| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 1,957,266 | 3,840,778 | +1,883,512 | 2.02 | 6.38 | +4.37 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,722,300 | +1,722,300 | 0.00 | 0.21 | +0.21 | buy |
| Capital World Investors | 666,564 | 2,315,553 | +1,648,989 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,598,730 | 2,960,855 | +1,362,125 | 0.01 | 0.03 | +0.02 | buy |
| FMR LLC | 11,781,024 | 13,026,187 | +1,245,163 | 0.03 | 0.05 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 269,938 | 1,478,059 | +1,208,121 | 0.00 | 0.01 | +0.01 | buy |
| Holocene Advisors, LP | 0 | 1,015,170 | +1,015,170 | 0.00 | 0.21 | +0.21 | buy |
| BlackRock, Inc. | 5,521,221 | 6,506,605 | +985,384 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 139,259 | 991,693 | +852,434 | 0.01 | 0.07 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,720,912 | 2,562,265 | +841,353 | 0.01 | 0.01 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 652,958 | +652,958 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 882,833 | 1,472,943 | +590,110 | 0.01 | 0.03 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 1,228,093 | 1,777,854 | +549,761 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 3,783,225 | 4,319,496 | +536,271 | 3.77 | 5.95 | +2.18 | buy |
| STATE STREET CORP | 2,607,031 | 3,057,416 | +450,385 | 0.00 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 53,970 | 431,694 | +377,724 | 0.00 | 0.03 | +0.03 | buy |
| Integral Health Asset Management, LLC | 0 | 325,000 | +325,000 | 0.00 | 1.18 | +1.18 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 207,314 | 522,071 | +314,757 | 0.00 | 0.01 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 0 | 303,180 | +303,180 | 0.00 | 0.02 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 292,126 | 553,980 | +261,854 | 0.01 | 0.03 | +0.02 | buy |
| MORGAN STANLEY | 246,719 | 499,963 | +253,244 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 18,630 | 259,923 | +241,293 | 0.00 | 0.01 | +0.01 | buy |
| Bellevue Group AG | 0 | 229,931 | +229,931 | 0.00 | 0.43 | +0.43 | buy |
| Cormorant Asset Management, LP | 0 | 225,000 | +225,000 | 0.00 | 1.02 | +1.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 201,616 | +201,616 | 0.00 | 0.24 | +0.24 | buy |
| AMERIPRISE FINANCIAL INC | 159,217 | 356,082 | +196,865 | 0.00 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 792,847 | 988,009 | +195,162 | 0.17 | 0.25 | +0.07 | buy |
| ORBIMED ADVISORS LLC | 0 | 186,145 | +186,145 | 0.00 | 0.31 | +0.31 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 182,931 | +182,931 | 0.00 | 0.15 | +0.15 | buy |
| Neuberger Berman Group LLC | 0 | 180,884 | +180,884 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 671,235 | 843,071 | +171,836 | 0.01 | 0.01 | +0.01 | buy |
| Siren, L.L.C. | 818,598 | 968,598 | +150,000 | 1.14 | 1.75 | +0.60 | buy |
| Soleus Capital Management, L.P. | 0 | 147,000 | +147,000 | 0.00 | 0.45 | +0.45 | buy |
| Squarepoint Ops LLC | 0 | 139,605 | +139,605 | 0.00 | 0.02 | +0.02 | buy |
| Pictet Asset Management Holding SA | 491,649 | 628,138 | +136,489 | 0.03 | 0.05 | +0.03 | buy |
| SEVEN GRAND MANAGERS, LLC | 100,000 | 225,000 | +125,000 | 0.34 | 0.80 | +0.47 | buy |
| Russell Investments Group, Ltd. | 9,931 | 134,455 | +124,524 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 0 | 119,300 | +119,300 | 0.00 | 1.00 | +1.00 | buy |
| JPMORGAN CHASE & CO | 979,299 | 1,093,026 | +113,727 | 0.00 | 0.01 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.67 | +0.67 | buy |
| NORTHERN TRUST CORP | 578,907 | 674,529 | +95,622 | 0.00 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 55,477 | 147,042 | +91,565 | 0.01 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 562,653 | 652,958 | +90,305 | 0.00 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 85,950 | +85,950 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 0 | 82,991 | +82,991 | 0.00 | 0.26 | +0.26 | buy |
| RTW INVESTMENTS, LP | 4,171,996 | 4,251,996 | +80,000 | 2.09 | 3.22 | +1.13 | buy |
| CITIGROUP INC | 12,006 | 82,593 | +70,587 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 67,007 | +67,007 | 0.00 | 0.04 | +0.04 | buy |
| Informed Momentum Co LLC | 0 | 60,393 | +60,393 | 0.00 | 0.48 | +0.48 | buy |
| Hudson Bay Capital Management LP | 0 | 58,387 | +58,387 | 0.00 | 0.02 | +0.02 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 4,299 | 59,747 | +55,448 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 191,395 | 245,193 | +53,798 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 0 | 51,789 | +51,789 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 146,639 | 196,712 | +50,073 | 0.01 | 0.01 | +0.01 | buy |
| Monashee Investment Management LLC | 0 | 50,000 | +50,000 | 0.00 | 7.45 | +7.45 | buy |
| WELLS FARGO & COMPANY/MN | 33,208 | 82,506 | +49,298 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 45,786 | 94,069 | +48,283 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 46,217 | +46,217 | 0.00 | 0.36 | +0.36 | buy |
| DEUTSCHE BANK AG\ | 129,242 | 174,459 | +45,217 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 42,458 | +42,458 | 0.00 | 0.68 | +0.68 | buy |
| Rock Springs Capital Management LP | 0 | 42,254 | +42,254 | 0.00 | 0.18 | +0.18 | buy |
| Woodline Partners LP | 265,892 | 306,049 | +40,157 | 0.05 | 0.08 | +0.03 | buy |
| Maven Securities LTD | 0 | 40,000 | +40,000 | 0.00 | 0.24 | +0.24 | buy |
| Engineers Gate Manager LP | 0 | 38,474 | +38,474 | 0.00 | 0.04 | +0.04 | buy |
| Caption Management, LLC | 0 | 36,000 | +36,000 | 0.00 | 0.11 | +0.11 | buy |
| RAYMOND JAMES FINANCIAL INC | 19,755 | 53,627 | +33,872 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 30,000 | +30,000 | 0.00 | 0.05 | +0.05 | buy |
| PRUDENTIAL FINANCIAL INC | 59,555 | 87,370 | +27,815 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 153,899 | 181,105 | +27,206 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 26,452 | +26,452 | 0.00 | 0.00 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 26,420 | +26,420 | 0.00 | 0.06 | +0.06 | buy |
| XTX Topco Ltd | 24,435 | 50,483 | +26,048 | 0.02 | 0.06 | +0.04 | buy |
| Handelsbanken Fonder AB | 0 | 26,000 | +26,000 | 0.00 | 0.01 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 25,222 | +25,222 | 0.00 | 0.08 | +0.08 | buy |
| Freestone Grove Partners LP | 0 | 22,777 | +22,777 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 70,900 | 92,540 | +21,640 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 27,430 | 48,978 | +21,548 | 0.09 | 0.17 | +0.08 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 19,089 | +19,089 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,523 | 45,030 | +18,507 | 0.00 | 0.01 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 0 | 18,146 | +18,146 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 120,931 | 137,588 | +16,657 | 0.20 | 0.34 | +0.14 | buy |
| ALGERT GLOBAL LLC | 0 | 16,460 | +16,460 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 96,500 | 112,500 | +16,000 | 0.00 | 0.01 | +0.00 | buy |
| FIFTH THIRD BANCORP | 5 | 15,638 | +15,633 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 15,000 | +15,000 | 0.00 | 0.47 | +0.47 | buy |
| Allianz Asset Management GmbH | 0 | 14,100 | +14,100 | 0.00 | 0.00 | +0.00 | buy |
| Neo Ivy Capital Management | 598 | 14,551 | +13,953 | 0.01 | 0.30 | +0.29 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 12,771 | +12,771 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 12,457 | +12,457 | 0.00 | 0.10 | +0.10 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,955 | 26,143 | +12,188 | 0.00 | 0.00 | +0.00 | buy |
| Calamos Advisors LLC | 0 | 11,323 | +11,323 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,962 | 39,311 | +10,349 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 15,486 | 25,713 | +10,227 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 10,000 | +10,000 | 0.00 | 0.09 | +0.09 | buy |
| RHUMBLINE ADVISERS | 85,121 | 94,763 | +9,642 | 0.00 | 0.01 | +0.00 | buy |
| Quantbot Technologies LP | 88 | 8,884 | +8,796 | 0.00 | 0.03 | +0.03 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,790,785 | 2,799,166 | +8,381 | 1.03 | 1.44 | +0.41 | buy |
| Brevan Howard Capital Management LP | 0 | 8,288 | +8,288 | 0.00 | 0.01 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 7,666 | +7,666 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 4,500 | 11,500 | +7,000 | 0.00 | 0.00 | +0.00 | buy |