -0.17 | sell |
| PERCEPTIVE ADVISORS LLC | 2,313,272 | 1,529,445 | -783,827 | 1.32 | 0.85 | -0.47 | sell |