| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 11,781,024 | 13,026,187 | +1,245,163 | 0.03 | 0.05 | +0.02 | buy |
| BlackRock, Inc. | 5,521,221 | 6,506,605 | +985,384 | 0.00 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 3,783,225 | 4,319,496 | +536,271 | 3.77 | 5.95 | +2.18 | buy |
| RTW INVESTMENTS, LP | 4,171,996 | 4,251,996 | +80,000 | 2.09 | 3.22 | +1.13 | buy |
| Paradigm Biocapital Advisors LP | 1,957,266 | 3,840,778 | +1,883,512 | 2.02 | 6.38 | +4.37 | buy |
| STATE STREET CORP | 2,607,031 | 3,057,416 | +450,385 | 0.00 | 0.01 | +0.00 | buy |
| VR Adviser, LLC | 3,685,448 | 2,985,448 | -700,000 | 6.94 | 8.04 | +1.10 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,598,730 | 2,960,855 | +1,362,125 | 0.01 | 0.03 | +0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,790,785 | 2,799,166 | +8,381 | 1.03 | 1.44 | +0.41 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,720,912 | 2,562,265 | +841,353 | 0.01 | 0.01 | +0.01 | buy |
| Capital World Investors | 666,564 | 2,315,553 | +1,648,989 | 0.00 | 0.02 | +0.02 | buy |
| TCG Crossover Management, LLC | 1,900,582 | 1,900,582 | 0 | 2.74 | 4.06 | +1.31 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,892,200 | 1,892,200 | 0 | 4.85 | 7.63 | +2.78 | hold |
| BANK OF AMERICA CORP /DE/ | 1,228,093 | 1,777,854 | +549,761 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,722,300 | +1,722,300 | 0.00 | 0.21 | +0.21 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,824,811 | 1,581,505 | -243,306 | 0.02 | 0.02 | +0.01 | sell |
| GOLDMAN SACHS GROUP INC | 269,938 | 1,478,059 | +1,208,121 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 882,833 | 1,472,943 | +590,110 | 0.01 | 0.03 | +0.02 | buy |
| Affinity Asset Advisors, LLC | 1,279,134 | 1,279,134 | 0 | 3.78 | 5.55 | +1.77 | hold |
| JPMORGAN CHASE & CO | 979,299 | 1,093,026 | +113,727 | 0.00 | 0.01 | +0.00 | buy |
| Holocene Advisors, LP | 0 | 1,015,170 | +1,015,170 | 0.00 | 0.21 | +0.21 | buy |
| MARSHALL WACE, LLP | 139,259 | 991,693 | +852,434 | 0.01 | 0.07 | +0.07 | buy |
| Polar Capital Holdings Plc | 792,847 | 988,009 | +195,162 | 0.17 | 0.25 | +0.07 | buy |
| Siren, L.L.C. | 818,598 | 968,598 | +150,000 | 1.14 | 1.75 | +0.60 | buy |
| Capital International Investors | 1,746,129 | 955,196 | -790,933 | 0.02 | 0.02 | -0.00 | sell |
| BRAIDWELL LP | 932,823 | 879,467 | -53,356 | 1.57 | 2.89 | +1.32 | sell |
| Commodore Capital LP | 1,912,380 | 846,786 | -1,065,594 | 5.58 | 4.48 | -1.10 | sell |
| UBS Group AG | 671,235 | 843,071 | +171,836 | 0.01 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 578,907 | 674,529 | +95,622 | 0.00 | 0.01 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 652,958 | +652,958 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 562,653 | 652,958 | +90,305 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 491,649 | 628,138 | +136,489 | 0.03 | 0.05 | +0.03 | buy |
| EMERALD ADVISERS, LLC | 613,365 | 567,430 | -45,935 | 0.98 | 1.19 | +0.21 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 292,126 | 553,980 | +261,854 | 0.01 | 0.03 | +0.02 | buy |
| Candriam S.C.A. | 610,282 | 546,312 | -63,970 | 0.16 | 0.22 | +0.06 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 207,314 | 522,071 | +314,757 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 246,719 | 499,963 | +253,244 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 53,970 | 431,694 | +377,724 | 0.00 | 0.03 | +0.03 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 408,113 | 401,271 | -6,842 | 1.00 | 1.25 | +0.25 | sell |
| SAMLYN CAPITAL, LLC | 396,661 | 400,075 | +3,414 | 0.34 | 0.59 | +0.25 | buy |
| AMERIPRISE FINANCIAL INC | 159,217 | 356,082 | +196,865 | 0.00 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 325,000 | +325,000 | 0.00 | 1.18 | +1.18 | buy |
| Woodline Partners LP | 265,892 | 306,049 | +40,157 | 0.05 | 0.08 | +0.03 | buy |
| JENNISON ASSOCIATES LLC | 0 | 303,180 | +303,180 | 0.00 | 0.02 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 338,323 | 283,982 | -54,341 | 1.03 | 1.19 | +0.16 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 18,630 | 259,923 | +241,293 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 191,395 | 245,193 | +53,798 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 0 | 229,931 | +229,931 | 0.00 | 0.43 | +0.43 | buy |
| Cormorant Asset Management, LP | 0 | 225,000 | +225,000 | 0.00 | 1.02 | +1.02 | buy |
| SEVEN GRAND MANAGERS, LLC | 100,000 | 225,000 | +125,000 | 0.34 | 0.80 | +0.47 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 201,616 | +201,616 | 0.00 | 0.24 | +0.24 | buy |
| MILLENNIUM MANAGEMENT LLC | 146,639 | 196,712 | +50,073 | 0.01 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 0 | 186,145 | +186,145 | 0.00 | 0.31 | +0.31 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 182,931 | +182,931 | 0.00 | 0.15 | +0.15 | buy |
| Nuveen, LLC | 153,899 | 181,105 | +27,206 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 180,884 | +180,884 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 129,242 | 174,459 | +45,217 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 170,381 | 172,923 | +2,542 | 0.01 | 0.02 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 55,477 | 147,042 | +91,565 | 0.01 | 0.02 | +0.02 | buy |
| Soleus Capital Management, L.P. | 0 | 147,000 | +147,000 | 0.00 | 0.45 | +0.45 | buy |
| Squarepoint Ops LLC | 0 | 139,605 | +139,605 | 0.00 | 0.02 | +0.02 | buy |
| ARMISTICE CAPITAL, LLC | 120,931 | 137,588 | +16,657 | 0.20 | 0.34 | +0.14 | buy |
| Russell Investments Group, Ltd. | 9,931 | 134,455 | +124,524 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 148,537 | 126,620 | -21,917 | 0.01 | 0.02 | +0.00 | sell |
| Invesco Ltd. | 132,390 | 120,541 | -11,849 | 0.00 | 0.00 | -0.00 | sell |
| Blackstone Inc. | 292,847 | 120,177 | -172,670 | 0.06 | 0.03 | -0.03 | sell |
| Rhenman & Partners Asset Management AB | 0 | 119,300 | +119,300 | 0.00 | 1.00 | +1.00 | buy |
| TD ASSET MANAGEMENT INC | 137,390 | 115,990 | -21,400 | 0.01 | 0.01 | +0.00 | sell |
| Swiss National Bank | 96,500 | 112,500 | +16,000 | 0.00 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 167,606 | 106,926 | -60,680 | 1.62 | 1.64 | +0.02 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 112,841 | 104,516 | -8,325 | 0.00 | 0.01 | +0.00 | sell |
| CITADEL ADVISORS LLC | 108,135 | 103,100 | -5,035 | 0.00 | 0.01 | +0.00 | sell |
| Boxer Capital Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.67 | +0.67 | buy |
| RHUMBLINE ADVISERS | 85,121 | 94,763 | +9,642 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 45,786 | 94,069 | +48,283 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 99,460 | 92,618 | -6,842 | 0.33 | 0.42 | +0.08 | sell |
| ALLIANCEBERNSTEIN L.P. | 70,900 | 92,540 | +21,640 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 59,555 | 87,370 | +27,815 | 0.00 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 85,950 | +85,950 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 0 | 82,991 | +82,991 | 0.00 | 0.26 | +0.26 | buy |
| CITIGROUP INC | 12,006 | 82,593 | +70,587 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 33,208 | 82,506 | +49,298 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 146,264 | 77,807 | -68,457 | 2.04 | 1.57 | -0.46 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 71,091 | 71,145 | +54 | 0.01 | 0.01 | +0.00 | buy |
| B Group, Inc. | 100,000 | 70,000 | -30,000 | 3.74 | 3.53 | -0.21 | sell |
| Trexquant Investment LP | 0 | 67,007 | +67,007 | 0.00 | 0.04 | +0.04 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 59,242 | 64,687 | +5,445 | 0.00 | 0.01 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 60,393 | +60,393 | 0.00 | 0.48 | +0.48 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 186,618 | 59,959 | -126,659 | 1.11 | 0.59 | -0.52 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 4,299 | 59,747 | +55,448 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 58,387 | +58,387 | 0.00 | 0.02 | +0.02 | buy |
| Atle Fund Management AB | 62,735 | 57,030 | -5,705 | 1.13 | 1.36 | +0.24 | sell |
| RAYMOND JAMES FINANCIAL INC | 19,755 | 53,627 | +33,872 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 53,101 | 53,101 | 0 | 0.04 | 0.08 | +0.04 | hold |
| ROYCE & ASSOCIATES LP | 0 | 51,789 | +51,789 | 0.00 | 0.04 | +0.04 | buy |
| XTX Topco Ltd | 24,435 | 50,483 | +26,048 | 0.02 | 0.06 | +0.04 | buy |
| Monashee Investment Management LLC | 0 | 50,000 | +50,000 | 0.00 | 7.45 | +7.45 | buy |
| Legal & General Group Plc | 44,792 | 49,141 | +4,349 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 27,430 | 48,978 | +21,548 | 0.09 | 0.17 | +0.08 | buy |
| DIMENSIONAL FUND ADVISORS LP | 47,697 | 47,698 | +1 | 0.00 | 0.00 | +0.00 | buy |