| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 2,050,000 | 3,200,000 | +1,150,000 | 1.83 | 2.42 | +0.59 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 248,542 | 930,481 | +681,939 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 0 | 626,703 | +626,703 | 0.00 | 0.09 | +0.09 | buy |
| BlackRock, Inc. | 3,572,674 | 4,007,296 | +434,622 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 335,467 | 671,044 | +335,577 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 197,068 | 523,416 | +326,348 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,898,267 | 3,066,586 | +168,319 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,059,563 | 1,227,232 | +167,669 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 55,833 | 223,320 | +167,487 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 450,000 | 613,665 | +163,665 | 0.14 | 0.17 | +0.02 | buy |
| Jefferies Financial Group Inc. | 1,248,854 | 1,388,854 | +140,000 | 0.35 | 0.34 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 481,678 | 606,678 | +125,000 | 1.22 | 1.34 | +0.13 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 106,142 | +106,142 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 251,846 | 354,116 | +102,270 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 22,368 | 113,968 | +91,600 | 0.00 | 0.00 | +0.00 | buy |
| Foresite Capital Management VI LLC | 0 | 70,000 | +70,000 | 0.00 | 0.59 | +0.59 | buy |
| ExodusPoint Capital Management, LP | 15,055 | 82,977 | +67,922 | 0.00 | 0.02 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 65,042 | +65,042 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 379,875 | 436,947 | +57,072 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 382,636 | 418,503 | +35,867 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 760,628 | 795,275 | +34,647 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 52,138 | 85,702 | +33,564 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 30,936 | +30,936 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 53,901 | 79,896 | +25,995 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 257,432 | 278,920 | +21,488 | 0.02 | 0.02 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 108,504 | 129,558 | +21,054 | 0.00 | 0.00 | -0.00 | buy |
| NATIXIS | 0 | 20,040 | +20,040 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 15,033 | 34,051 | +19,018 | 0.05 | 0.08 | +0.04 | buy |
| EMERALD ADVISERS, LLC | 547,827 | 565,863 | +18,036 | 0.40 | 0.31 | -0.09 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 17,973 | +17,973 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 114,240 | 132,150 | +17,910 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 95,159 | 112,805 | +17,646 | 0.59 | 0.62 | +0.03 | buy |
| RHUMBLINE ADVISERS | 56,023 | 73,168 | +17,145 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 9,038,553 | 9,053,034 | +14,481 | 0.01 | 0.01 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 12,873 | +12,873 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 10,843 | +10,843 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,068,892 | 1,079,443 | +10,551 | 0.02 | 0.02 | -0.00 | buy |
| B Group, Inc. | 70,000 | 80,000 | +10,000 | 0.98 | 1.03 | +0.05 | buy |
| Invesco Ltd. | 25,207 | 34,680 | +9,473 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,265 | 16,565 | +6,300 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 23,733 | 29,918 | +6,185 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 41,556 | 47,279 | +5,723 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 28,483 | 33,938 | +5,455 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 20,428 | 24,945 | +4,517 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 30,035 | 34,409 | +4,374 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,044 | 5,769 | +3,725 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,348 | 13,589 | +3,241 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,018 | 29,812 | +2,794 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 8,767 | 11,525 | +2,758 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 214,606 | 216,646 | +2,040 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 374 | 1,712 | +1,338 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 58,696 | 59,816 | +1,120 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 11,378 | 12,479 | +1,101 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,046 | 5,091 | +1,045 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 3,191 | 4,174 | +983 | 0.01 | 0.01 | +0.00 | buy |
| F/m Investments LLC | 51,844 | 52,546 | +702 | 0.03 | 0.03 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,598 | 33,201 | +603 | 0.00 | 0.00 | -0.00 | buy |
| Brooklyn Investment Group | 0 | 520 | +520 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 10,017 | 10,512 | +495 | 0.00 | 0.00 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 377 | +377 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 184 | 546 | +362 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 464,808 | 465,152 | +344 | 0.05 | 0.04 | -0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,016 | 2,331 | +315 | 0.00 | 0.00 | -0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 170 | +170 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 165 | +165 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 145 | +145 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 34,901 | 35,046 | +145 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 142 | +142 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 50 | 140 | +90 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 28 | 102 | +74 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 24 | 65 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,087 | 12,122 | +35 | 0.02 | 0.02 | -0.00 | buy |
| Waverly Advisors, LLC | 19,430 | 19,453 | +23 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 13 | 30 | +17 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 5 | 11 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 4 | 6 | +2 | 0.00 | 0.00 | 0.00 | buy |
| US BANCORP \DE\ | 9 | 10 | +1 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 36,230 | 36,230 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Blackstone Inc. | 489,248 | 489,248 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Capital World Investors | 350,774 | 350,774 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 206 | 206 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 3,621,996 | 3,621,996 | 0 | 0.89 | 0.77 | -0.12 | hold |
| Global Endowment Management, LP | 18,184 | 18,184 | 0 | 0.04 | 0.04 | -0.00 | hold |
| NBW CAPITAL LLC | 19,430 | 19,430 | 0 | 0.07 | 0.06 | -0.01 | hold |
| Candriam S.C.A. | 246,030 | 246,030 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Capital International Investors | 2,392,541 | 2,392,541 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Swiss National Bank | 68,600 | 68,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 2,685,448 | 2,685,448 | 0 | 3.69 | 3.01 | -0.67 | hold |
| KLP KAPITALFORVALTNING AS | 7,800 | 7,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fairmount Funds Management LLC | 4,018,101 | 4,018,101 | 0 | 10.06 | 7.79 | -2.26 | hold |
| Commodore Capital LP | 1,988,084 | 1,988,084 | 0 | 2.36 | 2.10 | -0.26 | hold |
| Deep Track Capital, LP | 219,015 | 219,015 | 0 | 0.11 | 0.11 | -0.01 | hold |
| BRAIDWELL LP | 2,578,404 | 2,578,404 | 0 | 1.46 | 1.32 | -0.14 | hold |
| Siren, L.L.C. | 368,598 | 368,598 | 0 | 0.34 | 0.29 | -0.05 | hold |
| GF FUND MANAGEMENT CO. LTD. | 1,502 | 1,502 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 1,589 | 1,589 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1,470 | 1,470 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 25,799 | 25,799 | 0 | 0.00 | 0.00 | -0.00 | hold |